ZA986144B - Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones - Google Patents

Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Info

Publication number
ZA986144B
ZA986144B ZA986144A ZA986144A ZA986144B ZA 986144 B ZA986144 B ZA 986144B ZA 986144 A ZA986144 A ZA 986144A ZA 986144 A ZA986144 A ZA 986144A ZA 986144 B ZA986144 B ZA 986144B
Authority
ZA
South Africa
Prior art keywords
noroxymorphone
naltrexone
hydroxynormorphinones
normorphinones
oxymorphone
Prior art date
Application number
ZA986144A
Other languages
English (en)
Inventor
Bao-Shan Huang
Yansong Lu
Ben-Yi Ji
Aris Christodoulou
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA986144(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Priority to ZA986144A priority Critical patent/ZA986144B/xx
Publication of ZA986144B publication Critical patent/ZA986144B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ZA986144A 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones ZA986144B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ZA986144A ZA986144B (en) 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
ZA986144A ZA986144B (en) 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Publications (1)

Publication Number Publication Date
ZA986144B true ZA986144B (en) 1999-05-19

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA986144A ZA986144B (en) 1997-07-11 1998-07-10 Preparation of 14-hydroxynormorphinones oxycodone noroxymorphone oxymorphone and naltrexone from normorphinones

Country Status (19)

Country Link
US (7) US5869669A (cs)
EP (1) EP1000065B1 (cs)
JP (1) JP2001518444A (cs)
KR (1) KR100363486B1 (cs)
CN (1) CN1152880C (cs)
AT (1) ATE291023T1 (cs)
AU (1) AU740822B2 (cs)
CA (1) CA2296035C (cs)
DE (1) DE69829379D1 (cs)
HU (1) HUP0003918A3 (cs)
IL (1) IL133792A0 (cs)
IN (1) IN1998KO01500A (cs)
NO (1) NO20000111L (cs)
RU (1) RU2183636C2 (cs)
SK (1) SK102000A3 (cs)
TR (1) TR200000033T2 (cs)
TW (1) TW505648B (cs)
WO (1) WO1999002529A1 (cs)
ZA (1) ZA986144B (cs)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912347A (en) * 1996-09-30 1999-06-15 Mallinckrodt Inc. Process for preparing a morphinan derivative
WO2000066588A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
HRP20040161A2 (en) * 2001-08-23 2004-06-30 Akzo Nobel Nv Process for the preparation of a 14-hydroxynormorphinone derivative
JP3961796B2 (ja) * 2001-08-27 2007-08-22 ソニー株式会社 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
MXPA05004759A (es) * 2002-11-08 2005-08-02 Mallinckrodt Inc Proceso para la preparacion de sales alcaloides n-alquil morfinan cuaternarias.
AU2003299659A1 (en) 2002-12-13 2004-07-09 Durect Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
ES2627995T3 (es) 2003-09-22 2017-08-01 Glaxosmithkline Australia Pty Ltd Procedimiento para la síntesis de compuestos de morfinano y productos intermedios de los mismos
US7875718B2 (en) * 2003-09-22 2011-01-25 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
HRP20080618T3 (hr) 2004-02-06 2009-01-31 Euro-Celtique S.A. Postupci za pripravljanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
CA2569758A1 (en) * 2004-06-08 2005-12-29 Mallinckrodt Inc. Extraction of alkaloids from opium
CA2569958C (en) 2004-06-12 2016-03-22 Jane C. Hirsh Abuse-deterrent drug formulations
GEP20094831B (en) 2004-09-17 2009-11-25 Durect Corp Control release system
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
GB0421687D0 (en) * 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
HRP20090387T1 (hr) * 2005-03-04 2009-08-31 Euro-Celtique S.A. Postupak reduciranja alfa, beta nezasićenih ketona u opioidnim sastavima
DK1873158T3 (en) * 2005-04-06 2016-06-27 Toray Industries Crystals of a morphinan derivative and process for preparing the same
US8071768B2 (en) * 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
ATE493417T1 (de) * 2005-06-16 2011-01-15 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
US8871779B2 (en) 2006-03-02 2014-10-28 Mallinckrodt Llc Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
CA2663909A1 (en) * 2006-09-20 2008-03-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
EP2073636B1 (en) * 2006-10-17 2012-09-05 Penick Corporation Process for preparing oxymorphone
WO2008066642A2 (en) 2006-11-03 2008-06-05 Durect Corporation Transdermal delivery systems comprising bupivacaine
CA2671518C (en) * 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
WO2008070656A2 (en) * 2006-12-04 2008-06-12 Noramco, Inc Process for reducing impurities in oxycodone base
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
JP5875748B2 (ja) * 2007-03-06 2016-03-02 マリンクロッド エルエルシー 第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2125824B2 (en) * 2007-03-23 2023-11-15 Mallinckrodt LLC Improved preparation of oxymorphone from oripavine
MX2009010931A (es) * 2007-04-16 2009-10-29 Mallinckrodt Inc Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
WO2008144320A2 (en) * 2007-05-17 2008-11-27 Endo Pharmaceuticals, Inc. Opioid and methods of making and using the same
EP2067471B1 (en) 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
AU2008338970B2 (en) * 2007-12-17 2013-08-22 SpecGx LLC Sinomenine derivatives and processes for their synthesis
ES2569655T3 (es) * 2007-12-17 2016-05-12 Mallinckrodt Llc Procedimientos para la producción de compuestos de (+)-'nal' morfinano
US7999105B2 (en) * 2008-02-29 2011-08-16 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
HRP20110824T1 (hr) * 2008-04-24 2012-01-31 Janssen Pharmaceutica N.V. Predlijekovi nalmefena
PL2285780T3 (pl) * 2008-05-27 2016-02-29 SpecGx LLC Sposoby i związki do wytwarzania normorfinanów
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
AU2009300379B2 (en) * 2008-09-30 2015-04-02 SpecGx LLC Processes for the alkylation of secondary amine groups of morphinan derivatives
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
EP2580218B1 (en) 2010-06-11 2015-02-25 Rhodes Technologies Process for n-dealkylation of tertiary amines
CA2936749C (en) 2010-06-11 2019-07-09 Joshua R. Giguere Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
CA2804101C (en) 2010-07-02 2021-01-19 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
RU2448709C1 (ru) * 2011-02-01 2012-04-27 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения налтрексона
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
EP2931726B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Spirocyclic morphinans and their use
EP2931725B1 (en) 2012-12-14 2017-02-15 Purdue Pharma LP Nitrogen containing morphinan derivatives and the use thereof
US8957084B2 (en) 2012-12-28 2015-02-17 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
ES2653265T3 (es) 2012-12-28 2018-02-06 Purdue Pharma Lp Morfinanos sustituidos y el uso de éstos
WO2014102591A1 (en) 2012-12-31 2014-07-03 Rhodes Technologies PROCESS FOR PREPARING 7β-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7β-SUBSTITUTED 6α,14α-ETHANOMORPHINANS
TW201521769A (zh) 2013-03-15 2015-06-16 Durect Corp 具有流變改質劑以減少溶解變異性之組成物
EP2829541A1 (en) * 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
GB2517000B (en) 2013-08-02 2018-05-09 Johnson Matthey Plc Process for the synthesis of oxymorphone alkaloid and oxymorphone salts
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US9340542B2 (en) 2013-12-26 2016-05-17 Purdue Pharma L.P. Propellane-based compounds and the use thereof
US9988392B2 (en) 2013-12-26 2018-06-05 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015102682A1 (en) 2013-12-30 2015-07-09 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
NZ731591A (en) 2014-11-25 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
US12274794B2 (en) 2016-07-06 2025-04-15 Orient Pharma Co., Ltd. Oral dosage form with drug composition, barrier layer and drug layer
PL3559010T3 (pl) 2016-12-23 2022-11-21 Minoryx Therapeutics S.L. Sposób wytwarzania 5-[[4-[2-[5-(1-hydroksyetylo)-2-pirydynylo]etoksy]fenylo]metylo]-2,4-tiazolidynodionu i jego soli
SK592017A3 (sk) 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
CN111836813A (zh) 2018-02-23 2020-10-27 罗德科技公司 新型阿片样化合物及其用途
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
WO2021007366A1 (en) * 2019-07-08 2021-01-14 St. Louis College Of Pharmacy G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
BR112022013784A2 (pt) 2020-01-13 2022-10-11 Durect Corp Sistemas de distribuição de fármacos de liberação prolongada com impurezas reduzidas e métodos relacionados
CN114621239A (zh) * 2020-12-10 2022-06-14 鲁南制药集团股份有限公司 一种纳曲酮的制备方法
KR20230127222A9 (ko) * 2020-12-28 2024-03-25 나빈 삭세나 리서치 앤드 테크놀로지 피브이티. 엘티디. 모르핀으로부터 노르옥시모르폰의 합성을 위한 신규의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819636A (en) * 1970-09-15 1974-06-25 American Home Prod 4a,10-(methaniminomethano)phenanthrene derivatives
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
EP0158476B1 (en) * 1984-03-27 1991-01-23 Mallinckrodt, Inc. (a Delaware corporation) Preparation of noroxymorphone from morphine
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives

