JP2015164660A - 光−音響イメージングデバイスおよび方法 - Google Patents
光−音響イメージングデバイスおよび方法 Download PDFInfo
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- JP2015164660A JP2015164660A JP2015126833A JP2015126833A JP2015164660A JP 2015164660 A JP2015164660 A JP 2015164660A JP 2015126833 A JP2015126833 A JP 2015126833A JP 2015126833 A JP2015126833 A JP 2015126833A JP 2015164660 A JP2015164660 A JP 2015164660A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6852—Catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/445—Details of catheter construction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
- A61B8/4461—Features of the scanning mechanism, e.g. for moving the transducer within the housing of the probe
Abstract
Description
本発明は、光学イメージングの分野に関し、より具体的には、光学コヒーレンス断層撮影(OCT;optical coherence tomography)と、超音波などの他の光学イメージングとのための光ファイバプローブの設計に関する。
近年、突然の心臓発作(急性心筋梗塞またはAMI)の潜在的な原因は、多くの注目の対象であった。冠動脈のゆるやかな閉塞のより古くからの支配的な説は、AMIが冠動脈壁の破裂、特に「易損性プラーク(vulnerable plaque)」の破裂の結果であるという広範囲にわたる組織病理学的な証拠に基づいた新しい理論によって取って代られている。易損性プラークはまた、薄いキャップを被せられた繊維性組織アルセローマ(TCFA;Thin−Capped Fibro−Artheroma)として知られており、動脈壁の下に位置する脂質プールを覆っている薄い繊維状のキャップによって特徴付けられる。従来のエックス線検査ベースの血管造影撮影法の技術は、動脈が狭くなることを検出するために用いられ得る。しかしながら、TCFAを検出するために、動脈壁の表面を直接的に観察することは必須である。従って、表面下の生物学的組織および脂質プールを検出し、そして視覚化することを可能にするプローブ設計に対するニーズが存在している。
本発明は、光および音響k技術を用いて、生物学的組織および他の材料を画像化するための方法および装置に関する。光学コヒーレンス断層撮影(OCT)と、干渉測定イメージング技術と、血管内超音波法(IVUS;Intravascular Ultrasound)との組み合わせは、理想的に、小口径のプローブを介する動脈壁などの生物学的組織の表面下の視覚化に適している。開示される方法は、各個々の技術の弱点を有利に克服するIVUS(血管内超音波法)技術とOCT(光学コヒーレンス断層撮影)技術との組み合わせに基づく。特に、IVUSとOCTとの両方の組み合わせは、多くの利点を有するロバストなプローブを可能にする。
以下の説明は、本発明の特定の実施形態を例示する添付の図面を参照する。他の実施形態が可能であり、本発明の精神および範囲から逸脱することなく実施形態に修正がなされ得る。従って、以下の詳細な説明は、本発明を制限することを意図されない。むしろ、本発明の範囲は、添付の特許請求の範囲によって定義される。
12 IVUS超音波トランスデューサ
14 光トランスデューサ
16 チップ光学レンズアセンブリ
18 シングルモード光ファイバ
20 小型RFケーブル
22 トルクケーブル
24 金属被覆されたファイバ
26 絶縁チューブ
28 内側コイル
30 外側コイル
32 同軸の伝送線
34 絶縁スペーサ
42 第一のコイル
44 回転アセンブリ
46 第二のコイル
48 コネクタ
50 駆動ユニット
Claims (9)
- 光−音響メージングデバイスが実行する血管のイメージング方法であって:
超音波センサと光学コヒーレンス断層撮像センサを有する回転可能なプローブを供する手順;
前記回転可能なプローブを回転させる手順;
前記血管に関する第1組の画像データが収集されるように超音波イメージングを実行する手順;
前記血管に関する第2組の画像データが収集されるように光学コヒーレンスイメージングを実行する手順;
前記血管を介して前記回転可能なプローブを引き戻す手順;及び、
OCT画像とIVUS画像を融合して複合画像を生成することにより、前記第1組の画像データの断面像と前記第2組の画像データの断面像とを一緒に登録する手順であって、前記第1組の画像データの断面像及び前記第2組の画像データの断面像の外側の境界がOCTの浸透限界の近傍に実質的に設定され、前記OCT画像部分は前記複合画像の中央部分に現れ、前記IVUS画像部分は前記複合画像の周辺部分に現れる、手順
を有する方法。 - 前記第1センサからの第1プローブビームと前記第2センサからの第2プローブビームが、前記プローブの長手軸に対して同一の角度となるように、前記第1プローブビームと第2プローブビームを配向させる手順をさらに有する、請求項1に記載の方法。
- 前記プローブが回転することで、前記第2組の画像データが、前記血管に関して追跡された螺旋パターンに沿って収集される、請求項1に記載の方法。
- 前記血管の一緒に登録された断面像を表示する手順をさらに有する、請求項1に記載の方法。
- 生理学的データと、前記血管の一緒に登録された断面像を含む複合画像を表示する手順をさらに有する、請求項1に記載の方法。
- 前記生理学的データが、表面下の脂質プールを含む、請求項5に記載の方法。
- 前記超音波イメージングが、第1時点で前記血管の第1部分に関して実行され、かつ、 前記光コヒーレンス断層撮像が、第2時点で前記血管の第2部分に関して実行される、請求項1に記載の方法。
- 生理学的データと、前記血管の一緒に登録された断面像を含む複合画像を表示する手順をさらに有する、請求項1に記載の方法。
- トルクワイヤを用いて出力を伝送することで前記超音波イメージングを実行する手順をさらに有する、請求項1に記載の方法。
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JP2013131070A Pending JP2013223757A (ja) | 2006-11-08 | 2013-06-21 | 光−音響イメージングデバイスおよび方法 |
JP2015126833A Active JP6216351B2 (ja) | 2006-11-08 | 2015-06-24 | 光−音響イメージングデバイスおよび方法 |
JP2017181989A Expired - Fee Related JP6584467B2 (ja) | 2006-11-08 | 2017-09-22 | 光−音響イメージングデバイス |
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JP2013223757A (ja) | 2013-10-31 |
EP2081486B1 (en) | 2014-04-09 |
JP2010508973A (ja) | 2010-03-25 |
US20110172511A1 (en) | 2011-07-14 |
CN101594819B (zh) | 2012-05-30 |
US7935060B2 (en) | 2011-05-03 |
US20080161696A1 (en) | 2008-07-03 |
EP2628443A1 (en) | 2013-08-21 |
US20130012811A1 (en) | 2013-01-10 |
US8449468B2 (en) | 2013-05-28 |
US8753281B2 (en) | 2014-06-17 |
JP6216351B2 (ja) | 2017-10-18 |
JP6584467B2 (ja) | 2019-10-02 |
EP2628443B1 (en) | 2021-05-12 |
JP2017217536A (ja) | 2017-12-14 |
JP2019217348A (ja) | 2019-12-26 |
US20140114182A1 (en) | 2014-04-24 |
WO2008057573A3 (en) | 2008-08-07 |
CN101594819A (zh) | 2009-12-02 |
EP2081486A2 (en) | 2009-07-29 |
WO2008057573A2 (en) | 2008-05-15 |
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