ZA958946B - Use of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta A4 formation in alzheimer's disease - Google Patents
Use of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta A4 formation in alzheimer's diseaseInfo
- Publication number
- ZA958946B ZA958946B ZA958946A ZA958946A ZA958946B ZA 958946 B ZA958946 B ZA 958946B ZA 958946 A ZA958946 A ZA 958946A ZA 958946 A ZA958946 A ZA 958946A ZA 958946 B ZA958946 B ZA 958946B
- Authority
- ZA
- South Africa
- Prior art keywords
- alpha
- alzheimer
- disease
- pct
- acetonitrile
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9421472A GB9421472D0 (en) | 1994-10-25 | 1994-10-25 | Novel methods |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA958946B true ZA958946B (en) | 1996-08-20 |
Family
ID=10763350
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA958946A ZA958946B (en) | 1994-10-25 | 1995-10-23 | Use of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo [2.2.2] oct-3-yl) acetonitrile to reduce amyloid beta A4 formation in alzheimer's disease |
Country Status (22)
Country | Link |
---|---|
US (1) | US5891887A (ko) |
EP (1) | EP0786998B1 (ko) |
JP (1) | JPH10509697A (ko) |
KR (1) | KR100393365B1 (ko) |
CN (1) | CN1085529C (ko) |
AT (1) | ATE214926T1 (ko) |
AU (1) | AU698695B2 (ko) |
BG (1) | BG101500A (ko) |
BR (1) | BR9509433A (ko) |
CZ (1) | CZ287370B6 (ko) |
DE (1) | DE69526102T2 (ko) |
DK (1) | DK0786998T3 (ko) |
ES (1) | ES2173977T3 (ko) |
GB (1) | GB9421472D0 (ko) |
HK (1) | HK1002057A1 (ko) |
HU (1) | HUT77007A (ko) |
NO (1) | NO312055B1 (ko) |
NZ (1) | NZ295155A (ko) |
PT (1) | PT786998E (ko) |
SK (1) | SK50497A3 (ko) |
WO (1) | WO1996012486A1 (ko) |
ZA (1) | ZA958946B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU751607B2 (en) * | 1995-07-29 | 2002-08-22 | Smithkline Beecham Plc | Method of treatment of dementia |
GB9619074D0 (en) * | 1996-09-12 | 1996-10-23 | Smithkline Beecham Plc | Composition |
DE19641180A1 (de) * | 1996-09-24 | 1998-03-26 | Schering Ag | Verfahren zur Darstellung von APP-Sekretase Modulation und deren Verwendung als Mittel zur Behandlung der Alzheimer'schen Erkrankung |
WO1999045924A1 (en) | 1998-03-11 | 1999-09-16 | Smithkline Beecham Plc | Composition |
GB9815383D0 (en) * | 1998-07-15 | 1998-09-16 | Smithkline Beecham Plc | Novel method of treatment |
US6245884B1 (en) * | 1998-10-16 | 2001-06-12 | Vivian Y. H. Hook | Secretases related to alzheimer's dementia |
US7816149B2 (en) * | 2004-03-29 | 2010-10-19 | Applied Photonics Worldwide, Inc. | Nanobioprocessor for protein and cell therapy |
GB0428170D0 (en) * | 2004-12-23 | 2005-01-26 | Biopartners Ltd | Mono and Combination Therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE269330T1 (de) * | 1989-04-13 | 2004-07-15 | Beecham Group Plc | Chemische verbindungen |
JPH0725786A (ja) * | 1990-05-16 | 1995-01-27 | Univ Rockefeller | アルツハイマー病を伴うアミロイドーシスの治療 |
US5385915A (en) * | 1990-05-16 | 1995-01-31 | The Rockefeller University | Treatment of amyloidosis associated with Alzheimer disease using modulators of protein phosphorylation |
