LU90324I2 - Plavix-clopidogrel - Google Patents

Plavix-clopidogrel

Info

Publication number
LU90324I2
LU90324I2 LU90324C LU90324C LU90324I2 LU 90324 I2 LU90324 I2 LU 90324I2 LU 90324 C LU90324 C LU 90324C LU 90324 C LU90324 C LU 90324C LU 90324 I2 LU90324 I2 LU 90324I2
Authority
LU
Luxembourg
Prior art keywords
plavix
clopidogrel
Prior art date
Application number
LU90324C
Other languages
English (en)
French (fr)
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26225786&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90324(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR8702025A external-priority patent/FR2612929B1/fr
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of LU90324I2 publication Critical patent/LU90324I2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
LU90324C 1987-02-17 1998-11-27 Plavix-clopidogrel LU90324I2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8702025A FR2612929B1 (fr) 1987-02-17 1987-02-17 Enantiomere dextrogyre de 1a-(tetrahydro- 4,5,6,7 thieno (3,2-c) pyridyl-5) (chloro-2 phenyl)-acetate de methyle, son procede de preparation et les compositions pharmaceutiques le renfermant
FR878716516A FR2623810B2 (fr) 1987-02-17 1987-11-27 Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant

Publications (1)

Publication Number Publication Date
LU90324I2 true LU90324I2 (fr) 1999-01-27

Family

ID=26225786

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90324C LU90324I2 (fr) 1987-02-17 1998-11-27 Plavix-clopidogrel

Country Status (36)

Country Link
US (1) US4847265A (xx)
EP (1) EP0281459B1 (xx)
JP (1) JPH0645622B2 (xx)
KR (1) KR960003615B1 (xx)
AR (1) AR243891A1 (xx)
AT (1) ATE121745T1 (xx)
AU (1) AU597784B2 (xx)
CA (1) CA1336777C (xx)
CS (1) CS274420B2 (xx)
CY (1) CY2087B1 (xx)
DE (2) DE19875053I2 (xx)
DK (1) DK173636B1 (xx)
ES (1) ES2071621T4 (xx)
FI (1) FI87216C (xx)
FR (1) FR2623810B2 (xx)
HK (1) HK1000093A1 (xx)
HR (1) HRP920923B1 (xx)
HU (2) HU197909B (xx)
IE (1) IE66922B1 (xx)
IL (1) IL85294A (xx)
LU (1) LU90324I2 (xx)
LV (1) LV5804B4 (xx)
MA (1) MA21184A1 (xx)
MX (1) MX9203026A (xx)
MY (1) MY103198A (xx)
NL (1) NL990002I1 (xx)
NO (2) NO165924C (xx)
NZ (1) NZ223475A (xx)
OA (1) OA08808A (xx)
PH (1) PH25960A (xx)
PL (1) PL156689B1 (xx)
PT (1) PT86726B (xx)
RO (1) RO99191B1 (xx)
SI (1) SI8810231A8 (xx)
TN (1) TNSN88012A1 (xx)
YU (1) YU46748B (xx)

