US10499813B2 - Methods, systems and apparatus for temporal calibration of an intravascular imaging system - Google Patents
Methods, systems and apparatus for temporal calibration of an intravascular imaging system Download PDFInfo
- Publication number
- US10499813B2 US10499813B2 US14/484,832 US201414484832A US10499813B2 US 10499813 B2 US10499813 B2 US 10499813B2 US 201414484832 A US201414484832 A US 201414484832A US 10499813 B2 US10499813 B2 US 10499813B2
- Authority
- US
- United States
- Prior art keywords
- oct
- angiography
- frame
- computing device
- frames
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active, expires
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
- A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0062—Arrangements for scanning
- A61B5/0066—Optical coherence imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/50—Clinical applications
- A61B6/504—Clinical applications involving diagnosis of blood vessels, e.g. by angiography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5205—Devices using data or image processing specially adapted for radiation diagnosis involving processing of raw data to produce diagnostic data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
- A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
- A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
- A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/54—Control of apparatus or devices for radiation diagnosis
- A61B6/545—Control of apparatus or devices for radiation diagnosis involving automatic set-up of acquisition parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/58—Testing, adjusting or calibrating apparatus or devices for radiation diagnosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/58—Testing, adjusting or calibrating apparatus or devices for radiation diagnosis
- A61B6/582—Calibration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2560/00—Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
- A61B2560/02—Operational features
- A61B2560/0223—Operational features of calibration, e.g. protocols for calibrating sensors
- A61B2560/0238—Means for recording calibration data
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2576/00—Medical imaging apparatus involving image processing or analysis
- A61B2576/02—Medical imaging apparatus involving image processing or analysis specially adapted for a particular organ or body part
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B6/00—Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
- A61B6/48—Diagnostic techniques
- A61B6/488—Diagnostic techniques involving pre-scan acquisition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/12—Diagnosis using ultrasonic, sonic or infrasonic waves in body cavities or body tracts, e.g. by using catheters
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H30/00—ICT specially adapted for the handling or processing of medical images
- G16H30/40—ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
Definitions
- the disclosure relates generally to the field of vascular system and peripheral vascular system imaging and data collection.
- Interventional cardiologists incorporate a variety of diagnostic tools during catheterization procedures in order to plan, guide, and assess therapies.
- Fluoroscopy is generally used to perform angiographic imaging of blood vessels.
- blood vessel imaging is used by physicians to diagnose, locate and treat blood vessel disease during interventions such as bypass surgery or stent placement.
- Intravascular imaging technologies such as optical coherence tomography (OCT) and acoustic technologies such as intravascular ultrasound (IVUS) and others are also valuable tools that can be used in lieu of or in combination with fluoroscopy to obtain high-resolution data regarding the condition of the blood vessels for a given subject.
- OCT optical coherence tomography
- IVUS intravascular ultrasound
- Intravascular optical coherence tomography is a catheter-based imaging modality that uses light to peer into coronary artery walls and generate images thereof for study. Utilizing coherent light, interferometry, and micro-optics, OCT can provide video-rate in-vivo tomography within a diseased vessel with micrometer level resolution. Viewing subsurface structures with high resolution using fiber-optic probes makes OCT especially useful for minimally invasive imaging of internal tissues and organs. This level of detail made possible with OCT allows a clinician to diagnose as well as monitor the progression of coronary artery disease.
- Angiography is a noninvasive x-ray imaging method that collects data from outside the body during injection of a radio-opaque contrast fluid.
- the disclosure relates to a multimodal diagnostic system and components thereof configured to co-register two or more of the following OCT, IVUS, FFR, and angiography.
- OCT images and angiography images are co-registered after calibrating a combined OCT and x-ray imaging system to determine a time delay to align or synchronize the two sets of frames of image data.
- the time delay is determined based upon a minimum value from multiple calibration trials.
- angiography systems can be used to obtain a cine sequence or set of cine images. Such a set or sequence includes one or more images that are obtained over time. This set of images is effectively a short movie with each image being a frame that can track and show movement and cardiovascular system changes as the heart progresses through the cardiac cycle.
- the initiation of an x-ray based imaging system such an angiography system can be caused by one or more control signals sent from one or more control systems.
- the initiation of an intravascular imaging system such an OCT system can be caused by one or more control signals sent from one or more control systems to a patient interface unit or PIU.
- the optical fiber and associated lens positioned to send and receive light rotates within a blood vessel.
- the PIU to which an intravascular data collection probe connects receives a control signal which causes the probe tip to rotate and then translates the probe tip as part of a pullback through the blood vessel.
- the probe tip captures an image along a ray or scan line as it rotates prior to translation along a support.
- an angiography initiating control signal is transmitted prior to transmitting an OCT initiating control signal.
- the angiography system captures one or more frames of angiography images such as J frames of angiography data prior to capturing a first frame of OCT image data.
- the first frame of OCT image data can include images obtained while the probe tip rotates prior to being translated along a vessel during a pullback.
- the disclosure relates to a method of calibrating a combination angiography and an optical coherence tomography (OCT) system.
- the method can include acquiring angiography frames prior to initiation of an OCT probe pullback; acquiring OCT data during the OCT probe pullback; acquiring angiography frames during the OCT probe pullback; generating a plurality of OCT frames using the OCT data obtained during the pullback; determining an initial frame of the OCT probe pullback from the plurality of OCT frames; determining an initial angiography frame that corresponds to the initial frame of OCT probe pullback; determining a time delay between the initial OCT frame and the initial angiography frame; and aligning OCT and angiography frames using the time delay.
- OCT optical coherence tomography
- the method further includes displaying one or more aligned OCT frames and angiography frames.
- determining a time delay includes performing a plurality of calibration trials to determine a plurality of delay periods and selecting the minimum delay period as the time delay.
- the plurality of calibration trials is N trials, wherein N ranges from 2 trials to about 12 trials.
- the method further includes initiating the OCT pullback at an initiation time, wherein a computing device stores the initiation time in memory.
- determining the initial frame of the OCT probe pullback includes identifying the OCT frame corresponding to the initiation time as the initial frame of the OCT probe pullback.
- determining the initial angiography frame includes determining a first angiography frame indicative of movement of a marker attached to the OCT probe and selecting a second angiography frame preceding the first angiography frame as the initial angiography frame.
- the disclosure relates to a method of calibrating an optical coherence tomography system and an angiography system.
- the method includes generating N sets of optical coherence tomography (OCT) image data, wherein each of the N sets of OCT image data is obtained by performing N ex vivo pullbacks of an intravascular data collection probe comprising a marker; generating N sets of angiography image data comprising a plurality of two-dimensional images, wherein each of the N sets of angiography image comprise a plurality of two-dimensional images of the marker in two or more different spatial positions; generating N sets of OCT frames using the N sets of OCT image data obtained during the N ex vivo pullbacks; determining an initial frame of the OCT probe pullback from the plurality of OCT frames for each set N; determining an initial angiography frame that corresponds to the initial frame of OCT probe pullback for each set N; determining a time delay between the initial OCT frame and the initial angiography frame for each set
- determining the initial angiography frame includes determining a first angiography frame indicative of movement of a marker attached to the OCT probe and selecting a second angiography frame preceding the first angiography frame as the initial angiography frame.
- N ranges from 2 to 12.
- the method further includes initiating the OCT pullback at an initiation time, wherein a computing device stores the initiation time in memory.
- determining the initial frame of the OCT probe pullback includes identifying the OCT frame corresponding to the initiation time as the initial frame of an ex vivo pullback.
- determining the initial angiography frame includes using a computing device to track pixel changes in angiography frames to identify marker movement.
- a frame rate of the OCT system is greater than the frame rate of the angiography system.
- the disclosure relates to a system for calibrating a combination intravascular and extravascular imaging system.
- the calibration system can include an x-ray based imaging subsystem and an optical imaging subsystem such as an interferometry-based subsystem.
- the calibration system includes an optical coherence tomography (OCT) probe comprising a marker, wherein the probe is disposed on a support and disposed within an imaging zone of an angiography system; an optical coherence data processing system comprising a computing device, wherein the computing device generates frames of OCT images based upon received intravascular probe signals; one or more memory devices; and a control signal input in electrical communication with the one or more memory devices, wherein the control signal input is in electrical communication with a controller programmed to initiate a plurality of ex vivo pullbacks of the OCT probe and transmit each ex vivo pullback initiation time to the one or more memory devices.
- OCT optical coherence tomography
- the computing device can include, in an embodiment, a calibration method stored in the one or more memory device as instructions to cause the computing device to determine an initial frame of the OCT probe for each ex vivo pullback.
- the computing device can include, in an embodiment, a calibration method stored in the one or more memory device as instructions to cause the computing device to determine an initial angiography frame that corresponds to the initial frame of OCT probe pullback.
- the computing device can include, in an embodiment, a calibration method stored in the one or more memory device as instructions to cause the computing device to determine a time delay between the initial OCT frame and the initial angiography frame.
- the computing device can include, in an embodiment, a calibration method stored in the one or more memory device as instructions to cause the computing device to align OCT and angiography frames using the time delay.
- the disclosure relates to a method of imaging a blood vessel and/or calibrating a system that images a blood vessel.
- the method includes generating a set of intravascular image data comprising a plurality of intravascular image frames at a first frame rate using an intravascular imaging system comprising a first clock; storing the intravascular image data in one or more non-transitory computer readable memory devices; generating a set of extravascular image data comprising a plurality of extravascular image frames at a second frame rate using an extravascular imaging system comprising a second clock; storing the extravascular image data in one or more non-transitory computer readable memory devices.
- the method includes detecting motion in one of the plurality of frames. The frame preceding the frame having detected motion is selected as an initial frame in one embodiment.
- the plurality of extravascular image frames comprises an angiography cine.
- an intravascular data collection system collects data simultaneously with but asynchronously relative to an extravascular data collection system.
- the method determines a delay or calibration period to synchronize frames obtained from the two asynchronous data collection systems.
- the method can include co-registering the OCT image data and the angiography data by aligning one or more OCT frames with one or more angiography frames by a calibration time period.
- the disclosure relates to a calibration method.
- the method includes synchronizing x-ray image frames and intravascular image frames using a calibration period determined from a plurality of trials.
- the method include programmatically generating a calibration period using an initial x-ray image frame having detected marker motion and an initial intravascular image frame determined by storing when a control signal to initiate marker motion is sent to an interface unit in mechanical communication with a marker and able to translate the marker over a plurality of positions.
- the disclosure relates to a method of calibrating a combination angiography and an optical coherence tomography (OCT) system.
- the method includes storing a plurality of angiography frames in one or more memory devices in electrical communication with a computing device; storing a plurality of OCT frames in one or more memory devices in electrical communication with the computing device, the OCT frames and angiography frames generated asynchronously during an overlapping time period corresponding to an OCT probe pullback; determining an initial frame of the OCT probe pullback from the plurality of OCT frames; determining an initial angiography frame that corresponds to the initial frame of OCT probe pullback; programmatically generating, using the computing device, a calibration period based upon a timestamp of the initial frame of OCT probe pullback and based upon a timestamp of the initial angiography frame; and synchronizing a plurality of the asynchronously generated OCT frames and angiography frames.
- the computing device is a microprocessor or
- FIG. 1 is a schematic diagram of a data collection system that collects intravascular data and extravascular data during overlapping periods of time suitable for calibration using one or more methods of the disclosure.
- FIG. 2 is a schematic diagram of various data collection events and time periods that can be calibrated using one or more of the systems and methods described herein.
- FIG. 3 is a schematic diagram illustrating various steps and events that can be implemented and tracked in conjunction with calibrating a multimodal imaging system and determining a calibration time period T 3 according to an embodiment of the disclosure.
- FIG. 4 is a schematic diagram illustrating various steps of an exemplary temporal calibration method suitable for increasing co-registration accuracy in a multimodal imaging system according to an embodiment of the disclosure.
- FIG. 5A is a schematic diagram of a data collection system that collects intravascular data and extravascular data during overlapping periods of time suitable for calibration using one or more methods of the disclosure.
- FIG. 5B is a schematic diagram that depicts three x-ray image frames of a blood vessel being imaged using the system of FIG. 5A that correspond to three points in time when a marker is not moving and then movement starts and then movement continues during an OCT pullback of a probe according to an embodiment of the disclosure.
- FIG. 6 illustrates an apparatus for performing temporal calibration according to an embodiment of the disclosure.
- Intravascular data collection such as imaging of a blood vessel can be performed by inserting a catheter comprising a data collection probe into an artery and advancing it until it reaches a region of interest within a blood vessel, such a coronary artery.
