AP2013006953A0 - Substituted 1-benzylcycloalkylcarboxlic acids and use thereof - Google Patents

Substituted 1-benzylcycloalkylcarboxlic acids and use thereof

Info

Publication number
AP2013006953A0
AP2013006953A0 AP2013006953A AP2013006953A AP2013006953A0 AP 2013006953 A0 AP2013006953 A0 AP 2013006953A0 AP 2013006953 A AP2013006953 A AP 2013006953A AP 2013006953 A AP2013006953 A AP 2013006953A AP 2013006953 A0 AP2013006953 A0 AP 2013006953A0
Authority
AP
ARIPO
Prior art keywords
benzylcycloalkylcarboxlic
acids
substituted
benzylcycloalkylcarboxlic acids
Prior art date
Application number
AP2013006953A
Other languages
English (en)
Inventor
Michael G Hahn
Thomas Lampe
Karl-Heinz Schlemmer
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102010062544A external-priority patent/DE102010062544A1/de
Priority claimed from DE102011006974A external-priority patent/DE102011006974A1/de
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of AP2013006953A0 publication Critical patent/AP2013006953A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
AP2013006953A 2010-12-07 2011-12-05 Substituted 1-benzylcycloalkylcarboxlic acids and use thereof AP2013006953A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102010062544A DE102010062544A1 (de) 2010-12-07 2010-12-07 Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung
DE102011006974A DE102011006974A1 (de) 2011-04-07 2011-04-07 Substituierte 1-Benzylcycloalkylcarbonsäuren und ihre Verwendung
PCT/EP2011/071747 WO2012076466A2 (de) 2010-12-07 2011-12-05 Substituierte 1-benzylcycloalkylcarbonsäuren und ihre verwendung

Publications (1)

Publication Number Publication Date
AP2013006953A0 true AP2013006953A0 (en) 2013-06-30

Family

ID=45463539

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2013006953A AP2013006953A0 (en) 2010-12-07 2011-12-05 Substituted 1-benzylcycloalkylcarboxlic acids and use thereof

Country Status (26)

Country Link
US (1) US9018258B2 (xx)
EP (1) EP2649045B1 (xx)
JP (1) JP5989660B2 (xx)
KR (1) KR20130136504A (xx)
CN (1) CN103492361B (xx)
AP (1) AP2013006953A0 (xx)
AR (1) AR084220A1 (xx)
AU (1) AU2011340721A1 (xx)
BR (1) BR112013013663A2 (xx)
CA (1) CA2819880C (xx)
CL (1) CL2013001600A1 (xx)
CO (1) CO6771409A2 (xx)
CR (1) CR20130259A (xx)
DO (1) DOP2013000125A (xx)
EA (1) EA201300669A1 (xx)
EC (1) ECSP13012668A (xx)
ES (1) ES2544532T3 (xx)
HK (1) HK1192879A1 (xx)
IL (1) IL226422A0 (xx)
MA (1) MA34721B1 (xx)
MX (1) MX2013006053A (xx)
SG (1) SG190296A1 (xx)
TW (1) TW201249782A (xx)
UY (1) UY33776A (xx)
WO (1) WO2012076466A2 (xx)
ZA (1) ZA201305076B (xx)

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TW201625601A (zh) 2014-07-02 2016-07-16 諾華公司 噻吩－２－基－吡啶－２－基－１ｈ－吡唑－４－羧酸衍生物及其作為可溶性鳥苷酸環化酶活化劑之用途
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CN111511745B (zh) 2018-02-06 2022-05-27 江苏恒瑞医药股份有限公司 吡唑并[1，5-a][1，3，5]三嗪-2-胺类衍生物、其制备方法及其应用
EP3787610A1 (en) 2018-04-30 2021-03-10 Bayer Aktiengesellschaft The use of sgc activators and sgc stimulators for the treatment of cognitive impairment
MA52616A (fr) 2018-05-15 2021-03-24 Bayer Ag Benzamides à substitution 1,3-thiazol-2-yl pour le traitement de maladies associées à la sensibilisation de fibres nerveuses
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US10905667B2 (en) 2018-07-24 2021-02-02 Bayer Pharma Aktiengesellschaft Orally administrable modified-release pharmaceutical dosage form
EP3911675A1 (en) 2019-01-17 2021-11-24 Bayer Aktiengesellschaft Methods to determine whether a subject is suitable of being treated with an agonist of soluble guanylyl cyclase (sgc)
WO2020164008A1 (en) 2019-02-13 2020-08-20 Bayer Aktiengesellschaft Process for the preparation of porous microparticles
WO2020245342A1 (en) 2019-06-07 2020-12-10 Bayer Aktiengesellschaft The use of sgc activators for the treatment of ophthalmologic diseases
WO2021209269A1 (en) * 2020-04-17 2021-10-21 Dsm Ip Assets B.V. A process for preparation of substituted enamine compounds
KR20230118143A (ko) 2020-12-10 2023-08-10 바이엘 악티엔게젤샤프트 안과 질환의 치료를 위한 sGC 활성화제의 용도
WO2023284860A1 (zh) * 2021-07-15 2023-01-19 江苏恒瑞医药股份有限公司 3-苯基丙酸类化合物、其制备方法及其在医药上的应用
CN114478326B (zh) * 2022-01-21 2023-10-03 安徽宁亿泰科技有限公司 一种苯嘧磺草胺关键中间体的合成方法
TW202342420A (zh) * 2022-02-18 2023-11-01 大陸商江蘇恆瑞醫藥股份有限公司 羧酸類化合物、其製備方法及其在醫藥上的應用
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Also Published As

Publication number Publication date
CA2819880C (en) 2019-01-22
JP2014510017A (ja) 2014-04-24
US20120172448A1 (en) 2012-07-05
US9018258B2 (en) 2015-04-28
ES2544532T3 (es) 2015-09-01
HK1192879A1 (zh) 2014-09-05
EP2649045A2 (de) 2013-10-16
KR20130136504A (ko) 2013-12-12
WO2012076466A3 (de) 2012-08-30
ZA201305076B (en) 2014-12-23
EP2649045B1 (de) 2015-05-27
BR112013013663A2 (pt) 2016-09-06
ECSP13012668A (es) 2013-08-30
DOP2013000125A (es) 2013-11-15
CO6771409A2 (es) 2013-10-15
AU2011340721A1 (en) 2013-06-20
MA34721B1 (fr) 2013-12-03
AR084220A1 (es) 2013-05-02
CR20130259A (es) 2013-06-28
CN103492361A (zh) 2014-01-01
EA201300669A1 (ru) 2013-11-29
CN103492361B (zh) 2015-07-15
CA2819880A1 (en) 2012-06-14
UY33776A (es) 2012-06-29
IL226422A0 (en) 2013-07-31
SG190296A1 (en) 2013-06-28
JP5989660B2 (ja) 2016-09-07
MX2013006053A (es) 2013-06-18
TW201249782A (en) 2012-12-16
WO2012076466A2 (de) 2012-06-14
CL2013001600A1 (es) 2013-10-25

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