Families Citing this family (138)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065421A (en) * 1957-05-21 1962-11-20 John M Hart Radio-telephone communication system having means for automatic direct dispatch between mobile stations
US3009149A (en) * 1957-09-30 1961-11-14 Mcdonald Ramsey Automatic dial radio telephone system
US3105118A (en) * 1960-04-13 1963-09-24 Ericsson Telefon Ab L M Mobile radio stations interconnected with a wire telephone system
US4906756A (en) * 1988-05-10 1990-03-06 Syntex (U.S.A.) Inc. 2-(2-nitrovinyl)thiophene reduction and synthesis of thieno[3,2-c]pyridine derivatives
GB8824400D0 (en) * 1988-10-18 1988-11-23 Glaxo Group Ltd Chemical compounds
FR2664596B1 (fr) * 1990-07-10 1994-06-10 Sanofi Sa Procede de preparation d'un derive n-phenylacetique de tetrahydrothieno [3,2-c] pyridine et son intermediaire de synthese.
FR2672801B1 (fr) * 1991-02-14 1995-03-03 Sanofi Sa Utilisation de derives de tetrahydrothienopyridine comme inhibiteurs de l'angiogenese.
NZ334389A (en) * 1996-08-28 2001-05-25 Ube Industries Cyclic amine derivatives
HU225504B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them
HU222283B1 (hu) * 1997-05-13 2003-05-28 Sanofi-Synthelabo Eljárás tieno[3,2-c]piridin-származékok előállítására
HU225503B1 (en) 1997-05-13 2007-01-29 Sanofi Aventis Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them
FR2769313B1 (fr) * 1997-10-06 2000-04-21 Sanofi Sa Derives d'esters hydroxyacetiques, leur procede de preparation et leur utilisation comme intermediaires de synthese
FR2779726B1 (fr) * 1998-06-15 2001-05-18 Sanofi Sa Forme polymorphe de l'hydrogenosulfate de clopidogrel
WO1999065500A1 (en) 1998-06-17 1999-12-23 Bristol-Myers Squibb Company Preventing cerebral infarction through administration of adp-receptor antiplatelet and antihypertensive drugs in combination
FR2792836B3 (fr) 1999-04-30 2001-07-27 Sanofi Sa Composition pharmaceutique sous forme unitaire contenant de l'aspirine et de l'hydrogenosulfate de clopidogrel
IN191030B (xx) * 2001-01-24 2003-09-13 Cadila Healthcare Ltd
CN100338068C (zh) * 2001-01-24 2007-09-19 卡地拉健康护理有限公司 制备氯吡格雷的方法
US6495691B1 (en) 2001-07-06 2002-12-17 Brantford Chemicals Inc. Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
GB0125708D0 (en) * 2001-10-26 2001-12-19 Generics Uk Ltd Novel compounds and processes
CA2363053C (en) 2001-11-09 2011-01-25 Bernard Charles Sherman Clopidogrel bisulfate tablet formulation
US6767913B2 (en) 2001-12-18 2004-07-27 Teva Pharmaceutical Industries Ltd. Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms
ES2316650T3 (es) * 2001-12-18 2009-04-16 Teva Pharmaceutical Industries Ltd. Polimorfos de hidrogenosulfato de clopidogrel.
US7074928B2 (en) 2002-01-11 2006-07-11 Teva Pharmaceutical Industries, Ltd. Polymorphs of clopidogrel hydrogensulfate
HUP0200438A3 (en) * 2002-02-06 2003-10-28 Egis Gyogyszergyar Nyilvanosan Novel clopidogrel hydrochloride polymorphs, process for the preparation thereof, their use and pharmaceutical compositions containing them
ATE494284T1 (de) 2002-04-16 2011-01-15 Schering Corp Tricyclischer thrombinrezeptorantagonist
US6800759B2 (en) * 2002-08-02 2004-10-05 Teva Pharmaceutical Industries Ltd. Racemization and enantiomer separation of clopidogrel
IL166593A0 (en) 2002-08-02 2006-01-15 Racemization and enantiomer separation of clopidogrel
