AP2743A - Macrocyclic indole derivatives useful as hepatitisC virus inhibitors - Google Patents

Macrocyclic indole derivatives useful as hepatitisC virus inhibitors

Info

Publication number
AP2743A
AP2743A AP2010005521A AP2010005521A AP2743A AP 2743 A AP2743 A AP 2743A AP 2010005521 A AP2010005521 A AP 2010005521A AP 2010005521 A AP2010005521 A AP 2010005521A AP 2743 A AP2743 A AP 2743A
Authority
AP
ARIPO
Prior art keywords
indole derivatives
derivatives useful
virus inhibitors
macrocyclic indole
hepatitisc
Prior art date
Application number
AP2010005521A
Other languages
English (en)
Other versions
AP2010005521A0 (en
Inventor
Sandrine Marie Helene Vendeville
Piere Jean-Marie Bernard Raboisson
Tse-I Lin
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AP2010005521A0 publication Critical patent/AP2010005521A0/xx
Application granted granted Critical
Publication of AP2743A publication Critical patent/AP2743A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AP2010005521A 2008-07-08 2009-07-08 Macrocyclic indole derivatives useful as hepatitisC virus inhibitors AP2743A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08159965 2008-07-08
EP08160254 2008-07-11
EP08161743 2008-08-04
PCT/EP2009/004942 WO2010003658A1 (en) 2008-07-08 2009-07-08 Macrocyclic indole derivatives useful as hepatitis c virus inhibitors

Publications (2)

Publication Number Publication Date
AP2010005521A0 AP2010005521A0 (en) 2010-12-31
AP2743A true AP2743A (en) 2013-09-30

Family

ID=40972916

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2010005521A AP2743A (en) 2008-07-08 2009-07-08 Macrocyclic indole derivatives useful as hepatitisC virus inhibitors

Country Status (32)

Country Link
US (2) US8921355B2 (is)
EP (1) EP2310396B1 (is)
JP (2) JP5426671B2 (is)
KR (1) KR101640374B1 (is)
CN (1) CN102089314B (is)
AP (1) AP2743A (is)
AR (1) AR072726A1 (is)
AU (1) AU2009267389B8 (is)
BR (1) BRPI0915887B8 (is)
CA (1) CA2729307C (is)
CL (1) CL2011000032A1 (is)
CO (1) CO6351793A2 (is)
CR (1) CR20110076A (is)
DK (1) DK2310396T3 (is)
EA (1) EA019008B1 (is)
EC (1) ECSP11010750A (is)
ES (1) ES2651038T3 (is)
HK (1) HK1155734A1 (is)
HN (1) HN2011000072A (is)
HR (1) HRP20171892T1 (is)
HU (1) HUE035244T2 (is)
IL (1) IL210086A (is)
LT (1) LT2310396T (is)
MX (1) MX2011000276A (is)
NI (1) NI201100010A (is)
NO (1) NO2310396T3 (is)
NZ (2) NZ603343A (is)
SI (1) SI2310396T1 (is)
SV (1) SV2011003796A (is)
TW (1) TWI454476B (is)
UY (1) UY31973A (is)
WO (1) WO2010003658A1 (is)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524716B2 (en) 2007-12-24 2013-09-03 Janssen R&D Ireland Macrocyclic indoles as hepatitis C virus inhibitors
TWI454476B (zh) 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UA108211C2 (uk) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензімідазолімідазольні похідні
EA201291042A1 (ru) 2010-04-13 2013-03-29 Янссен Фармасьютикалз, Инк. Комбинация макроциклического ингибитора hcv, ненуклеозида и нуклеозида
RU2559886C2 (ru) * 2010-06-24 2015-08-20 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД ПОЛУЧЕНИЕ 13-ЦИКЛОГЕКСИЛ-3-МЕТОКСИ-6-[МЕТИЛ-(2-{2-[МЕТИЛ-(СУЛЬФАМОИЛ)-АМИНО]-ЭТОКСИ}-ЭТИЛ)-КАРБАМОИЛ]-7Н-ИНДОЛО-[2,1-α]-[2]-БЕНЗАЗЕПИН-10-КАРБОНОВОЙ КИСЛОТЫ
PT2760821T (pt) 2011-09-02 2018-01-11 Novartis Ag Sal de colina de um composto anti-inflamatório de ciclobutenodiona substituída
US8716275B2 (en) * 2011-10-20 2014-05-06 Bristol-Myers Squibb Company Compound for the treatment of hepatitis C
MX2015002684A (es) 2012-08-31 2015-05-12 Janssen Pharmaceuticals Inc Combinacion de un inhibidor macrociclico de proteasas del vhc, un inhibidor del vhc no nucleosidico y ritonavir.
WO2014152275A1 (en) * 2013-03-14 2014-09-25 Concert Pharmaceuticals, Inc. Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055
US10450263B2 (en) 2017-02-10 2019-10-22 Southern Research Institute Benzo annulenes as antiviral agents
KR101974388B1 (ko) 2017-06-23 2019-05-02 (주)에니켐텍 알킬 디에틸렌 트리아민 유도체 및 이의 제조방법
US11066357B2 (en) 2017-12-26 2021-07-20 Southern Research Institute Benzoannulene derivatives as antiviral agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007140200A2 (en) * 2006-05-25 2007-12-06 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors

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US6054472A (en) * 1996-04-23 2000-04-25 Vertex Pharmaceuticals, Incorporated Inhibitors of IMPDH enzyme
US20050267836A1 (en) 1996-03-25 2005-12-01 Cfph, Llc Method and system for transacting with a trading application
EA004771B1 (ru) 1996-04-23 2004-08-26 Вертекс Фармасьютикалз Инкорпорейтед Производные мочевины и их применение в качестве ингибиторов инозин-5`-монофосфат- дегидрогеназы
WO1998040381A1 (en) 1997-03-14 1998-09-17 Vertex Pharmaceuticals Incorporated Inhibitors of impdh enzyme
PL211562B1 (pl) * 1999-03-19 2012-05-31 Vertex Pharma Związki, zawierające je kompozycje oraz ich zastosowania
JP4778665B2 (ja) 2000-08-30 2011-09-21 パナソニック株式会社 プラズマディスプレイ表示装置の製造方法
CA2552317C (en) 2004-01-30 2013-12-10 Medivir Ab Hcv ns-3 serine protease inhibitors
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
MX2008003032A (es) 2005-09-02 2008-03-24 Tibotec Pharm Ltd Benzodiazepinas como inhibidores del virus del la hepatitis c.
US7399758B2 (en) * 2005-09-12 2008-07-15 Meanwell Nicholas A Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
GB0522881D0 (en) 2005-11-10 2005-12-21 Angeletti P Ist Richerche Bio Therapeutic compounds
WO2007092000A1 (en) 2006-02-06 2007-08-16 Bristol-Myers Squibb Company Inhibitors of hcv replication
US7456166B2 (en) * 2006-05-17 2008-11-25 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
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TWI454476B (zh) 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
AR073603A1 (es) 2008-09-18 2010-11-17 Ortho Mcneil Janssen Pharm Combinaciones sinergicas de un inhibidor macrociclico del vhc y un nucleosido
CA2898529C (en) 2009-02-27 2017-10-17 Peter Jozef Maria Van Remoortere Amorphous sodium salt of tmc435 inhibitor of hcv
EA201291042A1 (ru) 2010-04-13 2013-03-29 Янссен Фармасьютикалз, Инк. Комбинация макроциклического ингибитора hcv, ненуклеозида и нуклеозида
RU2559886C2 (ru) 2010-06-24 2015-08-20 ЯНССЕН Ар ЭНД Ди АЙРЛЭНД ПОЛУЧЕНИЕ 13-ЦИКЛОГЕКСИЛ-3-МЕТОКСИ-6-[МЕТИЛ-(2-{2-[МЕТИЛ-(СУЛЬФАМОИЛ)-АМИНО]-ЭТОКСИ}-ЭТИЛ)-КАРБАМОИЛ]-7Н-ИНДОЛО-[2,1-α]-[2]-БЕНЗАЗЕПИН-10-КАРБОНОВОЙ КИСЛОТЫ
MX2015002684A (es) 2012-08-31 2015-05-12 Janssen Pharmaceuticals Inc Combinacion de un inhibidor macrociclico de proteasas del vhc, un inhibidor del vhc no nucleosidico y ritonavir.

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO2007140200A2 (en) * 2006-05-25 2007-12-06 Bristol-Myers Squibb Company Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors

Also Published As

Publication number Publication date
AU2009267389B2 (en) 2013-05-30
JP2011527299A (ja) 2011-10-27
LT2310396T (lt) 2017-12-27
AP2010005521A0 (en) 2010-12-31
US20110105473A1 (en) 2011-05-05
ECSP11010750A (es) 2011-08-31
BRPI0915887B8 (pt) 2021-05-25
CN102089314A (zh) 2011-06-08
CN102089314B (zh) 2014-07-23
JP5808370B2 (ja) 2015-11-10
DK2310396T3 (en) 2017-12-11
US8921355B2 (en) 2014-12-30
EP2310396B1 (en) 2017-09-06
IL210086A0 (en) 2011-02-28
BRPI0915887B1 (pt) 2020-02-18
TWI454476B (zh) 2014-10-01
CR20110076A (es) 2011-11-10
CL2011000032A1 (es) 2011-07-15
KR20110040889A (ko) 2011-04-20
AU2009267389A1 (en) 2010-01-14
NI201100010A (es) 2011-09-07
TW201014865A (en) 2010-04-16
EA201170153A1 (ru) 2011-08-30
UY31973A (es) 2010-01-29
SI2310396T1 (en) 2018-01-31
SV2011003796A (es) 2011-04-08
NO2310396T3 (is) 2018-02-03
US9427440B2 (en) 2016-08-30
HN2011000072A (es) 2013-09-01
AR072726A1 (es) 2010-09-15
NZ603343A (en) 2013-08-30
HUE035244T2 (hu) 2018-05-02
HRP20171892T1 (hr) 2018-01-12
ES2651038T3 (es) 2018-01-23
AU2009267389B8 (en) 2013-07-04
HK1155734A1 (en) 2012-05-25
NZ590073A (en) 2012-11-30
MX2011000276A (es) 2011-03-02
JP5426671B2 (ja) 2014-02-26
CA2729307C (en) 2017-08-29
AU2009267389A8 (en) 2013-07-04
JP2014028818A (ja) 2014-02-13
US20140107101A1 (en) 2014-04-17
IL210086A (en) 2014-05-28
KR101640374B1 (ko) 2016-07-18
EA019008B1 (ru) 2013-12-30
EP2310396A1 (en) 2011-04-20
BRPI0915887A2 (pt) 2015-11-03
WO2010003658A1 (en) 2010-01-14
CA2729307A1 (en) 2010-01-14
CO6351793A2 (es) 2011-12-20

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