PT2134685E - Derivados de índole não substituídos na posição 7 como inibidores de mcl-1 - Google Patents
Derivados de índole não substituídos na posição 7 como inibidores de mcl-1 Download PDFInfo
- Publication number
- PT2134685E PT2134685E PT87459343T PT08745934T PT2134685E PT 2134685 E PT2134685 E PT 2134685E PT 87459343 T PT87459343 T PT 87459343T PT 08745934 T PT08745934 T PT 08745934T PT 2134685 E PT2134685 E PT 2134685E
- Authority
- PT
- Portugal
- Prior art keywords
- nonsubstituted
- mcl
- inhibitors
- indole derivatives
- indole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91204907P | 2007-04-16 | 2007-04-16 | |
US94968307P | 2007-07-13 | 2007-07-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2134685E true PT2134685E (pt) | 2015-11-25 |
Family
ID=39683700
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT87459343T PT2134685E (pt) | 2007-04-16 | 2008-04-16 | Derivados de índole não substituídos na posição 7 como inibidores de mcl-1 |
Country Status (11)
Country | Link |
---|---|
US (2) | US7981888B2 (pt) |
EP (1) | EP2134685B1 (pt) |
JP (2) | JP5496876B2 (pt) |
CN (1) | CN101711235A (pt) |
CA (2) | CA2951295C (pt) |
DK (1) | DK2134685T3 (pt) |
ES (1) | ES2550753T3 (pt) |
MX (1) | MX2009011210A (pt) |
PL (1) | PL2134685T3 (pt) |
PT (1) | PT2134685E (pt) |
WO (1) | WO2008130970A1 (pt) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2134684B1 (en) | 2007-04-16 | 2017-08-02 | AbbVie Inc. | 7-substituted indole as mcl-1 inhibitors |
AU2009326259A1 (en) * | 2008-12-08 | 2011-07-28 | Boehringer Ingelheim International Gmbh | Compounds for treating cancer |
CA2747161C (en) | 2008-12-19 | 2017-07-18 | Abbott Laboratories | (hetero)aryl substituted (benzo[d]thiazol-2-ylcarbamoyl) 1,2,3,4-tetrahydroquinolins and related compounds and uses thereof for treating cancer and excess platelets |
EP2373163B1 (en) * | 2008-12-19 | 2015-06-10 | Genentech, Inc. | Heterocyclic compounds and methods of use |
US20130035304A1 (en) | 2010-01-29 | 2013-02-07 | Walensky Loren D | Small molecules for the modulation of mcl-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders |
EP2487159A1 (en) | 2011-02-11 | 2012-08-15 | MSD Oss B.V. | RorgammaT inhibitors |
EP2567698B1 (en) | 2011-09-07 | 2014-02-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | GPR 17 agonists and screening assay |
CN103958508B (zh) | 2011-10-14 | 2019-02-12 | 艾伯维公司 | 用于治疗癌症以及免疫与自身免疫性疾病的细胞凋亡诱导剂 |
WO2013142281A1 (en) * | 2012-03-20 | 2013-09-26 | Dana Farber Cancer Institute, Inc. | Inhibition of mcl-1 and/or bfl-1/a1 |
WO2014026330A1 (en) * | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 3-AMINOCYCLOALKYL COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
WO2014026327A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | 4-heteroaryl substituted benzoic acid compounds as rorgammat inhibitors and uses thereof |
WO2014026329A1 (en) | 2012-08-15 | 2014-02-20 | Merck Sharp & Dohme Corp. | N-alkylated indole and indazole compounds as rorgammat inhibitors and uses thereof |
US10093640B2 (en) | 2012-09-21 | 2018-10-09 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors |
EP3038618B1 (en) | 2013-08-28 | 2020-10-14 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
