AP714A - Benzopyrans and their use as therapeutic agents. - Google Patents

Benzopyrans and their use as therapeutic agents. Download PDF

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Publication number
AP714A
AP714A APAP/P/1996/000889A AP9600889A AP714A AP 714 A AP714 A AP 714A AP 9600889 A AP9600889 A AP 9600889A AP 714 A AP714 A AP 714A
Authority
AP
ARIPO
Prior art keywords
dihydro
acetyl
dimethyl
benzopyran
lbenzopyran
Prior art date
Application number
APAP/P/1996/000889A
Other languages
English (en)
Other versions
AP9600889A0 (en
Inventor
Wai Ngor Chan
Helen Kate Ann Morgan
Mervyn Thompson
John Morris Evans
Original Assignee
Smithkline Beecham Plc
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9411632A external-priority patent/GB9411632D0/en
Priority claimed from GB9411798A external-priority patent/GB9411798D0/en
Application filed by Smithkline Beecham Plc, Smithkline Beecham Farma filed Critical Smithkline Beecham Plc
Publication of AP9600889A0 publication Critical patent/AP9600889A0/xx
Application granted granted Critical
Publication of AP714A publication Critical patent/AP714A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
APAP/P/1996/000889A 1994-06-10 1995-05-31 Benzopyrans and their use as therapeutic agents. AP714A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9411632A GB9411632D0 (en) 1994-06-10 1994-06-10 Novel treatment
GB9411798A GB9411798D0 (en) 1994-06-13 1994-06-13 Novel treatment
PCT/EP1995/002076 WO1995034545A1 (en) 1994-06-10 1995-05-31 Benzopyrans and their use as therapeutic agents

Publications (2)

Publication Number Publication Date
AP9600889A0 AP9600889A0 (en) 1997-01-31
AP714A true AP714A (en) 1998-12-23

Family

ID=26305044

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1996/000889A AP714A (en) 1994-06-10 1995-05-31 Benzopyrans and their use as therapeutic agents.

Country Status (29)

Country Link
US (1) US5760074A (sk)
EP (2) EP0764157B1 (sk)
JP (2) JP3575767B2 (sk)
KR (1) KR100397721B1 (sk)
CN (2) CN1174975C (sk)
AP (1) AP714A (sk)
AT (2) ATE250052T1 (sk)
AU (1) AU701060B2 (sk)
BG (1) BG63339B1 (sk)
BR (1) BR9507980A (sk)
CA (1) CA2192480C (sk)
CY (1) CY2508B1 (sk)
CZ (1) CZ286081B6 (sk)
DE (2) DE69524871T2 (sk)
DK (2) DK1114821T3 (sk)
ES (2) ES2207590T3 (sk)
FI (1) FI120686B (sk)
HK (2) HK1001286A1 (sk)
HU (1) HUT76136A (sk)
NO (1) NO315651B1 (sk)
NZ (1) NZ287872A (sk)
OA (1) OA10593A (sk)
PL (1) PL188134B1 (sk)
PT (2) PT764157E (sk)
RO (1) RO113463B1 (sk)
SG (1) SG67930A1 (sk)
SI (2) SI0764157T1 (sk)
SK (1) SK281456B6 (sk)
WO (1) WO1995034545A1 (sk)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
US6492415B2 (en) * 1996-09-18 2002-12-10 Smithkline Beecham P.L.C. Use of benzopyranols to treat neurological disorders
GB9619492D0 (en) * 1996-09-18 1996-10-30 Smithkline Beecham Plc Novel treatment
GB9726543D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel compositions
GB9813949D0 (en) * 1998-06-29 1998-08-26 Smithkline Beecham Plc Novel compounds
GB0028697D0 (en) * 2000-11-23 2001-01-10 S P A Novel process
WO2006107019A1 (ja) * 2005-04-04 2006-10-12 Takeda Pharmaceutical Company Limited うつ病または不安神経症の予防または治療剤
WO2009147441A2 (en) * 2008-06-05 2009-12-10 Minster Research Limited Novel treatments
US20130281524A1 (en) * 2008-06-05 2013-10-24 Peter Blower Novel treatments
WO2011067608A1 (en) 2009-12-03 2011-06-09 Minster Research Ltd Treatment of allodynia and hyperalgesia
CA2782631A1 (en) 2009-12-03 2011-06-09 Proximagen Ltd Treatment of infectious diseases
AU2013285164A1 (en) 2012-07-03 2015-01-22 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
GB201322934D0 (en) 2013-12-23 2014-02-12 Proximagen Ltd Prodrug compounds
GB201322932D0 (en) * 2013-12-23 2014-02-12 Proximagen Ltd Pro-drug compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126311A2 (en) * 1983-05-18 1984-11-28 Beecham Group Plc Benzopyran derivatives.
WO1996022293A1 (en) * 1995-01-17 1996-07-25 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
EP0673373A1 (en) * 1992-12-11 1995-09-27 Smithkline Beecham Plc Bicyclic compounds with pharmaceutical activity
JP3568533B2 (ja) * 1992-12-11 2004-09-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 二環式化合物含有の医薬組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126311A2 (en) * 1983-05-18 1984-11-28 Beecham Group Plc Benzopyran derivatives.
WO1996022293A1 (en) * 1995-01-17 1996-07-25 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists

