AP139A - Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones. - Google Patents

Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones. Download PDF

Info

Publication number
AP139A
AP139A APAP/P/1990/000166A AP9000166A AP139A AP 139 A AP139 A AP 139A AP 9000166 A AP9000166 A AP 9000166A AP 139 A AP139 A AP 139A
Authority
AP
ARIPO
Prior art keywords
formula
alkyl
parts
hydrogen
methyl
Prior art date
Application number
APAP/P/1990/000166A
Other languages
English (en)
Other versions
AP9000166A0 (en
Inventor
Michael Joseph Kukla
Henry Joseph Breslin
Alfons Herman Margaretha Raeymaekers
GELDER Josephus Ludovicus Huberstus VAN
Paul Adriaan Jan Janssen
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898904108A external-priority patent/GB8904108D0/en
Priority claimed from GB898920354A external-priority patent/GB8920354D0/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AP9000166A0 publication Critical patent/AP9000166A0/xx
Application granted granted Critical
Publication of AP139A publication Critical patent/AP139A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
APAP/P/1990/000166A 1989-02-23 1990-02-21 Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones. AP139A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB898904108A GB8904108D0 (en) 1989-02-23 1989-02-23 Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones
GB898920354A GB8920354D0 (en) 1989-09-08 1989-09-08 Antiviral tetrahydroimidazo(1,4)benzodiazepin-2-thiones
US40662689A 1989-09-13 1989-09-13

Publications (2)

Publication Number Publication Date
AP9000166A0 AP9000166A0 (en) 1990-04-30
AP139A true AP139A (en) 1991-10-15

Family

ID=27264337

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1990/000166A AP139A (en) 1989-02-23 1990-02-21 Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones.

Country Status (28)

Country Link
EP (1) EP0384522B1 (de)
JP (1) JP2588624B2 (de)
AP (1) AP139A (de)
AT (1) ATE84534T1 (de)
AU (1) AU617926B2 (de)
CA (1) CA2010639C (de)
CY (1) CY1868A (de)
DE (1) DE69000743T2 (de)
DK (1) DK0384522T3 (de)
EG (1) EG19674A (de)
ES (1) ES2046671T3 (de)
FI (1) FI92830C (de)
GR (1) GR3006855T3 (de)
HK (1) HK114995A (de)
HU (2) HU204831B (de)
IE (1) IE63155B1 (de)
IL (1) IL93136A (de)
JO (1) JO1610B1 (de)
LV (1) LV5782B4 (de)
MA (1) MA21748A1 (de)
MY (1) MY106231A (de)
NO (1) NO173503C (de)
NZ (1) NZ232548A (de)
OA (1) OA09196A (de)
PH (1) PH27113A (de)
PT (1) PT93227B (de)
TN (1) TNSN90021A1 (de)
YU (1) YU47219B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8806449D0 (en) * 1988-03-18 1988-04-20 Janssen Pharmaceutica Nv Antiviral hexahydroimiazo(1 4)benzodiazepin-2-ones
NZ235137A (en) * 1989-09-13 1992-02-25 Janssen Pharmaceutica Nv Tetrahydroimidazo(1,4)benzodiazepine derivatives, preparation and pharmaceutical compositions thereof
NZ238664A (en) * 1990-07-06 1992-12-23 Janssen Pharmaceutica Nv Substituted tetrahydroimidazo(1,4)benzodiazepin-2-(thi)ones and pharmaceutical anti-viral compositions
DE4036552C1 (de) * 1990-11-16 1992-02-06 Boehringer Mannheim Gmbh, 6800 Mannheim, De
DE4103803A1 (de) * 1991-02-08 1992-08-13 Boehringer Mannheim Gmbh Neue 4,5,6,7-tetrahydro-imidazo-(4,5,ljk)(1,4)- benzodiazepin-2-(1h)-thione, verfahren zu ihrer herstellung sowie arzneimittel und zwischenprodukte zur herstellung dieser verbindungen
GB9109557D0 (en) * 1991-05-02 1991-06-26 Wellcome Found Chemical compounds
DK0513917T4 (da) * 1991-05-16 2001-06-25 Glaxo Group Ltd Antivirale kombinationer indeholdende nukleosidanaloger
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds
ATE160147T1 (de) * 1991-09-24 1997-11-15 Janssen Pharmaceutica Nv Verfahren zur herstellung von enantiomer reinem imidazo (4,5,1-jk) (1,4)-benzodiazepin-2(1h)- thionen
EP0639971B1 (de) * 1992-05-13 1999-09-22 The Wellcome Foundation Limited Therapeutische kombinationen
US6177435B1 (en) 1992-05-13 2001-01-23 Glaxo Wellcome Inc. Therapeutic combinations
GR920100326A (el) * 1992-07-21 1994-03-31 Medivir Ag Ενώσεις και μέ?οδοι αναστολής του HIV και των σχετικών ιών.
US5663169A (en) * 1992-08-07 1997-09-02 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
DE19946289A1 (de) * 1999-09-28 2001-03-29 Basf Ag Benzodiazepin-Derivate, deren Herstellung und Anwendung