Also Published As

Publication number Publication date
HK1028025A1 (en) 2001-02-02
US5869669A (en) 1999-02-09
EP1000065A4 (en) 2001-09-12
NO20000111D0 (no) 2000-01-10
US5948788A (en) 1999-09-07
SK102000A3 (en) 2000-07-11
DE69829379D1 (de) 2005-04-21
KR20010021693A (ko) 2001-03-15
EP1000065B1 (en) 2005-03-16
IN1998KO01500A (cs) 2005-03-11
ATE291023T1 (de) 2005-04-15
US6008355A (en) 1999-12-28
US5952495A (en) 1999-09-14
TR200000033T2 (tr) 2000-12-21
WO1999002529A1 (en) 1999-01-21
US5922876A (en) 1999-07-13
EP1000065A1 (en) 2000-05-17
TW505648B (en) 2002-10-11
HUP0003918A2 (hu) 2001-07-30
NO20000111L (no) 2000-02-25
IL133792A0 (en) 2001-04-30
US6008354A (en) 1999-12-28
KR100363486B1 (ko) 2002-12-16
CA2296035A1 (en) 1999-01-21
AU740822B2 (en) 2001-11-15
CA2296035C (en) 2004-04-13
RU2183636C2 (ru) 2002-06-20
CN1272845A (zh) 2000-11-08
CN1152880C (zh) 2004-06-09
HUP0003918A3 (en) 2003-04-28
JP2001518444A (ja) 2001-10-16
AU8379198A (en) 1999-02-08
US6013796A (en) 2000-01-11

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