Also Published As

Publication number Publication date
SK158796A3 (en) 1997-07-09
BG63339B1 (bg) 2001-10-31
JPH10501251A (ja) 1998-02-03
EP1114821A1 (en) 2001-07-11
DK0764157T3 (da) 2002-04-22
ES2207590T3 (es) 2004-06-01
NZ287872A (en) 1998-05-27
PT764157E (pt) 2002-06-28
EP0764157A1 (en) 1997-03-26
FI964936A (fi) 1997-02-06
CN1336369A (zh) 2002-02-20
DE69531801T2 (de) 2004-07-01
RO113463B1 (ro) 1998-07-30
CN1174975C (zh) 2004-11-10
CN1154698A (zh) 1997-07-16
EP0764157B1 (en) 2002-01-02
CA2192480C (en) 2007-07-24
CA2192480A1 (en) 1995-12-21
AP9600889A0 (en) 1997-01-31
HU9603415D0 (en) 1997-02-28
JP3575767B2 (ja) 2004-10-13
DE69531801D1 (de) 2003-10-23
SK281456B6 (sk) 2001-03-12
NO965260L (no) 1997-02-06
HUT76136A (en) 1997-06-30
CZ286081B6 (cs) 2000-01-12
CZ361796A3 (en) 1997-08-13
DE69524871T2 (de) 2002-08-22
KR100397721B1 (ko) 2004-04-28
AU701060B2 (en) 1999-01-21
US5760074A (en) 1998-06-02
SI0764157T1 (en) 2002-06-30
FI120686B (fi) 2010-01-29
HK1039115A1 (en) 2002-04-12
DK1114821T3 (da) 2004-02-02
CY2508B1 (en) 2005-12-23
PL188134B1 (pl) 2004-12-31
NO315651B1 (no) 2003-10-06
WO1995034545A1 (en) 1995-12-21
PT1114821E (pt) 2004-02-27
SG67930A1 (en) 1999-10-19
HK1001286A1 (en) 1998-06-12
JP2003238554A (ja) 2003-08-27
FI964936A0 (fi) 1996-12-10
EP1114821B1 (en) 2003-09-17
SI1114821T1 (en) 2004-02-29
BG101040A (en) 1997-08-29
ATE211469T1 (de) 2002-01-15
DE69524871D1 (de) 2002-02-07
OA10593A (en) 2002-07-10
ES2170798T3 (es) 2002-08-16
CN1234702C (zh) 2006-01-04
PL317579A1 (en) 1997-04-14
HK1039115B (zh) 2004-08-13
ATE250052T1 (de) 2003-10-15
BR9507980A (pt) 1997-08-12
NO965260D0 (no) 1996-12-09
AU2672795A (en) 1996-01-05

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