ZA9711606B - Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them. - Google Patents

Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.

Info

Publication number
ZA9711606B
ZA9711606B ZA9711606A ZA9711606A ZA9711606B ZA 9711606 B ZA9711606 B ZA 9711606B ZA 9711606 A ZA9711606 A ZA 9711606A ZA 9711606 A ZA9711606 A ZA 9711606A ZA 9711606 B ZA9711606 B ZA 9711606B
Authority
ZA
South Africa
Prior art keywords
contain
preparation
pharmaceutical compositions
cyclosporin derivatives
derivatives
Prior art date
Application number
ZA9711606A
Other languages
English (en)
Inventor
Jean-Claude Barriere
Georges Bashiardes
Jean-Christophe Carry
Michel Evers
Bruno Filoche
Jean-Pierre Leconte
Serge Mignani
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA9711606B publication Critical patent/ZA9711606B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA9711606A 1996-12-24 1997-12-23 Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them. ZA9711606B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9615956A FR2757522B1 (fr) 1996-12-24 1996-12-24 Derives de cyclosporine, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ZA9711606B true ZA9711606B (en) 1998-06-25

Family

ID=9499089

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9711606A ZA9711606B (en) 1996-12-24 1997-12-23 Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them.

Country Status (14)

Country Link
US (1) US5965527A (xx)
EP (1) EP0948527B1 (xx)
JP (1) JP4172822B2 (xx)
AT (1) ATE218580T1 (xx)
AU (1) AU5669298A (xx)
DE (1) DE69713148D1 (xx)
DK (1) DK0948527T3 (xx)
ES (1) ES2178037T3 (xx)
FR (1) FR2757522B1 (xx)
MA (1) MA26459A1 (xx)
PT (1) PT948527E (xx)
TN (1) TNSN97211A1 (xx)
WO (1) WO1998028329A1 (xx)
ZA (1) ZA9711606B (xx)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69912952T2 (de) * 1998-06-12 2004-09-02 C-Chem Ag Cyclosporine
US6927208B1 (en) 1998-07-01 2005-08-09 Debiopharm S.A. Cyclosporin with improved activity profile
US6254860B1 (en) 1999-04-13 2001-07-03 Allergan Sales, Inc. Ocular treatment using cyclosporin-A derivatives
MY145753A (en) * 2001-10-19 2012-03-30 Isotechnika Inc Novel cyclosporin analog formulations
SI1436321T1 (sl) 2001-10-19 2006-12-31 Isotechnika Inc Sinteza analogov ciklosporina
KR20040039622A (ko) * 2002-11-04 2004-05-12 주식회사 엘지생활건강 모발 성장 효과를 갖는 사이클로스포린 3 위치 유도체를유효성분으로 하는 모발 성장 촉진제
US6987090B2 (en) * 2002-05-09 2006-01-17 Lg Household & Health Care Ltd. Use of 3-position cyclosporin derivatives for hair growth
GB0320638D0 (en) 2003-09-03 2003-10-01 Novartis Ag Organic compounds
KR101309409B1 (ko) * 2004-10-01 2013-09-23 싸이넥시스, 인크. Ｃ형 간염 바이러스 감염의 치료 및 예방을 위한 ３-에테르및 ３-티오에테르 치환된 시클로스포린 유도체
US7196161B2 (en) * 2004-10-01 2007-03-27 Scynexis Inc. 3-ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection
AU2005290984B2 (en) 2004-10-01 2010-09-09 Debiopharm Sa Use of [D-MeAla]3-[EtVal]4-cyclosporin for the treatment of hepatitis C infection and pharmaceutical composition comprising said [D-MeAla]3-[EtVal]4-cyclosporin
MX2007007721A (es) * 2004-12-23 2007-08-14 Novartis Ag Compuestos para el tratamiento de flaviviridae.
EP1830871A1 (en) * 2004-12-23 2007-09-12 Novartis AG Compositions for hcv treatment
WO2007041631A1 (en) 2005-09-30 2007-04-12 Scynexis, Inc. ARYIiALKYL AND HETEROARYLALKYL DERIVATIVES OF CYCLOSPORINE A FOR THE TREATMENT AND PREVENTION OF VIRAL INFECTION
US7754685B2 (en) * 2005-09-30 2010-07-13 Scynexis, Inc. Methods and pharmaceutical compositions for the treatment and prevention of hepatitis C infection
US7696165B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US7696166B2 (en) 2006-03-28 2010-04-13 Albany Molecular Research, Inc. Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
CA2652662C (en) 2006-05-19 2015-11-03 Scynexis, Inc. Methods for the treatment and prevention of ocular disorders
KR101089112B1 (ko) * 2006-06-02 2011-12-06 피씨 제스띠옹 에스.아.에스. 활성 전자 관리
WO2008043797A1 (en) * 2006-10-12 2008-04-17 Novartis Ag Use of modified cyclosporins
WO2008069917A2 (en) 2006-11-20 2008-06-12 Scynexis, Inc. Novel cyclic peptides
US20080255038A1 (en) * 2007-04-11 2008-10-16 Samuel Earl Hopkins Pharmaceutical compositions
EP2195009B1 (en) 2007-09-26 2014-07-30 Oregon Health and Science University Cyclic undecapeptides and derivatives as multiple sclerosis therapies
WO2009148615A1 (en) * 2008-06-06 2009-12-10 Scynexis, Inc. Cyclosporin analogs and their use in the treatment of hcv infections
US9090671B2 (en) * 2008-06-06 2015-07-28 Scynexis, Inc. Macrocyclic peptides
RU2521358C2 (ru) * 2008-07-10 2014-06-27 Аллерган, Инк. Производные циклоспорина для лечения глазных и кожных заболеваний и состояний
DE102008060549A1 (de) 2008-12-04 2010-06-10 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
AU2009334790B2 (en) 2008-12-31 2016-09-08 Scynexis, Inc. Derivatives of cyclosporin A
AU2010254316A1 (en) 2009-05-27 2011-12-22 Allergan, Inc. Cyclosporin derivatives for treating inflammatory diseases and conditions
GB0912584D0 (en) * 2009-07-20 2009-08-26 Ucl Business Plc Cyclosporin conjugates
CN103153329A (zh) * 2010-07-16 2013-06-12 美国科技环球有限公司 新颖的环孢霉素a衍生物在病毒感染的治疗和预防中的应用
US9573978B2 (en) 2010-08-12 2017-02-21 S&T Global, Inc. Cyclosporin derivatives for the treatment and prevention of a viral infection
AU2011316690C1 (en) * 2010-10-12 2017-01-19 Allergan, Inc. Cyclosporin analogs
AU2011316689B2 (en) * 2010-10-12 2016-07-14 Allergan, Inc. Cyclosporin analogs
US9890198B2 (en) 2010-12-03 2018-02-13 S&T Global Inc. Cyclosporin derivatives and uses thereof
US9200038B2 (en) 2010-12-15 2015-12-01 Ciclofilin Pharmaceuticals Corp. Cyclosporine analogue molecules modified at amino acid 1 and 3
EP2705856A1 (en) 2012-09-07 2014-03-12 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. Compounds for the treatment of neurodegenerative disorders