US5242932A (en) * | 1991-12-17 | 1993-09-07 | The Rockefeller University | Treatment of amyloidosis associated with alzheimer disease |
MX9300875A (es) * | 1992-02-20 | 1993-08-31 | Smithkline Beecham Plc | Procedimiento para la preparacion de compuestos azabiciclicos. |
WO1994009370A1 (en) * | 1992-10-09 | 1994-04-28 | Massachusetts Institute Of Technology | Release of alzheimer amyloid precursor stimulated by activation of muscarinic acetylcholine receptors |
GB9409705D0 (en) * | 1994-05-14 | 1994-07-06 | Smithkline Beecham Plc | Novel compounds |
-
1994
- 1994-10-25 GB GB9421472A patent/GB9421472D0/en active Pending
-
1995
- 1995-10-17 US US08/836,013 patent/US5891887A/en not_active Expired - Fee Related
- 1995-10-17 AT AT95936515T patent/ATE214926T1/de not_active IP Right Cessation
- 1995-10-17 ES ES95936515T patent/ES2173977T3/es not_active Expired - Lifetime
- 1995-10-17 KR KR1019970702700A patent/KR100393365B1/ko not_active IP Right Cessation
- 1995-10-17 DK DK95936515T patent/DK0786998T3/da active
- 1995-10-17 JP JP8513628A patent/JPH10509697A/ja not_active Ceased
- 1995-10-17 BR BR9509433A patent/BR9509433A/pt not_active Application Discontinuation
- 1995-10-17 SK SK504-97A patent/SK50497A3/sk unknown
- 1995-10-17 AU AU38431/95A patent/AU698695B2/en not_active Ceased
- 1995-10-17 DE DE69526102T patent/DE69526102T2/de not_active Expired - Fee Related
- 1995-10-17 WO PCT/EP1995/004082 patent/WO1996012486A1/en active IP Right Grant
- 1995-10-17 PT PT95936515T patent/PT786998E/pt unknown
- 1995-10-17 HU HU9701815A patent/HUT77007A/hu unknown
- 1995-10-17 EP EP95936515A patent/EP0786998B1/en not_active Expired - Lifetime
- 1995-10-17 CN CN95196837A patent/CN1085529C/zh not_active Expired - Fee Related
- 1995-10-17 CZ CZ19971251A patent/CZ287370B6/cs not_active IP Right Cessation
- 1995-10-17 NZ NZ295155A patent/NZ295155A/en unknown
- 1995-10-23 ZA ZA958946A patent/ZA958946B/xx unknown
-
1997
- 1997-04-24 NO NO19971899A patent/NO312055B1/no not_active IP Right Cessation
- 1997-05-20 BG BG101500A patent/BG101500A/xx unknown
-
1998
- 1998-02-05 HK HK98100893A patent/HK1002057A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1002057A1 (en) | 1998-07-31 |
EP0786998A1 (en) | 1997-08-06 |
KR100393365B1 (ko) | 2003-12-18 |
PT786998E (pt) | 2002-09-30 |
BR9509433A (pt) | 1997-09-16 |
DE69526102T2 (de) | 2002-10-31 |
US5891887A (en) | 1999-04-06 |
NZ295155A (en) | 2000-07-28 |
AU698695B2 (en) | 1998-11-05 |
KR970706816A (ko) | 1997-12-01 |
CZ287370B6 (en) | 2000-11-15 |
NO971899L (no) | 1997-04-24 |
NO971899D0 (no) | 1997-04-24 |
JPH10509697A (ja) | 1998-09-22 |
AU3843195A (en) | 1996-05-15 |
DE69526102D1 (de) | 2002-05-02 |
ATE214926T1 (de) | 2002-04-15 |
DK0786998T3 (da) | 2002-07-15 |
ES2173977T3 (es) | 2002-11-01 |
WO1996012486A1 (en) | 1996-05-02 |
HUT77007A (hu) | 1998-03-02 |
CN1170365A (zh) | 1998-01-14 |
GB9421472D0 (en) | 1994-12-07 |
EP0786998B1 (en) | 2002-03-27 |
CN1085529C (zh) | 2002-05-29 |
MX9703077A (es) | 1997-07-31 |
CZ125197A3 (en) | 1997-07-16 |
NO312055B1 (no) | 2002-03-11 |
SK50497A3 (en) | 1997-09-10 |
BG101500A (en) | 1998-01-30 |
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