EP3122353B1 (en) * | 2014-03-27 | 2020-10-28 | Vanderbilt University | Substituted indole mcl-1 inhibitors |
US9949965B2 (en) | 2014-10-17 | 2018-04-24 | Vanderbilt University | Tricyclic indole Mcl-1 inhibitors and uses thereof |
CA2965173A1 (en) | 2014-10-29 | 2016-05-06 | The Walter And Eliza Hall Institute Of Medical Research | Use of therapeutic agents |
JP2018510135A (ja) | 2015-02-11 | 2018-04-12 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | RORγT阻害剤としての置換ピラゾール化合物及びその使用 |
WO2016200726A1 (en) | 2015-06-08 | 2016-12-15 | Texas Tech University System | Inhibitors of mci-1 as drugs to overcome resistance to braf inhibitors and mek inhibitors |
WO2017075178A1 (en) | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | SUBSTITUTED BICYCLIC PYRAZOLE COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF |
EP3368539B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Substituted indazole compounds as ror gamma t inhibitors and uses thereof |
EP3368535B1 (en) | 2015-10-27 | 2020-12-02 | Merck Sharp & Dohme Corp. | Heteroaryl substituted benzoic acids as rorgammat inhibitors and uses thereof |
WO2017077535A1 (en) * | 2015-11-02 | 2017-05-11 | Carmel-Haifa University Economic Corporation Ltd. | Apoptosis related protein in the tgf-beta signaling pathway (arts) mimetic compounds, compositions, methods and uses thereof in induction of differentiation and/or apoptosis of premalignant and malignant cells, thereby restoring their normal-like phenotype |
CA3016182C (en) * | 2016-03-04 | 2024-02-27 | Vanderbilt Universtiy | Substituted indole mcl-1 inhibitors |
TWI742074B (zh) | 2016-04-22 | 2021-10-11 | 瑞典商阿斯特捷利康公司 | Mcl-1抑制劑及其使用方法 |
EP3458459B1 (en) | 2016-05-19 | 2022-04-27 | Bayer Aktiengesellschaft | Macrocyclic indole derivatives |
CA3024482A1 (en) | 2016-05-19 | 2017-11-23 | Bayer Aktiengesellschaft | Macrocyclic indole derivatives |
CN111093659A (zh) * | 2017-04-30 | 2020-05-01 | 财团法人生物技术开发中心 | 一种抗癌干性的药物 |
WO2019096911A1 (en) | 2017-11-17 | 2019-05-23 | The Broad Institute, Inc. | Macrocyclic indole derivatives |
EP3710449B1 (en) | 2017-11-17 | 2022-07-06 | The Broad Institute, Inc. | Macrocyclic fluorine substituted indole derivatives as mcl-1 inhibitors, for use in the treatment of cancer |
EP3710447A1 (en) | 2017-11-17 | 2020-09-23 | Bayer Aktiengesellschaft | Aryl annulated macrocyclic indole derivatives |
WO2019096914A1 (en) | 2017-11-17 | 2019-05-23 | Bayer Aktiengesellschaft | Macrocyclic chlorine substituted indole derivatives |
EP3710448A1 (en) | 2017-11-17 | 2020-09-23 | Bayer Aktiengesellschaft | Macrocyclic chlorine substituted indole derivatives |
JP7234250B2 (ja) | 2017-11-17 | 2023-03-07 | バイエル アクチェンゲゼルシャフト | 置換大環状インドール誘導体 |
KR20210070312A (ko) * | 2018-09-30 | 2021-06-14 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 인돌 거대 고리 유도체, 이의 제조 방법, 및 의약에서 이의 응용 |
WO2020103864A1 (en) * | 2018-11-22 | 2020-05-28 | Ascentage Pharma (Suzhou) Co., Ltd. | Macrocyclic indoles as mcl-1 inhibitors |
WO2021092053A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Mcl-1 inhibitor macrocycle compounds for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer |
WO2021092061A1 (en) * | 2019-11-08 | 2021-05-14 | Unity Biotechnology, Inc. | Combination treatment for senescence-associated diseases |