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0194972B1 (en) * 1985-03-11 1992-07-29 Sandoz Ag Novel cyclosporins
US4814323A (en) * 1986-03-25 1989-03-21 Andrieu J M Process for the treatment and the prevention of AIDS and other disorders induced by the LAV/HTLV III virus
EP0484281B2 (en) * 1990-11-02 2000-11-22 Novartis AG Cyclosporins
JP3920919B2 (ja) * 1995-07-17 2007-05-30 シネクシス・インコーポレイテッド 抗−ｈｉｖ−作用を有するシクロスポリン誘導体

Also Published As

Publication number Publication date
EP0948527A1 (fr) 1999-10-13
EP0948527B1 (fr) 2002-06-05
JP4172822B2 (ja) 2008-10-29
US5965527A (en) 1999-10-12
ES2178037T3 (es) 2002-12-16
TNSN97211A1 (fr) 2005-03-15
FR2757522A1 (fr) 1998-06-26
ATE218580T1 (de) 2002-06-15
DK0948527T3 (da) 2002-09-16
PT948527E (pt) 2002-11-29
AU5669298A (en) 1998-07-17
JP2001507346A (ja) 2001-06-05
DE69713148D1 (de) 2002-07-11
MA26459A1 (fr) 2004-12-20
FR2757522B1 (fr) 1999-01-29
WO1998028329A1 (fr) 1998-07-02

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