- An angiography system can obtain external angiographic images of that vessel, such as a cine sequence, during the imaging of the blood vessel.
- the region of interest is imaged by pulling the data collection probe through the catheter while optical, acoustic, or other sensors in the probe collect intravascular data.
- the process of pulling the data collecting probe through a region of interest in a blood vessel is referred to as a pullback in one embodiment. According to the disclosure, it is advantageous to initiate the angiography image capture prior to initiating the pullback for purposes of subsequently co-registering the angiographic and intravascular image data sets.
- OCT/angiography or x-ray based coregistration facilitate visualization of a position of or a subset of an OCT image on a corresponding angiography image acquired at a similar point in time.
- Such coregistration methods can be implemented using hardware, software, or combinations thereof
- the disclosure relates to various systems, components thereof, and methods for use in a catheter lab or other facility to perform one or more calibration processes to improve co-registration accuracy with respect to data collected with regard to a subject.
- the data can include one or more cine sequences obtained using an x-ray system such as an angiography system.
- the data can include intravascular data.
- An example of intravascular data is OCT data which can be obtained using an intravascular imaging probe and an OCT system.
- the OCT data can be stored in computer-readable memory as scan lines, images, or in other data formats.
- Intravascular ultrasound data is another type of intravascular data.
- FIG. 1 shows a system 10 that includes various data collection subsystems suitable for collecting data, detecting a feature of, sensing a condition, and imaging a region of interest in a subject using one or more imaging modalities or otherwise generating diagnostic data.
- the region of interest in a subject can include a blood vessel 15 .
- an intravascular data collection probe is pulled back through the vessel 15 .
- the probe includes one or more of a guidewire, a pressure sensing wire-based probe, an optical fiber and other components.
- An optical fiber 18 is shown extending from where the probe would be disposed in the vessel 15 .
- the tip of a given data collection probe can include a marker.
- These markers are identified by M as shown herein in the non-invasively acquired image frames such as the x-ray generated images. As shown in FIG. 1 , a series of overlapping sequential angiography images are shown from a top down perspective with the dots corresponding to markers M shown over the sequence of their movement through the vessel 15 .
- the marker M is a radiopaque marker that is part of the data collection probe.
- a radiopaque marker M can be disposed near a lens or other beam-directing element of a probe.
- the points F in the OCT frames are included to illustrate a feature F that changes its appearance as the pullback progresses. In this way, different cross-sections of the blood vessel being imaged with different features F correspond to different positions in the angiography frames.
- the optical fiber is in optical communication with the beam director or lens.
- a torque wire can be part of the probe defines a bore in which an optical fiber is disposed.
- the probe also includes the sheath such as a polymer sheath (not shown) which forms part of a catheter.
- the optical fiber which in the context of an OCT system is a portion of the sample arm of an interferometer, is optically coupled to a patient interface unit (PIU) as shown.
- the PIU can be operated using various controls that can be used to initiate the pullback of the probe through the vessel.
- the data collection system 10 includes a noninvasive imaging system 20 such as a nuclear magnetic resonance, x-ray, angiography, computer aided tomography, or other suitable noninvasive imaging technology.
- a noninvasive imaging system 20 such as a nuclear magnetic resonance, x-ray, angiography, computer aided tomography, or other suitable noninvasive imaging technology.
- an angiography system such as suitable for generating cines is shown.
- the angiography system can include a fluoroscopy system.
- the noninvasive imaging system collects extravascular or peripheral imaging data while the intravascular imaging probe pulled back through the vessel generates cross-sectional views 50 as shown. Theses intravascular images 50 can be cross-sectional view, longitudinal views, or other views generated using data from an intravascular data collection probe.
- the noninvasive imaging system 20 and the PIU are in communication with separate data storage and processing systems 55 , 57 or can be in communication with one data storage and processing system 60 .
- One or more of such systems 55 , 57 , or 60 can be used individually or integrated together.
- These systems can be implemented as a workstation or server in one embodiment or generally as a computing device.
- a computing device may include a server computer, a client user computer, a personal computer (PC), a laptop computer, a tablet PC, a desktop computer, a control system, a microprocessor or any computing device capable of executing a set of instructions (sequential or otherwise) that specify actions to be taken by that computing device.
- the term “computing device” shall also be taken to include any collection of computing devices that individually or jointly execute a set (or multiple sets) of instructions to perform any one or more of the software features or methods such as interface.
- the computing device is an optical coherence tomography computer programmed to perform one or more temporal calibration methods as described herein.
- the programs, instructions, and control signal information and related co-registration methods that can use a calibration time can be implemented using software instructions stored in memory 65 or as a hardware-based integrated circuit 68 .
- an external database 70 is used to store image frames, calibration time periods, co-registered OCT and x-ray images and other information described herein with respect to the systems and collected image data.
- the time delay outputs of multiple calibration trials can be stored in memory such as database 70 or in the systems described herein and ranked to select a minimum time delay using one or more processors or computing devices.
- memory 65 receives an OCT pullback initiation time corresponding to one the OCT probe pullback starts. This initiation time can be correlated with a corresponding captured OCT frame, which can be identified as the initial frame of the OCT pullback.
- the patient interface unit includes a probe connector suitable to receive an end of the probe and be optically coupled thereto.
- the PIU includes suitable joints and elements based on the type of data collection probe being used. In addition to being pulled back, the probe tip is also typically rotated by the PIU. In this way, a blood vessel of the subject 10 can be imaged longitudinally or via cross-sections.
- the PIU is connected to one or more intravascular data collection systems 55 or 60 as described herein.
- the intravascular data collection system 55 , 60 can be an OCT system, an IVUS system, another imaging system, and combinations of the foregoing.
- the system 60 in the context of a probe being an OCT probe can include the sample arm of an interferometer, the reference arm of an interferometer, photodiodes, a control system, and patient interface unit.
- the intravascular image data such as the frames of intravascular data generated using the data collection probe can be routed to the data collection processing system 60 coupled to the probe via PIU.
- the noninvasive image data generated using system 20 can be transmitted to, stored in, and processed by one or more computing devices.
- a video frame grabber device such as a computer board configured to capture the angiography image data from system 20 can be used in various embodiments as part of systems 55 , 57 , or 60 .
- a set of angiography data such as cine sequence of images is acquired during an OCT pullback.
- the marker M disposed on or in the OCT probe moves with it and is identifiable and trackable in the set of simultaneously captured angiography frames. If a coregistration calibration method of the angiography system and the OCT system is not performed or is inadequate to calibrate the relevant imaging system, the OCT frames and the angiography frames may not be aligned.
- two steps are performed to achieve accurate coregistration in conjunction with a calibrated multimodal imaging system such as an OCT and angiography system.
- the first step is identifying or locating a reference point or section of an intravascular data collection probe throughout a set of image frames such as angiography frames that constitute a cine sequence.
- the reference point or section can include a marker, a probe tip, a lens, a pressure transducer, a beam director, or other probe locus, portion, component or combinations thereof. All of the foregoing can be used as markers M shown in the relevant figures.
- a lens is used to direct and receive light and collect data that corresponds to depth measurements such that a tomographic image of the imaged region can be generated.
- the second factor is temporally aligning the angiographic and OCT data sets.
- the disclosure relates to calibration methods that can be performed when installing an OCT system in catheter lab to operate in conjunction with an angiography system.
- the calibration of an OCT system is also performed when an angiography system is changed that is used in conjunction with the OCT system. When a change in such a multimodal imaging system occurs, re-calibration is often necessary to prevent or fix co-registration anomalies.
- the calibration methods described herein improve the accuracy when co-registering a set of intravascular data, such as for example, a set of OCT images, and a set of peripheral or extravascular data such as a set of angiography images.
- the disclosure relates to determining the relative time period between OCT and angiographic data sets. This time period can be determined and the can be used as a temporal calibration factor for the angiography coregistration software.
- OCT and angiography image data are acquired simultaneously during an OCT catheter pullback with regard to blood vessel
- a physical event E 1 in the real world (such as the initiation of the OCT catheter pullback) occurs at a certain point in time, indicated by the “Event” arrow such as a zero point in time, T 0 or some other origin or reference point.
- This physical event E 1 is subsequently captured in an OCT image frame, which can be considered as a second event E 2 that is stored into computer memory at a future point in time “T 1 ” after the physical event.
- the event capturing of the pullback initiation using OCT is event E 2 which corresponds to the imaging of the blood vessel 15 .
- the angiography system lags the OCT system such that the angiography image capture of the blood vessel 15 and the moving OCT probe disposed therein is delayed by a delay period T 3 relative to the OCT image capture.
- the same physical event E 1 is also captured in an angiography image frame that is stored into computer memory at a future point in time “T 2 ” after the physical event E 1 and after its OCT capture E 2 as effectively a third event E 3 .
- the time periods T 1 and T 2 represent the finite time required to generate, transmit, and process the OCT and angiography images, respectively.
- the time period T 1 ranges from about several microseconds to about several seconds.
- the time period T 2 ranges from about several microseconds to about several seconds.
- the time period T 3 ranges from about several microseconds to about several seconds.
- the frame rate of an OCT system ranges from about 20 frames per second to about 1000 frames per second.
- the frame rate of a non-invasive imaging system such as an x-ray-based system ranges from about 10 frames per second to about 60 frames per second.
- T 1 and T 2 may be different, a fixed time period T 3 exists between when the OCT frame is stored into computer memory E 2 and when the corresponding angiography frame is stored into computer memory E 3 . If this time period T 3 is not compensated for, OCT frame positions are displayed on the incorrect angiography frame. In turn, such a failure to compensate for such a time lag T 3 can lead to inaccuracies in coregistration. As described herein, T 3 can be accurately determined using a calibration method.
- the OCT and angiography data sets can be temporally aligned. After alignment using the determined T 3 value the OCT frame positions can be displayed on the correct angiography frame using the systems described herein.
- One or more calibration systems 100 can be used to determine T 3 .
- the calibration system can be implemented using one or more of the components of system 10 of FIG. 1 , system 110 of FIG. 5A and system 120 of FIG. 6 .
- FIG. 3 illustrates a schematic representation of various image frames and method steps for determining the time period T 3 .
- an OCT pullback is acquired with simultaneous angiography.
- the frames shown at the top portion of FIG. 3 are frames of intravascular image data such as OCT data frames.
- An OCT image feature F is visible at a position within each OCT data frame and changes position when the OCT pullback commences.
- the frames below that include a top down view of an exemplary blood vessel are extravascular image data such as angiography data frames. Both datasets are generated, transmitted, processed, and stored in a central computer.
- the OCT dataset includes frames of OCT image data numbered from 1 to 8. In contrast, three frames of angiography image data numbered 1 to 3 are also shown.
- the OCT dataset includes a series of time stamped frames in the computer memory, where each timestamp represents the time at which the frame entered computer memory.
- the corresponding series of time stamped angiography frames is also present in computer memory.
- the timestamps are generated by a common system clock but are applied to each dataset independently.
- the common system clock is the clock of the data processing system 60 .
- the computer memory can be part of system 60 for example of FIG. 1 and similar data processing systems as described herein.
- OCT frame represents the initial frame of the pullback.
- a human may inspect the OCT image data and estimate which frame represents the initial frame of the pullback.
- a computing device can be used to determine the initial frame of the pullback such as by automatically logging the time at which a command was sent to initiate the OCT pullback.
- Machine vision and image processing software can also be used by a computing device to determine the initial frame of the pullback.
- the initial OCT frame is the third frame of the dataset.
- the initial angiography frame is the second frame of the dataset.
- the radio-opaque marker M will not appear to move until the subsequent angio frame 3 , since the initial OCT pullback frame 3 is generated with the catheter at an initial resting position. Knowing the time stamps associated with OCT frame 3 and angiography frame 2 , the time period T 3 can be calculated and applied to realign the two datasets.
- FIG. 4 includes an overview of these method steps and other related or supplemental steps as shown. Exemplary steps 10 to 80 are shown. Steps can be omitted as optional, performed simultaneously, or performed out of order in one or more embodiments.
- the disclosure relates to the implementation of various steps or a subset thereof.
- the steps include acquiring OCT data during OCT probe pullback; acquiring angiography data during OCT probe pullback; determining initial frame of OCT probe pullback from set of OCT frames; determining initial angiography frame that corresponds to initial frame of OCT probe pullback; determining time delay between initial OCT frame and initial angiography frame; selecting minimum time delay from multiple calibration trials; aligning OCT and angiography frames using minimum time delay; and displaying one or more aligned OCT and angiography frames.
