AP2005003227A0 - Synergistic combination of an alpha-2-delta ligandand a PDEV inhibitor for use in the treatment of pain. - Google Patents
Synergistic combination of an alpha-2-delta ligandand a PDEV inhibitor for use in the treatment of pain.Info
- Publication number
- AP2005003227A0 AP2005003227A0 AP2005003227A AP2005003227A AP2005003227A0 AP 2005003227 A0 AP2005003227 A0 AP 2005003227A0 AP 2005003227 A AP2005003227 A AP 2005003227A AP 2005003227 A AP2005003227 A AP 2005003227A AP 2005003227 A0 AP2005003227 A0 AP 2005003227A0
- Authority
- AP
- ARIPO
- Prior art keywords
- ligandand
- delta
- pain
- alpha
- treatment
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000011885 synergistic combination Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0219024.7A GB0219024D0 (en) | 2002-08-15 | 2002-08-15 | Synergistic combinations |
PCT/IB2003/003476 WO2004016259A1 (en) | 2002-08-15 | 2003-08-04 | Synergistic combination of an alpha-2-delta ligand and a pdev inhibitor for use in the treatment of pain |
Publications (1)
Publication Number | Publication Date |
---|---|
AP2005003227A0 true AP2005003227A0 (en) | 2005-03-31 |
Family
ID=9942388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AP2005003227A AP2005003227A0 (en) | 2002-08-15 | 2003-08-04 | Synergistic combination of an alpha-2-delta ligandand a PDEV inhibitor for use in the treatment of pain. |
Country Status (40)
Country | Link |
---|---|
EP (1) | EP1536782B1 (de) |
JP (1) | JP2006502139A (de) |
KR (2) | KR20070009746A (de) |
CN (1) | CN1674884A (de) |
AP (1) | AP2005003227A0 (de) |
AR (1) | AR040871A1 (de) |
AT (1) | ATE359775T1 (de) |
AU (1) | AU2003249476B2 (de) |
BR (1) | BR0313484A (de) |
CA (1) | CA2495433A1 (de) |
CR (1) | CR7687A (de) |
DE (1) | DE60313330T2 (de) |
DK (1) | DK1536782T3 (de) |
EA (1) | EA007504B1 (de) |
EC (1) | ECSP055593A (de) |
ES (1) | ES2285230T3 (de) |
GB (1) | GB0219024D0 (de) |
GE (1) | GEP20084366B (de) |
GT (1) | GT200300173A (de) |
HN (1) | HN2003000247A (de) |
HR (1) | HRP20050136A2 (de) |
IL (1) | IL166415A0 (de) |
IS (1) | IS7643A (de) |
MA (1) | MA27381A1 (de) |
MX (1) | MXPA05001835A (de) |
NO (1) | NO20050782L (de) |
NZ (1) | NZ537818A (de) |
OA (1) | OA12899A (de) |
PA (1) | PA8577301A1 (de) |
PE (1) | PE20040992A1 (de) |
PL (1) | PL375553A1 (de) |
PT (1) | PT1536782E (de) |
RS (1) | RS20050078A (de) |
SI (1) | SI1536782T1 (de) |
TN (1) | TNSN05042A1 (de) |
TW (1) | TW200404531A (de) |
UA (1) | UA77329C2 (de) |
UY (1) | UY27936A1 (de) |
WO (1) | WO2004016259A1 (de) |
ZA (1) | ZA200500369B (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NI200300043A (es) | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
RU2006107534A (ru) * | 2003-09-12 | 2007-09-20 | Уорнер-Ламберт Компани Ллс (Us) | Комбинация, включающая альфа-2-дельта-лиганд анд и ssri и/или snri, для лечения депрессии и тревожного расстройства |
AU2004276072A1 (en) * | 2003-09-25 | 2005-04-07 | Warner-Lambert Company Llc | Amino acids with affinity for the alpha2delta-protein |
RU2344121C2 (ru) * | 2003-09-25 | 2009-01-20 | УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си | Способы лечения заболеваний у млекопитающих |
GB0405200D0 (en) * | 2004-03-08 | 2004-04-21 | Pfizer Ltd | Combinations comprising alpha-2-delta ligands |
KR20080019732A (ko) * | 2004-07-09 | 2008-03-04 | 워너-램버트 캄파니 엘엘씨 | 알파-2-델타 단백질에 대한 친화도를 갖는 베타-아미노산의제조 방법 |
ITMI20041447A1 (it) * | 2004-07-20 | 2004-10-20 | Zambon Spa | Composizione farmaceutica comprendente gabapentina |
US20090227562A1 (en) * | 2004-08-10 | 2009-09-10 | Pfizer Inc. | Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor |
JP2008512436A (ja) * | 2004-09-07 | 2008-04-24 | ファイザー・インク | 片頭痛治療用の5−HT(1)受容体アゴニストとα2δリガンドの組み合わせ |
WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
