PE20040992A1 - Combinaciones sinergicas entre un ligando alfa-2-delta y un inhibidor de pdev - Google Patents
Combinaciones sinergicas entre un ligando alfa-2-delta y un inhibidor de pdevInfo
- Publication number
- PE20040992A1 PE20040992A1 PE2003000806A PE2003000806A PE20040992A1 PE 20040992 A1 PE20040992 A1 PE 20040992A1 PE 2003000806 A PE2003000806 A PE 2003000806A PE 2003000806 A PE2003000806 A PE 2003000806A PE 20040992 A1 PE20040992 A1 PE 20040992A1
- Authority
- PE
- Peru
- Prior art keywords
- alpha
- pdev inhibitor
- delta
- synergic combinations
- linkage
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 230000002195 synergetic effect Effects 0.000 title 1
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 abstract 2
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960002870 gabapentin Drugs 0.000 abstract 1
- 238000002638 palliative care Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960001233 pregabalin Drugs 0.000 abstract 1
- AYXYPKUFHZROOJ-ZETCQYMHSA-N pregabalin Chemical compound CC(C)C[C@H](CN)CC(O)=O AYXYPKUFHZROOJ-ZETCQYMHSA-N 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A UNA COMBINACION QUE COMPRENDE: A) UN LIGANDO ALFA-2-DELTA SELECCIONADO ENTRE GABAPENTINA, PREGABALINA, ACIDO [(1R,5R,6S)-6-(AMINOMETIL)BICICLO-[3.2.0]HEPT-6-IL]ACETICO, ENTRE OTROS; B) UN INHIBIDOR DE cGMP PDEV COMPRENDIDO ENTRE SILDENAFILO, TALADAFILO,VARDENAFILO, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA UTIL PARA EL TRATAMIENTO CUURATIVO, PROFILACTICO O PALIATIVO DEL DOLOR
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0219024.7A GB0219024D0 (en) | 2002-08-15 | 2002-08-15 | Synergistic combinations |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20040992A1 true PE20040992A1 (es) | 2004-12-29 |
Family
ID=9942388
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2003000806A PE20040992A1 (es) | 2002-08-15 | 2003-08-12 | Combinaciones sinergicas entre un ligando alfa-2-delta y un inhibidor de pdev |
Country Status (40)
Country | Link |
---|---|
EP (1) | EP1536782B1 (es) |
JP (1) | JP2006502139A (es) |
KR (2) | KR20070009746A (es) |
CN (1) | CN1674884A (es) |
AP (1) | AP2005003227A0 (es) |
AR (1) | AR040871A1 (es) |
AT (1) | ATE359775T1 (es) |
AU (1) | AU2003249476B2 (es) |
BR (1) | BR0313484A (es) |
CA (1) | CA2495433A1 (es) |
CR (1) | CR7687A (es) |
DE (1) | DE60313330T2 (es) |
DK (1) | DK1536782T3 (es) |
EA (1) | EA007504B1 (es) |
EC (1) | ECSP055593A (es) |
ES (1) | ES2285230T3 (es) |
GB (1) | GB0219024D0 (es) |
GE (1) | GEP20084366B (es) |
GT (1) | GT200300173A (es) |
HN (1) | HN2003000247A (es) |
HR (1) | HRP20050136A2 (es) |
IL (1) | IL166415A0 (es) |
IS (1) | IS7643A (es) |
MA (1) | MA27381A1 (es) |
MX (1) | MXPA05001835A (es) |
NO (1) | NO20050782L (es) |
NZ (1) | NZ537818A (es) |
OA (1) | OA12899A (es) |
PA (1) | PA8577301A1 (es) |
PE (1) | PE20040992A1 (es) |
PL (1) | PL375553A1 (es) |
PT (1) | PT1536782E (es) |
RS (1) | RS20050078A (es) |
SI (1) | SI1536782T1 (es) |
TN (1) | TNSN05042A1 (es) |
TW (1) | TW200404531A (es) |
UA (1) | UA77329C2 (es) |
UY (1) | UY27936A1 (es) |
WO (1) | WO2004016259A1 (es) |
ZA (1) | ZA200500369B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NI200300043A (es) | 2002-03-28 | 2003-11-05 | Warner Lambert Co | AMINOACIDOS CON AFINIDAD POR LA PROTEINA a2DELTA. |