- FIG. 5A is a schematic diagram of an exemplary multimodal system that include an angiography system shown as non-invasive system 20 and an OCT system that includes a probe with a marker M that has been pulled back through the blood vessel 15 shown.
- FIG. 5B shows the angiography frames corresponding to the pullback performed using the system of FIG. 5A .
- a 1 At a time prior to the initiation of the pullback A 1 , there is no marker motion.
- movement of the marker M occurs from rest moving from top to bottom from times A 1 to A 3 in the three angiography frames shown.
- Angiography frame motion is detected using machine vision, human inspection, or another mechanism.
- the angiography frame that is selected as the frame corresponding to initial probe or marker M movement is the frame before the frame for which motion is detected.
- a 3 is not selected as the frame having initial movement. Instead, the frame before it, the middle frame corresponding to time A 2 is selected. If frame A 2 were detected as the frame having initial marker or probe motion then as part of the calibration method the first frame A 1 would be set as the initial movement angiography frame. This approach effectively sets the origin at which motion starts earlier to help improve calibration results.
- frames of angiography data are processed, scanned or viewed to identify the occurrence of marker M movement or another probe feature. Once a frame has been identified as depicting probe movement, the frame immediately prior to that is identified for the purposes of the calibration method and the determination of time T 3 as the angiography frame having initial movement. This process of adjusting for movement errors has been found to improve system calibration by reducing the likelihood that the frame of initial movement is missed.
- FIG. 6 illustrates a system 120 for conducting the temporal calibration methods described herein.
- An imaging catheter 125 is placed on a support 130 within the field of view of the X-ray system 20 such as an angiography system.
- the imaging catheter includes an intravascular imaging probe such as an OCT probe.
- the OCT probe can be pulled back within a bore defined by the catheter.
- the X-ray system 20 is activated first and acquires a cine sequence. If the OCT catheter includes a radio-opaque feature, such as a marker M, that moves in tandem with the catheter pullback, this motion will subsequently be visible on the acquired cine sequence.
- a radio-opaque feature such as a marker M
- a marker M disposed on the probe such as near the lens of the OCT probe translates within the bore of a catheter along the support 130 as one or more motors in the PIU pull a torque wire in which is disposed an optical fiber in optical communication with a lens or beam director.
- Each frame of the angiography dataset is transmitted to an OCT computer, digitized by a frame grabber, and time stamped as the frame is stored in memory.
- an OCT dataset is generated by an OCT engine and transmitted to the same OCT computing device.
- Each OCT frame is time stamped as it enters memory.
- the methods described herein such as shown in FIG. 2 can be executed and T 3 can be calculated.
- the process of pulling an imaging probe back along a support while being imaged by an x-ray system can be performed a plurality of times to determine a set of candidate T 3 values for the intravascular and X-ray based systems.
- selecting the appropriate T 3 value improves co-registration of frames generated by an intravascular system such as OCT and a non-invasive system such as angiography.
- T 3 Angiography and angiography datasets are generated asynchronously (i.e., the OCT and angiography systems are independent devices with no master clocking mechanism).
- the second source of T 3 errors or variation is that because the angiography frame rate is typically much lower than the OCT frame rate, the calculated value of T 3 may vary by up to +/ ⁇ one angiography frame period.
- T 3 calibration delay period by repeated calculation and minimum value selection allows for an accurate assessment of the actual lag time period T 3 between the OCT and angiography datasets.
- T 3 in an exemplary set of T 3 values can range from about 1 millisecond to about 500 milliseconds.
- the smallest value in the set of N time delays is selected.
- the smallest value has been determined to be a suitable estimate from N samples.
- N ranges from 2 to 15.
- N ranges from 4 to 10.
- This error can be understood in terms of an angiography frame being shown as co-registered with a particular OCT or other intravascular imaging frame while the distance between wherein the respective frames are incorrectly aligned and as much as between greater than 0 mm to about 3 mm apart in terms of their actual respective location in a subject.
- the present disclosure also relates to the apparatus for performing the operations herein.
- This apparatus may be specially constructed for the required purposes, or it may comprise a general purpose computer selectively activated or reconfigured by a computer program stored in the computer.
- Embodiments of the disclosure may be implemented in many different forms, including, but in no way limited to, computer program logic for use with a processor (e.g., a microprocessor, microcontroller, digital signal processor, or general purpose computer), programmable logic for use with a programmable logic device, (e.g., a Field Programmable Gate Array (FPGA) or other PLD), discrete components, integrated circuitry (e.g., an Application Specific Integrated Circuit (ASIC)), or any other means including any combination thereof.
- a processor e.g., a microprocessor, microcontroller, digital signal processor, or general purpose computer
- programmable logic for use with a programmable logic device e.g., a Field Programmable Gate Array (FPGA) or other PLD
- FPGA Field Programmable Gate Array
- ASIC Application Specific Integrated Circuit
- some or all of the processing of the data collected using an OCT probe, an FFR probe, an angiography system, and other imaging and subject monitoring devices and the processor-based system is implemented as a set of computer program instructions that is converted into a computer executable form, stored as such in a computer readable medium, and executed by a microprocessor under the control of an operating system.
- user interface instructions and triggers based upon the completion of a pullback or a co-registration request are transformed into processor understandable instructions suitable for generating OCT data, performing image procession using various and other features and embodiments described above.
- Source code may include a series of computer program instructions implemented in any of various programming languages (e.g., an object code, an assembly language, or a high-level language such as Fortran, C, C++, JAVA, or HTML) for use with various operating systems or operating environments.
- the source code may define and use various data structures and communication messages.
- the source code may be in a computer executable form (e.g., via an interpreter), or the source code may be converted (e.g., via a translator, assembler, or compiler) into a computer executable form.
- the computer program may be fixed in any form (e.g., source code form, computer executable form, or an intermediate form) either permanently or transitorily in a tangible storage medium, such as a semiconductor memory device (e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM), a magnetic memory device (e.g., a diskette or fixed disk), an optical memory device (e.g., a CD-ROM), a PC card (e.g., PCMCIA card), or other memory device.
- a semiconductor memory device e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM
- a magnetic memory device e.g., a diskette or fixed disk
- an optical memory device e.g., a CD-ROM
- PC card e.g., PCMCIA card
- the computer program may be fixed in any form in a signal that is transmittable to a computer using any of various communication technologies, including, but in no way limited to, analog technologies, digital technologies, optical technologies, wireless technologies (e.g., Bluetooth), networking technologies, and internetworking technologies.
- the computer program may be distributed in any form as a removable storage medium with accompanying printed or electronic documentation (e.g., shrink-wrapped software), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the communication system (e.g., the internet or World Wide Web).
- Hardware logic including programmable logic for use with a programmable logic device
- implementing all or part of the functionality previously described herein may be designed using traditional manual methods, or may be designed, captured, simulated, or documented electronically using various tools, such as Computer Aided Design (CAD), a hardware description language (e.g., VHDL or AHDL), or a PLD programming language (e.g., PALASM, ABEL, or CUPL).
- CAD Computer Aided Design
- a hardware description language e.g., VHDL or AHDL
- PLD programming language e.g., PALASM, ABEL, or CUPL
- Programmable logic may be fixed either permanently or transitorily in a tangible storage medium, such as a semiconductor memory device (e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM), a magnetic memory device (e.g., a diskette or fixed disk), an optical memory device (e.g., a CD-ROM), or other memory device.
- a semiconductor memory device e.g., a RAM, ROM, PROM, EEPROM, or Flash-Programmable RAM
- a magnetic memory device e.g., a diskette or fixed disk
- an optical memory device e.g., a CD-ROM
- the programmable logic may be fixed in a signal that is transmittable to a computer using any of various communication technologies, including, but in no way limited to, analog technologies, digital technologies, optical technologies, wireless technologies (e.g., Bluetooth), networking technologies, and internetworking technologies.
- the programmable logic may be distributed as a removable storage medium with accompanying printed or electronic documentation (e.g., shrink-wrapped software), preloaded with a computer system (e.g., on system ROM or fixed disk), or distributed from a server or electronic bulletin board over the communication system (e.g., the internet or World Wide Web).
- printed or electronic documentation e.g., shrink-wrapped software
- a computer system e.g., on system ROM or fixed disk
- server or electronic bulletin board e.g., the internet or World Wide Web
- a module refers to software, hardware, or firmware suitable for performing a specific data processing or data transmission task.
- a module refers to a software routine, program, or other memory resident application suitable for receiving, transforming, routing and processing instructions, or various types of data such as angiography data, OCT data, timestamps, calibration periods, marker position data, movement data, pixel information, calibration trial data and other information of interest as described herein.
- Computers and computer systems described herein may include operatively associated computer-readable media such as memory for storing software applications used in obtaining, processing, storing and/or communicating data. It can be appreciated that such memory can be internal, external, remote or local with respect to its operatively associated computer or computer system.
- Memory may also include any means for storing software or other instructions including, for example and without limitation, a hard disk, an optical disk, floppy disk, DVD (digital versatile disc), CD (compact disc), memory stick, flash memory, ROM (read only memory), RAM (random access memory), DRAM (dynamic random access memory), PROM (programmable ROM), EEPROM (extended erasable PROM), and/or other like computer-readable media.
- a hard disk an optical disk, floppy disk, DVD (digital versatile disc), CD (compact disc), memory stick, flash memory, ROM (read only memory), RAM (random access memory), DRAM (dynamic random access memory), PROM (programmable ROM), EEPROM (extended erasable PROM), and/or other like computer-readable media.
- computer-readable memory media applied in association with embodiments of the disclosure described herein may include any memory medium capable of storing instructions executed by a programmable apparatus. Where applicable, method steps described herein may be embodied or executed as instructions stored on a computer-readable memory medium or memory media. These instructions may be software embodied in various programming languages such as C++, C, Java, and/or a variety of other kinds of software programming languages that may be applied to create instructions in accordance with embodiments of the disclosure.
- arrow heads showing directionality in a given figure or the lack thereof are not intended to limit or require a direction in which information can flow.
- a given connector such as the arrows and lines shown connecting the elements shown in the figures information can flow in one or more directions or in only one direction as suitable for a given embodiment.
- the connections can include various suitable data transmitting connections such as optical, wire, power, wireless, or electrical connections.
- compositions are described as having, including, or comprising specific components, or where processes are described as having, including or comprising specific process steps, it is contemplated that compositions of the present teachings also consist essentially of, or consist of, the recited components, and that the processes of the present teachings also consist essentially of, or consist of, the recited process steps.
- each intervening value between the upper and lower limits of that range or list of values is individually contemplated and is encompassed within the disclosure as if each value were specifically enumerated herein.
- smaller ranges between and including the upper and lower limits of a given range are contemplated and encompassed within the disclosure.
- the listing of exemplary values or ranges is not a disclaimer of other values or ranges between and including the upper and lower limits of a given range.