EP4061820A1 (en) | 2019-11-21 | 2022-09-28 | Janssen Pharmaceutica NV | Macrocyclic sulfonyl derivatives as mcl-1 inhibitors |
KR20220103984A (ko) | 2019-11-21 | 2022-07-25 | 얀센 파마슈티카 엔.브이. | Mcl-1 억제제로서의 거대환식 인돌 유도체 |
EP4066895A1 (en) | 2019-11-29 | 2022-10-05 | ONO Pharmaceutical Co., Ltd. | Compound having lysophosphatidic acid receptor agonistic activity and pharmaceutical use of said compound |
CN115335384A (zh) * | 2020-03-30 | 2022-11-11 | 江苏恒瑞医药股份有限公司 | 一种吲哚类大环衍生物的结晶形式及其制备方法 |
EP4157852A1 (en) | 2020-05-29 | 2023-04-05 | JANSSEN Pharmaceutica NV | Macrocyclic 7-pyrazol-5-yl-indole derivatives as inhibitors of mcl-1 |
EP4168412A1 (en) | 2020-06-19 | 2023-04-26 | JANSSEN Pharmaceutica NV | N-linked macrocyclic 7-(pyrazol-5-yl)-indole derivatives as inhibitors of mcl-1 |
US11957693B2 (en) | 2021-06-11 | 2024-04-16 | Gilead Sciences, Inc. | Combination MCL-1 inhibitors with anti-cancer agents |
TW202317200A (zh) | 2021-06-11 | 2023-05-01 | 美商基利科學股份有限公司 | Mcl-1抑制劑與抗體藥物接合物之組合 |
Family Cites Families (31)
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US3632805A (en) | 1967-12-08 | 1972-01-04 | Sumitomo Chemical Co | Process for producing 1-aminoalkyl-benzodiazepine derivatives |
FR2187318B1 (pt) * | 1972-06-08 | 1975-06-20 | Delalande Sa | |
US4994477A (en) | 1988-03-24 | 1991-02-19 | Abbott Laboratories | Heterocyclic renin inhibitors |
JP2000515529A (ja) * | 1996-08-01 | 2000-11-21 | メルクル・ゲーエムベーハー | 細胞質ホスホリパーゼa▲下2▼の阻害剤としてのアシルピロリドンジカルボン酸およびアシルインドールジカルボン酸ならびにその誘導体 |
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
EP1004567B1 (en) | 1998-11-27 | 2004-04-07 | Mitsubishi Chemical Corporation | Process for the production of maleic anhydride |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB0000626D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
MXPA03003174A (es) * | 2000-10-10 | 2003-07-14 | Smithkline Beecham Corp | Indoles substituidos, composiciones farmaceuticas que contienen dichos indoles y su uso como agentes de enlace ppar-y.. |
DE10153346A1 (de) * | 2001-10-29 | 2004-04-22 | Grünenthal GmbH | Substituierte Indole |
JP2005516908A (ja) * | 2001-11-30 | 2005-06-09 | ザ バーナム インスティチュート | 癌細胞におけるアポトーシスの誘導 |
CA2473740A1 (en) * | 2002-01-18 | 2003-07-31 | David Solow-Cordero | Methods of treating conditions associated with an edg receptor |
WO2003091214A1 (en) | 2002-04-23 | 2003-11-06 | Aventis Pharmaceuticals Inc. | 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo |
ES2401330T3 (es) * | 2003-02-26 | 2013-04-18 | Sugen, Inc. | Compuesto de heteroarilamino inhibidores de proteín quinasas |
US7141600B2 (en) * | 2003-04-15 | 2006-11-28 | The Regents Of The University Of California | Small molecule inhibition of a PDZ-domain interaction |
SE0302035D0 (sv) * | 2003-07-09 | 2003-07-09 | Biolipox Ab | New compound |
US7268159B2 (en) * | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
ITMI20040874A1 (it) * | 2004-04-30 | 2004-07-30 | Ist Naz Stud Cura Dei Tumori | Derivati indolici ed azaindolici con azione antitumorale |
WO2005123675A1 (en) * | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
CA2570363A1 (en) * | 2004-06-18 | 2005-12-29 | Biolipox Ab | Indoles useful in the treatment of inflammation |