EP1675582A1 (en) * | 2003-09-12 | 2006-07-05 | Warner-Lambert Company LLC | Combination comprising an alpha-2-delta ligand and an ssri and/or snri for treatment of depression and anxiety disorders |
KR100768974B1 (ko) * | 2003-09-25 | 2007-10-22 | 워너-램버트 캄파니 엘엘씨 | 알파2델타-단백질에 대한 친화성을 갖는 아미노산 |
CN1856301A (zh) * | 2003-09-25 | 2006-11-01 | 沃尼尔·朗伯有限责任公司 | 治疗性β-氨基酸 |
GB0405200D0 (en) * | 2004-03-08 | 2004-04-21 | Pfizer Ltd | Combinations comprising alpha-2-delta ligands |
RU2007100355A (ru) * | 2004-07-09 | 2008-07-20 | Уорнер-Ламберт Компани Ллс (Us) | Получение бета-аминокислот, обладающих аффинностью к альфа-2-дельта-белку |
ITMI20041447A1 (it) * | 2004-07-20 | 2004-10-20 | Zambon Spa | Composizione farmaceutica comprendente gabapentina |
US20090227562A1 (en) * | 2004-08-10 | 2009-09-10 | Pfizer Inc. | Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor |
CA2578990A1 (en) * | 2004-09-07 | 2006-03-16 | Pfizer Inc. | Combination of a 5-ht(1) receptor agonist and an alpha-2-delta ligand for the treatment of migraine |
WO2006092692A1 (en) * | 2005-03-01 | 2006-09-08 | Pfizer Limited | Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain |
MX2009011858A (es) * | 2007-04-30 | 2010-01-14 | Adolor Corp | Composiciones de (-)-e-10-oh-nt y metodos para su sintesis y uso. |
WO2008132589A1 (en) * | 2007-05-01 | 2008-11-06 | Pfizer Limited | Combinations comprising pregabalin |
US20090148532A1 (en) * | 2007-12-06 | 2009-06-11 | Venkatesh Gopi M | Preparation of controlled release skeletal muscle relaxant dosage forms |
TWI531362B (zh) | 2008-07-21 | 2016-05-01 | 艾爾康股份有限公司 | 具有治療劑遞送能力之眼科裝置 |
CA2805371C (en) * | 2010-07-30 | 2017-10-31 | Toray Industries, Inc. | Therapeutic agent or prophylactic agent for neuropathic pain |
US9376438B2 (en) | 2011-05-17 | 2016-06-28 | Principia Biopharma, Inc. | Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors |
SI2710005T1 (sl) | 2011-05-17 | 2017-03-31 | Principia Biopharma Inc. | Zaviralci tirozinske kinaze |
US9580427B2 (en) | 2011-05-17 | 2017-02-28 | The Regents Of The University Of California | Kinase inhibitors |
WO2013084182A1 (en) * | 2011-12-08 | 2013-06-13 | Glenmark Pharmaceuticals S.A. | Pharmaceutical composition that includes a pde4 enzyme inhibitor and an analgesic agent |
DK3181567T3 (da) | 2012-09-10 | 2019-06-11 | Principia Biopharma Inc | Pyrazolopyrimidinforbindelser som kinasehæmmere |
US8957080B2 (en) | 2013-04-09 | 2015-02-17 | Principia Biopharma Inc. | Tyrosine kinase inhibitors |
CN112353806A (zh) | 2014-02-21 | 2021-02-12 | 普林斯匹亚生物制药公司 | Btk抑制剂的盐和固体形式 |
PT3233103T (pt) | 2014-12-18 | 2021-01-18 | Principia Biopharma Inc | Tratamento de pênfigo |
TW201718572A (zh) | 2015-06-24 | 2017-06-01 | 普林斯匹亞生物製藥公司 | 酪胺酸激酶抑制劑 |
CA3028169A1 (en) | 2016-06-29 | 2018-01-04 | Principia Biopharma Inc. | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
CN114195661B (zh) * | 2021-12-21 | 2023-12-22 | 苏州楚凯药业有限公司 | 一种苯磺酸米洛巴林的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE41920E1 (en) * | 1996-07-24 | 2010-11-09 | Warner-Lambert Company Llc | Isobutylgaba and its derivatives for the treatment of pain |
NZ503963A (en) * | 1997-12-16 | 2002-09-27 | Warner Lambert Co | 1-substituted-1-aminomethyl-cycloalkane derivatives, or gabapentin analogues, preparation and use in the treatment of neurological disorders |
HN2000000224A (es) * | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
