ZA975198B - Improved process for preparing potassium clavulanate. - Google Patents

Improved process for preparing potassium clavulanate.

Info

Publication number
ZA975198B
ZA975198B ZA9705198A ZA975198A ZA975198B ZA 975198 B ZA975198 B ZA 975198B ZA 9705198 A ZA9705198 A ZA 9705198A ZA 975198 A ZA975198 A ZA 975198A ZA 975198 B ZA975198 B ZA 975198B
Authority
ZA
South Africa
Prior art keywords
improved process
potassium clavulanate
preparing potassium
preparing
clavulanate
Prior art date
Application number
ZA9705198A
Other languages
English (en)
Inventor
Paul Gerard Butterly
Gilroy John Keohane
Esin Fatma Kosal
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of ZA975198B publication Critical patent/ZA975198B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
ZA9705198A 1996-06-13 1997-06-12 Improved process for preparing potassium clavulanate. ZA975198B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2048096P 1996-06-13 1996-06-13

Publications (1)

Publication Number Publication Date
ZA975198B true ZA975198B (en) 1997-12-15

Family

ID=21798851

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9705198A ZA975198B (en) 1996-06-13 1997-06-12 Improved process for preparing potassium clavulanate.

Country Status (18)

Country Link
US (1) US6414142B1 (xx)
EP (1) EP0918520A4 (xx)
JP (1) JP2000512297A (xx)
KR (1) KR20000016544A (xx)
CN (1) CN1115147C (xx)
AR (1) AR008605A1 (xx)
AU (1) AU712904B2 (xx)
BR (1) BR9711803A (xx)
CO (1) CO4970806A1 (xx)
CZ (1) CZ407298A3 (xx)
IL (1) IL127415A (xx)
NO (1) NO985824L (xx)
NZ (1) NZ333177A (xx)
PL (1) PL186484B1 (xx)
TR (1) TR199802452T2 (xx)
TW (1) TW477700B (xx)
WO (1) WO1997047301A1 (xx)
ZA (1) ZA975198B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
WO1999024441A1 (en) * 1997-11-10 1999-05-20 Dsm N.V. Crystallization of beta-lactam compounds
CN1209099C (zh) * 1999-04-01 2005-07-06 Dsm公司 结晶化附聚物
BRPI0714391A2 (pt) * 2006-07-20 2013-04-24 Sicor Inc processo para preparaÇço de um ingrediente farmacÊutico ativo sàlido estÉril
WO2011152807A1 (en) 2010-06-03 2011-12-08 Bilgic Mahmut Pharmaceutical formulation comprising cefpodoxime proxetil and clavulanic acid

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1543563A (en) * 1975-02-07 1979-04-04 Glaxo Lab Ltd Beta-lactam antibiotic in purified form
US4454069A (en) * 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US5288861A (en) * 1987-01-29 1994-02-22 Beecham Group Plc Potassium clavulanate in rosette form
ES2074048T3 (es) 1987-01-29 1995-09-01 Beecham Group Plc Procedimiento para la cristalizacion de clavulanato de potasio.
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
GB9305565D0 (en) 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
US5821364A (en) * 1993-03-26 1998-10-13 Gist-Brocades N.V. Diamine salts of clavulanic acid
JPH06298779A (ja) 1993-04-15 1994-10-25 Hoechst Japan Ltd ヘテロ環イミノビスメチレンビスホスホン酸誘導体
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
TR199700828T1 (xx) * 1995-02-25 1998-04-21 Spurcourt Limited .Klavulanik asit tuzlar�.
GB9515809D0 (en) 1995-08-02 1995-10-04 Smithkline Beecham Plc Process

Also Published As

Publication number Publication date
WO1997047301A1 (en) 1997-12-18
PL186484B1 (pl) 2004-01-30
NO985824D0 (no) 1998-12-11
CN1227488A (zh) 1999-09-01
JP2000512297A (ja) 2000-09-19
US6414142B1 (en) 2002-07-02
NO985824L (no) 1999-02-10
IL127415A0 (en) 1999-10-28
IL127415A (en) 2003-10-31
PL330639A1 (en) 1999-05-24
CO4970806A1 (es) 2000-11-07
NZ333177A (en) 2000-05-26
KR20000016544A (ko) 2000-03-25
AR008605A1 (es) 2000-02-09
EP0918520A1 (en) 1999-06-02
BR9711803A (pt) 1999-08-24
TR199802452T2 (xx) 1999-02-22
AU712904B2 (en) 1999-11-18
CZ407298A3 (cs) 1999-05-12
AU3392797A (en) 1998-01-07
CN1115147C (zh) 2003-07-23
TW477700B (en) 2002-03-01
EP0918520A4 (en) 2000-01-12

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