Abstract
Description
Claims (12)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/484,832 US10499813B2 (en) | 2014-09-12 | 2014-09-12 | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
JP2017534518A JP6649386B2 (en) | 2014-09-12 | 2015-07-30 | Methods, systems, and devices for calibration over time of an intravascular imaging system |
PCT/US2015/042849 WO2016039884A1 (en) | 2014-09-12 | 2015-07-30 | Methods and system for temporal calibration of an intravascular imaging system |
EP15750872.2A EP3190954B1 (en) | 2014-09-12 | 2015-07-30 | Method and system for temporal calibration of an intravascular imaging system |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/484,832 US10499813B2 (en) | 2014-09-12 | 2014-09-12 | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
Publications (2)
Publication Number | Publication Date |
---|---|
US20160073885A1 US20160073885A1 (en) | 2016-03-17 |
US10499813B2 true US10499813B2 (en) | 2019-12-10 |
Family
ID=53872158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/484,832 Active 2037-10-18 US10499813B2 (en) | 2014-09-12 | 2014-09-12 | Methods, systems and apparatus for temporal calibration of an intravascular imaging system |
Country Status (4)
Country | Link |
---|---|
US (1) | US10499813B2 (en) |
EP (1) | EP3190954B1 (en) |
JP (1) | JP6649386B2 (en) |
WO (1) | WO2016039884A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20190154595A1 (en) * | 2016-05-20 | 2019-05-23 | Perimeter Medical Imaging, Inc. | Method and system for combining microscopic imaging with x-ray |
US11064873B2 (en) | 2015-08-31 | 2021-07-20 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US11278206B2 (en) | 2015-04-16 | 2022-03-22 | Gentuity, Llc | Micro-optic probes for neurology |
US11344373B2 (en) | 2018-05-29 | 2022-05-31 | Lightlab Imaging, Inc. | Stent expansion display, systems, and methods |
US11684242B2 (en) | 2017-11-28 | 2023-06-27 | Gentuity, Llc | Imaging system |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10222956B2 (en) | 2015-05-17 | 2019-03-05 | Lightlab Imaging, Inc. | Intravascular imaging user interface systems and methods |
US10140712B2 (en) | 2015-05-17 | 2018-11-27 | Lightlab Imaging, Inc. | Detection of stent struts relative to side branches |
US9996921B2 (en) | 2015-05-17 | 2018-06-12 | LIGHTLAB IMAGING, lNC. | Detection of metal stent struts |
US10109058B2 (en) | 2015-05-17 | 2018-10-23 | Lightlab Imaging, Inc. | Intravascular imaging system interfaces and stent detection methods |
US10646198B2 (en) | 2015-05-17 | 2020-05-12 | Lightlab Imaging, Inc. | Intravascular imaging and guide catheter detection methods and systems |
EP3324830B1 (en) | 2015-07-25 | 2023-01-04 | Lightlab Imaging, Inc. | Intravascular data visualization method and device |
WO2017087477A1 (en) | 2015-11-18 | 2017-05-26 | Lightlab Imaging, Inc. | Detection of stent struts relative to side branches |
CN115998310A (en) | 2015-11-23 | 2023-04-25 | 光学实验室成像公司 | Detection and verification of shadows in intravascular images |
JP7027331B2 (en) | 2016-04-14 | 2022-03-01 | ライトラボ・イメージング・インコーポレーテッド | Identification of blood vessel branches |
ES2854729T3 (en) | 2016-05-16 | 2021-09-22 | Lightlab Imaging Inc | Method and system for the detection of self-expanding endoprosthesis, or stent, absorbable intravascular |
WO2018017547A1 (en) * | 2016-07-19 | 2018-01-25 | Cygnus Investment Corporation C/O Solaris Corporate Services Ltd. | Pressure sensing guidewire assemblies and systems |
CN109716446B (en) | 2016-09-28 | 2023-10-03 | 光学实验室成像公司 | Stent planning system and method using vascular manifestations |
EP3911239A4 (en) * | 2019-03-08 | 2022-10-05 | William E. Butler | Temporal calibration of an angiographic imaging system |
JP7426355B2 (en) * | 2020-08-06 | 2024-02-01 | キヤノン ユーエスエイ,インコーポレイテッド | Automatic pullback trigger method for intracoronary imaging device or system with blood clearing |
US20230389892A1 (en) * | 2022-06-02 | 2023-12-07 | Canon U.S.A., Inc. | Devices, systems, and methods for automated delay detection between medical-imaging devices |
Citations (159)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4548473A (en) | 1983-05-12 | 1985-10-22 | Honeywell Inc. | Optical filter |
JPS63127201A (en) | 1986-11-17 | 1988-05-31 | Matsushita Electric Ind Co Ltd | Color filter |
US5321501A (en) | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US5509093A (en) | 1993-10-13 | 1996-04-16 | Micron Optics, Inc. | Temperature compensated fiber fabry-perot filters |
US5518810A (en) | 1993-06-30 | 1996-05-21 | Mitsubishi Materials Corporation | Infrared ray cutoff material and infrared cutoff powder use for same |
US5586201A (en) | 1990-11-14 | 1996-12-17 | Cedars-Sinai Medical Center | Coronary tracking display |
US5619368A (en) | 1995-05-16 | 1997-04-08 | Massachusetts Inst. Of Technology | Optical frequency shifter |
US5632767A (en) | 1994-09-09 | 1997-05-27 | Rare Earth Medical, Inc. | Loop diffusers for diffusion of optical radiation |
US5643253A (en) | 1995-06-06 | 1997-07-01 | Rare Earth Medical, Inc. | Phototherapy apparatus with integral stopper device |
US5715827A (en) | 1994-09-02 | 1998-02-10 | Cardiometrics, Inc. | Ultra miniature pressure sensor and guide wire using the same and method |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US5784352A (en) | 1995-07-21 | 1998-07-21 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
US5908415A (en) | 1994-09-09 | 1999-06-01 | Rare Earth Medical, Inc. | Phototherapy methods and apparatus |
US5947959A (en) | 1994-09-09 | 1999-09-07 | Rare Earth Medical, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US5965355A (en) | 1995-09-21 | 1999-10-12 | Agritope, Inc. | Antibodies and proteins useful for assaying virus infection in grape plants |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6148095A (en) | 1997-09-08 | 2000-11-14 | University Of Iowa Research Foundation | Apparatus and method for determining three-dimensional representations of tortuous vessels |
US6160826A (en) | 1991-04-29 | 2000-12-12 | Massachusetts Institute Of Technology | Method and apparatus for performing optical frequency domain reflectometry |
US6191862B1 (en) | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6195445B1 (en) | 1997-06-30 | 2001-02-27 | Siemens Corporate Research, Inc. | Motion compensation of an image sequence using optimal polyline tracking |
US6270492B1 (en) | 1994-09-09 | 2001-08-07 | Cardiofocus, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US6302875B1 (en) | 1996-10-11 | 2001-10-16 | Transvascular, Inc. | Catheters and related devices for forming passageways between blood vessels or other anatomical structures |
US6348960B1 (en) | 1998-11-06 | 2002-02-19 | Kimotot Co., Ltd. | Front scattering film |
US6445939B1 (en) | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US20020161351A1 (en) | 1998-09-01 | 2002-10-31 | Samson Wilfred J. | Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6501551B1 (en) | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US6552796B2 (en) | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US6564087B1 (en) | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US6565514B2 (en) | 2000-08-25 | 2003-05-20 | Radi Medical Systems Ab | Method and system for determining physiological variables |
US6570659B2 (en) | 2001-03-16 | 2003-05-27 | Lightlab Imaging, Llc | Broadband light source system and method and light source combiner |
US20040006277A1 (en) | 2002-07-02 | 2004-01-08 | Langenhove Glenn Van | Determining vulnerable plaque in blood vessels |
US6692824B2 (en) | 1991-12-21 | 2004-02-17 | Roehm Gmbh & Co. Kg | Infrared-reflecting bodies |
US6706004B2 (en) | 2001-05-31 | 2004-03-16 | Infraredx, Inc. | Balloon catheter |
US6718089B2 (en) | 2001-02-16 | 2004-04-06 | Indigo Medical Incorporated | Optical fiber including a diffuser portion and continuous sleeve for the transmission of light |
US6728566B1 (en) | 2001-11-21 | 2004-04-27 | Koninklijke Philips Electronics, N.V. | Vessel tracking and tree extraction method and apparatus |
US6731973B2 (en) | 2001-06-12 | 2004-05-04 | Ge Medical Systems Information Technologies, Inc. | Method and apparatus for processing physiological data |
US6760112B2 (en) | 2001-02-17 | 2004-07-06 | Lucent Technologies Inc. | Grin-fiber lens based optical endoscopes |
US20050043614A1 (en) | 2003-08-21 | 2005-02-24 | Huizenga Joel T. | Automated methods and systems for vascular plaque detection and analysis |
US6879851B2 (en) | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
US6891984B2 (en) | 2002-07-25 | 2005-05-10 | Lightlab Imaging, Llc | Scanning miniature optical probes with optical distortion correction and rotational control |
US6932809B2 (en) | 2002-05-14 | 2005-08-23 | Cardiofocus, Inc. | Safety shut-off device for laser surgical instruments employing blackbody emitters |
US6937696B1 (en) | 1998-10-23 | 2005-08-30 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating |
US6942657B2 (en) | 1999-07-14 | 2005-09-13 | Cardiofocus, Inc. | Intralumenal contact sensor |
US6973202B2 (en) | 1998-10-23 | 2005-12-06 | Varian Medical Systems Technologies, Inc. | Single-camera tracking of an object |
US6974557B1 (en) | 2001-12-18 | 2005-12-13 | Advanced Cardiovasculer Systems, Inc. | Methods for forming an optical window for an intracorporeal device and for joining parts |
US20060095065A1 (en) | 2004-09-24 | 2006-05-04 | Tetsuaki Tanimura | Fluid occluding devices and methods |
US7068831B2 (en) | 2000-08-31 | 2006-06-27 | Koninklijke Philips Electronics, N.V. | Image processing method and system for extracting a string of points following a threadlike structure in a sequence of images |
US20060241465A1 (en) * | 2005-01-11 | 2006-10-26 | Volcano Corporation | Vascular image co-registration |
US7134994B2 (en) | 2002-05-20 | 2006-11-14 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition and display |
US20060264743A1 (en) | 2005-05-06 | 2006-11-23 | Siemens Aktiengesellschaft | Method for tomographically displaying a cavity by optical coherence tomography (OCT) and an OCT device for carrying out the method |
US20070024617A1 (en) | 2005-08-01 | 2007-02-01 | Ian Poole | Method for determining a path along a biological object with a lumen |
US20070027390A1 (en) | 2005-07-13 | 2007-02-01 | Michael Maschke | System for performing and monitoring minimally invasive interventions |
US7191100B2 (en) | 1998-10-23 | 2007-03-13 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating of radiation therapy |
US20070066890A1 (en) | 2005-09-22 | 2007-03-22 | Siemens Aktiengesellschaft | Catheter device |
US7208333B2 (en) | 2001-03-12 | 2007-04-24 | Axsun Technologies, Inc. | Process for fabricating MEMS membrane with integral mirror/lens |
US7231243B2 (en) | 2000-10-30 | 2007-06-12 | The General Hospital Corporation | Optical methods for tissue analysis |
US20070135803A1 (en) | 2005-09-14 | 2007-06-14 | Amir Belson | Methods and apparatus for performing transluminal and other procedures |
US7241286B2 (en) | 2003-04-25 | 2007-07-10 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US7298478B2 (en) | 2003-08-14 | 2007-11-20 | Cytonome, Inc. | Optical detector for a particle sorting system |
US7301644B2 (en) | 2004-12-02 | 2007-11-27 | University Of Miami | Enhanced optical coherence tomography for anatomical mapping |
US7321677B2 (en) | 2000-05-09 | 2008-01-22 | Paieon Inc. | System and method for three-dimensional reconstruction of an artery |
US7412141B2 (en) | 2004-11-16 | 2008-08-12 | Biotex, Inc. | Light diffusing tip |
US20080194996A1 (en) * | 2003-02-21 | 2008-08-14 | Kassab Ghassan S | Device, system and method for measuring cross-sectional areas in luminal organs |
US7415049B2 (en) | 2005-03-28 | 2008-08-19 | Axsun Technologies, Inc. | Laser with tilted multi spatial mode resonator tuning element |
US7414779B2 (en) | 2005-01-20 | 2008-08-19 | Massachusetts Institute Of Technology | Mode locking methods and apparatus |
US20080221440A1 (en) | 2007-03-08 | 2008-09-11 | Sync-Rx, Ltd. | Imaging and tools for use with moving organs |