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595745A (en) * 1977-02-25 1981-08-19 Lilly Co Eli Pyrroloquinoxalinones and pyrrolobenzodiazepinones
EP0146369A2 (de) * 1983-12-16 1985-06-26 JOHN WYETH & BROTHER LIMITED Imidazochinolinderivate
US4585770A (en) * 1982-10-12 1986-04-29 Roussel Uclaf Novel 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-j-k][1]-benzazepin-2-(1H)-one
EP0336466A1 (de) * 1988-03-18 1989-10-11 Janssen Pharmaceutica N.V. Antivirale Tetrahydroimidazo(1,4)benzodiazepin-2-one

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1595745A (en) * 1977-02-25 1981-08-19 Lilly Co Eli Pyrroloquinoxalinones and pyrrolobenzodiazepinones
US4585770A (en) * 1982-10-12 1986-04-29 Roussel Uclaf Novel 6-amino-7-hydroxy-4,5,6,7-tetrahydro-imidazo[4,5,1-j-k][1]-benzazepin-2-(1H)-one
EP0146369A2 (de) * 1983-12-16 1985-06-26 JOHN WYETH & BROTHER LIMITED Imidazochinolinderivate
EP0336466A1 (de) * 1988-03-18 1989-10-11 Janssen Pharmaceutica N.V. Antivirale Tetrahydroimidazo(1,4)benzodiazepin-2-one

Also Published As

Publication number Publication date
LV5782A4 (lv) 1996-12-20
IE63155B1 (en) 1995-03-22
HK114995A (en) 1995-07-21
DE69000743D1 (de) 1993-02-25
EP0384522A1 (de) 1990-08-29
AP9000166A0 (en) 1990-04-30
AU5003890A (en) 1990-08-30
NZ232548A (en) 1991-03-26
GR3006855T3 (de) 1993-06-30
FI92830B (fi) 1994-09-30
YU47219B (sh) 1995-01-31
DK0384522T3 (da) 1993-04-19
IL93136A0 (en) 1990-11-05
JO1610B1 (en) 1990-07-01
JP2588624B2 (ja) 1997-03-05
EP0384522B1 (de) 1993-01-13
NO173503B (no) 1993-09-13
ES2046671T3 (es) 1994-02-01
PT93227A (pt) 1990-08-31
NO900848L (no) 1990-08-24
CA2010639C (en) 2001-04-17
HU211250A9 (en) 1995-11-28
NO900848D0 (no) 1990-02-22
AU617926B2 (en) 1991-12-05
CA2010639A1 (en) 1990-08-23
HU900896D0 (en) 1990-05-28
MY106231A (en) 1995-04-29
EG19674A (en) 1996-06-30
TNSN90021A1 (fr) 1991-03-05
IE900650L (en) 1990-08-23
FI92830C (fi) 1995-01-10
YU33490A (sh) 1992-09-07
JPH02270876A (ja) 1990-11-05
PH27113A (en) 1993-03-16
OA09196A (en) 1992-06-30
MA21748A1 (fr) 1990-10-01
FI900897A0 (fi) 1990-02-22
PT93227B (pt) 1996-01-31
HUT54158A (en) 1991-01-28
DE69000743T2 (de) 1993-05-13
NO173503C (no) 1993-12-22
HU204831B (en) 1992-02-28
CY1868A (en) 1996-04-05
IL93136A (en) 1995-01-24
ATE84534T1 (de) 1993-01-15
LV5782B4 (lv) 1997-06-20

Similar Documents

Publication Publication Date Title
AP139A (en) Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones.
EP0336466B1 (de) Antivirale Tetrahydroimidazo(1,4)benzodiazepin-2-one
US6201119B1 (en) Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2(thi) ones
AP262A (en) Novel antiviral tetrahydroimidazo (1,4) benzodiazepin-2-(thi) ones.
AP174A (en) Antiviral tetrahydroimidazo (1,4) benzodiazepines.
HRP930480A2 (en) Antiviral tetrahydroimidazo (1,4) benzodiazepine-2-thiones
DD293119A5 (de) Verfahren zur herstellung von tetrahydro[1,4]benzodiazepin-2-thionen
HU207322B (en) Process for producing imidazo-benzodiazepin-2/1h/-one derivatives and pharmaceutical compositions containing them