BRPI0810773A2 (pt) * | 2007-04-30 | 2014-10-07 | Adolor Corp | Composição farmacêutica, métodos para tratar dor em um mamífero, para tratar depressão em um mamífero, para tratar um distúrbio em um paciente, para fabricar um composto, e para inibir a captação de norepinefrina, composto, e, uso de uma composição. |
WO2008132589A1 (en) * | 2007-05-01 | 2008-11-06 | Pfizer Limited | Combinations comprising pregabalin |
US20090148532A1 (en) * | 2007-12-06 | 2009-06-11 | Venkatesh Gopi M | Preparation of controlled release skeletal muscle relaxant dosage forms |
TWI531362B (zh) | 2008-07-21 | 2016-05-01 | 艾爾康股份有限公司 | 具有治療劑遞送能力之眼科裝置 |
CN103002893B (zh) | 2010-07-30 | 2017-05-10 | 东丽株式会社 | 神经障碍性疼痛的治疗药或预防药 |
JP5974084B2 (ja) | 2011-05-17 | 2016-08-23 | プリンシピア バイオファーマ インコーポレイテッド | チロシンキナーゼ阻害剤 |
US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
DK2710007T3 (da) | 2011-05-17 | 2020-01-27 | Principia Biopharma Inc | Kinasehæmmere |
WO2013084182A1 (en) * | 2011-12-08 | 2013-06-13 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent |
AU2013312296B2 (en) | 2012-09-10 | 2017-06-22 | Principia Biopharma Inc. | Pyrazolopyrimidine compounds as kinase inhibitors |
US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
EA033900B1 (ru) | 2014-02-21 | 2019-12-06 | Принсипиа Биофарма Инк. | СОЛЕВЫЕ И АМОРФНЫЕ ФОРМЫ 2-[(3R)-3-[4-АМИНО-3-(2-ФТОР-4-ФЕНОКСИФЕНИЛ)ПИРАЗОЛО[3,4-d]ПИРИМИДИН-1-ИЛ]ПИПЕРИДИН-1-КАРБОНИЛ]-4-МЕТИЛ-4-[4-(ОКСЕТАН-3-ИЛ)ПИПЕРАЗИН-1-ИЛ]ПЕНТ-2-ЕННИТРИЛА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ И СПОСОБ ЛЕЧЕНИЯ ПУЗЫРЧАТКИ ОБЫКНОВЕННОЙ И ПУЗЫРЧАТКИ ЛИСТОВИДНОЙ С ИХ ПРИМЕНЕНИЕМ |
EA036269B1 (ru) | 2014-12-18 | 2020-10-21 | Принсипиа Биофарма Инк. | Лечение пузырчатки |
US20180305350A1 (en) | 2015-06-24 | 2018-10-25 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
US20190231784A1 (en) | 2016-06-29 | 2019-08-01 | Principia Biopharma Inc. | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
CN114195661B (zh) * | 2021-12-21 | 2023-12-22 | 苏州楚凯药业有限公司 | 一种苯磺酸米洛巴林的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998003167A1 (en) * | 1996-07-24 | 1998-01-29 | Warner-Lambert Company | Isobutylgaba and its derivatives for the treatment of pain |
AU765802B2 (en) * | 1997-12-16 | 2003-10-02 | Warner-Lambert Company | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
IL139073A0 (en) * | 1999-10-21 | 2001-11-25 | Pfizer | Treatment of neuropathy |
WO2002019213A2 (en) * | 2000-08-30 | 2002-03-07 | Lilly Icos Llc | Method for treatment of migraine using pde5 inhibitors |
TNSN03094A1 (fr) * | 2001-04-19 | 2005-12-23 | Warner Lambert Co | Amino-acides condenses bicycliques ou tricycliques |
-
2002
- 2002-08-15 GB GBGB0219024.7A patent/GB0219024D0/en not_active Ceased
-
2003
- 2003-04-08 UA UAA200501347A patent/UA77329C2/uk unknown
- 2003-07-11 PA PA20038577301A patent/PA8577301A1/es unknown
- 2003-08-04 AU AU2003249476A patent/AU2003249476B2/en not_active Ceased
- 2003-08-04 AT AT03787957T patent/ATE359775T1/de not_active IP Right Cessation
- 2003-08-04 JP JP2004528754A patent/JP2006502139A/ja not_active Withdrawn
- 2003-08-04 WO PCT/IB2003/003476 patent/WO2004016259A1/en active IP Right Grant
- 2003-08-04 OA OA1200500037A patent/OA12899A/en unknown
- 2003-08-04 ES ES03787957T patent/ES2285230T3/es not_active Expired - Lifetime
- 2003-08-04 KR KR1020077000033A patent/KR20070009746A/ko not_active Application Discontinuation
- 2003-08-04 DE DE60313330T patent/DE60313330T2/de not_active Expired - Fee Related
- 2003-08-04 EP EP03787957A patent/EP1536782B1/de not_active Expired - Lifetime
- 2003-08-04 CN CNA038190737A patent/CN1674884A/zh active Pending
- 2003-08-04 GE GEAP8632A patent/GEP20084366B/en unknown
- 2003-08-04 RS RSP-2005/0078A patent/RS20050078A/sr unknown