US20080283771A1 (en) * | 2007-05-17 | 2008-11-20 | General Electric Company | System and method of combining ultrasound image acquisition with fluoroscopic image acquisition |
USRE40608E1 (en) | 1999-01-06 | 2008-12-16 | Volcano Corporation | Arrangement of IVUS system components including remote and adjacent components |
US20090174931A1 (en) | 2005-01-20 | 2009-07-09 | Huber Robert A | Fourier domain mode locking: method and apparatus for control and improved performance |
US7593559B2 (en) | 2005-11-18 | 2009-09-22 | Duke University | Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests |
US20090306520A1 (en) | 2008-06-02 | 2009-12-10 | Lightlab Imaging, Inc. | Quantitative methods for obtaining tissue characteristics from optical coherence tomography images |
US20100076320A1 (en) | 2003-04-25 | 2010-03-25 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US7697972B2 (en) | 2002-11-19 | 2010-04-13 | Medtronic Navigation, Inc. | Navigation system for cardiac therapies |
US7711413B2 (en) | 2003-04-28 | 2010-05-04 | Volcano Corporation | Catheter imaging probe and method |
US7729746B2 (en) | 2005-11-04 | 2010-06-01 | Siemens Aktiengesellschaft | Three-dimensional co-registration between intravascular and angiographic data |
US7742797B2 (en) | 2005-06-30 | 2010-06-22 | Siemens Aktiengesellschaft | Device and method for intraluminal imaging for the reconstruction of 3D image data sets |
US20100161022A1 (en) | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Pre-deployment positioning of an implantable device within a moving organ |
JP2010148778A (en) | 2008-12-26 | 2010-07-08 | Toshiba Corp | Image display and image display method |
US7783337B2 (en) | 2005-06-06 | 2010-08-24 | Board Of Regents, The University Of Texas System | OCT using spectrally resolved bandwidth |
US7792342B2 (en) | 2006-02-16 | 2010-09-07 | Siemens Medical Solutions Usa, Inc. | System and method for detecting and tracking a guidewire in a fluoroscopic image sequence |
US7813609B2 (en) | 2007-11-12 | 2010-10-12 | Lightlab Imaging, Inc. | Imaging catheter with integrated reference reflector |
US7848791B2 (en) | 2005-02-10 | 2010-12-07 | Lightlab Imaging, Inc. | Optical coherence tomography apparatus and methods |
US7853316B2 (en) | 2003-04-28 | 2010-12-14 | Board Of Regents, The University Of Texas System | Rotating optical catheter tip for optical coherence tomography |
US7869663B2 (en) | 2005-08-01 | 2011-01-11 | Bioptigen, Inc. | Methods, systems and computer program products for analyzing three dimensional data sets obtained from a sample |
US7872759B2 (en) | 2005-09-29 | 2011-01-18 | The General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
US20110071404A1 (en) | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US7916387B2 (en) | 2007-01-10 | 2011-03-29 | Lightlab Imaging, Inc. | Methods and apparatus for swept-source optical coherence tomography |
US7918793B2 (en) | 2005-10-28 | 2011-04-05 | Biosense Webster, Inc. | Synchronization of ultrasound imaging data with electrical mapping |
US7925327B2 (en) | 2002-12-04 | 2011-04-12 | Koninklijke Philips Electronics N.V. | Apparatus and method for assisting the navigation of a catheter in a vessel |
US7935060B2 (en) | 2006-11-08 | 2011-05-03 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
US7967743B2 (en) | 2006-02-23 | 2011-06-28 | Olympus Corporation | Endoscope observation device, observation device and observation method using endoscope |
US20110157686A1 (en) | 2008-09-03 | 2011-06-30 | Lightlab Imaging, Inc. | Wavelength-Tunable Light Source |
US7991105B2 (en) | 2006-10-17 | 2011-08-02 | Koninklijke Philips Electronics N.V. | Visualization of 3D images in combination with 2D projection images |
US7988633B2 (en) | 2005-10-12 | 2011-08-02 | Volcano Corporation | Apparatus and method for use of RFID catheter intelligence |
US20110190586A1 (en) | 2008-03-28 | 2011-08-04 | Volcano Corporation | Methods and systems for intravascular imaging and flushing |
US20110228280A1 (en) | 2010-03-17 | 2011-09-22 | Lightlab Imaging, Inc. | Intensity Noise Reduction Methods and Apparatus for Interferometric Sensing and Imaging Systems |
US20110230758A1 (en) | 2008-12-03 | 2011-09-22 | Uzi Eichler | System and method for determining the position of the tip of a medical catheter within the body of a patient |
US8029447B2 (en) | 2006-10-10 | 2011-10-04 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition including an enhanced dynamically configured graphical display |
US20110319752A1 (en) * | 2008-11-18 | 2011-12-29 | Sync-Rx, Ltd. | Image super enhancement |
US20120004529A1 (en) | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Automatic display of previously-acquired endoluminal images |
US20120004537A1 (en) | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US20120029339A1 (en) * | 2010-07-29 | 2012-02-02 | Sync-Rx, Ltd. | Accounting for forward motion during pullback of an endoluminal imaging probe |
US20120075638A1 (en) | 2010-08-02 | 2012-03-29 | Case Western Reserve University | Segmentation and quantification for intravascular optical coherence tomography images |
US8206374B2 (en) | 2010-03-15 | 2012-06-26 | Medtronic Vascular, Inc. | Catheter having improved traceability |
US8206377B2 (en) | 2009-12-22 | 2012-06-26 | Lightlab Imaging, Inc. | Torque limiter for an OCT catheter |
US20120162660A1 (en) | 2007-07-12 | 2012-06-28 | Volcano Corporation | Automatic calibration systems and methods of use |
JP2012130680A (en) | 2010-12-17 | 2012-07-12 | General Electric Co <Ge> | Synchronization for medical imaging systems |
US8259303B2 (en) | 2008-05-15 | 2012-09-04 | Axsun Technologies, Inc. | OCT combining probes and integrated systems |
US20120224751A1 (en) | 2007-07-12 | 2012-09-06 | Volcano Corporation | Automatic calibration systems and methods of use |
US20120238869A1 (en) | 2010-01-19 | 2012-09-20 | Lightlab Imaging, Inc. | Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories |
US20120250028A1 (en) | 2011-03-31 | 2012-10-04 | Lightlab Imaging, Inc. | Optical Buffering Methods, Apparatus, and Systems for Increasing the Repetition Rate of Tunable Light Sources |
US8298147B2 (en) | 2005-06-24 | 2012-10-30 | Volcano Corporation | Three dimensional co-registration for intravascular diagnosis and therapy |
US20120310081A1 (en) | 2011-05-31 | 2012-12-06 | Lightlab Imaging, Inc. | Multimodal Imaging System, Apparatus, and Methods |
WO2012176191A1 (en) | 2011-06-23 | 2012-12-27 | Sync-Rx, Ltd. | Luminal background cleaning |
US20130006105A1 (en) | 2011-06-30 | 2013-01-03 | Terumo Kabushiki Kaisha | Optical coherent tomographic image forming apparatus and control method thereof |
US8351665B2 (en) | 2005-04-28 | 2013-01-08 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
US20130023761A1 (en) | 2009-12-22 | 2013-01-24 | Lightlab Imaging, Inc. | Torque Limiter for an OCT Catheter |
US20130051728A1 (en) | 2011-08-31 | 2013-02-28 | Lightlab Imaging, Inc. | Optical Imaging Probes and Related Methods |
US8412312B2 (en) | 2009-09-23 | 2013-04-02 | Lightlab Imaging, Inc. | Apparatus, systems, and methods of in-vivo blood clearing in a lumen |
US8423121B2 (en) | 2008-08-11 | 2013-04-16 | Siemens Aktiengesellschaft | Method and system for guidewire tracking in fluoroscopic image sequences |
US20130123616A1 (en) | 2011-11-16 | 2013-05-16 | Volcano Corporation | Medical Workflow System and Method |
US8457375B2 (en) | 2009-09-25 | 2013-06-04 | Siemens Aktiengesellschaft | Visualization method and imaging system |
US8457440B1 (en) | 2009-01-27 | 2013-06-04 | Axsun Technologies, Inc. | Method and system for background subtraction in medical optical coherence tomography system |
US8478387B2 (en) | 2008-10-14 | 2013-07-02 | Lightlab Imaging, Inc. | Methods for stent strut detection and related measurement and display using optical coherence tomography |
US20130281832A1 (en) | 2012-04-24 | 2013-10-24 | John Baumgart | System for Coregistration of Optical Coherence Tomography and Angiographic X-ray Image Data |
US8571639B2 (en) | 2003-09-05 | 2013-10-29 | Varian Medical Systems, Inc. | Systems and methods for gating medical procedures |
US8582109B1 (en) | 2011-08-01 | 2013-11-12 | Lightlab Imaging, Inc. | Swept mode-hopping laser system, methods, and devices for frequency-domain optical coherence tomography |
US8582619B2 (en) | 2011-03-15 | 2013-11-12 | Lightlab Imaging, Inc. | Methods, systems, and devices for timing control in electromagnetic radiation sources |
US8581643B1 (en) | 2011-10-28 | 2013-11-12 | Lightlab Imaging, Inc. | Phase-lock loop-based clocking system, methods and apparatus |
US8582934B2 (en) | 2007-11-12 | 2013-11-12 | Lightlab Imaging, Inc. | Miniature optical elements for fiber-optic beam shaping |
WO2013175472A2 (en) | 2012-05-21 | 2013-11-28 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
WO2014002095A2 (en) | 2012-06-26 | 2014-01-03 | Sync-Rx, Ltd. | Flow-related image processing in luminal organs |
US20140024931A1 (en) | 2012-07-20 | 2014-01-23 | Lightlab Imaging, Inc. | Data Encoders for Medical Devices and Related Methods |
US8687201B2 (en) | 2012-08-31 | 2014-04-01 | Lightlab Imaging, Inc. | Optical coherence tomography control systems and methods |
US20140094691A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Apparatus and methods for mapping a sequence of images to a roadmap image |
US20140094692A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points |
US20140094697A1 (en) | 2011-05-27 | 2014-04-03 | Lightlab Imaging, Inc. | Optical coherence tomography and pressure based systems and methods |
US20140094689A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Apparatus and methods for determining a plurality of local calibration factors for an image |
US20140094660A1 (en) * | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe |
US20140094693A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Accounting for skipped imaging locations during movement of an endoluminal imaging probe |
US8700130B2 (en) | 2007-03-08 | 2014-04-15 | Sync-Rx, Ltd. | Stepwise advancement of a medical tool |
US20140142432A1 (en) | 2012-11-19 | 2014-05-22 | Christopher Hutchins | Multimodal Imaging Systems, Probes and Methods |
US20140142427A1 (en) | 2012-11-16 | 2014-05-22 | Lightlab Imaging, Inc. | Automated Fluid Delivery Catheter and System |
US20140187920A1 (en) | 2012-12-31 | 2014-07-03 | Volcano Corporation | Devices, Systems, and Methods For Assessment of Vessels |
US20140218210A1 (en) | 2011-08-24 | 2014-08-07 | Volcano Corporation | Medical Communication Hub and Associated Methods |
US8831321B1 (en) | 2011-11-07 | 2014-09-09 | Lightlab Imaging, Inc. | Side branch detection methods, systems and devices |
US20140270445A1 (en) | 2013-03-13 | 2014-09-18 | Volcano Corporation | System and method for oct depth calibration |
US20140268167A1 (en) | 2013-03-15 | 2014-09-18 | Lightlab Imaging, Inc. | Calibration and Image Processing Devices, Methods, and Systems |
US20140276011A1 (en) | 2009-09-23 | 2014-09-18 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US8855744B2 (en) | 2008-11-18 | 2014-10-07 | Sync-Rx, Ltd. | Displaying a device within an endoluminal image stack |
US20140309536A1 (en) | 2011-06-30 | 2014-10-16 | Lightlab Imaging, Inc. | Catheter with flush valve and related systems and methods |
US8909323B2 (en) | 2009-08-06 | 2014-12-09 | Siemens Medical Solutions Usa, Inc. | System for processing angiography and ultrasound image data |
US8913084B2 (en) | 2012-12-21 | 2014-12-16 | Volcano Corporation | Method and apparatus for performing virtual pullback of an intravascular imaging device |
US20140379269A1 (en) | 2011-08-03 | 2014-12-25 | Lightlab Imaging, Inc. | Systems, methods and apparatus for determining a fractional flow reserve |
US8953911B1 (en) | 2011-10-28 | 2015-02-10 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
US20150141808A1 (en) * | 2012-06-28 | 2015-05-21 | Koninklijke Philips N.V. | Fiber optic sensor guided navigation for vascular visualization and monitoring |
