AP161A - Novel Quinoline derivatives. - Google Patents

Novel Quinoline derivatives. Download PDF

Info

Publication number
AP161A
AP161A APAP/P/1990/000197A AP9000197A AP161A AP 161 A AP161 A AP 161A AP 9000197 A AP9000197 A AP 9000197A AP 161 A AP161 A AP 161A
Authority
AP
ARIPO
Prior art keywords
ethyl
tetrazol
alkyl
formula
biphenyl
Prior art date
Application number
APAP/P/1990/000197A
Other languages
English (en)
Other versions
AP9000197A0 (en
Inventor
David Anthony Roberts
Simon Thomas Russell
Robert James Pearce
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898918402A external-priority patent/GB8918402D0/en
Priority claimed from GB909003187A external-priority patent/GB9003187D0/en
Application filed by Ici Plc filed Critical Ici Plc
Publication of AP9000197A0 publication Critical patent/AP9000197A0/xx
Application granted granted Critical
Publication of AP161A publication Critical patent/AP161A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
APAP/P/1990/000197A 1989-08-11 1990-08-10 Novel Quinoline derivatives. AP161A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898918402A GB8918402D0 (en) 1989-08-11 1989-08-11 Nitrogen compounds
GB909003187A GB9003187D0 (en) 1990-02-13 1990-02-13 Nitrogen compounds

Publications (2)

Publication Number Publication Date
AP9000197A0 AP9000197A0 (en) 1990-10-31
AP161A true AP161A (en) 1991-12-20

Family

ID=26295741

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000197A AP161A (en) 1989-08-11 1990-08-10 Novel Quinoline derivatives.

Country Status (18)

Country Link
US (1) US5444071A (fr)
EP (1) EP0412848B1 (fr)
JP (1) JP3010056B2 (fr)
KR (1) KR910004571A (fr)
CN (1) CN1050187A (fr)
AP (1) AP161A (fr)
AT (1) ATE117294T1 (fr)
AU (1) AU623546B2 (fr)
BG (1) BG92674A (fr)
DE (1) DE69016125T2 (fr)
FI (1) FI903966A7 (fr)
HU (1) HUT54991A (fr)
IE (1) IE902909A1 (fr)
NO (1) NO903525L (fr)
NZ (1) NZ234854A (fr)
PL (1) PL286445A1 (fr)
PT (1) PT94960A (fr)
YU (1) YU155290A (fr)

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GB9017479D0 (en) * 1990-08-09 1990-09-26 Ici Plc Process
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
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US6004979A (en) * 1991-02-07 1999-12-21 Hoechst Marion Roussel Nitrogenous bicycles
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US6608048B2 (en) 2000-03-28 2003-08-19 Wyeth Holdings Tricyclic protein kinase inhibitors
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WO2012004743A1 (fr) 2010-07-09 2012-01-12 Pfizer Limited Benzènesulfonamides utiles en tant qu'inhibiteurs des canaux sodiques
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WO2019175132A1 (fr) 2018-03-13 2019-09-19 Onxeo Molécule dbait contre la résistance acquise dans le traitement du cancer
WO2021148581A1 (fr) 2020-01-22 2021-07-29 Onxeo Nouvelle molécule dbait et son utilisation
SMT202500447T1 (it) 2021-11-02 2026-01-12 Flare Therapeutics Inc Agonisti inversi di pparg e loro usi
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WO2024261243A1 (fr) 2023-06-21 2024-12-26 Hemispherian As Combinaison comprenant un dérivé de désoxycytidine et un inhibiteur de parp destiné à être utilisé dans une méthode de traitement du cancer déficient en hr

Citations (3)

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Publication number Priority date Publication date Assignee Title
US3932416A (en) * 1972-07-03 1976-01-13 Allen & Hanburys Limited N-tetrazolyl quinaldamides
US4576953A (en) * 1983-03-29 1986-03-18 Imperial Chemical Industries Plc Quinoline derivatives
US4607040A (en) * 1982-04-07 1986-08-19 Imperial Chemical Industries Plc Quinoline derivatives which are 5-hydroxytryptamine antagonists

Family Cites Families (16)

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WO1987005510A1 (fr) * 1986-03-13 1987-09-24 Rorer International (Overseas) Inc. Tetrazoles de thioether ou d'ether de quinolinyle utilises comme agents pour le traitement de troubles d'hypersensibilite
CA1334092C (fr) * 1986-07-11 1995-01-24 David John Carini Imidazoles bloquant les recepteurs de l'angiotensine ii
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
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US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4880904A (en) * 1987-12-04 1989-11-14 Shell Oil Company Polyketone-based structural adhesive
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
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IL89029A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
US5246944A (en) * 1991-08-13 1993-09-21 Merck & Co., Inc. Quinoline angiotensin ii antagonists incorporating a substituted benzyl element
US5227387A (en) * 1991-09-03 1993-07-13 Dowelanco Quinoline nematicidal method

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US3932416A (en) * 1972-07-03 1976-01-13 Allen & Hanburys Limited N-tetrazolyl quinaldamides
US4607040A (en) * 1982-04-07 1986-08-19 Imperial Chemical Industries Plc Quinoline derivatives which are 5-hydroxytryptamine antagonists
US4576953A (en) * 1983-03-29 1986-03-18 Imperial Chemical Industries Plc Quinoline derivatives

Also Published As

Publication number Publication date
PL286445A1 (en) 1991-04-22
PT94960A (pt) 1991-04-18
JPH03169863A (ja) 1991-07-23
FI903966A7 (fi) 1991-02-12
HUT54991A (en) 1991-04-29
CN1050187A (zh) 1991-03-27
DE69016125D1 (de) 1995-03-02
EP0412848B1 (fr) 1995-01-18
FI903966A0 (fi) 1990-08-10
IE902909A1 (en) 1991-02-27
YU155290A (sh) 1993-05-28
DE69016125T2 (de) 1995-06-01
NZ234854A (en) 1993-02-25
NO903525D0 (no) 1990-08-10
EP0412848A3 (en) 1991-04-10
BG92674A (bg) 1993-12-24
AU6095590A (en) 1991-02-14
US5444071A (en) 1995-08-22
AU623546B2 (en) 1992-05-14
EP0412848A2 (fr) 1991-02-13
HU904961D0 (en) 1991-01-28
ATE117294T1 (de) 1995-02-15
AP9000197A0 (en) 1990-10-31
JP3010056B2 (ja) 2000-02-14
NO903525L (no) 1991-02-12
KR910004571A (ko) 1991-03-28

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