ZA966588B - New process for preparing norbenzomorphan-an intrmediate product in the production of pharmaceutically valuable benzomorphan derivatives in particular of (-)-(1r,5s,s"r)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomorphan - Google Patents

New process for preparing norbenzomorphan-an intrmediate product in the production of pharmaceutically valuable benzomorphan derivatives in particular of (-)-(1r,5s,s"r)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomorphan

Info

Publication number
ZA966588B
ZA966588B ZA966588A ZA966588A ZA966588B ZA 966588 B ZA966588 B ZA 966588B ZA 966588 A ZA966588 A ZA 966588A ZA 966588 A ZA966588 A ZA 966588A ZA 966588 B ZA966588 B ZA 966588B
Authority
ZA
South Africa
Prior art keywords
benzomorphan
intrmediate
norbenzomorphan
methoxypropyl
trimethyl
Prior art date
Application number
ZA966588A
Other languages
English (en)
Inventor
Matthias Grauert
Herbert Merz
Hanfried Baltes
Original Assignee
Boehringer Ingelheim Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg
Publication of ZA966588B publication Critical patent/ZA966588B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/26—Benzomorphans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA966588A 1995-08-03 1996-08-02 New process for preparing norbenzomorphan-an intrmediate product in the production of pharmaceutically valuable benzomorphan derivatives in particular of (-)-(1r,5s,s"r)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomorphan ZA966588B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19528472A DE19528472A1 (de) 1995-08-03 1995-08-03 Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Publications (1)

Publication Number Publication Date
ZA966588B true ZA966588B (en) 1997-02-03

Family

ID=7768562

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA966588A ZA966588B (en) 1995-08-03 1996-08-02 New process for preparing norbenzomorphan-an intrmediate product in the production of pharmaceutically valuable benzomorphan derivatives in particular of (-)-(1r,5s,s"r)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomorphan

Country Status (31)