IL139073A0 (en) * | 1999-10-21 | 2001-11-25 | Pfizer | Treatment of neuropathy |
WO2002019213A2 (en) * | 2000-08-30 | 2002-03-07 | Lilly Icos Llc | Method for treatment of migraine using pde5 inhibitors |
CA2444053C (en) * | 2001-04-19 | 2008-06-17 | Warner-Lambert Company Llc | Fused bicyclic or tricyclic amino acids |
-
2002
- 2002-08-15 GB GBGB0219024.7A patent/GB0219024D0/en not_active Ceased
-
2003
- 2003-04-08 UA UAA200501347A patent/UA77329C2/uk unknown
- 2003-07-11 PA PA20038577301A patent/PA8577301A1/es unknown
- 2003-08-04 AP AP2005003227A patent/AP2005003227A0/xx unknown
- 2003-08-04 CA CA002495433A patent/CA2495433A1/en not_active Abandoned
- 2003-08-04 MX MXPA05001835A patent/MXPA05001835A/es active IP Right Grant
- 2003-08-04 KR KR1020077000033A patent/KR20070009746A/ko not_active Application Discontinuation
- 2003-08-04 EP EP03787957A patent/EP1536782B1/en not_active Expired - Lifetime
- 2003-08-04 DE DE60313330T patent/DE60313330T2/de not_active Expired - Fee Related
- 2003-08-04 GE GEAP8632A patent/GEP20084366B/en unknown
- 2003-08-04 SI SI200330810T patent/SI1536782T1/sl unknown
- 2003-08-04 RS RSP-2005/0078A patent/RS20050078A/sr unknown
- 2003-08-04 AT AT03787957T patent/ATE359775T1/de not_active IP Right Cessation
- 2003-08-04 WO PCT/IB2003/003476 patent/WO2004016259A1/en active IP Right Grant
- 2003-08-04 IL IL16641503A patent/IL166415A0/xx unknown
- 2003-08-04 NZ NZ537818A patent/NZ537818A/en unknown
- 2003-08-04 BR BR0313484-9A patent/BR0313484A/pt not_active IP Right Cessation
- 2003-08-04 ES ES03787957T patent/ES2285230T3/es not_active Expired - Lifetime
- 2003-08-04 CN CNA038190737A patent/CN1674884A/zh active Pending
- 2003-08-04 PT PT03787957T patent/PT1536782E/pt unknown
- 2003-08-04 DK DK03787957T patent/DK1536782T3/da active
- 2003-08-04 OA OA1200500037A patent/OA12899A/en unknown
- 2003-08-04 AU AU2003249476A patent/AU2003249476B2/en not_active Ceased
- 2003-08-04 PL PL03375553A patent/PL375553A1/xx not_active Application Discontinuation
- 2003-08-04 KR KR1020057002450A patent/KR20050042154A/ko not_active Application Discontinuation
- 2003-08-04 EA EA200500207A patent/EA007504B1/ru not_active IP Right Cessation
- 2003-08-04 JP JP2004528754A patent/JP2006502139A/ja not_active Withdrawn
- 2003-08-12 UY UY27936A patent/UY27936A1/es not_active Application Discontinuation
- 2003-08-12 PE PE2003000806A patent/PE20040992A1/es not_active Application Discontinuation
- 2003-08-13 AR AR20030102933A patent/AR040871A1/es not_active Application Discontinuation
- 2003-08-14 HN HN2003000247A patent/HN2003000247A/es unknown
- 2003-08-14 TW TW092122363A patent/TW200404531A/zh unknown
- 2003-08-14 GT GT200300173A patent/GT200300173A/es unknown
-
2005
- 2005-01-12 IS IS7643A patent/IS7643A/is unknown
- 2005-01-14 ZA ZA200500369A patent/ZA200500369B/en unknown
- 2005-02-10 EC EC2005005593A patent/ECSP055593A/es unknown
- 2005-02-14 HR HR20050136A patent/HRP20050136A2/xx not_active Application Discontinuation
- 2005-02-14 CR CR7687A patent/CR7687A/es not_active Application Discontinuation
- 2005-02-14 NO NO20050782A patent/NO20050782L/no not_active Application Discontinuation
- 2005-02-15 TN TNP2005000042A patent/TNSN05042A1/fr unknown
- 2005-02-15 MA MA28104A patent/MA27381A1/fr unknown
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