CZ297472B6 (cs) * 2002-08-27 2006-12-13 Zentiva, A.S. Zpusob výroby clopidogrelu hydrogensulfátu krystalické formy I
AU2003270861A1 (en) * 2002-10-02 2004-04-23 Bristol-Myers Squibb Company Novel combination of a factor xa inhibitor and clopidogrel
US6812363B2 (en) * 2002-10-15 2004-11-02 Usv Limited Racemization of optically active 2-substituted phenyl glycine esters
ITMI20022228A1 (it) * 2002-10-21 2004-04-22 Dinamite Dipharma S P A Sali di clopidogrel con acidi alchil-solforici.
AU2003285841A1 (en) * 2002-11-28 2004-06-18 Anpharm Przedsiebiorstwo Farmaceutyczne S.A. A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate
EP1606231A1 (en) * 2003-02-03 2005-12-21 Nadkarni, Sunil Sadanand Process for preparation of clopidogrel, its salts and pharmaceutical compositions
DE10305984A1 (de) * 2003-02-13 2004-09-02 Helm Ag Salze organischer Säuren mit Clopidogrel und deren Verwendung zur Herstellung phamazeutischer Formulierungen
EP1603920A1 (en) 2003-03-12 2005-12-14 Cadila Healthcare Ltd. Polymorph and amorphous form of (s)-(+)-clopidogrel bisulfate
US6858734B2 (en) * 2003-04-23 2005-02-22 Rhodia Pharma Solutions Inc. Preparation of (S)-Clopidogrel and related compounds
WO2004106344A2 (en) * 2003-04-25 2004-12-09 Cadila Healthcare Limited Salts of clopidogrel and process for preparation
CA2530446A1 (en) * 2003-07-02 2005-01-13 Egis Gyogyszergyar Rt. Process for the preparation of amorphous form of a platelet aggregation inhibitor drug
CZ200641A3 (cs) * 2003-07-02 2006-05-17 EGIS Gyógyszergyár Rt. Zpusob prípravy krystalického polymorfu inhibitoru srázení krevních desticek
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
GB0321256D0 (en) 2003-09-11 2003-10-08 Generics Uk Ltd Novel crystalline compounds
AU2008200919B2 (en) * 2003-09-11 2009-05-21 Generics (Uk) Limited Novel crystalline polymorphs of clopidogrel
EP1680430B1 (en) * 2003-11-03 2010-01-20 Cadila Healthcare Ltd. Processes for preparing form i of (s)-(+)- clopidogrel bisulfate
CA2454015C (en) * 2003-12-23 2009-11-24 Brantford Chemicals Inc. A process for the preparation of tetrahydrothieno [3,2-c] pyridine derivatives
CA2457459A1 (en) * 2004-02-11 2005-08-11 Brantford Chemicals Inc. Resolution of racemates of methyl alpha-5-(4,5,6,7-tetrahydro(3,2-c)thienopyridyl)-(2-chlorophenyl) acetate
JP2007523203A (ja) * 2004-02-24 2007-08-16 ジークフリート・ジェネリクス・インターナショナル・アクチェンゲゼルシャフト クロピドグレルの薬理学的に許容できる塩
US7629465B2 (en) * 2004-03-05 2009-12-08 Ipca Laboratories Ltd. Industrial process for preparation of Clopidogrel hydrogen sulphate
TW200534879A (en) * 2004-03-25 2005-11-01 Bristol Myers Squibb Co Coated tablet formulation and method
KR100563455B1 (ko) * 2004-04-09 2006-03-23 한미약품 주식회사 결정성 클로피도그렐 나프탈렌술폰산염 또는 이의 수화물,이의 제조방법 및 이를 함유하는 약학적 조성물
JP4550884B2 (ja) 2004-04-09 2010-09-22 ハンミ ファーム． シーオー．， エルティーディー． 結晶性クロピドグレルナフタレンスルホン酸塩又はその水和物、その製造方法及びそれを含む医薬組成物
US7999106B2 (en) 2004-04-19 2011-08-16 Krka, Tovarna Zdravil, D.D., Novo Mesto Processes for the preparation of clopidogrel hydrogen sulfate polymorphic form I
CN1997648A (zh) * 2004-04-20 2007-07-11 赛诺菲-安万特 (+)－(S)－α－(2－氯苯基)－6,7－二氢噻吩并[3,2－C]吡啶－5(4H)乙酸甲酯氢溴酸盐，即氯吡格雷氢溴酸盐的多晶型物
BRPI0510008A (pt) * 2004-04-20 2007-09-18 Sanofi Aventis sal de clopidogrel e formas polimórficas deste
US7829720B2 (en) 2004-05-04 2010-11-09 Bristol-Myers Squibb Company Process for preparing atazanavir bisulfate and novel forms
