ZA977698B - Substituted cyclic amine metalloprotease inhibitors. - Google Patents

Substituted cyclic amine metalloprotease inhibitors.

Info

Publication number
ZA977698B
ZA977698B ZA9707698A ZA977698A ZA977698B ZA 977698 B ZA977698 B ZA 977698B ZA 9707698 A ZA9707698 A ZA 9707698A ZA 977698 A ZA977698 A ZA 977698A ZA 977698 B ZA977698 B ZA 977698B
Authority
ZA
South Africa
Prior art keywords
cyclic amine
substituted cyclic
metalloprotease inhibitors
compounds
pharmaceutical compositions
Prior art date
Application number
ZA9707698A
Other languages
English (en)
Inventor
Michael George Natchus
Biswanath De
Stanislaw Pikul
Neil Gregory Almstead
Roger Gunnard Bookland
Yetunde Olabisi Taiwo
Menyan Cheng
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble filed Critical Procter & Gamble
Publication of ZA977698B publication Critical patent/ZA977698B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/42—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
ZA9707698A 1996-08-28 1997-08-27 Substituted cyclic amine metalloprotease inhibitors. ZA977698B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2484296P 1996-08-28 1996-08-28

Publications (1)

Publication Number Publication Date
ZA977698B true ZA977698B (en) 1998-02-23

Family

ID=21822685

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9707698A ZA977698B (en) 1996-08-28 1997-08-27 Substituted cyclic amine metalloprotease inhibitors.

Country Status (30)

Country Link
US (6) US6417219B1 (es)
EP (1) EP0927161B1 (es)
JP (2) JP3541043B2 (es)
KR (1) KR100323272B1 (es)
CN (1) CN1232451A (es)
AT (1) ATE226193T1 (es)
AU (1) AU741893B2 (es)
BR (1) BR9713465A (es)
CA (1) CA2263928A1 (es)
CO (1) CO4900036A1 (es)
CZ (1) CZ63199A3 (es)
DE (1) DE69716449T2 (es)
DK (1) DK0927161T3 (es)
ES (1) ES2201318T3 (es)
HK (1) HK1020962A1 (es)
HU (1) HUP0000478A3 (es)
ID (1) ID18143A (es)
IL (1) IL128666A (es)
MY (1) MY116959A (es)
NO (1) NO315371B1 (es)
NZ (1) NZ334256A (es)
PE (1) PE109098A1 (es)
PL (1) PL331802A1 (es)
PT (1) PT927161E (es)
RU (1) RU2221782C2 (es)
SK (1) SK25099A3 (es)
TR (1) TR199900431T2 (es)
TW (1) TWI232218B (es)
WO (1) WO1998008815A1 (es)
ZA (1) ZA977698B (es)

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Also Published As

Publication number Publication date
JP3541043B2 (ja) 2004-07-07
NO990855D0 (no) 1999-02-23
IL128666A0 (en) 2000-01-31
DE69716449T2 (de) 2003-08-07
US20050154019A1 (en) 2005-07-14
JP2000516955A (ja) 2000-12-19
PT927161E (pt) 2003-12-31
AU741893B2 (en) 2001-12-13
PE109098A1 (es) 1999-02-19
CA2263928A1 (en) 1998-03-05
MY116959A (en) 2004-04-30
TWI232218B (en) 2005-05-11
EP0927161A1 (en) 1999-07-07
NZ334256A (en) 2000-11-24
DK0927161T3 (da) 2003-02-17
CN1232451A (zh) 1999-10-20
US20030191163A1 (en) 2003-10-09
PL331802A1 (en) 1999-08-02
HUP0000478A2 (hu) 2000-09-28
US20050101567A1 (en) 2005-05-12
US6417219B1 (en) 2002-07-09
US6858628B2 (en) 2005-02-22
ES2201318T3 (es) 2004-03-16
ID18143A (id) 1998-03-05
SK25099A3 (en) 2000-02-14
KR20000035922A (ko) 2000-06-26
WO1998008815A1 (en) 1998-03-05
HK1020962A1 (en) 2000-05-26
EP0927161B1 (en) 2002-10-16
BR9713465A (pt) 2000-03-28
TR199900431T2 (xx) 1999-04-21
KR100323272B1 (ko) 2002-02-06
US6569855B2 (en) 2003-05-27
NO315371B1 (no) 2003-08-25
JP2004115531A (ja) 2004-04-15
CZ63199A3 (cs) 1999-08-11
RU2221782C2 (ru) 2004-01-20
IL128666A (en) 2005-09-25
DE69716449D1 (de) 2002-11-21
HUP0000478A3 (en) 2000-10-30
NO990855L (no) 1999-04-23
ATE226193T1 (de) 2002-11-15
US20020072517A1 (en) 2002-06-13
US20020061877A1 (en) 2002-05-23
CO4900036A1 (es) 2000-03-27
AU4074197A (en) 1998-03-19

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