AP161A - Novel Quinoline derivatives. - Google Patents

Novel Quinoline derivatives. Download PDF

Info

Publication number
AP161A
AP161A APAP/P/1990/000197A AP9000197A AP161A AP 161 A AP161 A AP 161A AP 9000197 A AP9000197 A AP 9000197A AP 161 A AP161 A AP 161A
Authority
AP
ARIPO
Prior art keywords
ethyl
tetrazol
alkyl
formula
biphenyl
Prior art date
Application number
APAP/P/1990/000197A
Other languages
English (en)
Other versions
AP9000197A0 (en
Inventor
David Anthony Roberts
Simon Thomas Russell
Robert James Pearce
Original Assignee
Ici Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898918402A external-priority patent/GB8918402D0/en
Priority claimed from GB909003187A external-priority patent/GB9003187D0/en
Application filed by Ici Plc filed Critical Ici Plc
Publication of AP9000197A0 publication Critical patent/AP9000197A0/xx
Application granted granted Critical
Publication of AP161A publication Critical patent/AP161A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
APAP/P/1990/000197A 1989-08-11 1990-08-10 Novel Quinoline derivatives. AP161A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898918402A GB8918402D0 (en) 1989-08-11 1989-08-11 Nitrogen compounds
GB909003187A GB9003187D0 (en) 1990-02-13 1990-02-13 Nitrogen compounds

Publications (2)

Publication Number Publication Date
AP9000197A0 AP9000197A0 (en) 1990-10-31
AP161A true AP161A (en) 1991-12-20

Family

ID=26295741

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000197A AP161A (en) 1989-08-11 1990-08-10 Novel Quinoline derivatives.

Country Status (18)

Country Link
US (1) US5444071A (de)
EP (1) EP0412848B1 (de)
JP (1) JP3010056B2 (de)
KR (1) KR910004571A (de)
CN (1) CN1050187A (de)
AP (1) AP161A (de)
AT (1) ATE117294T1 (de)
AU (1) AU623546B2 (de)
BG (1) BG92674A (de)
DE (1) DE69016125T2 (de)
FI (1) FI903966A7 (de)
HU (1) HUT54991A (de)
IE (1) IE902909A1 (de)
NO (1) NO903525L (de)
NZ (1) NZ234854A (de)
PL (1) PL286445A1 (de)
PT (1) PT94960A (de)
YU (1) YU155290A (de)

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GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
GB9017479D0 (en) * 1990-08-09 1990-09-26 Ici Plc Process
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
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FR2672596B1 (fr) * 1991-02-07 1995-07-13 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
FR2680510B1 (fr) * 1991-08-20 1995-06-23 Roussel Uclaf Nouveaux derives bicycliques azotes, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US6004979A (en) * 1991-02-07 1999-12-21 Hoechst Marion Roussel Nitrogenous bicycles
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GB9113628D0 (en) * 1991-06-25 1991-08-14 Ici Plc Heterocyclic derivatives
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US5616591A (en) * 1992-03-27 1997-04-01 E.R. Squibb & Sons, Inc. Indole- and benzimidazole-substituted quinoline derivatives
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CN121398822A (zh) 2023-06-21 2026-01-23 四方生物科学有限公司 用于在治疗hr功能正常的癌症的方法中的用途的包含脱氧胞苷衍生物和parp抑制剂的组合

Citations (3)

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Publication number Priority date Publication date Assignee Title
US3932416A (en) * 1972-07-03 1976-01-13 Allen & Hanburys Limited N-tetrazolyl quinaldamides
US4576953A (en) * 1983-03-29 1986-03-18 Imperial Chemical Industries Plc Quinoline derivatives
US4607040A (en) * 1982-04-07 1986-08-19 Imperial Chemical Industries Plc Quinoline derivatives which are 5-hydroxytryptamine antagonists

Family Cites Families (16)

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AU612569B2 (en) * 1986-03-13 1991-07-18 Rorer International (Overseas) Inc. Quinolinyl ether or thioether tetrazoles as agents for the treatment of hypersensitive ailments
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4920130A (en) * 1987-11-02 1990-04-24 Rorer Pharamceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US4920131A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
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US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
IL89029A (en) * 1988-01-29 1993-01-31 Lilly Co Eli Fungicidal quinoline and cinnoline derivatives, compositions containing them, and fungicidal methods of using them
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GB9010394D0 (en) * 1990-05-09 1990-06-27 Ici Plc Heterocyclic compounds
GB9017482D0 (en) * 1990-08-09 1990-09-26 Ici Plc Manufacturing process
GB9025123D0 (en) * 1990-11-19 1991-01-02 Ici Plc Nitrogen compounds
US5246944A (en) * 1991-08-13 1993-09-21 Merck & Co., Inc. Quinoline angiotensin ii antagonists incorporating a substituted benzyl element
US5227387A (en) * 1991-09-03 1993-07-13 Dowelanco Quinoline nematicidal method

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US3932416A (en) * 1972-07-03 1976-01-13 Allen & Hanburys Limited N-tetrazolyl quinaldamides
US4607040A (en) * 1982-04-07 1986-08-19 Imperial Chemical Industries Plc Quinoline derivatives which are 5-hydroxytryptamine antagonists
US4576953A (en) * 1983-03-29 1986-03-18 Imperial Chemical Industries Plc Quinoline derivatives

Also Published As

Publication number Publication date
HU904961D0 (en) 1991-01-28
HUT54991A (en) 1991-04-29
KR910004571A (ko) 1991-03-28
FI903966A7 (fi) 1991-02-12
NZ234854A (en) 1993-02-25
NO903525D0 (no) 1990-08-10
JP3010056B2 (ja) 2000-02-14
CN1050187A (zh) 1991-03-27
BG92674A (bg) 1993-12-24
AU623546B2 (en) 1992-05-14
IE902909A1 (en) 1991-02-27
AP9000197A0 (en) 1990-10-31
YU155290A (sh) 1993-05-28
EP0412848A3 (en) 1991-04-10
AU6095590A (en) 1991-02-14
NO903525L (no) 1991-02-12
ATE117294T1 (de) 1995-02-15
DE69016125D1 (de) 1995-03-02
JPH03169863A (ja) 1991-07-23
US5444071A (en) 1995-08-22
EP0412848A2 (de) 1991-02-13
FI903966A0 (fi) 1990-08-10
EP0412848B1 (de) 1995-01-18
PT94960A (pt) 1991-04-18
PL286445A1 (en) 1991-04-22
DE69016125T2 (de) 1995-06-01

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