US20050256314A1 (en) * 2004-05-04 2005-11-17 Soojin Kim Process employing controlled crystallization in forming crystals of a pharmaceutical
US20050288343A1 (en) * 2004-05-19 2005-12-29 Andrew Rusowicz Process of preparing substituted carbamates and intermediates thereof
TWI415635B (zh) * 2004-05-28 2013-11-21 必治妥施貴寶公司 加衣錠片調製物及製備彼之方法
WO2005117866A1 (en) * 2004-06-01 2005-12-15 Ivax Pharmaceuticals S.R.O. Amorphous clopidogrel hydrochloride and its antithrombotic use
US20060154957A1 (en) * 2004-09-21 2006-07-13 Nina Finkelstein Crystalline clopidogrel hydrobromide and processes for preparation thereof
US7446200B2 (en) * 2004-10-04 2008-11-04 Usv, Ltd. Rapid resolution process of clopidogrel base and a process for preparation of clopidogrel bisulfate polymorph-form I
CZ20041048A3 (cs) * 2004-10-18 2005-11-16 Zentiva, A. S Způsob výroby klopidogrelu
EP1674468A1 (en) * 2004-12-21 2006-06-28 Ratiopharm GmbH Polymorphs of clopidogrel hydrobromide
AU2005327776A1 (en) * 2005-02-15 2006-08-24 Usv Limited Rapid resolution process for clopidogrel base and a process for preparation of Clopidogrel bisulfate polymorph - Form I
TW200640932A (en) * 2005-02-24 2006-12-01 Teva Pharma Clopidogrel base suitable for pharmaceutical formulation and preparation thereof
CZ299213B6 (cs) 2005-03-08 2008-05-21 Zentiva, A. S Zpusob racemizace R(-) izomeru methylesteru kyseliny (2-chlorfenyl)-6,7-dihydro-thieno[3,2-c]pyridin-5(4H)-octové
US7772398B2 (en) * 2005-03-11 2010-08-10 Dr. Reddy's Laboratories, Inc. Process for making crystalline form I of clopidogrel hydrogen sulphate
CN101212954A (zh) * 2005-05-10 2008-07-02 伊兰制药国际有限公司 纳米粒氯吡格雷制剂
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
EP1902058A2 (en) * 2005-07-12 2008-03-26 RPG Life Sciences Limited A process for preparation of methyl-(+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno(3,2-c)pyridine-5(4h)-acetic acid methyl ester or salts thereof having higher chiral purity and products thereof
KR20070009851A (ko) * 2005-07-14 2007-01-19 씨제이 주식회사 클로피도그렐 황산수소염 함유 약학 조성물
WO2007052300A2 (en) 2005-09-05 2007-05-10 Cadila Healthcare Limited Processes for the preparation of different forms of (s)-(+)-clopidogrel besylate
EP1926736A4 (en) * 2005-09-21 2010-08-25 Chong Kun Dang Pharm Corp NEW RESINATE COMPLEX OF S-CLOPIDOGREL AND METHOD FOR THE PRODUCTION THEREOF
KR100783286B1 (ko) * 2005-09-26 2007-12-06 주식회사종근당 클로피도그렐 우선성 광학이성체의 유리염기를 함유하는고형의 약제학적 조성물
DE102005060690B4 (de) * 2005-12-15 2008-09-25 Capsulution Nanoscience Ag Salze von Clopidogrel mit Polyanionen und ihre Verwendung zur Herstellung pharmazeutischer Formulierungen
KR101235117B1 (ko) * 2005-12-26 2013-02-20 에스케이케미칼주식회사 광학분리에 의한 (ｓ)-(＋)-클로피도그렐의 제조방법
KR20070094230A (ko) * 2006-03-17 2007-09-20 한미약품 주식회사 클로피도그렐 캄파술폰산염 또는 이의 결정다형을 함유하는약학 조성물
US20070225320A1 (en) * 2006-03-27 2007-09-27 Eswaraiah Sajja Process for preparing clopidogrel
KR101784001B1 (ko) 2006-04-04 2017-10-23 케이지 액퀴지션 엘엘씨 항혈소판제와 산 억제제를 포함하는 경구 투여용 약학 조성물
KR20090013794A (ko) * 2006-04-27 2009-02-05 인드-스위프트 래버러토리즈 리미티드 클로피도그렐 히드로겐 설페이트의 다형태의 제조방법
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
DK2064217T3 (da) * 2006-09-04 2011-05-09 Ranbaxy Lab Ltd Forbedret fremgangsmåde til fremstilling af clopidogrel og dets farmaceutisk acceptable salte