Country Link
US (3) US5945535A (ja)
EP (1) EP0842153B1 (ja)
JP (1) JP3887756B2 (ja)
KR (1) KR100399669B1 (ja)
CN (1) CN1125053C (ja)
AR (1) AR003167A1 (ja)
AT (1) ATE201672T1 (ja)
AU (1) AU703700B2 (ja)
BR (1) BR9609959A (ja)
CA (1) CA2228511C (ja)
CO (1) CO4750808A1 (ja)
CZ (1) CZ292589B6 (ja)
DE (2) DE19528472A1 (ja)
DK (1) DK0842153T3 (ja)
ES (1) ES2157004T3 (ja)
GR (1) GR3036417T3 (ja)
HK (2) HK1010537A1 (ja)
HU (1) HU222038B1 (ja)
IL (1) IL118992A (ja)
MX (1) MX9800357A (ja)
NO (1) NO308247B1 (ja)
NZ (1) NZ316463A (ja)
PL (1) PL185218B1 (ja)
PT (1) PT842153E (ja)
RU (1) RU2167868C2 (ja)
SI (1) SI0842153T1 (ja)
TR (1) TR199800164T1 (ja)
TW (1) TW350847B (ja)
UA (1) UA64699C2 (ja)
WO (1) WO1997006146A1 (ja)
ZA (1) ZA966588B (ja)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan
DE19740110A1 (de) * 1997-09-12 1999-03-18 Boehringer Ingelheim Pharma Substituierte 1,2,3,4,5,6-Hexahydro-2,6-methano-3-benzazocin-10-ole, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19822822A1 (de) * 1998-05-20 1999-11-25 Boehringer Ingelheim Pharma Verbessertes Verfahren zur Herstellung von pharmazeutisch wertvollen Norbenzomorphanderivaten
DE19826365A1 (de) * 1998-06-12 1999-12-16 Gruenenthal Gmbh Verwendung von Benzomorphanderivaten als Analgetikum
US6495694B2 (en) 2000-06-16 2002-12-17 Boehringer Ingelheim Pharma Kg Efficient separation of enantiomers of piperidone derivatives by precipitation of the desired eantiomer during in situ racemization of the unwanted enantiomer
DE10029851A1 (de) * 2000-06-16 2001-12-20 Boehringer Ingelheim Pharma Enantiomerentrennung von Piperidon-Derivaten unter gleichzeitiger in situ Racemisierung des unerwünschten Enantiomers
CN1171892C (zh) * 2001-06-25 2004-10-20 李晶 具有抗炎镇痛活性的噻吩并噻嗪化合物及其制备方法和用途
DE10130020A1 (de) * 2001-06-25 2003-12-04 Gruenenthal Gmbh Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate
KR20040039732A (ko) * 2002-11-04 2004-05-12 주식회사 동진쎄미켐 캠포릴이 결합된 펜던트 기를 가지는 화학적으로 증폭된고분자와 그 제조방법, 및 이를 포함하는 레지스트 조성물
CN104829662B (zh) * 2015-03-30 2017-11-07 石药集团欧意药业有限公司 一种阿奇霉素有关物质的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34235B1 (en) * 1969-06-04 1975-03-19 Acf Chemiefarma Nv 6,7-benzomorphans and their preparation
US4012392A (en) * 1969-06-04 1977-03-15 Acf Chemiefarma N.V. 2-Benzyl-4-piperidones useful as intermediates in the production of 6,7-benzomorphan derivatives
DE2828039A1 (de) * 1978-06-26 1980-01-10 Boehringer Sohn Ingelheim 2-(2-alkoxyethyl)-2'-hydroxy-6,7-benzomorphane deren saeureadditionssalze diese enthaltende arzneimittel und verfahren zu deren herstellung
NL7907800A (nl) * 1979-10-23 1981-04-27 Acf Chemiefarma Nv Nieuwe 6,7-benzomorfanderivaten en zuuradditiezouten daarvan, farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen en de farmaceutische preparaten.
US5607941A (en) * 1992-06-26 1997-03-04 Boehringer Ingelheim Kg Useful for treating neurodegenerative diseases
DE4121821A1 (de) * 1991-07-02 1993-01-14 Boehringer Ingelheim Kg Neue benzomorphane und ihre verwendung als arzneimittel
DE19528472A1 (de) * 1995-08-03 1997-02-06 Boehringer Ingelheim Kg Neues Verfahren zur Herstellung von Norbenzomorphan einer Zwischenstufe bei Herstellung von pharmazeutisch wertvollen Benzomorphanderivaten, insbesondere von (-)-(1R,5S,S"R)-3'-Hydroxy-2-(2-methoxypropyl-)-5,9,9-trimethyl-6,7 benzomorphan

Also Published As

Publication number Publication date
TW350847B (en) 1999-01-21
EP0842153B1 (de) 2001-05-30
ES2157004T3 (es) 2001-08-01
UA64699C2 (en) 2004-03-15
CZ31598A3 (cs) 1998-07-15
HUP9900360A2 (hu) 1999-06-28
CA2228511A1 (en) 1997-02-20
DK0842153T3 (da) 2001-08-06
CZ292589B6 (cs) 2003-10-15
DE59607007D1 (de) 2001-07-05
US6140502A (en) 2000-10-31
CN1190959A (zh) 1998-08-19
BR9609959A (pt) 1999-02-02
AR003167A1 (es) 1998-07-08
US6054604A (en) 2000-04-25
HK1015362A1 (en) 1999-10-15
IL118992A (en) 2000-06-01
GR3036417T3 (en) 2001-11-30
PT842153E (pt) 2001-09-28
HK1010537A1 (en) 1999-06-25
NO980449D0 (no) 1998-02-02
HU222038B1 (hu) 2003-03-28
DE19528472A1 (de) 1997-02-06
RU2167868C2 (ru) 2001-05-27
PL185218B1 (pl) 2003-04-30
EP0842153A1 (de) 1998-05-20
CN1125053C (zh) 2003-10-22
HUP9900360A3 (en) 1999-11-29
AU6870296A (en) 1997-03-05
ATE201672T1 (de) 2001-06-15
AU703700B2 (en) 1999-04-01
US5945535A (en) 1999-08-31
CA2228511C (en) 2007-11-06
SI0842153T1 (en) 2001-10-31
IL118992A0 (en) 1996-11-14
NO980449L (no) 1998-02-02
NZ316463A (en) 1999-07-29
PL324859A1 (en) 1998-06-22
TR199800164T1 (xx) 1998-04-21
NO308247B1 (no) 2000-08-21
KR19990036091A (ko) 1999-05-25
JP3887756B2 (ja) 2007-02-28
CO4750808A1 (es) 1999-03-31
KR100399669B1 (ko) 2004-03-24
WO1997006146A1 (de) 1997-02-20
JPH11511135A (ja) 1999-09-28
MX9800357A (es) 1998-07-31

