ZA962670B - Controlled release biodegradable micro- and nanospheres containing cyclosporin - Google Patents

Controlled release biodegradable micro- and nanospheres containing cyclosporin

Info

Publication number
ZA962670B
ZA962670B ZA962670A ZA962670A ZA962670B ZA 962670 B ZA962670 B ZA 962670B ZA 962670 A ZA962670 A ZA 962670A ZA 962670 A ZA962670 A ZA 962670A ZA 962670 B ZA962670 B ZA 962670B
Authority
ZA
South Africa
Prior art keywords
lactide
poly
cyclosporin
nanospheres
formulation
Prior art date
Application number
ZA962670A
Other languages
English (en)
Inventor
Zebunnissa Ramtoola
Original Assignee
Elan Corp Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Corp Plc filed Critical Elan Corp Plc
Publication of ZA962670B publication Critical patent/ZA962670B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/70—Nanostructure
    • Y10S977/788—Of specified organic or carbon-based composition
    • Y10S977/795—Composed of biological material
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/915—Therapeutic or pharmaceutical composition
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/931—Medical device coating
ZA962670A 1995-04-03 1996-04-03 Controlled release biodegradable micro- and nanospheres containing cyclosporin ZA962670B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IE950233A IE75744B1 (en) 1995-04-03 1995-04-03 Controlled release biodegradable micro- and nanospheres containing cyclosporin

Publications (1)

Publication Number Publication Date
ZA962670B true ZA962670B (en) 1996-10-09

Family

ID=11040700

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA962670A ZA962670B (en) 1995-04-03 1996-04-03 Controlled release biodegradable micro- and nanospheres containing cyclosporin

Country Status (14)