EP1900358A1 (en) 2006-09-16 2008-03-19 Cimex Pharma AG Pharmaceutical formulations comprising clopidogrel
SI22383A (sl) * 2006-09-22 2008-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze klopidogrela in nove oblike njegovih farmacevtsko sprejemljivih soli
KR100978498B1 (ko) * 2006-10-17 2010-08-30 최중헌 클로피도그렐 황산수소염의 제조방법
WO2008060934A2 (en) * 2006-11-14 2008-05-22 Acusphere, Inc. Formulations of tetrahydropyridine antiplatelet agents for parenteral or oral administration
CA2673228A1 (en) * 2006-12-22 2008-07-03 Schering Corporation Disintegration promoters in solid dose wet granulation formulations
EP1970054A3 (en) 2007-03-14 2009-06-03 Ranbaxy Laboratories Limited Clopidogrel tablets
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
EP1980563A1 (en) 2007-04-09 2008-10-15 BATTULA, Srinivasa Reddy Procedure for the preparation of methyl (+)-(S)-Alpha-(O-chlorophenyl)-6,7-dihydrothieno-[3,2-C]pyridine-5(4H) acetate
BRPI0803101A2 (pt) * 2007-04-18 2014-04-22 Teva Pharma Processos melhores para preparação de clopidogrel
KR20160033792A (ko) 2007-04-27 2016-03-28 사이덱스 파마슈티칼스, 인크. 클로피도그렐 및 설포알킬 에테르 사이클로덱스트린을 함유하는 제형 및 사용 방법
US20100297621A1 (en) * 2007-06-20 2010-11-25 University Of Utah Research Foundation Use of pre-mrna splicing in platelet cells for the diagnosis of disease
MX2009013461A (es) * 2007-06-22 2010-01-15 Bristol Myers Squibb Co Composiciones comprimidas que contienen atazanavir.
AU2008268627A1 (en) * 2007-06-22 2008-12-31 Bristol-Myers Squibb Company Tableted compositions containing atazanavir
US20100178340A1 (en) * 2007-06-22 2010-07-15 Bristol-Myers Squibb Company Tableted compositions containing atazanavir
SI2170292T1 (sl) * 2007-06-22 2014-05-30 Bristol-Myers Squibb Holdings Ireland Tabletirani sestavki, ki vsebujejo atazanavir
KR20090022616A (ko) * 2007-08-31 2009-03-04 한올제약주식회사 베실산클로피도그렐 함유 경구투여용 약제
JP2011506950A (ja) * 2007-12-14 2011-03-03 ジェネリクス・（ユーケー）・リミテッド クロピドグレルを分析するためのｈｐｌｃ法
WO2009080469A1 (en) * 2007-12-24 2009-07-02 Sandoz Ag Process for the preparation of clopidogrel bisulphate form i
EP2095815B1 (en) 2008-02-26 2011-10-26 Laboratorios Lesvi, S.L. Pharmaceutical formulations containing clopidogrel
US20110034504A1 (en) 2008-04-01 2011-02-10 Astellas Pharma Inc. Agent for preventing and/or treating vascular diseases
EP2107061A1 (en) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of optically enriched clopidogrel
US20090264460A1 (en) * 2008-04-21 2009-10-22 Mamta Mishra Clopidogrel pharmaceutical formulations
KR100990949B1 (ko) 2008-06-09 2010-10-29 엔자이텍 주식회사 클로피도그렐 및 그의 유도체의 제조방법
US8299097B2 (en) * 2008-09-12 2012-10-30 The Brigham And Women's Hospital, Inc. Methods for treating inflammatory disorders
EP2346879A1 (en) * 2008-10-24 2011-07-27 Sandoz AG A process for the preparation of s-clopidogrel
CA2758322C (en) 2009-04-10 2019-04-02 Tufts Medical Center, Inc. Par-1 activation by metalloproteinase-1 (mmp-1)
US8236782B2 (en) 2009-05-13 2012-08-07 Cydex Pharmaceuticals, Inc. Pharmaceutical compositions comprising prasugrel and cyclodextrin derivatives and methods of making and using the same
CN101885730B (zh) * 2009-05-13 2012-07-04 连云港恒邦医药科技有限公司 抗血栓的化合物
AU2010259003A1 (en) 2009-06-08 2011-11-10 Merck Sharp & Dohme Corp. A thrombin receptor antagonist and clopidogrel fixed dose tablet
