ZA95756B - Macrocyclic difluorostatone derivatives useful as antiviral agents - Google Patents

Macrocyclic difluorostatone derivatives useful as antiviral agents

Info

Publication number
ZA95756B
ZA95756B ZA95756A ZA95756A ZA95756B ZA 95756 B ZA95756 B ZA 95756B ZA 95756 A ZA95756 A ZA 95756A ZA 95756 A ZA95756 A ZA 95756A ZA 95756 B ZA95756 B ZA 95756B
Authority
ZA
South Africa
Prior art keywords
pct
hiv
antiviral agents
macrocyclic
useful
Prior art date
Application number
ZA95756A
Other languages
English (en)
Inventor
Robert A Farr
Brent L Podlogar
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA95756B publication Critical patent/ZA95756B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
ZA95756A 1994-02-04 1995-01-31 Macrocyclic difluorostatone derivatives useful as antiviral agents ZA95756B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19208094A 1994-02-04 1994-02-04

Publications (1)

Publication Number Publication Date
ZA95756B true ZA95756B (en) 1995-10-05

Family

ID=22708156

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA95756A ZA95756B (en) 1994-02-04 1995-01-31 Macrocyclic difluorostatone derivatives useful as antiviral agents

Country Status (20)

Country Link
US (1) US5969132A (de)
EP (1) EP0742791B1 (de)
JP (1) JP3574455B2 (de)
KR (1) KR100367379B1 (de)
CN (1) CN1142830A (de)
AT (1) ATE198602T1 (de)
AU (1) AU684875B2 (de)
CA (1) CA2182476C (de)
DE (1) DE69426574T2 (de)
DK (1) DK0742791T3 (de)
ES (1) ES2155515T3 (de)
FI (1) FI963073A0 (de)
GR (1) GR3035623T3 (de)
HU (1) HUT74384A (de)
IL (1) IL112514A0 (de)
NO (1) NO963254L (de)
NZ (1) NZ277410A (de)
PT (1) PT742791E (de)
WO (1) WO1995021186A1 (de)
ZA (1) ZA95756B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1633774B1 (de) 2003-06-18 2010-02-17 Tranzyme Pharma Inc. Makrozyklische motilin rezeptorantagonisten

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH672792A5 (de) * 1985-02-19 1989-12-29 Sandoz Ag
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
HUT58764A (en) * 1988-07-08 1992-03-30 Smithkline Beckman Corp Process for producing peptides, pharmaceutical compositions containing them and amino-acid intermediates
US5071837A (en) * 1990-11-28 1991-12-10 Warner-Lambert Company Novel renin inhibiting peptides
CA2098020C (en) * 1991-01-02 2003-10-21 Daniel Schirlin Anti-viral compounds
EP0773926A1 (de) * 1994-07-15 1997-05-21 Merrell Pharmaceuticals Inc. Difluorostatone als antivirale mittel

Also Published As

Publication number Publication date
JPH09508417A (ja) 1997-08-26
WO1995021186A1 (en) 1995-08-10
ATE198602T1 (de) 2001-01-15
FI963073A (fi) 1996-08-02
DE69426574D1 (de) 2001-02-15
IL112514A0 (en) 1995-05-26
NZ277410A (en) 1997-02-24
HU9602158D0 (en) 1996-09-30
EP0742791B1 (de) 2001-01-10
NO963254D0 (no) 1996-08-02
DE69426574T2 (de) 2001-08-09
DK0742791T3 (da) 2001-04-02
HUT74384A (en) 1996-12-30
AU684875B2 (en) 1998-01-08
ES2155515T3 (es) 2001-05-16
GR3035623T3 (en) 2001-06-29
KR100367379B1 (ko) 2003-04-11
NO963254L (no) 1996-08-02
AU1262295A (en) 1995-08-21
FI963073A0 (fi) 1996-08-02
JP3574455B2 (ja) 2004-10-06
US5969132A (en) 1999-10-19
CA2182476C (en) 2000-12-26
CN1142830A (zh) 1997-02-12
EP0742791A1 (de) 1996-11-20
PT742791E (pt) 2001-06-29

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