Country Link
US (1) US5641745A (fr)
EP (1) EP0818996B1 (fr)
JP (1) JP3875721B2 (fr)
AT (1) ATE232722T1 (fr)
AU (1) AU700612B2 (fr)
CA (1) CA2217462C (fr)
DE (1) DE69626278T2 (fr)
DK (1) DK0818996T3 (fr)
ES (1) ES2189868T3 (fr)
IE (1) IE75744B1 (fr)
NZ (1) NZ304975A (fr)
PT (1) PT818996E (fr)
WO (1) WO1996031202A1 (fr)
ZA (1) ZA962670B (fr)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
DE19732903A1 (de) 1997-07-30 1999-02-04 Falk Pharma Gmbh Pellet-Formulierung zur Behandlung des Intestinaltraktes
EP1010435B1 (fr) * 1997-09-05 2010-11-03 Maruho K.K. Preparations de nanocapsules destinees au traitement de maladies intra-articulaires
NZ328751A (en) * 1997-09-16 1999-01-28 Bernard Charles Sherman Solid medicament containing an anionic surfactant and cyclosporin
PL192273B1 (pl) * 1997-09-25 2006-09-29 Bayer Ag Preparat środka leczniczego w postaci pastylki o kontrolowanej dyfuzji lub w postaci układu matrycowego, o kontrolowanym uwalnianiu substancji czynnej
US6657104B1 (en) 1997-10-16 2003-12-02 Texas Systems, University Of The Board Of The Regents Transgenic mouse model for cardiac hypertrophy and methods of use thereof
DE19821951A1 (de) * 1998-05-15 1999-11-18 Basf Ag Cyclosporin-Zubereitungen
US20040259895A1 (en) * 1998-05-28 2004-12-23 Medical Research Institute Oral formulation of lipid soluble thiamine and lipoic acid
US6197340B1 (en) 1998-05-28 2001-03-06 Medical Research Institute Controlled release lipoic acid
US20050085498A1 (en) * 1998-05-28 2005-04-21 Byrd Edward A. Oral formulation of lipid soluble thiamine, lipoic acid, creatine derivative, and L-arginine alpha-ketoglutarate
US6905707B2 (en) * 1998-05-28 2005-06-14 Medical Research Institute Controlled release arginine alpha ketoglutarate
US6984404B1 (en) 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
IL143604A0 (en) 1998-12-30 2002-04-21 Dexcel Ltd Dispersable concentrate for the delivery of cyclosporin
US6253463B1 (en) 1999-04-26 2001-07-03 Niro A/S Method of spray drying
US6406745B1 (en) 1999-06-07 2002-06-18 Nanosphere, Inc. Methods for coating particles and particles produced thereby
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
GB2381453A (en) * 1999-08-31 2003-05-07 Bradford Particle Design Ltd Active/polymer coformulations
US6656504B1 (en) * 1999-09-09 2003-12-02 Elan Pharma International Ltd. Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions
US6682754B2 (en) 1999-11-24 2004-01-27 Willmar Poultry Company, Inc. Ovo delivery of an immunogen containing implant
US7732404B2 (en) * 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
US6565888B1 (en) * 2000-08-23 2003-05-20 Alkermes Controlled Therapeutics, Inc. Methods and compositions for the targeted delivery of biologically active agents
US20030072807A1 (en) * 2000-12-22 2003-04-17 Wong Joseph Chung-Tak Solid particulate antifungal compositions for pharmaceutical use
US8067032B2 (en) * 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US6607784B2 (en) * 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6951656B2 (en) * 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US6884436B2 (en) * 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US20040256749A1 (en) * 2000-12-22 2004-12-23 Mahesh Chaubal Process for production of essentially solvent-free small particles
US9700866B2 (en) * 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6977085B2 (en) * 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US20050048126A1 (en) * 2000-12-22 2005-03-03 Barrett Rabinow Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug
AR033711A1 (es) * 2001-05-09 2004-01-07 Novartis Ag Composiciones farmaceuticas
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
KR100978836B1 (ko) * 2001-10-19 2010-08-30 이소테크니카 인코포레이티드 신규한 시클로스포린 유사체 미세유화액 예비농축물
DK1714977T3 (da) 2001-10-19 2009-07-06 Isotechnika Inc Syntese af cyclosporinanaloger
KR20030065831A (ko) * 2002-02-01 2003-08-09 주식회사 태평양 사이클로스포린을 함유한 지속 방출형 약학적 조성물
MXPA04009385A (es) * 2002-03-26 2005-01-25 Teva Pharma Microparticulas de drogas.
EP1576138B1 (fr) 2002-11-15 2017-02-01 Idenix Pharmaceuticals LLC. 2'-MÉTHYL-NUCLEOSIDES EN COMBInaISON AVEC l'INTERFÉRON ET MUTATION DE FLAVIVIRIDAE
US20040150061A1 (en) * 2003-01-30 2004-08-05 Hsin Chung Hsien Package structure of a photosensor
US7507823B2 (en) 2004-05-06 2009-03-24 Bristol-Myers Squibb Company Process of making aripiprazole particles
GB0413729D0 (en) * 2004-06-18 2004-07-21 Tillotts Pharma Ag A pharmaceutical composition and its use
GB0413730D0 (en) * 2004-06-18 2004-07-21 Tillotts Pharma Ag A pharmaceutical composition and its use
US20080280973A1 (en) * 2004-06-28 2008-11-13 Wender Paul A Laulimalide Analogues as Therapeutic Agents
KR20070100836A (ko) * 2005-02-03 2007-10-11 신벤션 아게 졸/겔 기술에 의하여 제조된 약물 전달 물질
CN1323096C (zh) * 2005-05-26 2007-06-27 中国科学院长春应用化学研究所 生物可降解聚酯微粒及其制备方法和用途
US20060280787A1 (en) * 2005-06-14 2006-12-14 Baxter International Inc. Pharmaceutical formulation of the tubulin inhibitor indibulin for oral administration with improved pharmacokinetic properties, and process for the manufacture thereof
CA2608930A1 (fr) * 2005-06-14 2006-12-28 Baxter International Inc. Preparations pharmaceutiques permettant de reduire les interactions entre medicaments
CA2628630A1 (fr) * 2005-11-15 2007-05-24 Baxter International Inc. Compositions d'inhibiteurs de lipoxygenase
US20070298067A1 (en) * 2006-06-22 2007-12-27 Boston Scientific Scimed, Inc. Control release drug coating for medical devices
US7794495B2 (en) * 2006-07-17 2010-09-14 Advanced Cardiovascular Systems, Inc. Controlled degradation of stents
US8426467B2 (en) 2007-05-22 2013-04-23 Baxter International Inc. Colored esmolol concentrate
US8722736B2 (en) 2007-05-22 2014-05-13 Baxter International Inc. Multi-dose concentrate esmolol with benzyl alcohol
EP2200613B1 (fr) 2007-09-21 2018-09-05 The Johns Hopkins University Dérivés de phénazine et leurs utilisations
US9994585B2 (en) 2007-12-31 2018-06-12 Aphios Corporation Transplantation therapies
US20170065533A1 (en) * 2011-01-24 2017-03-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Nanoparticles for dermal and systemic delivery of drugs
US10624847B2 (en) * 2011-08-02 2020-04-21 AnPac BioMedical Science Co., Ltd. Decomposable apparatus and methods for fabricating same
EP2785184B1 (fr) 2011-11-30 2020-06-10 Emory University Compositions contenant des inhibiteurs de jak et des médicaments haart destinées à la prévention ou au traitement du vih
US9034347B2 (en) * 2011-12-19 2015-05-19 Arphios Corporation Drug delivery system and method for the treatment of neuro-degenerative disease
EP2925314B1 (fr) 2012-11-28 2020-04-01 Aphios Corporation Thérapeutique combinée et méthodes de traitement de maladies neurodégénératives et autres
WO2015138919A1 (fr) 2014-03-14 2015-09-17 The University Of North Carolina At Chapel Hill Petites molécules pour inhiber la fertilité mâle
GB201522441D0 (en) * 2015-12-18 2016-02-03 Midatech Pharma Wales Ltd Sustained release cyclosporine-loaded microparticles