EA021588B1 (ru) 2009-06-25 2015-07-30 Тетра Сиа Бетаиновые соли ацетилсалициловой кислоты
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
WO2011010318A1 (en) * 2009-07-23 2011-01-27 Praveen Laboratories Private Limited Process for the preparation of clopidogrel polymorphous form 1 using seed chrystals
WO2011042804A2 (en) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited An improved process for the preparation of clopidogrel hydrogen sulfate form i
WO2011051976A2 (en) 2009-10-30 2011-05-05 Matrix Laboratories Ltd An improved process for the preparation of clopidogrel bisulfate form i
CN102863457B (zh) * 2010-02-02 2013-10-09 江苏威凯尔医药科技有限公司 光学活性2-羟基四氢噻吩并吡啶衍生物及其制备方法与在制药中的用途
CN101766573B (zh) 2010-02-05 2013-02-13 上海安必生制药技术有限公司 硫酸氢氯吡格雷固体制剂的制备工艺
WO2011101865A2 (en) 2010-02-19 2011-08-25 Cadila Healthcare Limited Stable pharmaceutical compositions of clopidogrel for parenteral delivery
CN101787033B (zh) * 2010-03-16 2011-08-31 天津市中央药业有限公司 一种硫酸氢氯吡格雷有关物质c的合成方法
WO2011125069A1 (en) 2010-03-22 2011-10-13 Rpg Life Sciences Limited A process for preparation of crystalline form i of clopidogrel bisulfate
EP2560644B1 (en) 2010-04-19 2016-06-29 Cadila Healthcare Limited A pharmaceutical composition comprising antiplatelet agents and an erythropoiesis stimulating agent
CN101863902B (zh) * 2010-06-29 2012-06-27 天津药物研究院 2-取代苯基-2-(4,5,6,7-四氢噻吩并[3,2-c]吡啶-5（4H）-基)乙酸(取代烷基醇)酯的制备方法和用途
WO2012007019A1 (en) 2010-07-13 2012-01-19 Pharmathen S.A. Process for the preparation of clopidogrel and salts thereof
WO2012123958A1 (en) 2011-02-14 2012-09-20 Cadila Healthcare Limited Highly pure salts of clopidogrel free of genotoxic impurities
CN102199160B (zh) * 2011-03-22 2016-06-22 浙江华海药业股份有限公司 一种制备ⅰ型硫酸氢氯吡格雷的方法
EP2675813A4 (en) 2011-06-27 2014-04-30 Ipca Lab Ltd ANTI THROMBOSIS CONNECTIONS
CA2858522A1 (en) 2011-12-09 2013-06-13 Wockhardt Limited Methods for treating cardiovascular disorder
CN103665042B (zh) * 2012-09-21 2016-03-16 北京普禄德医药科技有限公司 光学活性的2-羟基四氢噻吩并吡啶衍生物及其制备方法和用途
WO2014118802A1 (en) 2013-01-31 2014-08-07 Pharmazell Gmbh An improved process for the preparation of clopidogrel bisulfate form-i
CN104761567A (zh) * 2014-01-02 2015-07-08 上海医药工业研究院 一种硫酸氢氯吡格雷、其中间体及制备方法
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
HUP1400294A2 (hu) 2014-06-13 2015-12-28 Skillpharm Kft Clopidogrel új alkalmazása
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN107698620A (zh) 2015-06-23 2018-02-16 江苏天士力帝益药业有限公司 一种氘代噻吩并哌啶衍生物、制备方法及其应用
CN110831592A (zh) 2017-06-30 2020-02-21 兴和株式会社 医药
CN110627808B (zh) * 2018-06-21 2022-04-01 江苏同禾药业有限公司 一种硫酸氢氯吡格雷拆分母液的回收处理工艺
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide
US20230059869A1 (en) 2021-08-03 2023-02-23 Liqmeds Worldwide Limited Oral pharmaceutical solution of clopidogrel

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2530247B1 (fr) * 1982-07-13 1986-05-16 Sanofi Sa Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique
DE3621413A1 (de) * 1986-06-26 1988-01-07 Boehringer Ingelheim Kg Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
DE3736664A1 (de) * 1987-10-29 1989-05-11 Boehringer Ingelheim Kg Tetrahydro-furo- und -thieno(2,3-c)pyridine, ihre verwendung als arzneimittel und verfahren zu ihrer herstellung

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FR2623810A2 (fr) 1989-06-02
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