-
2014
- 2014-09-12 US US14/484,832 patent/US10499813B2/en active Active
-
2015
- 2015-07-30 EP EP15750872.2A patent/EP3190954B1/en active Active
- 2015-07-30 WO PCT/US2015/042849 patent/WO2016039884A1/en active Application Filing
- 2015-07-30 JP JP2017534518A patent/JP6649386B2/en not_active Expired - Fee Related
Patent Citations (215)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4548473A (en) | 1983-05-12 | 1985-10-22 | Honeywell Inc. | Optical filter |
JPS63127201A (en) | 1986-11-17 | 1988-05-31 | Matsushita Electric Ind Co Ltd | Color filter |
US5586201A (en) | 1990-11-14 | 1996-12-17 | Cedars-Sinai Medical Center | Coronary tracking display |
US5822391A (en) | 1990-11-14 | 1998-10-13 | Cedar Sinai Medical Center | Coronary tracking display |
US6111645A (en) | 1991-04-29 | 2000-08-29 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US5321501A (en) | 1991-04-29 | 1994-06-14 | Massachusetts Institute Of Technology | Method and apparatus for optical imaging with means for controlling the longitudinal range of the sample |
US6421164B2 (en) | 1991-04-29 | 2002-07-16 | Massachusetts Institute Of Technology | Interferometeric imaging with a grating based phase control optical delay line |
US5465147A (en) | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
US6485413B1 (en) | 1991-04-29 | 2002-11-26 | The General Hospital Corporation | Methods and apparatus for forward-directed optical scanning instruments |
US6282011B1 (en) | 1991-04-29 | 2001-08-28 | Massachusetts Institute Of Technology | Grating based phase control optical delay line |
US6501551B1 (en) | 1991-04-29 | 2002-12-31 | Massachusetts Institute Of Technology | Fiber optic imaging endoscope interferometer with at least one faraday rotator |
US6160826A (en) | 1991-04-29 | 2000-12-12 | Massachusetts Institute Of Technology | Method and apparatus for performing optical frequency domain reflectometry |
US5459570A (en) | 1991-04-29 | 1995-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements |
US6564087B1 (en) | 1991-04-29 | 2003-05-13 | Massachusetts Institute Of Technology | Fiber optic needle probes for optical coherence tomography imaging |
US6134003A (en) | 1991-04-29 | 2000-10-17 | Massachusetts Institute Of Technology | Method and apparatus for performing optical measurements using a fiber optic imaging guidewire, catheter or endoscope |
US6692824B2 (en) | 1991-12-21 | 2004-02-17 | Roehm Gmbh & Co. Kg | Infrared-reflecting bodies |
US5518810A (en) | 1993-06-30 | 1996-05-21 | Mitsubishi Materials Corporation | Infrared ray cutoff material and infrared cutoff powder use for same |
US5509093A (en) | 1993-10-13 | 1996-04-16 | Micron Optics, Inc. | Temperature compensated fiber fabry-perot filters |
US5715827A (en) | 1994-09-02 | 1998-02-10 | Cardiometrics, Inc. | Ultra miniature pressure sensor and guide wire using the same and method |
US5908415A (en) | 1994-09-09 | 1999-06-01 | Rare Earth Medical, Inc. | Phototherapy methods and apparatus |
US5947959A (en) | 1994-09-09 | 1999-09-07 | Rare Earth Medical, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US6270492B1 (en) | 1994-09-09 | 2001-08-07 | Cardiofocus, Inc. | Phototherapeutic apparatus with diffusive tip assembly |
US5632767A (en) | 1994-09-09 | 1997-05-27 | Rare Earth Medical, Inc. | Loop diffusers for diffusion of optical radiation |
US5619368A (en) | 1995-05-16 | 1997-04-08 | Massachusetts Inst. Of Technology | Optical frequency shifter |
US5643253A (en) | 1995-06-06 | 1997-07-01 | Rare Earth Medical, Inc. | Phototherapy apparatus with integral stopper device |
US5784352A (en) | 1995-07-21 | 1998-07-21 | Massachusetts Institute Of Technology | Apparatus and method for accessing data on multilayered optical media |
US5965355A (en) | 1995-09-21 | 1999-10-12 | Agritope, Inc. | Antibodies and proteins useful for assaying virus infection in grape plants |
US5748598A (en) | 1995-12-22 | 1998-05-05 | Massachusetts Institute Of Technology | Apparatus and methods for reading multilayer storage media using short coherence length sources |
US6302875B1 (en) | 1996-10-11 | 2001-10-16 | Transvascular, Inc. | Catheters and related devices for forming passageways between blood vessels or other anatomical structures |
US6195445B1 (en) | 1997-06-30 | 2001-02-27 | Siemens Corporate Research, Inc. | Motion compensation of an image sequence using optimal polyline tracking |
US6148095A (en) | 1997-09-08 | 2000-11-14 | University Of Iowa Research Foundation | Apparatus and method for determining three-dimensional representations of tortuous vessels |
US20020161351A1 (en) | 1998-09-01 | 2002-10-31 | Samson Wilfred J. | Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion |
US6973202B2 (en) | 1998-10-23 | 2005-12-06 | Varian Medical Systems Technologies, Inc. | Single-camera tracking of an object |
US6937696B1 (en) | 1998-10-23 | 2005-08-30 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating |
US7191100B2 (en) | 1998-10-23 | 2007-03-13 | Varian Medical Systems Technologies, Inc. | Method and system for predictive physiological gating of radiation therapy |
US6348960B1 (en) | 1998-11-06 | 2002-02-19 | Kimotot Co., Ltd. | Front scattering film |
USRE40608E1 (en) | 1999-01-06 | 2008-12-16 | Volcano Corporation | Arrangement of IVUS system components including remote and adjacent components |
US6191862B1 (en) | 1999-01-20 | 2001-02-20 | Lightlab Imaging, Llc | Methods and apparatus for high speed longitudinal scanning in imaging systems |
US6942657B2 (en) | 1999-07-14 | 2005-09-13 | Cardiofocus, Inc. | Intralumenal contact sensor |
US6445939B1 (en) | 1999-08-09 | 2002-09-03 | Lightlab Imaging, Llc | Ultra-small optical probes, imaging optics, and methods for using same |
US7321677B2 (en) | 2000-05-09 | 2008-01-22 | Paieon Inc. | System and method for three-dimensional reconstruction of an artery |
US6565514B2 (en) | 2000-08-25 | 2003-05-20 | Radi Medical Systems Ab | Method and system for determining physiological variables |
US7068831B2 (en) | 2000-08-31 | 2006-06-27 | Koninklijke Philips Electronics, N.V. | Image processing method and system for extracting a string of points following a threadlike structure in a sequence of images |
US7231243B2 (en) | 2000-10-30 | 2007-06-12 | The General Hospital Corporation | Optical methods for tissue analysis |
US6718089B2 (en) | 2001-02-16 | 2004-04-06 | Indigo Medical Incorporated | Optical fiber including a diffuser portion and continuous sleeve for the transmission of light |
US6760112B2 (en) | 2001-02-17 | 2004-07-06 | Lucent Technologies Inc. | Grin-fiber lens based optical endoscopes |
US7208333B2 (en) | 2001-03-12 | 2007-04-24 | Axsun Technologies, Inc. | Process for fabricating MEMS membrane with integral mirror/lens |
US6570659B2 (en) | 2001-03-16 | 2003-05-27 | Lightlab Imaging, Llc | Broadband light source system and method and light source combiner |
US6552796B2 (en) | 2001-04-06 | 2003-04-22 | Lightlab Imaging, Llc | Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography |
US6706004B2 (en) | 2001-05-31 | 2004-03-16 | Infraredx, Inc. | Balloon catheter |
US6879851B2 (en) | 2001-06-07 | 2005-04-12 | Lightlab Imaging, Llc | Fiber optic endoscopic gastrointestinal probe |
US6731973B2 (en) | 2001-06-12 | 2004-05-04 | Ge Medical Systems Information Technologies, Inc. | Method and apparatus for processing physiological data |
US6728566B1 (en) | 2001-11-21 | 2004-04-27 | Koninklijke Philips Electronics, N.V. | Vessel tracking and tree extraction method and apparatus |
US6974557B1 (en) | 2001-12-18 | 2005-12-13 | Advanced Cardiovasculer Systems, Inc. | Methods for forming an optical window for an intracorporeal device and for joining parts |
US6932809B2 (en) | 2002-05-14 | 2005-08-23 | Cardiofocus, Inc. | Safety shut-off device for laser surgical instruments employing blackbody emitters |
US8556820B2 (en) | 2002-05-20 | 2013-10-15 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition and display |
US7134994B2 (en) | 2002-05-20 | 2006-11-14 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition and display |
US8562537B2 (en) | 2002-05-20 | 2013-10-22 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition and display |
US20040006277A1 (en) | 2002-07-02 | 2004-01-08 | Langenhove Glenn Van | Determining vulnerable plaque in blood vessels |
US6891984B2 (en) | 2002-07-25 | 2005-05-10 | Lightlab Imaging, Llc | Scanning miniature optical probes with optical distortion correction and rotational control |
US20050201662A1 (en) | 2002-07-25 | 2005-09-15 | Petersen Christopher L. | Scanning miniature optical probes with optical distortion correction and rotational control |
US7697972B2 (en) | 2002-11-19 | 2010-04-13 | Medtronic Navigation, Inc. | Navigation system for cardiac therapies |
US7925327B2 (en) | 2002-12-04 | 2011-04-12 | Koninklijke Philips Electronics N.V. | Apparatus and method for assisting the navigation of a catheter in a vessel |
US20080194996A1 (en) * | 2003-02-21 | 2008-08-14 | Kassab Ghassan S | Device, system and method for measuring cross-sectional areas in luminal organs |
US20100076320A1 (en) | 2003-04-25 | 2010-03-25 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US7625366B2 (en) | 2003-04-25 | 2009-12-01 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US7241286B2 (en) | 2003-04-25 | 2007-07-10 | Lightlab Imaging, Llc | Flush catheter with flow directing sheath |
US7711413B2 (en) | 2003-04-28 | 2010-05-04 | Volcano Corporation | Catheter imaging probe and method |
US7853316B2 (en) | 2003-04-28 | 2010-12-14 | Board Of Regents, The University Of Texas System | Rotating optical catheter tip for optical coherence tomography |
US7298478B2 (en) | 2003-08-14 | 2007-11-20 | Cytonome, Inc. | Optical detector for a particle sorting system |
US7355699B2 (en) | 2003-08-14 | 2008-04-08 | Cytonome, Inc. | Optical detector for a particle sorting system |
US7576861B2 (en) | 2003-08-14 | 2009-08-18 | Cytonome/St, Llc | Optical detector for a particle sorting system |
US7492522B2 (en) | 2003-08-14 | 2009-02-17 | Cytonome, Inc. | Optical detector for a particle sorting system |
US20050043614A1 (en) | 2003-08-21 | 2005-02-24 | Huizenga Joel T. | Automated methods and systems for vascular plaque detection and analysis |
US8571639B2 (en) | 2003-09-05 | 2013-10-29 | Varian Medical Systems, Inc. | Systems and methods for gating medical procedures |
US20060095065A1 (en) | 2004-09-24 | 2006-05-04 | Tetsuaki Tanimura | Fluid occluding devices and methods |
US7412141B2 (en) | 2004-11-16 | 2008-08-12 | Biotex, Inc. | Light diffusing tip |
US7301644B2 (en) | 2004-12-02 | 2007-11-27 | University Of Miami | Enhanced optical coherence tomography for anatomical mapping |
US7930014B2 (en) | 2005-01-11 | 2011-04-19 | Volcano Corporation | Vascular image co-registration |
US20060241465A1 (en) * | 2005-01-11 | 2006-10-26 | Volcano Corporation | Vascular image co-registration |
US7414779B2 (en) | 2005-01-20 | 2008-08-19 | Massachusetts Institute Of Technology | Mode locking methods and apparatus |
US20090174931A1 (en) | 2005-01-20 | 2009-07-09 | Huber Robert A | Fourier domain mode locking: method and apparatus for control and improved performance |
US7848791B2 (en) | 2005-02-10 | 2010-12-07 | Lightlab Imaging, Inc. | Optical coherence tomography apparatus and methods |
US7415049B2 (en) | 2005-03-28 | 2008-08-19 | Axsun Technologies, Inc. | Laser with tilted multi spatial mode resonator tuning element |
US8351665B2 (en) | 2005-04-28 | 2013-01-08 | The General Hospital Corporation | Systems, processes and software arrangements for evaluating information associated with an anatomical structure by an optical coherence ranging technique |
US20060264743A1 (en) | 2005-05-06 | 2006-11-23 | Siemens Aktiengesellschaft | Method for tomographically displaying a cavity by optical coherence tomography (OCT) and an OCT device for carrying out the method |
US7408648B2 (en) | 2005-05-06 | 2008-08-05 | Siemens Aktiengesellschaft | Method for tomographically displaying a cavity by optical coherence tomography (OCT) and an OCT device for carrying out the method |
