AP877A - Tetrahydroquinoline derivatives as EAA antagonists. - Google Patents

Tetrahydroquinoline derivatives as EAA antagonists. Download PDF

Info

Publication number
AP877A
AP877A APAP/P/1999/001459A AP9901459A AP877A AP 877 A AP877 A AP 877A AP 9901459 A AP9901459 A AP 9901459A AP 877 A AP877 A AP 877A
Authority
AP
ARIPO
Prior art keywords
group
formula
compound
carboxylic acid
hydrogen
Prior art date
Application number
APAP/P/1999/001459A
Other languages
English (en)
Other versions
AP9901459A0 (en
Inventor
Romano D-Fabio
Alessandra Pasquarello
Fabio Maria Sabbatini
Original Assignee
Glaxo Wellcome Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa
Publication of AP9901459A0 publication Critical patent/AP9901459A0/xx
Application granted granted Critical
Publication of AP877A publication Critical patent/AP877A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1999/001459A 1996-08-17 1997-08-14 Tetrahydroquinoline derivatives as EAA antagonists. AP877A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9617305.9A GB9617305D0 (en) 1996-08-17 1996-08-17 Heterocyclic compounds
PCT/EP1997/004440 WO1998007704A1 (en) 1996-08-17 1997-08-14 Tetrahydroquinoline derivatives as eaa antagonists

Publications (2)

Publication Number Publication Date
AP9901459A0 AP9901459A0 (en) 1999-03-31
AP877A true AP877A (en) 2000-09-27

Family

ID=10798623

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1999/001459A AP877A (en) 1996-08-17 1997-08-14 Tetrahydroquinoline derivatives as EAA antagonists.

Country Status (34)

Country Link
US (1) US6479488B1 (ko)
EP (1) EP0922034B1 (ko)
JP (1) JP4108129B2 (ko)
KR (1) KR100552864B1 (ko)
CN (1) CN1131214C (ko)
AP (1) AP877A (ko)
AR (1) AR008296A1 (ko)
AT (1) ATE221052T1 (ko)
AU (1) AU724473B2 (ko)
BR (1) BR9711311B1 (ko)
CA (1) CA2264118C (ko)
CO (1) CO4900066A1 (ko)
CZ (1) CZ296250B6 (ko)
DE (1) DE69714265T2 (ko)
DK (1) DK0922034T3 (ko)
EA (1) EA001704B1 (ko)
ES (1) ES2181030T3 (ko)
GB (1) GB9617305D0 (ko)
HU (1) HU225797B1 (ko)
ID (1) ID18095A (ko)
IL (1) IL128141A0 (ko)
IS (1) IS4953A (ko)
MY (1) MY116952A (ko)
NO (1) NO312241B1 (ko)
NZ (1) NZ333812A (ko)
PE (1) PE107098A1 (ko)
PL (1) PL194532B1 (ko)
PT (1) PT922034E (ko)
SI (1) SI0922034T1 (ko)
TR (1) TR199900336T2 (ko)
TW (1) TW449582B (ko)
WO (1) WO1998007704A1 (ko)
YU (1) YU6799A (ko)
ZA (1) ZA977326B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9706294D0 (en) * 1997-03-26 1997-05-14 Glaxo Wellcome Spa Heterocyclic compound
MY125037A (en) * 1998-06-10 2006-07-31 Glaxo Wellcome Spa 1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en) * 2000-08-09 2002-09-24 Magnesium Diagnostics, Inc. Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) * 1999-12-08 2000-02-02 Glaxo Wellcome Spa Heterocyclic derivatives
DE10132725A1 (de) 2001-07-05 2006-08-03 Grünenthal GmbH Substituierte γ-Lactonverbindungen
WO2003057672A2 (en) * 2001-12-28 2003-07-17 Acadia Pharmaceuticals, Inc. Tetrahydroquinoline analogues as muscarinic agonists
WO2004064753A2 (en) * 2003-01-23 2004-08-05 Acadia Pharmaceuticals Inc Use of n-desmethylclozapine to treat human neuropsychiatric disease
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
WO2004073639A2 (en) * 2003-02-19 2004-09-02 Merck & Co. Inc. Treatment of psychosis with a muscarinic m1 receptor ectopic activator
SI1696931T1 (sl) * 2003-12-22 2009-08-31 Acadia Pharm Inc Amino substituirani diaril(a,d)cikloheptenski analogi kot muskarinski agonisti in postopki za zdravljenje nevropsihiatričnih motenj
US20050282800A1 (en) * 2004-04-01 2005-12-22 Bo-Ragnar Tolf Method of synthesis and isolation of solid N-desmethylclozapine and crystalline forms thereof
RU2451014C2 (ru) * 2005-07-22 2012-05-20 Мотида Фармасьютикал Ко., Лтд. Новое производное гетероциклиден ацетамида
ES2531621T3 (es) 2005-07-22 2015-03-18 Mochida Pharmaceutical Co., Ltd. Derivado de heterociclidenacetamida novedoso
AU2006291134C1 (en) 2005-09-12 2013-08-15 Abela Pharmaceuticals, Inc. Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same
US9427419B2 (en) 2005-09-12 2016-08-30 Abela Pharmaceuticals, Inc. Compositions comprising dimethyl sulfoxide (DMSO)
WO2007033180A1 (en) 2005-09-12 2007-03-22 Abela Pharmaceuticals, Inc. Materials for facilitating administration of dimethyl sulfoxide (dmso) and related compounds
US8480797B2 (en) 2005-09-12 2013-07-09 Abela Pharmaceuticals, Inc. Activated carbon systems for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
BRPI0921494A2 (pt) 2008-11-03 2018-10-30 Prad Reasearch And Development Ltd método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração.
US9839609B2 (en) 2009-10-30 2017-12-12 Abela Pharmaceuticals, Inc. Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis
AU2012321345B2 (en) 2011-10-03 2016-03-17 The University Of Utah Research Foundation Application of 5-HT6 receptor antagonists for the alleviation of cognitive deficits of down syndrome