Similar Documents

Publication Publication Date Title
HUP9802300A3 (en) N-heteroaryl-pyridinesulfonamide derivatives, pharmaceutical compositions containing them, process for producing them and their use
HUP9602122A2 (en) Camptothecin derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HUP9602685A3 (en) Substituted quinoline-2-carboxylic-amides, process for producing them, their use as medicines and intermediates
HUP9600071A3 (en) Indolo-piperidine derivatives, pharmaceutical compositions containing them, process for producing them and their use
HUP9802679A3 (en) Tetralin derivatives with mdr activity, process for producing them and pharmaceutical compositions containing them
ZA966588B (en) New process for preparing norbenzomorphan-an intrmediate product in the production of pharmaceutically valuable benzomorphan derivatives in particular of (-)-(1r,5s,s"r)-3'-hydroxy-2-(2-methoxypropyl)-5,9,9-trimethyl-6,7-benzomorphan
HUP9802213A3 (en) Benzofused thieno- and furopyrans, phenanthridine derivatives, process for their preparation, pharmaceutical compositions containing them and intermediates of the synthesis
HUP9900040A3 (en) Tetrahydroquinolines as nmda antagonists, process for producing them and pharmaceutical compositions containing them
AU7239794A (en) Process for preparing 5,8-dihydronaphthoquinone derivatives, novel 5,8-dihydronaphthoquinone derivatives and their use as anticancer agent
IL134572A (en) Substituted 1,2,3,4,5,6-hexahydro-2, 6-methano-3-benzazocin - 10 -ols, methods for their production and use thereof as medicaments
HUP9602748A2 (en) Novel n-pyrimidinyl-sulfonamides, process for producing them and pharmaceutical compositions containing them
HUT59381A (en) Process for producing new 5h-2,3-benzodiazepine derivative and pharmaceutical compositions comprising same
AU4729396A (en) Process for the preparation of 1,2-benzisothiazolin-3-ones
AU4920996A (en) Novel process for preparing 2,3-dihydro-benzofuranol derivatives
AU5083196A (en) New cyclohexane compounds, process for their preparation and pharmaceutical compositions containing them
HRP960063B1 (en) Substituted benzenesulfonylureas and -thioureas, process for their preparation and their use in the production of pharmaceutical preparations as well as pharmaceutical preparations containing them
AU2910900A (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, method for producing them and their use as medicaments
AU6414996A (en) Process for the hydrogenation of imines in the presence of imobilized ir-diphosphine catalysts
AU7560996A (en) Process for preparing a lignocellulose-based product, and product obtainable by the process
HUP0202310A3 (en) Phenanthridine derivatives, methods of producing them and medicaments containing phenanthridine derivatives
HUP9602374A3 (en) 2-azabicyclo[3,3,0]octan derivates, process for producing them and pharmaceutical compositions containing the same
AU6764796A (en) Process for the preparation of 3,3,5-trichloroglutarimide
ZA969296B (en) New process for the preparation of morphinans
HU9500939D0 (en) New benzimidazol-2-yl derivatives, process for producing them and pharmaceutical compositions containing them
LT95039A (en) Fermented milk product and process for the preparation thereof