AP253A - Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and thei phamaceutical use. - Google Patents

Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and thei phamaceutical use. Download PDF

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Publication number
AP253A
AP253A APAP/P/1991/000286A AP9100286A AP253A AP 253 A AP253 A AP 253A AP 9100286 A AP9100286 A AP 9100286A AP 253 A AP253 A AP 253A
Authority
AP
ARIPO
Prior art keywords
compound
methyl
salt
mmol
compound according
Prior art date
Application number
APAP/P/1991/000286A
Other languages
English (en)
Other versions
AP9100286A0 (en
Inventor
Arne Elof Brandstrom
Per Lennart Lindberg
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9002207A external-priority patent/SE9002207D0/xx
Priority claimed from SE9002206A external-priority patent/SE9002206D0/xx
Application filed by Ab Astra filed Critical Ab Astra
Publication of AP9100286A0 publication Critical patent/AP9100286A0/xx
Application granted granted Critical
Publication of AP253A publication Critical patent/AP253A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
APAP/P/1991/000286A 1990-06-20 1991-06-19 Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and thei phamaceutical use. AP253A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9002207A SE9002207D0 (sv) 1990-06-20 1990-06-20 New compounds i
SE9002206A SE9002206D0 (sv) 1990-06-20 1990-06-20 New compounds

Publications (2)

Publication Number Publication Date
AP9100286A0 AP9100286A0 (en) 1991-07-31
AP253A true AP253A (en) 1993-05-03

Family

ID=26660803

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000286A AP253A (en) 1990-06-20 1991-06-19 Dialkoxy-pyridinyl-benzimidazole derivatives process for their preparation and thei phamaceutical use.

Country Status (29)

Country Link
US (1) US5430042A (pl)
EP (1) EP0593463B1 (pl)
JP (1) JP3049367B2 (pl)
CN (1) CN1058213A (pl)
AP (1) AP253A (pl)
AT (1) ATE184602T1 (pl)
AU (1) AU649456B2 (pl)
BG (1) BG97198A (pl)
CA (1) CA2083606C (pl)
CZ (1) CZ279434B6 (pl)
DE (1) DE69131627T2 (pl)
EG (1) EG19752A (pl)
ES (1) ES2140391T3 (pl)
FI (1) FI925767A7 (pl)
HU (1) HUT62882A (pl)
IE (1) IE912026A1 (pl)
IL (1) IL98472A (pl)
IS (1) IS3720A7 (pl)
LV (1) LV10269B (pl)
MA (1) MA22198A1 (pl)
NO (1) NO924650D0 (pl)
NZ (1) NZ238545A (pl)
OA (1) OA09683A (pl)
PL (2) PL165898B1 (pl)
PT (1) PT98036A (pl)
RO (1) RO110497B1 (pl)
TN (1) TNSN91050A1 (pl)
WO (1) WO1991019712A1 (pl)
YU (1) YU104091A (pl)