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1311686C (fr) * 1986-06-25 1992-12-22 John Weldon Shell Systeme d'administration de medicaments bioerodables a degagement controle
DE3851152T2 (de) * 1987-09-03 1995-01-26 Univ Georgia Res Found Cyclosporin-augenmittel.
GB2209937B (en) * 1987-09-21 1991-07-03 Depiopharm S A Water insoluble polypeptides
US5185152A (en) * 1990-01-10 1993-02-09 Peyman Gholam A Method and apparatus for controlled release drug delivery to the cornea and anterior chamber of the eye
WO1991016057A1 (fr) * 1990-04-18 1991-10-31 University Of Utah FORMES DE DOSAGE DE MEDICAMENTS ABSORBES PAR VOIE ORALE ET DESTINES A ETRE LIBERES DANS LE COLON, REALISEES A PARTIR D'HYDROGELS RETICULES RENFERMANT DES LIAISONS AZOÏQUES ET PRESENTANT UN GONFLEMENT DEPENDANT DU pH
US5171217A (en) * 1991-02-28 1992-12-15 Indiana University Foundation Method for delivery of smooth muscle cell inhibitors
DE69225979T2 (de) * 1992-08-13 1998-12-17 Teikoku Seiyaku Kk Orale zubereitung zur freisetzung im unteren verdauungstract

Also Published As

Publication number Publication date
CA2217462A1 (fr) 1996-10-10
WO1996031202A1 (fr) 1996-10-10
IE950233A1 (en) 1996-10-16
EP0818996B1 (fr) 2003-02-19
AU5286696A (en) 1996-10-23
PT818996E (pt) 2003-06-30
EP0818996A1 (fr) 1998-01-21
ATE232722T1 (de) 2003-03-15
DE69626278T2 (de) 2003-07-24
JP3875721B2 (ja) 2007-01-31
JPH11503147A (ja) 1999-03-23
IE75744B1 (en) 1997-09-24
DK0818996T3 (da) 2003-06-10
ES2189868T3 (es) 2003-07-16
CA2217462C (fr) 2010-08-03
US5641745A (en) 1997-06-24
DE69626278D1 (de) 2003-03-27
AU700612B2 (en) 1999-01-07
NZ304975A (en) 1998-09-24

Similar Documents

Publication Publication Date Title
ZA962670B (en) Controlled release biodegradable micro- and nanospheres containing cyclosporin
AU2001255509B2 (en) Taste masking coating composition
BR9810124A (pt) Um itraconazol exibindo solibilidade incrementada, o método de preparação do mesmo e a composição farmacêutica para administração oral contendo o mesmo
MX9804008A (es) Formulaciones farmaceuticas.
CA2285266A1 (fr) Formulations a liberation prolongee de derives d'erythromycine
IL111647A (en) Pharmaceutical compositions comprising microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles and their preparation
WO1999059544A3 (fr) Comprimes se desintegrant dans la bouche
GEP20032912B (en) Enteric Coated Pharmaceutical Tablets and Method of Manufacturing
WO1998009597A3 (fr) Boulettes tampons et comprime les renfermant pour former une suspension
WO1997013502A3 (fr) Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf)
CA2217485A1 (fr) Nanoparticules biodegradables a liberation lente renfermant de l'insuline
BG104620A (en) Oral pharmaceutical extended release dosage form
AU5895596A (en) Treatment of inflammatory bowel disease using oral dosage forms of omega-3 polyunsaturated acids
CA2272586A1 (fr) Compositions medicinales a desintegration rapide
WO2003013433A3 (fr) Formulations d'antagoniste sequestre
BR0008059A (pt) Composições de valdecoxib
IL84167A0 (en) Compositions containing bioactive materials adapted for oral administration and methods for administration thereof
NZ510563A (en) Multiple unit controlled food effect-independent release pharmaceutical preparations and method for preparing the same
CA2219777A1 (fr) Nanoparticules pour l'administration orale d'agents pharmaceutiques de faible solubilite
HK1043945A1 (en) Pharmaceutical capsule compositions containing loratadine and pseudoephedrine.
AP1485A (en) Orally administered controlled delivery system for once daily administration of ciprofloxacin.
RS20050866A (en) Controlled release pharmaceutical composition comprising an acid- insoluble and a bioadhesive polymer
HK1039743A1 (en) Gastroresistant multi-unitary pharmaceutical preparations containing piroxicam
CA2234585A1 (fr) Liberation prolongee de facteurs stimulant les colonies de granulocytes-macrophages (gm-csf)
MY114610A (en) Controlled drug delivery system for diltiazem.