US7783337B2 (en) | 2005-06-06 | 2010-08-24 | Board Of Regents, The University Of Texas System | OCT using spectrally resolved bandwidth |
US8298147B2 (en) | 2005-06-24 | 2012-10-30 | Volcano Corporation | Three dimensional co-registration for intravascular diagnosis and therapy |
US7742797B2 (en) | 2005-06-30 | 2010-06-22 | Siemens Aktiengesellschaft | Device and method for intraluminal imaging for the reconstruction of 3D image data sets |
US20070027390A1 (en) | 2005-07-13 | 2007-02-01 | Michael Maschke | System for performing and monitoring minimally invasive interventions |
US7869663B2 (en) | 2005-08-01 | 2011-01-11 | Bioptigen, Inc. | Methods, systems and computer program products for analyzing three dimensional data sets obtained from a sample |
US20070024617A1 (en) | 2005-08-01 | 2007-02-01 | Ian Poole | Method for determining a path along a biological object with a lumen |
US20070135803A1 (en) | 2005-09-14 | 2007-06-14 | Amir Belson | Methods and apparatus for performing transluminal and other procedures |
US20070066890A1 (en) | 2005-09-22 | 2007-03-22 | Siemens Aktiengesellschaft | Catheter device |
US7872759B2 (en) | 2005-09-29 | 2011-01-18 | The General Hospital Corporation | Arrangements and methods for providing multimodality microscopic imaging of one or more biological structures |
US7988633B2 (en) | 2005-10-12 | 2011-08-02 | Volcano Corporation | Apparatus and method for use of RFID catheter intelligence |
US7918793B2 (en) | 2005-10-28 | 2011-04-05 | Biosense Webster, Inc. | Synchronization of ultrasound imaging data with electrical mapping |
US7729746B2 (en) | 2005-11-04 | 2010-06-01 | Siemens Aktiengesellschaft | Three-dimensional co-registration between intravascular and angiographic data |
US7593559B2 (en) | 2005-11-18 | 2009-09-22 | Duke University | Method and system of coregistrating optical coherence tomography (OCT) with other clinical tests |
US7792342B2 (en) | 2006-02-16 | 2010-09-07 | Siemens Medical Solutions Usa, Inc. | System and method for detecting and tracking a guidewire in a fluoroscopic image sequence |
US7967743B2 (en) | 2006-02-23 | 2011-06-28 | Olympus Corporation | Endoscope observation device, observation device and observation method using endoscope |
US8029447B2 (en) | 2006-10-10 | 2011-10-04 | Volcano Corporation | Multipurpose host system for invasive cardiovascular diagnostic measurement acquisition including an enhanced dynamically configured graphical display |
US7991105B2 (en) | 2006-10-17 | 2011-08-02 | Koninklijke Philips Electronics N.V. | Visualization of 3D images in combination with 2D projection images |
US7935060B2 (en) | 2006-11-08 | 2011-05-03 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
US20130012811A1 (en) | 2006-11-08 | 2013-01-10 | Lightlab Imaging, Inc. | Opto-Acoustic Imaging Devices and Methods |
US8449468B2 (en) | 2006-11-08 | 2013-05-28 | Lightlab Imaging, Inc. | Opto-acoustic imaging devices and methods |
US20140114182A1 (en) | 2006-11-08 | 2014-04-24 | Lightlab Imaging, Inc. | Opto-Acoustic Imaging Devices and Methods |
US20110101207A1 (en) | 2007-01-10 | 2011-05-05 | Lightlab Imaging, Inc. | Methods and Apparatus for Swept-Source Optical Coherence Tomography |
US8325419B2 (en) | 2007-01-10 | 2012-12-04 | Lightlab Imaging, Inc. | Methods and apparatus for swept-source optical coherence tomography |
US7916387B2 (en) | 2007-01-10 | 2011-03-29 | Lightlab Imaging, Inc. | Methods and apparatus for swept-source optical coherence tomography |
US20120004529A1 (en) | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Automatic display of previously-acquired endoluminal images |
US20080221440A1 (en) | 2007-03-08 | 2008-09-11 | Sync-Rx, Ltd. | Imaging and tools for use with moving organs |
US20100172556A1 (en) | 2007-03-08 | 2010-07-08 | Sync-Rx, Ltd. | Automatic enhancement of an image stream of a moving organ |
US20100228076A1 (en) | 2007-03-08 | 2010-09-09 | Sync-Rx, Ltd | Controlled actuation and deployment of a medical device |
US20100191102A1 (en) | 2007-03-08 | 2010-07-29 | Sync-Rx, Ltd. | Automatic correction and utilization of a vascular roadmap comprising a tool |
US20100161023A1 (en) | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Automatic tracking of a tool upon a vascular roadmap |
US8781193B2 (en) | 2007-03-08 | 2014-07-15 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis |
US20100157041A1 (en) | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Automatic stabilization of an image stream of a moving organ |
US20100160773A1 (en) | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Automatic quantitative vessel analysis at the location of an automatically-detected tool |
US20100222671A1 (en) | 2007-03-08 | 2010-09-02 | Sync-Rx, Ltd. | Identification and presentation of device-to-vessel relative motion |
US8700130B2 (en) | 2007-03-08 | 2014-04-15 | Sync-Rx, Ltd. | Stepwise advancement of a medical tool |
US8693756B2 (en) | 2007-03-08 | 2014-04-08 | Sync-Rx, Ltd. | Automatic reduction of interfering elements from an image stream of a moving organ |
US20100160764A1 (en) | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Automatic generation and utilization of a vascular roadmap |
US8670603B2 (en) | 2007-03-08 | 2014-03-11 | Sync-Rx, Ltd. | Apparatus and methods for masking a portion of a moving image stream |
US20100290693A1 (en) | 2007-03-08 | 2010-11-18 | Sync-Rx, Ltd. | Location-sensitive cursor control and its use for vessel analysis |
US20120004537A1 (en) | 2007-03-08 | 2012-01-05 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
US20080221439A1 (en) | 2007-03-08 | 2008-09-11 | Sync-Rx, Ltd. | Tools for use with moving organs |
US8290228B2 (en) | 2007-03-08 | 2012-10-16 | Sync-Rx, Ltd. | Location-sensitive cursor control and its use for vessel analysis |
US20100161022A1 (en) | 2007-03-08 | 2010-06-24 | Sync-Rx, Ltd. | Pre-deployment positioning of an implantable device within a moving organ |
US8463007B2 (en) | 2007-03-08 | 2013-06-11 | Sync-Rx, Ltd. | Automatic generation of a vascular skeleton |
US20080221442A1 (en) | 2007-03-08 | 2008-09-11 | Sync-Rx, Ltd. | Imaging for use with moving organs |
US8542900B2 (en) | 2007-03-08 | 2013-09-24 | Sync-Rx Ltd. | Automatic reduction of interfering elements from an image stream of a moving organ |
US20080283771A1 (en) * | 2007-05-17 | 2008-11-20 | General Electric Company | System and method of combining ultrasound image acquisition with fluoroscopic image acquisition |
US20120162660A1 (en) | 2007-07-12 | 2012-06-28 | Volcano Corporation | Automatic calibration systems and methods of use |
US20120224751A1 (en) | 2007-07-12 | 2012-09-06 | Volcano Corporation | Automatic calibration systems and methods of use |
US8582934B2 (en) | 2007-11-12 | 2013-11-12 | Lightlab Imaging, Inc. | Miniature optical elements for fiber-optic beam shaping |
US20140249407A1 (en) | 2007-11-12 | 2014-09-04 | Lightlab Imaging, Inc. | Miniature Optical Elements for Fiber-Optic Beam Shaping |
US8116605B2 (en) | 2007-11-12 | 2012-02-14 | Lightlab Imaging, Inc. | Imaging catheter with integrated reference reflector |
US8503844B2 (en) | 2007-11-12 | 2013-08-06 | Lightlab Imaging, Inc. | Imaging catheter with integrated reference reflector |
US20130010303A1 (en) | 2007-11-12 | 2013-01-10 | Lightlab Imaging, Inc. | Imaging Catheter With Integrated Reference Reflector |
US7813609B2 (en) | 2007-11-12 | 2010-10-12 | Lightlab Imaging, Inc. | Imaging catheter with integrated reference reflector |
US20110190586A1 (en) | 2008-03-28 | 2011-08-04 | Volcano Corporation | Methods and systems for intravascular imaging and flushing |
US20120300216A1 (en) | 2008-05-15 | 2012-11-29 | Axsun Technologies, Inc. | Integrated Optical Coherence Analysis System |
US20120300215A1 (en) | 2008-05-15 | 2012-11-29 | Axsun Technologies, Inc. | OCT Combining Probes and Integrated Systems |
US8259303B2 (en) | 2008-05-15 | 2012-09-04 | Axsun Technologies, Inc. | OCT combining probes and integrated systems |
US20090306520A1 (en) | 2008-06-02 | 2009-12-10 | Lightlab Imaging, Inc. | Quantitative methods for obtaining tissue characteristics from optical coherence tomography images |
US8423121B2 (en) | 2008-08-11 | 2013-04-16 | Siemens Aktiengesellschaft | Method and system for guidewire tracking in fluoroscopic image sequences |
US8358461B2 (en) | 2008-09-03 | 2013-01-22 | Lightlab Imaging Inc. | Wavelength-tunable light source |
US20110157686A1 (en) | 2008-09-03 | 2011-06-30 | Lightlab Imaging, Inc. | Wavelength-Tunable Light Source |
US20140018669A1 (en) | 2008-10-14 | 2014-01-16 | Lightlab Imaging, Inc. | Methods for Stent Strut Detection and Related Measurement and Display Using Optical Coherence Tomography |
US8478387B2 (en) | 2008-10-14 | 2013-07-02 | Lightlab Imaging, Inc. | Methods for stent strut detection and related measurement and display using optical coherence tomography |
US20140094660A1 (en) * | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Accounting for non-uniform longitudinal motion during movement of an endoluminal imaging probe |
US8855744B2 (en) | 2008-11-18 | 2014-10-07 | Sync-Rx, Ltd. | Displaying a device within an endoluminal image stack |
US20140094692A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Apparatus and methods for determining a dimension of a portion of a stack of endoluminal data points |
US20140094691A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Apparatus and methods for mapping a sequence of images to a roadmap image |
US20140094689A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Apparatus and methods for determining a plurality of local calibration factors for an image |
US20110319752A1 (en) * | 2008-11-18 | 2011-12-29 | Sync-Rx, Ltd. | Image super enhancement |
US20140094693A1 (en) | 2008-11-18 | 2014-04-03 | Sync-Rx, Ltd. | Accounting for skipped imaging locations during movement of an endoluminal imaging probe |
US20110230758A1 (en) | 2008-12-03 | 2011-09-22 | Uzi Eichler | System and method for determining the position of the tip of a medical catheter within the body of a patient |
JP2010148778A (en) | 2008-12-26 | 2010-07-08 | Toshiba Corp | Image display and image display method |
US8457440B1 (en) | 2009-01-27 | 2013-06-04 | Axsun Technologies, Inc. | Method and system for background subtraction in medical optical coherence tomography system |
US8909323B2 (en) | 2009-08-06 | 2014-12-09 | Siemens Medical Solutions Usa, Inc. | System for processing angiography and ultrasound image data |
US20130072805A1 (en) | 2009-09-23 | 2013-03-21 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US20110071404A1 (en) | 2009-09-23 | 2011-03-24 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US20130310698A1 (en) | 2009-09-23 | 2013-11-21 | Lightlab Imaging, Inc. | Apparatus, Systems, and Methods of In-Vivo Blood Clearing in a Lumen |
US8412312B2 (en) | 2009-09-23 | 2013-04-02 | Lightlab Imaging, Inc. | Apparatus, systems, and methods of in-vivo blood clearing in a lumen |
US20140276011A1 (en) | 2009-09-23 | 2014-09-18 | Lightlab Imaging, Inc. | Lumen Morphology and Vascular Resistance Measurements Data Collection Systems, Apparatus and Methods |
US8457375B2 (en) | 2009-09-25 | 2013-06-04 | Siemens Aktiengesellschaft | Visualization method and imaging system |
US8206377B2 (en) | 2009-12-22 | 2012-06-26 | Lightlab Imaging, Inc. | Torque limiter for an OCT catheter |
US20130023761A1 (en) | 2009-12-22 | 2013-01-24 | Lightlab Imaging, Inc. | Torque Limiter for an OCT Catheter |
US20140187929A1 (en) | 2010-01-19 | 2014-07-03 | Lightlab Imaging, Inc. | Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories |
US8478384B2 (en) | 2010-01-19 | 2013-07-02 | Lightlab Imaging, Inc. | Intravascular optical coherence tomography system with pressure monitoring interface and accessories |
US20120238869A1 (en) | 2010-01-19 | 2012-09-20 | Lightlab Imaging, Inc. | Intravascular Optical Coherence Tomography System with Pressure Monitoring Interface and Accessories |