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EP1078628B1 (en) * 1994-07-08 2008-11-19 AstraZeneca AB Multiple unit tableted dosage form
SE9402431D0 (sv) * 1994-07-08 1994-07-08 Astra Ab New tablet formulation
GB9423970D0 (en) * 1994-11-28 1995-01-11 Astra Ab Oxidation
SE9500422D0 (sv) * 1995-02-06 1995-02-06 Astra Ab New oral pharmaceutical dosage forms
SE9500478D0 (sv) * 1995-02-09 1995-02-09 Astra Ab New pharmaceutical formulation and process
US5545661A (en) * 1995-05-16 1996-08-13 Eli Lilly And Company Methods for inhibiting bone loss with bis-pyrone oxovanadium compounds
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SE9600070D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
AU6551198A (en) * 1997-05-30 1998-12-30 Dr. Reddy's Research Foundation Novel benzimidazole derivatives as antiulcer agents, process for their preparation and pharmaceutical compositions containing them
DE69826900T2 (de) * 1997-07-11 2005-11-24 Eisai Co., Ltd. Verfahren zur Herstellung von Pyridinderivaten
GB9805558D0 (en) * 1998-03-17 1998-05-13 Knoll Ag Chemical process`
PL346000A1 (en) * 1998-08-10 2002-01-14 Partnership Of Michael E Garst Prodrugs of proton pump inhibitors
US6093734A (en) * 1998-08-10 2000-07-25 Partnership Of Michael E. Garst, George Sachs, And Jai Moo Shin Prodrugs of proton pump inhibitors
SE0101379D0 (sv) 2001-04-18 2001-04-18 Diabact Ab Komposition som hämmar utsöndring av magsyra
US8206741B2 (en) 2001-06-01 2012-06-26 Pozen Inc. Pharmaceutical compositions for the coordinated delivery of NSAIDs
JP2005521662A (ja) * 2002-01-25 2005-07-21 サンタラス インコーポレイティッド プロトンポンプ阻害剤の経粘膜送達
JP4732696B2 (ja) 2002-04-09 2011-07-27 フラメル・テクノロジー 活性成分の改変された放出のための、マイクロカプセルの水性懸濁液形態での経口医薬品製剤
KR100822981B1 (ko) * 2002-07-19 2008-04-16 윈스턴 파마슈티컬즈, 엘엘씨 벤즈이미다졸 유도체 및 이들의 프로톤 펌프 억제제의프로드럭으로서의 이용
SE0203065D0 (sv) 2002-10-16 2002-10-16 Diabact Ab Gastric acid secretion inhibiting composition
WO2004073654A2 (en) * 2003-02-20 2004-09-02 Santarus, Inc. A novel formulation, omeprazole antacid complex-immediate release for rapid and sustained supression of gastric acid
CA2529984C (en) * 2003-06-26 2012-09-25 Isa Odidi Oral multi-functional pharmaceutical capsule preparations of proton pump inhibitors
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2531566C (en) * 2003-07-18 2013-05-07 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
KR20060092255A (ko) 2003-09-26 2006-08-22 알자 코포레이션 고도의 약물적재를 제공하는 약물코팅제 및 그의 제조방법
WO2005039640A1 (en) * 2003-10-03 2005-05-06 Allergan Inc. Compositions comprising trefoil factor family peptides and/or mucoadhesives and proton pump inhibitor prodrugs
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
BRPI0507784A (pt) * 2004-02-18 2007-07-17 Allergan Inc métodos e composições para a administração de pró-fármacos de inibidores da bomba de prótons
AU2005216863A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Methods and compositions for the intravenous administration of compounds related to proton pump inhibitors
TW200606163A (en) * 2004-04-22 2006-02-16 Eisai Co Ltd Imidazopyridine compound
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
JP3921497B2 (ja) * 2004-08-06 2007-05-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ベンズイミダゾール誘導体とアミンとの塩およびその製造方法
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
US8541026B2 (en) 2004-09-24 2013-09-24 Abbvie Inc. Sustained release formulations of opioid and nonopioid analgesics
US20070015782A1 (en) * 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7803817B2 (en) 2005-05-11 2010-09-28 Vecta, Ltd. Composition and methods for inhibiting gastric acid secretion
US7981908B2 (en) 2005-05-11 2011-07-19 Vecta, Ltd. Compositions and methods for inhibiting gastric acid secretion
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CA2648280C (en) 2006-04-03 2014-03-11 Isa Odidi Controlled release delivery device comprising an organosol coat
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US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
JP5492417B2 (ja) 2006-10-13 2014-05-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 胃酸分泌抑制作用を有するベンズイミダゾール化合物
JP2009196894A (ja) * 2006-10-13 2009-09-03 Eisai R & D Management Co Ltd スルフィニルベンズイミダゾール化合物またはその塩の製造方法
CA2667682A1 (en) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprising acid labile proton pump inhibiting agents, at least one other pharmaceutically active agent and methods of using same
US20080194307A1 (en) * 2007-02-13 2008-08-14 Jeff Sanger Sports-based game of chance
US8247440B2 (en) 2008-02-20 2012-08-21 Curators Of The University Of Missouri Composition comprising omeprazole, lansoprazole and at least one buffering agent
EA201100313A1 (ru) 2008-09-09 2011-10-31 Астразенека Аб Способ доставки фармацевтической композиции пациенту, нуждающемуся в этом
SG176724A1 (en) 2009-06-25 2012-01-30 Astrazeneca Ab Method for treating a patient at risk for developing an nsaid-associated ulcer
WO2011080500A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
WO2011080502A2 (en) 2009-12-29 2011-07-07 Orexo Ab New pharmaceutical dosage form for the treatment of gastric acid-related disorders
US20120294937A1 (en) 2009-12-29 2012-11-22 Novartis Ag New pharmaceutical dosage form for the treatment of gastric acid-related disorders
EP2601947A1 (en) 2011-12-05 2013-06-12 Abo Bakr Mohammed Ali Al-Mehdar Fixed-dose combination for treatment of helicobacter pylori associated diseases
CA2860231A1 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid

Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1986002646A1 (fr) * 1984-10-31 1986-05-09 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M Nouveaux derives de picoline, leur procede de preparation, leur utilisation et medicaments les contenant
EP0208452A2 (en) * 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
WO1989005299A1 (fr) * 1987-12-11 1989-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux derives benzoglyoxaline
WO1989011479A1 (fr) * 1988-05-25 1989-11-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux composes fluores d'alkoxyde

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US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
SE8500996D0 (sv) * 1985-03-01 1985-03-01 Haessle Ab Method of treatment
SE8505112D0 (sv) * 1985-10-29 1985-10-29 Haessle Ab Novel pharmacological compounds
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DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
EP0338066A1 (en) * 1987-10-30 1989-10-25 Aktiebolaget Hässle 2-pyridinylmethyl (sulfinyl or thio)benzimidazoles for treatment of diseases related to bone loss
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US4965269A (en) * 1989-12-20 1990-10-23 Ab Hassle Therapeutically active chloro substituted benzimidazoles

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
WO1986002646A1 (fr) * 1984-10-31 1986-05-09 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M Nouveaux derives de picoline, leur procede de preparation, leur utilisation et medicaments les contenant
EP0208452A2 (en) * 1985-07-02 1987-01-14 Takeda Chemical Industries, Ltd. Pyridine derivatives, their production and use
WO1989005299A1 (fr) * 1987-12-11 1989-06-15 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux derives benzoglyoxaline
WO1989011479A1 (fr) * 1988-05-25 1989-11-30 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouveaux composes fluores d'alkoxyde

Also Published As

Publication number Publication date
IS3720A7 (is) 1991-12-21
HUT62882A (en) 1993-06-28
DE69131627T2 (de) 2000-04-27
CA2083606A1 (en) 1991-12-21
PL166209B1 (pl) 1995-04-28
WO1991019712A1 (en) 1991-12-26
AU649456B2 (en) 1994-05-26
ATE184602T1 (de) 1999-10-15
US5430042A (en) 1995-07-04
LV10269B (en) 1995-10-20
NO924650L (no) 1992-12-02
EG19752A (en) 1996-01-31
EP0593463A1 (en) 1994-04-27
LV10269A (lv) 1994-10-20
CZ279434B6 (cs) 1995-04-12
PL297295A1 (pl) 1992-07-13
MA22198A1 (fr) 1992-04-01
RO110497B1 (ro) 1996-01-30
FI925767A0 (fi) 1992-12-18
NZ238545A (en) 1993-08-26
TNSN91050A1 (fr) 1992-10-25
PL165898B1 (pl) 1995-02-28
YU104091A (sh) 1994-01-20
ES2140391T3 (es) 2000-03-01
NO924650D0 (no) 1992-12-02
IE912026A1 (en) 1992-01-01
CN1058213A (zh) 1992-01-29
HU9204034D0 (en) 1993-03-29
DE69131627D1 (de) 1999-10-21
PL297294A1 (pl) 1992-07-13
JPH05507714A (ja) 1993-11-04
AP9100286A0 (en) 1991-07-31
BG97198A (bg) 1993-12-24
OA09683A (en) 1993-05-15
CA2083606C (en) 2001-08-21
IL98472A (en) 1995-08-31
JP3049367B2 (ja) 2000-06-05
AU8061791A (en) 1992-01-07
FI925767A7 (fi) 1992-12-18
PT98036A (pt) 1992-03-31
IL98472A0 (en) 1992-07-15
EP0593463B1 (en) 1999-09-15
CS189391A3 (en) 1992-06-17

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