WO2009005069A1 - ルテニウム触媒を用いた重水素化方法 - Google Patents

ルテニウム触媒を用いた重水素化方法 Download PDF

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Publication number
WO2009005069A1
WO2009005069A1 PCT/JP2008/061924 JP2008061924W WO2009005069A1 WO 2009005069 A1 WO2009005069 A1 WO 2009005069A1 JP 2008061924 W JP2008061924 W JP 2008061924W WO 2009005069 A1 WO2009005069 A1 WO 2009005069A1
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WO
WIPO (PCT)
Prior art keywords
ruthenium catalyst
deuteration
deuterating
copresence
reacted
Prior art date
Application number
PCT/JP2008/061924
Other languages
English (en)
French (fr)
Inventor
Hironao Sajiki
Tomohiro Maegawa
Yasunari Monguchi
Yuta Fujiwara
Yuya Inagaki
Original Assignee
Wako Pure Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wako Pure Chemical Industries, Ltd. filed Critical Wako Pure Chemical Industries, Ltd.
Priority to JP2009521638A priority Critical patent/JP5454140B2/ja
Publication of WO2009005069A1 publication Critical patent/WO2009005069A1/ja

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/38Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals
    • B01J23/40Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of noble metals of the platinum group metals
    • B01J23/46Ruthenium, rhodium, osmium or iridium
    • B01J23/462Ruthenium
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)

Abstract

課題  ルテニウム触媒を用いることにより、基質を効率よく重水素化する方法を提供すること 解決手段  本発明は、ルテニウム触媒と水素ガスの共存下、ヒドロキシル基、置換基を有していてもよいアミノ基、エーテル結合又は/及び-NH-基を有する化合物を重水素源と反応させることを特徴とする重水素化方法、の発明である。
PCT/JP2008/061924 2007-07-05 2008-07-01 ルテニウム触媒を用いた重水素化方法 WO2009005069A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009521638A JP5454140B2 (ja) 2007-07-05 2008-07-01 ルテニウム触媒を用いた重水素化方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007177565 2007-07-05
JP2007-177565 2007-07-05

Publications (1)

Publication Number Publication Date
WO2009005069A1 true WO2009005069A1 (ja) 2009-01-08

Family

ID=40226114

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061924 WO2009005069A1 (ja) 2007-07-05 2008-07-01 ルテニウム触媒を用いた重水素化方法

Country Status (2)

Country Link
JP (1) JP5454140B2 (ja)
WO (1) WO2009005069A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011129314A1 (ja) * 2010-04-13 2011-10-20 和光純薬工業株式会社 糖類の重水素化方法
WO2012160015A1 (en) 2011-05-23 2012-11-29 Sanofi Process for the preparation of deuterated compounds containing n-alkyl groups
WO2014006433A2 (en) 2012-07-06 2014-01-09 Debreceni Egyetem Process for the activation of the c-h bond of organic compounds and a reactions system serving the process
CN108358803A (zh) * 2018-01-29 2018-08-03 长沙贝塔医药科技有限公司 一种氘代甘氨酸、马尿酸-l-薄荷酯(2,2-d2)及其中间体的合成方法
JP2020518576A (ja) * 2017-04-27 2020-06-25 デューテリア ビバレッジズ、エルエルシー D2oからの重水素化エタノールの調製方法
CN114920897A (zh) * 2021-10-29 2022-08-19 北京绮一舟新材料技术有限公司 两种氘代聚合物及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060831A1 (ja) * 2002-12-27 2004-07-22 Wako Pure Chemical Industries, Ltd. 重水素化方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004060831A1 (ja) * 2002-12-27 2004-07-22 Wako Pure Chemical Industries, Ltd. 重水素化方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEMISTRY LETTERS, vol. 34, no. 2, 2005, pages 192 - 193 *
JOURNAL OF ORGANIC CHEMISTRY, vol. 39, no. 2, 1974, pages 260 - 261 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011129314A1 (ja) * 2010-04-13 2011-10-20 和光純薬工業株式会社 糖類の重水素化方法
JP5803907B2 (ja) * 2010-04-13 2015-11-04 和光純薬工業株式会社 糖類の重水素化方法
WO2012160015A1 (en) 2011-05-23 2012-11-29 Sanofi Process for the preparation of deuterated compounds containing n-alkyl groups
JP2014524888A (ja) * 2011-05-23 2014-09-25 サノフイ N−アルキル基を含有するジュウテリウム化化合物の製造方法
US9340489B2 (en) 2011-05-23 2016-05-17 Sanofi Process for the preparation of deuterated compounds containing N-alkyl groups
WO2014006433A2 (en) 2012-07-06 2014-01-09 Debreceni Egyetem Process for the activation of the c-h bond of organic compounds and a reactions system serving the process
JP2020518576A (ja) * 2017-04-27 2020-06-25 デューテリア ビバレッジズ、エルエルシー D2oからの重水素化エタノールの調製方法
JP7064507B2 (ja) 2017-04-27 2022-05-10 デューテリア ビバレッジズ、エルエルシー D2oからの重水素化エタノールの調製方法
CN108358803A (zh) * 2018-01-29 2018-08-03 长沙贝塔医药科技有限公司 一种氘代甘氨酸、马尿酸-l-薄荷酯(2,2-d2)及其中间体的合成方法
CN108358803B (zh) * 2018-01-29 2024-04-19 长沙贝塔医药科技有限公司 一种氘代甘氨酸、马尿酸-l-薄荷酯(2,2-d2)及其中间体的合成方法
CN114920897A (zh) * 2021-10-29 2022-08-19 北京绮一舟新材料技术有限公司 两种氘代聚合物及其制备方法

Also Published As

Publication number Publication date
JPWO2009005069A1 (ja) 2010-08-26
JP5454140B2 (ja) 2014-03-26

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