US8206374B2 (en) | 2010-03-15 | 2012-06-26 | Medtronic Vascular, Inc. | Catheter having improved traceability |
US20110228280A1 (en) | 2010-03-17 | 2011-09-22 | Lightlab Imaging, Inc. | Intensity Noise Reduction Methods and Apparatus for Interferometric Sensing and Imaging Systems |
JP2013537444A (en) | 2010-07-29 | 2013-10-03 | エスワイエヌシー−アールエックス、リミテッド | Combined use of intraluminal data and extraluminal imaging |
US20120029339A1 (en) * | 2010-07-29 | 2012-02-02 | Sync-Rx, Ltd. | Accounting for forward motion during pullback of an endoluminal imaging probe |
US20120075638A1 (en) | 2010-08-02 | 2012-03-29 | Case Western Reserve University | Segmentation and quantification for intravascular optical coherence tomography images |
JP2012130680A (en) | 2010-12-17 | 2012-07-12 | General Electric Co <Ge> | Synchronization for medical imaging systems |
US8948228B2 (en) | 2011-03-15 | 2015-02-03 | Lightlab Imaging, Inc. | Methods, systems, and devices for timing control in electromagnetic radiation sources |
US8582619B2 (en) | 2011-03-15 | 2013-11-12 | Lightlab Imaging, Inc. | Methods, systems, and devices for timing control in electromagnetic radiation sources |
US20120250028A1 (en) | 2011-03-31 | 2012-10-04 | Lightlab Imaging, Inc. | Optical Buffering Methods, Apparatus, and Systems for Increasing the Repetition Rate of Tunable Light Sources |
US20140094697A1 (en) | 2011-05-27 | 2014-04-03 | Lightlab Imaging, Inc. | Optical coherence tomography and pressure based systems and methods |
US20120310081A1 (en) | 2011-05-31 | 2012-12-06 | Lightlab Imaging, Inc. | Multimodal Imaging System, Apparatus, and Methods |
WO2012176191A1 (en) | 2011-06-23 | 2012-12-27 | Sync-Rx, Ltd. | Luminal background cleaning |
US20130006105A1 (en) | 2011-06-30 | 2013-01-03 | Terumo Kabushiki Kaisha | Optical coherent tomographic image forming apparatus and control method thereof |
US20140309536A1 (en) | 2011-06-30 | 2014-10-16 | Lightlab Imaging, Inc. | Catheter with flush valve and related systems and methods |
US8582109B1 (en) | 2011-08-01 | 2013-11-12 | Lightlab Imaging, Inc. | Swept mode-hopping laser system, methods, and devices for frequency-domain optical coherence tomography |
US20140379269A1 (en) | 2011-08-03 | 2014-12-25 | Lightlab Imaging, Inc. | Systems, methods and apparatus for determining a fractional flow reserve |
US20140218210A1 (en) | 2011-08-24 | 2014-08-07 | Volcano Corporation | Medical Communication Hub and Associated Methods |
US20130051728A1 (en) | 2011-08-31 | 2013-02-28 | Lightlab Imaging, Inc. | Optical Imaging Probes and Related Methods |
US8953911B1 (en) | 2011-10-28 | 2015-02-10 | Lightlab Imaging, Inc. | Spectroscopic imaging probes, devices, and methods |
US8581643B1 (en) | 2011-10-28 | 2013-11-12 | Lightlab Imaging, Inc. | Phase-lock loop-based clocking system, methods and apparatus |
US8786336B1 (en) | 2011-10-28 | 2014-07-22 | Lightlab Imaging, Inc. | Phase-lock loop-based clocking system, methods and apparatus |
US8831321B1 (en) | 2011-11-07 | 2014-09-09 | Lightlab Imaging, Inc. | Side branch detection methods, systems and devices |
US20130123616A1 (en) | 2011-11-16 | 2013-05-16 | Volcano Corporation | Medical Workflow System and Method |
US20130281832A1 (en) | 2012-04-24 | 2013-10-24 | John Baumgart | System for Coregistration of Optical Coherence Tomography and Angiographic X-ray Image Data |
WO2013175472A2 (en) | 2012-05-21 | 2013-11-28 | Sync-Rx, Ltd. | Co-use of endoluminal data and extraluminal imaging |
WO2014002095A2 (en) | 2012-06-26 | 2014-01-03 | Sync-Rx, Ltd. | Flow-related image processing in luminal organs |
US20140100451A1 (en) | 2012-06-26 | 2014-04-10 | Sync-Rx, Ltd. | Coregistration of endoluminal data points with values of a luminal-flow-related index |
US20140107479A1 (en) | 2012-06-26 | 2014-04-17 | Sync-Rx, Ltd. | Determining a luminal-flow-related index of a lumen by performing image processing on two-dimensional images of the lumen |
US20140114184A1 (en) | 2012-06-26 | 2014-04-24 | Sync-Rx, Ltd. | Determining a luminal-flow-related index using blood velocity determination |
US20140114185A1 (en) | 2012-06-26 | 2014-04-24 | Sync-Rx, Ltd. | Determining a characteristic of a lumen by measuring temporal changes in contrast agent density |
US20150141808A1 (en) * | 2012-06-28 | 2015-05-21 | Koninklijke Philips N.V. | Fiber optic sensor guided navigation for vascular visualization and monitoring |
US20140024931A1 (en) | 2012-07-20 | 2014-01-23 | Lightlab Imaging, Inc. | Data Encoders for Medical Devices and Related Methods |
US20140218742A1 (en) | 2012-08-31 | 2014-08-07 | Lightlab Imaging, Inc. | Optical Coherence Tomography Control Systems and Methods |
US8687201B2 (en) | 2012-08-31 | 2014-04-01 | Lightlab Imaging, Inc. | Optical coherence tomography control systems and methods |
US20140142427A1 (en) | 2012-11-16 | 2014-05-22 | Lightlab Imaging, Inc. | Automated Fluid Delivery Catheter and System |
US20140142432A1 (en) | 2012-11-19 | 2014-05-22 | Christopher Hutchins | Multimodal Imaging Systems, Probes and Methods |
US20140142436A1 (en) | 2012-11-19 | 2014-05-22 | Christopher Hutchins | Interface Devices, Systems and Methods for Multimodal Probes |
US8913084B2 (en) | 2012-12-21 | 2014-12-16 | Volcano Corporation | Method and apparatus for performing virtual pullback of an intravascular imaging device |
US20140187920A1 (en) | 2012-12-31 | 2014-07-03 | Volcano Corporation | Devices, Systems, and Methods For Assessment of Vessels |
US20140270445A1 (en) | 2013-03-13 | 2014-09-18 | Volcano Corporation | System and method for oct depth calibration |
US20140268167A1 (en) | 2013-03-15 | 2014-09-18 | Lightlab Imaging, Inc. | Calibration and Image Processing Devices, Methods, and Systems |
Non-Patent Citations (14)
Title |
---|
Annex to Form PCT/ISA206 Communication Relating to the Results of the Partial International Search for International Application No. PCT/US2008/012701, dated Feb. 27, 2009 (3 pages). |
Dave Fornell, "The Advantages and Disadvantages of OCT vs. IVUS", Diagnostic and Interventional Cardiology, May 18, 2011, pp. 1-4. |
International Preliminary Report on Patentability for International application No. PCT/US2015/042849 issued from the International Bureau of WIPO dated Mar. 14, 2017 (11 pages). |
International Search Report and Written Opinion mailed from the International Searching Authority dated Jun. 27, 2014 for International Application No. PCT/US2013/030623 (17 pages). |
International Search Report and Written Opinion of the International Searching Authority for International Application No. PCT/US2015/042849 mailed from the International Searching Authority dated Nov. 2, 2015 (16 pages). |
International Search Report for International Application No. PCT/US2008/012701, dated May 14, 2009 (7 pages). |
JP 2017-534518, Notification of Reason(s) for Refusal, dated May 14, 2019, (5 pages). |
Palti-Wasserman et al., "Identifying and Tracking a Guide Wire in the Coronary Arteries During Angioplasty from X-Ray Images", IEEE transactions on biomedical engineering, 44:2, Feb. 1997, pp. 152-164. |
PCT International Preliminary Report on Patentability for International Application No. PCT/US2008/012701, dated May 18, 2010 (10 pages). |
PCT International Search Report and Written Opinion of International Searching Authority for International Application No. PCT/US2013/078500, dated Jul. 8, 2014 (14 pages). |
Perez-Rovira et al., "Deformable Registration of Retinal Fluorescein Angiogram Sequences Using Vasculature Structures", 32nd Annual Conf. of IEEE EMBS, 2010, pp. 4383-4386. |
Shengxian Tu et al., "In vivo comparison of arterial lumen dimensions assessed by co-registered three-dimensional (3D) quantitative coronary angiography, intravascular ultrasound and optical coherence tomography", Int. J. Cardiovasc Imaging (2012) 28:1315-1327. |
Tung et al., "Automatic Detection of Coronary Stent Struts in Intravascular OCT Imaging", Proceedings of SPIE, vol. 8315, Feb. 22, 2012 (8 pages). |
Written Opinion of the International Searching Authority for International Application No. PCT/US2008/012701, dated May 14, 2009 (10 pages). |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11278206B2 (en) | 2015-04-16 | 2022-03-22 | Gentuity, Llc | Micro-optic probes for neurology |
US11064873B2 (en) | 2015-08-31 | 2021-07-20 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US11583172B2 (en) | 2015-08-31 | 2023-02-21 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US11937786B2 (en) | 2015-08-31 | 2024-03-26 | Gentuity, Llc | Imaging system includes imaging probe and delivery devices |
US20190154595A1 (en) * | 2016-05-20 | 2019-05-23 | Perimeter Medical Imaging, Inc. | Method and system for combining microscopic imaging with x-ray |
US11058388B2 (en) * | 2016-05-20 | 2021-07-13 | Perimeter Medical Imaging, Inc. | Method and system for combining microscopic imaging with X-Ray imaging |
US11684242B2 (en) | 2017-11-28 | 2023-06-27 | Gentuity, Llc | Imaging system |
US11344373B2 (en) | 2018-05-29 | 2022-05-31 | Lightlab Imaging, Inc. | Stent expansion display, systems, and methods |
Also Published As
Publication number | Publication date |
---|---|
WO2016039884A1 (en) | 2016-03-17 |
JP2017532173A (en) | 2017-11-02 |
JP6649386B2 (en) | 2020-02-19 |
EP3190954B1 (en) | 2020-01-15 |
US20160073885A1 (en) | 2016-03-17 |
EP3190954A1 (en) | 2017-07-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10499813B2 (en) | Methods, systems and apparatus for temporal calibration of an intravascular imaging system | |
US10687777B2 (en) | Vascular data processing and image registration systems, methods, and apparatuses | |
AU2013387679B2 (en) | Vascular data processing and image registration systems, methods, and apparatuses | |
US9811939B2 (en) | Method and system for registering intravascular images | |
EP3378036B1 (en) | X-ray image feature detection and registration systems and methods | |
JP7133346B2 (en) | Method of operation and imaging device for quantitative flow analysis of fluid flowing through a conduit from a sequence of successive image frames of said conduit | |
US11344373B2 (en) | Stent expansion display, systems, and methods | |
JP2024020239A (en) | Intravascular data acquisition and processing system | |
US20160206267A1 (en) | Image processing apparatus, image display system, imaging system, image processing method, and program | |
AU2015308394A1 (en) | System and method for evaluating a cardiac system by determining minimum ratio PD/PA (distal pressure / arterial pressure) | |
US20210085275A1 (en) | Systems And Methods Of Combined Imaging | |
JP7436548B2 (en) | How the processor device works | |
US11481957B2 (en) | Medical image processing apparatus and storage medium | |
US20230054891A1 (en) | Systems And Methods Of Identifying Vessel Attributes Using Extravascular Images | |
JP6726714B2 (en) | Method of operating system for detecting intravascular probe marker, and method of operating system for superimposing and registering angiographic data and intravascular data acquired for a blood vessel | |
US8879808B2 (en) | Synchronization of medical imaging systems | |
US20230210381A1 (en) | Systems and methods for vascular image co-registration |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: LIGHTLAB IMAGING, INC., MASSACHUSETTS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:ADLER, DESMOND;REEL/FRAME:035488/0429 Effective date: 20150312 |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: FINAL REJECTION MAILED |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: DOCKETED NEW CASE - READY FOR EXAMINATION |
|
STPP | Information on status: patent application and granting procedure in general |
Free format text: NOTICE OF ALLOWANCE MAILED -- APPLICATION RECEIVED IN OFFICE OF PUBLICATIONS |
|
STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
MAFP | Maintenance fee payment |
Free format text: PAYMENT OF MAINTENANCE FEE, 4TH YEAR, LARGE ENTITY (ORIGINAL EVENT CODE: M1551); ENTITY STATUS OF PATENT OWNER: LARGE ENTITY Year of fee payment: 4 |