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386839A2 (en) * 1989-03-08 1990-09-12 Merck Sharp & Dohme Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL186781B1 (pl) * 1995-09-29 2004-02-27 Glaxo Wellcome Spa Nowy związek, pochodna tetrahydrochinoliny, sposób wytwarzania pochodnej tetrahydrochinoliny, środek farmaceutyczny i zastosowanie

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0386839A2 (en) * 1989-03-08 1990-09-12 Merck Sharp & Dohme Ltd. Tetrahydroquinoline derivatives useful for neurodegenerative disorders

Also Published As

Publication number Publication date
MY116952A (en) 2004-04-30
EA001704B1 (ru) 2001-06-25
PL194532B1 (pl) 2007-06-29
EA199900121A1 (ru) 1999-10-28
DE69714265D1 (de) 2002-08-29
CZ296250B6 (cs) 2006-02-15
NO312241B1 (no) 2002-04-15
IS4953A (is) 1999-01-22
TW449582B (en) 2001-08-11
NZ333812A (en) 2000-07-28
GB9617305D0 (en) 1996-09-25
US6479488B1 (en) 2002-11-12
ID18095A (id) 1998-02-26
CA2264118C (en) 2008-06-17
YU6799A (sh) 2000-03-21
AR008296A1 (es) 1999-12-29
ES2181030T3 (es) 2003-02-16
NO990723L (no) 1999-04-14
HU225797B1 (en) 2007-09-28
EP0922034A1 (en) 1999-06-16
EP0922034B1 (en) 2002-07-24
AP9901459A0 (en) 1999-03-31
DE69714265T2 (de) 2003-03-06
CO4900066A1 (es) 2000-03-27
BR9711311A (pt) 1999-08-17
PT922034E (pt) 2002-12-31
AU724473B2 (en) 2000-09-21
CA2264118A1 (en) 1998-02-26
KR100552864B1 (ko) 2006-02-20
JP2001508031A (ja) 2001-06-19
TR199900336T2 (xx) 1999-04-21
HUP9903108A3 (en) 2004-04-28
ATE221052T1 (de) 2002-08-15
WO1998007704A1 (en) 1998-02-26
SI0922034T1 (en) 2003-02-28
PE107098A1 (es) 1999-01-15
PL331562A1 (en) 1999-07-19
DK0922034T3 (da) 2002-11-18
JP4108129B2 (ja) 2008-06-25
NO990723D0 (no) 1999-02-16
CN1227544A (zh) 1999-09-01
AU4551897A (en) 1998-03-06
KR20000068172A (ko) 2000-11-25
CN1131214C (zh) 2003-12-17
BR9711311B1 (pt) 2009-01-13
ZA977326B (en) 1999-02-15
CZ52999A3 (cs) 1999-07-14
IL128141A0 (en) 1999-11-30

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