- 2003-08-04 KR KR1020057002450A patent/KR20050042154A/ko not_active Application Discontinuation
- 2003-08-04 MX MXPA05001835A patent/MXPA05001835A/es active IP Right Grant
- 2003-08-04 DK DK03787957T patent/DK1536782T3/da active
- 2003-08-04 NZ NZ537818A patent/NZ537818A/en unknown
- 2003-08-04 IL IL16641503A patent/IL166415A0/xx unknown
- 2003-08-04 PT PT03787957T patent/PT1536782E/pt unknown
- 2003-08-04 CA CA002495433A patent/CA2495433A1/en not_active Abandoned
- 2003-08-04 AP AP2005003227A patent/AP2005003227A0/xx unknown
- 2003-08-04 BR BR0313484-9A patent/BR0313484A/pt not_active IP Right Cessation
- 2003-08-04 SI SI200330810T patent/SI1536782T1/sl unknown
- 2003-08-04 PL PL03375553A patent/PL375553A1/xx not_active Application Discontinuation
- 2003-08-04 EA EA200500207A patent/EA007504B1/ru not_active IP Right Cessation
- 2003-08-12 PE PE2003000806A patent/PE20040992A1/es not_active Application Discontinuation
- 2003-08-12 UY UY27936A patent/UY27936A1/es not_active Application Discontinuation
- 2003-08-13 AR AR20030102933A patent/AR040871A1/es not_active Application Discontinuation
- 2003-08-14 GT GT200300173A patent/GT200300173A/es unknown
- 2003-08-14 TW TW092122363A patent/TW200404531A/zh unknown
- 2003-08-14 HN HN2003000247A patent/HN2003000247A/es unknown
-
2005
- 2005-01-12 IS IS7643A patent/IS7643A/is unknown
- 2005-01-14 ZA ZA200500369A patent/ZA200500369B/en unknown
- 2005-02-10 EC EC2005005593A patent/ECSP055593A/es unknown
- 2005-02-14 HR HR20050136A patent/HRP20050136A2/xx not_active Application Discontinuation
- 2005-02-14 CR CR7687A patent/CR7687A/es not_active Application Discontinuation
- 2005-02-14 NO NO20050782A patent/NO20050782L/no not_active Application Discontinuation
- 2005-02-15 MA MA28104A patent/MA27381A1/fr unknown
- 2005-02-15 TN TNP2005000042A patent/TNSN05042A1/fr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20050136A2 (en) | Synergistic combination of an alpha-2-delta ligandand a pdev inhibitor for use in the treatment of pain | |
HUP0402568A3 (en) | Ultrasound treatment device | |
GB0201850D0 (en) | Therapeutic treatment | |
GB0216321D0 (en) | Therapeutic treatment | |
HUP0402569A3 (en) | Ultrasound treatment device | |
HUS1300035I1 (hu) | Dihidroimidazolonok alkalmazása epilepszia kezelésére kutyákban | |
HK1078784A1 (en) | Therapeutic treatment | |
AU2003235798A8 (en) | Use of a gsk-3beta inhibitor in the manufacture of a medicament for increasing bone formation | |
GB0223367D0 (en) | Therapeutic treatment | |
IL176386A0 (en) | Vaccine comprising an angiomotin or a polynucleotide encoding an angiomotin and its uses for the treatment of angiogenic-related disorders | |
AU2003206945A8 (en) | Use of proteinase inhibitors in the treatment of autoimmune diseases | |
GB0219660D0 (en) | Therapeutic use | |
ZA200405853B (en) | Use of adapalene for the treatment of dermatological disorders | |
PL374082A1 (en) | Carnitine in the treatment of geriatric depression | |
SG110107A1 (en) | Compound and use in treatment | |
GB0210464D0 (en) | Therapeutic treatment | |
HUP0300990D0 (en) | Synergistic combination for the prophylaxis and treatment of diabetes | |
IL164951A0 (en) | The treatment of pain with lfendropil | |
GB0310147D0 (en) | A composition for use in the treatment of a skin condition in a subject | |
PL370839A1 (en) | Use of proton pump inhibitors for the treatment of airway disorders | |
IL174968A0 (en) | The use of ifenprodil in the treatment of pain | |
GB0316927D0 (en) | A composition for use in the treatment of a surface | |
GB0211297D0 (en) | Pain treatment | |
IL165935A0 (en) | Use of vasopeptidase inhibitors in the treatment of nephropathy | |
AU2003217043A8 (en) | Delivery assembly for use in surgery |