MX2009011858A - Composiciones de (-)-e-10-oh-nt y metodos para su sintesis y uso. - Google Patents
Composiciones de (-)-e-10-oh-nt y metodos para su sintesis y uso.Info
- Publication number
- MX2009011858A MX2009011858A MX2009011858A MX2009011858A MX2009011858A MX 2009011858 A MX2009011858 A MX 2009011858A MX 2009011858 A MX2009011858 A MX 2009011858A MX 2009011858 A MX2009011858 A MX 2009011858A MX 2009011858 A MX2009011858 A MX 2009011858A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- synthesis
- cycloheptene
- compositions
- norepinephrine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Addiction (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Agronomy & Crop Science (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
Abstract
La presente descripción proporciona descripciones que comprenden metabolitos de E-10-OH-NT de AT y NT, métodos para su síntesis y métodos para su uso. En una modalidad, el compuesto (-)-E-5-(i-bromopropilideno)-10,11-dihidro-IO-hidroxi-5H-dibenzo[ a,d]-cicloheptano. El mismo es preparado reduciendo E-5-(i-bromopropilideno)-10,11-dihidro-lO-oxo-5H-dibenzo[a,d]-cic loheptano en presencia de un catalizador oxazaborolidina específicos crurales. En otra modalidad, el método para inhibir la toma de norepinefrina que comprende una transportador de norepinefrina con una composición que comprende E-lO-OH-NT que es enriquecida con el enantiómero es descrito.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91510307P | 2007-04-30 | 2007-04-30 | |
US2781408P | 2008-02-11 | 2008-02-11 | |
US2812208P | 2008-02-12 | 2008-02-12 | |
PCT/US2008/061189 WO2008134325A1 (en) | 2007-04-30 | 2008-04-22 | Compositions of (-)-e-10-oh-nt and methods for their synthesis and use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011858A true MX2009011858A (es) | 2010-01-14 |
Family
ID=39926044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011858A MX2009011858A (es) | 2007-04-30 | 2008-04-22 | Composiciones de (-)-e-10-oh-nt y metodos para su sintesis y uso. |
Country Status (14)
Country | Link |
---|---|
US (2) | US20080275131A1 (es) |
EP (1) | EP2152074A4 (es) |
JP (1) | JP2010526075A (es) |
KR (1) | KR20100019985A (es) |
CN (1) | CN101720186A (es) |
AU (1) | AU2008245836A1 (es) |
BR (1) | BRPI0810773A2 (es) |
CA (1) | CA2685395A1 (es) |
IL (1) | IL201766A0 (es) |
MX (1) | MX2009011858A (es) |
NO (1) | NO20093448L (es) |
NZ (1) | NZ581391A (es) |
RU (1) | RU2469715C2 (es) |
WO (1) | WO2008134325A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090233958A1 (en) * | 2008-02-19 | 2009-09-17 | Adolor Corporation | (+)-beloxepin and methods for its synthesis and use |
US20090233959A1 (en) * | 2008-02-19 | 2009-09-17 | Adolor Corporation | Beloxepin and analogs for the treatment of pain |
US20090233957A1 (en) * | 2008-02-19 | 2009-09-17 | Adolor Corporation | (-)-beloxepin and methods for its synthesis and use |
ES2540151B1 (es) * | 2013-10-11 | 2016-02-29 | Farmalider S.A. | Composición farmacéutica de ibuprofeno y tramadol para uso oftálmico |
EP3322412B1 (en) * | 2015-07-15 | 2021-04-07 | Theranexus | Use of amitriptyline for blocking brain hemichannels and method for potentiating its effect in vivo |
CN110143944A (zh) * | 2019-05-08 | 2019-08-20 | 上海升华医药科技有限公司 | 一种手性二苯并[b,e]硫杂*-11-醇的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3547998A (en) * | 1968-08-09 | 1970-12-15 | Lilly Co Eli | Intermediate and process for the preparation of nortriptyline |
US4593031A (en) * | 1982-03-22 | 1986-06-03 | Sandoz, Inc. | Method of treating depression |
AU659929B2 (en) * | 1992-05-14 | 1995-06-01 | Pfizer Inc. | Enantioselective oxazaborolidine catalysts |
AU4467396A (en) * | 1994-12-12 | 1996-07-10 | Omeros Medical Systems, Inc. | Irrigation solution and method for inhibition of pain, inflammation and spasm |
EP1007041A4 (en) * | 1997-04-11 | 2001-03-07 | Lilly Co Eli | COMPOSITION FOR TREATING PAIN |
DK1459750T3 (da) * | 1999-07-01 | 2005-08-15 | Pharmacia & Upjohn Co Llc | (S,S)-rebexetin til behandling af fibromyalgi og andre somatoforme lidelser |
ES2330837T3 (es) * | 2001-07-09 | 2009-12-16 | Combinatorx, Incorporated | Combinaciones para el tratamiento de trastornos inflamatorios. |
US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
EP1448512A1 (en) * | 2001-11-17 | 2004-08-25 | NeuroSearch A/S | Prodrugs of antidepressants and their use for treating depressions |
GB0219024D0 (en) * | 2002-08-15 | 2002-09-25 | Pfizer Ltd | Synergistic combinations |
-
2008
- 2008-04-22 BR BRPI0810773-4A2A patent/BRPI0810773A2/pt not_active IP Right Cessation
- 2008-04-22 NZ NZ581391A patent/NZ581391A/en not_active IP Right Cessation
- 2008-04-22 US US12/107,742 patent/US20080275131A1/en not_active Abandoned
- 2008-04-22 AU AU2008245836A patent/AU2008245836A1/en not_active Abandoned
- 2008-04-22 EP EP08746582A patent/EP2152074A4/en not_active Withdrawn
- 2008-04-22 WO PCT/US2008/061189 patent/WO2008134325A1/en active Application Filing
- 2008-04-22 JP JP2010506436A patent/JP2010526075A/ja active Pending
- 2008-04-22 RU RU2009144121/15A patent/RU2469715C2/ru not_active IP Right Cessation
- 2008-04-22 KR KR1020097024989A patent/KR20100019985A/ko not_active Application Discontinuation
- 2008-04-22 CA CA002685395A patent/CA2685395A1/en not_active Abandoned
- 2008-04-22 CN CN200880022883A patent/CN101720186A/zh active Pending
- 2008-04-22 MX MX2009011858A patent/MX2009011858A/es not_active Application Discontinuation
-
2009
- 2009-10-26 IL IL201766A patent/IL201766A0/en unknown
- 2009-11-30 NO NO20093448A patent/NO20093448L/no not_active Application Discontinuation
-
2012
- 2012-03-22 US US13/427,744 patent/US20120178815A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
RU2469715C2 (ru) | 2012-12-20 |
EP2152074A4 (en) | 2011-07-27 |
CA2685395A1 (en) | 2008-11-06 |
CN101720186A (zh) | 2010-06-02 |
AU2008245836A1 (en) | 2008-11-06 |
NZ581391A (en) | 2012-06-29 |
JP2010526075A (ja) | 2010-07-29 |
IL201766A0 (en) | 2010-06-16 |
WO2008134325A1 (en) | 2008-11-06 |
KR20100019985A (ko) | 2010-02-19 |
US20120178815A1 (en) | 2012-07-12 |
NO20093448L (no) | 2010-02-01 |
US20080275131A1 (en) | 2008-11-06 |
BRPI0810773A2 (pt) | 2014-10-07 |
RU2009144121A (ru) | 2011-06-10 |
EP2152074A1 (en) | 2010-02-17 |
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Legal Events
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HH | Correction or change in general | ||
FA | Abandonment or withdrawal |