ZA989138B - Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics - Google Patents

Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

Info

Publication number
ZA989138B
ZA989138B ZA989138A ZA989138A ZA989138B ZA 989138 B ZA989138 B ZA 989138B ZA 989138 A ZA989138 A ZA 989138A ZA 989138 A ZA989138 A ZA 989138A ZA 989138 B ZA989138 B ZA 989138B
Authority
ZA
South Africa
Prior art keywords
galactose
pain
agents
analgesics
conjugates
Prior art date
Application number
ZA989138A
Other languages
English (en)
Inventor
Michael John Duggan
John Andrew Chaddock
Original Assignee
Speywood Lab Ltd
Microbiological Res Authority
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Speywood Lab Ltd, Microbiological Res Authority filed Critical Speywood Lab Ltd
Publication of ZA989138B publication Critical patent/ZA989138B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
ZA989138A 1997-10-08 1998-10-07 Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics ZA989138B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9721189.0A GB9721189D0 (en) 1997-10-08 1997-10-08 Analgesic conjugates

Publications (1)

Publication Number Publication Date
ZA989138B true ZA989138B (en) 1999-05-27

Family

ID=10820129

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA989138A ZA989138B (en) 1997-10-08 1998-10-07 Conjugates of galactose-binding lectins and clostridial neurotoxins as analgesics

Country Status (13)

Country Link
US (2) US7052702B1 (fr)
EP (1) EP0996468B1 (fr)
JP (1) JP4629225B2 (fr)
AT (1) ATE240747T1 (fr)
AU (1) AU741456B2 (fr)
CA (1) CA2306350C (fr)
DE (1) DE69814858T2 (fr)
DK (1) DK0996468T3 (fr)
ES (1) ES2198750T3 (fr)
GB (1) GB9721189D0 (fr)
PT (1) PT996468E (fr)
WO (1) WO1999017806A1 (fr)
ZA (1) ZA989138B (fr)

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Also Published As

Publication number Publication date
GB9721189D0 (en) 1997-12-03
CA2306350A1 (fr) 1999-04-15
EP0996468B1 (fr) 2003-05-21
DE69814858D1 (de) 2003-06-26
ATE240747T1 (de) 2003-06-15
AU741456B2 (en) 2001-11-29
CA2306350C (fr) 2008-09-02
DK0996468T3 (da) 2003-09-15
DE69814858T2 (de) 2004-03-11
AU9357498A (en) 1999-04-27
PT996468E (pt) 2003-09-30
US20060121056A1 (en) 2006-06-08
US7052702B1 (en) 2006-05-30
ES2198750T3 (es) 2004-02-01
EP0996468A1 (fr) 2000-05-03
JP4629225B2 (ja) 2011-02-09
WO1999017806A1 (fr) 1999-04-15
US7452543B2 (en) 2008-11-18
JP2001518522A (ja) 2001-10-16

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