ZA948310B - Delta16unsaturated c17 heterocyclic steroids useful as steroid c17-20lyase inhibitors - Google Patents

Delta16unsaturated c17 heterocyclic steroids useful as steroid c17-20lyase inhibitors

Info

Publication number
ZA948310B
ZA948310B ZA948310A ZA948310A ZA948310B ZA 948310 B ZA948310 B ZA 948310B ZA 948310 A ZA948310 A ZA 948310A ZA 948310 A ZA948310 A ZA 948310A ZA 948310 B ZA948310 B ZA 948310B
Authority
ZA
South Africa
Prior art keywords
steroid
inhibitors
20lyase
steroids useful
heterocyclic
Prior art date
Application number
ZA948310A
Other languages
English (en)
Inventor
Norton P Peet
Cynthia A Gates
Joseph P Burkhart
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA948310B publication Critical patent/ZA948310B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA948310A 1993-10-27 1994-10-21 Delta16unsaturated c17 heterocyclic steroids useful as steroid c17-20lyase inhibitors ZA948310B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US14367993A 1993-10-27 1993-10-27

Publications (1)

Publication Number Publication Date
ZA948310B true ZA948310B (en) 1995-06-14

Family

ID=22505119

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA948310A ZA948310B (en) 1993-10-27 1994-10-21 Delta16unsaturated c17 heterocyclic steroids useful as steroid c17-20lyase inhibitors

Country Status (19)

Country Link
US (3) US5677293A (de)
EP (1) EP0724591B1 (de)
JP (1) JPH09511214A (de)
KR (1) KR960705838A (de)
CN (1) CN1046736C (de)
AT (1) ATE177751T1 (de)
AU (2) AU684844B2 (de)
CA (1) CA2173729C (de)
DE (1) DE69417248T2 (de)
DK (1) DK0724591T3 (de)
ES (1) ES2133582T3 (de)
FI (1) FI961792A (de)
GR (1) GR3030263T3 (de)
HU (1) HUT73855A (de)
IL (1) IL111364A0 (de)
NO (1) NO961693D0 (de)
NZ (1) NZ274694A (de)
WO (1) WO1995011914A1 (de)
ZA (1) ZA948310B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1079859B1 (de) 1998-05-22 2010-07-14 The Board Of Trustees Of The Leland Stanford Junior University Bifunktionelle moleküle sowie darauf basierende therapien.
AU6087700A (en) * 1999-07-15 2001-02-05 Procter & Gamble Company, The Nitrogen-containing steroid compounds and their use to regulate hair growth
EP2147679B1 (de) 2001-07-25 2014-06-25 Raptor Pharmaceutical, Inc. Zusammensetzungen für den Blut-Hirn-Schrankentransport
US6562457B1 (en) 2001-10-31 2003-05-13 E. I. Du Pont De Nemours And Company Polyether ester elastomer comprising polytrimethylene ether ester soft segment and tetramethylene ester hard segment
US8569275B2 (en) 2002-08-28 2013-10-29 Harbor Therapeutics, Inc. Steroids having 7-oxgen and 17-heteroaryl substitution
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
DK2398500T3 (da) 2009-02-20 2019-05-13 2 Bbb Medicines B V Glutathion-baseret lægemiddelafgivelsessystem
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Preparations for administration through the skin that include complexes of an active substance with calcium phosphate and methods of using them
WO2011088160A2 (en) * 2010-01-15 2011-07-21 Biomarin Pharmaceutical Inc. Novel cyp17 inhibitors
CA2807149C (en) 2010-08-04 2017-05-02 Pellficure Pharmaceuticals, Inc. Novel treatment of prostate carcinoma
CN102746358B (zh) * 2011-04-22 2016-02-10 天津金耀集团有限公司 一种合成孕甾21位溴化物的工艺
CN102898495B (zh) * 2012-11-12 2014-11-26 浙江神洲药业有限公司 醋酸阿比特龙酯的制备方法
CN103059091B (zh) * 2012-11-22 2017-04-19 常州靶点医药科技有限公司 一种避免重金属残留的醋酸阿比特龙的制备方法
CA2902335C (en) 2013-03-14 2021-09-14 Pellficure Pharmaceuticals, Inc. Novel therapy for prostate carcinoma
EP3191087A1 (de) 2014-09-12 2017-07-19 Pellficure Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur behandlung von prostatakrebs
HUP1500055A1 (hu) 2015-02-09 2016-08-29 Druggability Technologies Ip Holdco Ltd Abirateron acetát komplexei, eljárás elõállításukra, és az azokat tartalmazó gyógyászati készítmények
EP3528799A1 (de) 2016-10-24 2019-08-28 Pellficure Pharmaceuticals, Inc. Pharmazeutische zusammensetzungen aus 5-hydroxy-2-methylnaphthalen-1,4-dion
CN106866773A (zh) * 2017-02-14 2017-06-20 西北农林科技大学 一组具有抗癌活性吡唑基甾体衍生物的制备方法及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081647A (en) * 1965-04-01 1967-08-31 Shionogi & Co Furan compounds
AT253975B (de) * 1965-06-15 1967-05-10 Carinthia Elektrogeraete Ges M Trockenrasierapparat
US3436390A (en) * 1966-05-24 1969-04-01 American Home Prod 4,4-dihydroxy-2-butenoic acid lactones
US3398138A (en) * 1966-05-24 1968-08-20 American Home Prod Novel cardenolides and derivatives
US4259240A (en) * 1979-09-28 1981-03-31 Advance Biofactures Corporation Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom
US4380624A (en) * 1981-07-31 1983-04-19 Advance Biofactures Corp. Novel isomers of bufalin and resibufogenin and their preparation
US4523917A (en) * 1983-12-27 1985-06-18 Dana Corporation Variable pitch diameter torque sensing pulley assembly
US5232917A (en) * 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
DE69327096T2 (de) * 1992-03-31 2000-06-21 Btg Int Ltd 17-substituierte steroide, verwendbar bei behandlung von krebs
DE4221636C1 (de) * 1992-07-01 1994-03-31 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17beta-(3-furyl)-3-Derivate

Also Published As

Publication number Publication date
ES2133582T3 (es) 1999-09-16
US5977094A (en) 1999-11-02
NO961693L (no) 1996-04-26
ATE177751T1 (de) 1999-04-15
DE69417248D1 (de) 1999-04-22
AU695341B2 (en) 1998-08-13
EP0724591A1 (de) 1996-08-07
GR3030263T3 (en) 1999-08-31
FI961792A0 (fi) 1996-04-26
US5965548A (en) 1999-10-12
DK0724591T3 (da) 1999-09-27
JPH09511214A (ja) 1997-11-11
NO961693D0 (no) 1996-04-26
US5677293A (en) 1997-10-14
EP0724591B1 (de) 1999-03-17
IL111364A0 (en) 1994-12-29
HUT73855A (en) 1996-09-30
AU684844B2 (en) 1998-01-08
AU7922394A (en) 1995-05-22
CA2173729A1 (en) 1995-05-04
CN1133596A (zh) 1996-10-16
HU9601113D0 (en) 1996-07-29
FI961792A (fi) 1996-04-26
NZ274694A (en) 1998-01-26
AU3993097A (en) 1998-01-08
DE69417248T2 (de) 1999-08-19
CA2173729C (en) 2001-05-15
WO1995011914A1 (en) 1995-05-04
CN1046736C (zh) 1999-11-24
KR960705838A (ko) 1996-11-08

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