BRPI0512253A (pt) * | 2004-06-18 | 2008-02-19 | Biolipox Ab | composto, formulação farmacêutica, uso de um composto, método de tratamento de uma doença, produto combinado, e, processo para a preparação de um composto |
WO2006041961A1 (en) * | 2004-10-05 | 2006-04-20 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES | Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same |
FR2878849B1 (fr) * | 2004-12-06 | 2008-09-12 | Aventis Pharma Sa | Indoles substitues, compositions les contenant, procede de fabrication et utilisation |
US8097623B2 (en) * | 2005-01-19 | 2012-01-17 | Biolipox Ab | Indoles useful in the treatment of inflammation |
JP2008527030A (ja) * | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
EP1904047B1 (en) * | 2005-07-07 | 2013-01-02 | Abbott Laboratories | Apoptosis promoters |
CL2007002516A1 (es) * | 2006-08-31 | 2008-05-16 | Smithkline Beecham Corp | Compuestos derivados de indol indano; composicion farmaceutica; y su uso para tratar hiperglicemia, diabetes tipo 2, tolerancia deteriorada a la glucosa, resistencia a la insulina, sindrome x, dislipidemia. |
EP2134684B1 (en) * | 2007-04-16 | 2017-08-02 | AbbVie Inc. | 7-substituted indole as mcl-1 inhibitors |
EP2373163B1 (en) | 2008-12-19 | 2015-06-10 | Genentech, Inc. | Heterocyclic compounds and methods of use |
CA2747161C (en) | 2008-12-19 | 2017-07-18 | Abbott Laboratories | (hetero)aryl substituted (benzo[d]thiazol-2-ylcarbamoyl) 1,2,3,4-tetrahydroquinolins and related compounds and uses thereof for treating cancer and excess platelets |
-
2008
- 2008-04-16 CN CN200880020451A patent/CN101711235A/zh active Pending
- 2008-04-16 ES ES08745934.3T patent/ES2550753T3/es active Active
- 2008-04-16 JP JP2010504205A patent/JP5496876B2/ja active Active
- 2008-04-16 CA CA2951295A patent/CA2951295C/en active Active
- 2008-04-16 CA CA2682354A patent/CA2682354C/en active Active
- 2008-04-16 WO PCT/US2008/060427 patent/WO2008130970A1/en active Application Filing
- 2008-04-16 DK DK08745934.3T patent/DK2134685T3/en active
- 2008-04-16 PT PT87459343T patent/PT2134685E/pt unknown
- 2008-04-16 PL PL08745934T patent/PL2134685T3/pl unknown
- 2008-04-16 US US12/104,319 patent/US7981888B2/en active Active
- 2008-04-16 EP EP08745934.3A patent/EP2134685B1/en active Active
- 2008-04-16 MX MX2009011210A patent/MX2009011210A/es active IP Right Grant
-
2011
- 2011-04-15 US US13/088,206 patent/US8853209B2/en active Active
-
2014
- 2014-03-04 JP JP2014041214A patent/JP5895011B2/ja active Active
Also Published As
Publication number | Publication date |
---|---|
JP2014129396A (ja) | 2014-07-10 |
US20090124616A1 (en) | 2009-05-14 |
US8853209B2 (en) | 2014-10-07 |
ES2550753T3 (es) | 2015-11-12 |
CN101711235A (zh) | 2010-05-19 |
US7981888B2 (en) | 2011-07-19 |
JP5895011B2 (ja) | 2016-03-30 |
EP2134685A1 (en) | 2009-12-23 |
PL2134685T3 (pl) | 2016-02-29 |
JP2010524955A (ja) | 2010-07-22 |
CA2682354A1 (en) | 2008-10-30 |
DK2134685T3 (en) | 2015-12-07 |
CA2951295A1 (en) | 2008-10-30 |
US20110263599A1 (en) | 2011-10-27 |
MX2009011210A (es) | 2009-10-30 |
EP2134685B1 (en) | 2015-09-02 |
WO2008130970A1 (en) | 2008-10-30 |
JP5496876B2 (ja) | 2014-05-21 |
CA2951295C (en) | 2020-04-28 |
CA2682354C (en) | 2016-12-13 |
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