ZA959377B - A storage stable water solution for infusion containing a thrombin inhibitor - Google Patents

A storage stable water solution for infusion containing a thrombin inhibitor

Info

Publication number
ZA959377B
ZA959377B ZA959377A ZA959377A ZA959377B ZA 959377 B ZA959377 B ZA 959377B ZA 959377 A ZA959377 A ZA 959377A ZA 959377 A ZA959377 A ZA 959377A ZA 959377 B ZA959377 B ZA 959377B
Authority
ZA
South Africa
Prior art keywords
pct
storage stable
thrombin inhibitor
water solution
stable water
Prior art date
Application number
ZA959377A
Other languages
English (en)
Inventor
Ulla Stjernfelt
Mats Sundgren
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of ZA959377B publication Critical patent/ZA959377B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA959377A 1994-11-08 1995-11-06 A storage stable water solution for infusion containing a thrombin inhibitor ZA959377B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9403831A SE504185C2 (sv) 1994-11-08 1994-11-08 Lagringsstabil vattenlösning för infusion av trombininhibitorer

Publications (1)

Publication Number Publication Date
ZA959377B true ZA959377B (en) 1996-05-08

Family

ID=20395892

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA959377A ZA959377B (en) 1994-11-08 1995-11-06 A storage stable water solution for infusion containing a thrombin inhibitor

Country Status (31)

Country Link
US (1) US5830865A (zh)
EP (1) EP0789585B1 (zh)
JP (1) JPH10508598A (zh)
KR (1) KR100416677B1 (zh)
CN (1) CN1090508C (zh)
AT (1) ATE205399T1 (zh)
AU (1) AU695719B2 (zh)
BR (1) BR9509634A (zh)
CA (1) CA2203396A1 (zh)
CZ (1) CZ287256B6 (zh)
DE (1) DE69522702T2 (zh)
DK (1) DK0789585T3 (zh)
EE (1) EE9700218A (zh)
ES (1) ES2163528T3 (zh)
FI (1) FI971949A (zh)
HU (1) HU217073B (zh)
IL (1) IL115879A (zh)
IS (1) IS4468A (zh)
MX (1) MX9703339A (zh)
MY (1) MY112593A (zh)
NO (1) NO322048B1 (zh)
NZ (1) NZ295492A (zh)
PL (1) PL320342A1 (zh)
PT (1) PT789585E (zh)
RU (1) RU2164803C2 (zh)
SE (1) SE504185C2 (zh)
SK (1) SK53597A3 (zh)
TR (1) TR199501391A2 (zh)
TW (1) TW407057B (zh)
WO (1) WO1996014084A1 (zh)
ZA (1) ZA959377B (zh)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6984627B1 (en) * 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
TW541316B (en) * 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
SE9802974D0 (sv) 1998-09-03 1998-09-03 Astra Ab New crystalline forms
US6462021B1 (en) 2000-11-06 2002-10-08 Astrazeneca Ab Use of low molecular weight thrombin inhibitor
WO2004050637A2 (en) 2002-12-03 2004-06-17 Axys Pharmaceuticals, Inc. 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors
US7345093B2 (en) * 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
US9402812B2 (en) * 2009-09-23 2016-08-02 Indu JAVERI Methods for the preparation of liposomes
US20110070294A1 (en) * 2009-09-23 2011-03-24 Javeri Indu Methods for the Administration of Drugs Using Liposomes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103612D0 (sv) * 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
US5466131A (en) * 1994-03-22 1995-11-14 Micropump Corporation Multiple-chamber gear pump with hydraulically connected chambers

Also Published As

Publication number Publication date
MY112593A (en) 2001-07-31
ES2163528T3 (es) 2002-02-01
EP0789585B1 (en) 2001-09-12
CN1090508C (zh) 2002-09-11
CN1162921A (zh) 1997-10-22
AU695719B2 (en) 1998-08-20
KR970706844A (ko) 1997-12-01
NZ295492A (en) 1998-06-26
SE504185C2 (sv) 1996-12-02
IS4468A (is) 1997-04-21
IL115879A (en) 2001-08-08
TW407057B (en) 2000-10-01
NO322048B1 (no) 2006-08-07
US5830865A (en) 1998-11-03
FI971949A0 (fi) 1997-05-07
KR100416677B1 (ko) 2004-06-16
PL320342A1 (en) 1997-09-29
DE69522702D1 (de) 2001-10-18
CZ287256B6 (en) 2000-10-11
ATE205399T1 (de) 2001-09-15
AU3884695A (en) 1996-05-31
DK0789585T3 (da) 2001-11-12
DE69522702T2 (de) 2002-07-11
SK53597A3 (en) 1998-07-08
NO972065L (no) 1997-05-05
EP0789585A1 (en) 1997-08-20
IL115879A0 (en) 1996-01-31
CA2203396A1 (en) 1996-05-17
SE9403831D0 (sv) 1994-11-08
HU217073B (hu) 1999-11-29
MX9703339A (es) 1997-07-31
BR9509634A (pt) 1998-01-06
SE9403831L (sv) 1996-05-09
CZ129497A3 (cs) 1998-02-18
TR199501391A2 (tr) 1996-06-21
RU2164803C2 (ru) 2001-04-10
NO972065D0 (no) 1997-05-05
FI971949A (fi) 1997-05-07
PT789585E (pt) 2002-01-30
WO1996014084A1 (en) 1996-05-17
JPH10508598A (ja) 1998-08-25
HUT77560A (hu) 1998-06-29
EE9700218A (et) 1998-02-16

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