EA199700045A1 - ЭПИМЕРЫ (22RS)-N-(1,1,1-ТРИФТОР-2-ФЕНИЛПРОП-2-ИЛ)-3-ОКСО-4-АЗА-5α-АНДРОСТ-1-ЕН-17β-КАРБОКСАМИДА - Google Patents

ЭПИМЕРЫ (22RS)-N-(1,1,1-ТРИФТОР-2-ФЕНИЛПРОП-2-ИЛ)-3-ОКСО-4-АЗА-5α-АНДРОСТ-1-ЕН-17β-КАРБОКСАМИДА

Info

Publication number
EA199700045A1
EA199700045A1 EA199700045A EA199700045A EA199700045A1 EA 199700045 A1 EA199700045 A1 EA 199700045A1 EA 199700045 A EA199700045 A EA 199700045A EA 199700045 A EA199700045 A EA 199700045A EA 199700045 A1 EA199700045 A1 EA 199700045A1
Authority
EA
Eurasian Patent Office
Prior art keywords
androst
aza
oxo
triftor
penilprop
Prior art date
Application number
EA199700045A
Other languages
English (en)
Inventor
Акилле Панцери
Марчелла Неси
Энрико Ди Салле
Original Assignee
Фармация Энд Апджон С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон С.П.А. filed Critical Фармация Энд Апджон С.П.А.
Publication of EA199700045A1 publication Critical patent/EA199700045A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к эпимерам (22R)-N-(1,1,1-трифтор-2-фенил-проп-2-ил)-3-оксо-4-аза-5α-андрост-1-ен-17β-карбоксамиду и (22S)-N-(1,1,1-трифтор-2-фенилпроп-2-ил)-3-оксо-4-аза-5α-андрост-1-ен-17β-карбоксамиду, полезным в качестве ингибиторов фермента 5α-редуктазы тестостерона, к способу их получения и к фармацевтическим композициям, содержащим их.
EA199700045A 1995-07-21 1997-04-18 ЭПИМЕРЫ (22RS)-N-(1,1,1-ТРИФТОР-2-ФЕНИЛПРОП-2-ИЛ)-3-ОКСО-4-АЗА-5α-АНДРОСТ-1-ЕН-17β-КАРБОКСАМИДА EA199700045A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95MI001587A IT1275594B1 (it) 1995-07-21 1995-07-21 Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
PCT/EP1996/002830 WO1997004002A1 (en) 1995-07-21 1996-06-28 EPIMERS OF (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5α-ANDROST-1-ENE-17β-CARBOXAMIDE

Publications (1)

Publication Number Publication Date
EA199700045A1 true EA199700045A1 (ru) 1997-12-30

Family

ID=11372032

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199700045A EA199700045A1 (ru) 1995-07-21 1997-04-18 ЭПИМЕРЫ (22RS)-N-(1,1,1-ТРИФТОР-2-ФЕНИЛПРОП-2-ИЛ)-3-ОКСО-4-АЗА-5α-АНДРОСТ-1-ЕН-17β-КАРБОКСАМИДА

Country Status (17)

Country Link
EP (1) EP0782582A1 (ru)
JP (1) JPH10506411A (ru)
KR (1) KR970706298A (ru)
CN (1) CN1159195A (ru)
AR (1) AR003967A1 (ru)
AU (1) AU6418396A (ru)
BR (1) BR9606527A (ru)
CA (1) CA2199273A1 (ru)
EA (1) EA199700045A1 (ru)
HU (1) HUP9702465A3 (ru)
IL (1) IL120343A0 (ru)
IT (1) IT1275594B1 (ru)
MX (1) MX9701948A (ru)
NO (1) NO971196L (ru)
PL (1) PL319351A1 (ru)
WO (1) WO1997004002A1 (ru)
ZA (1) ZA965678B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000013509A1 (en) * 1998-09-09 2000-03-16 Merck & Co., Inc. Method of determining and reducing the risk of bph-related urologic events
ATE290862T1 (de) * 1999-01-25 2005-04-15 Smithkline Beecham Corp Anti-androgene und verfahren zur behandlung von krankheiten
CN100355772C (zh) * 2005-12-28 2007-12-19 天津大学 具有5α－还原酶抑制活性的甾体化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Also Published As

Publication number Publication date
BR9606527A (pt) 1997-12-23
EP0782582A1 (en) 1997-07-09
MX9701948A (es) 1997-06-28
IL120343A0 (en) 1997-06-10
ITMI951587A1 (it) 1997-01-21
CN1159195A (zh) 1997-09-10
PL319351A1 (en) 1997-08-04
HUP9702465A3 (en) 1998-11-30
KR970706298A (ko) 1997-11-03
ITMI951587A0 (it) 1995-07-21
WO1997004002A1 (en) 1997-02-06
NO971196D0 (no) 1997-03-14
HUP9702465A2 (hu) 1998-05-28
JPH10506411A (ja) 1998-06-23
IT1275594B1 (it) 1997-08-06
AU6418396A (en) 1997-02-18
NO971196L (no) 1997-03-14
AR003967A1 (es) 1998-09-30
ZA965678B (en) 1997-01-24
CA2199273A1 (en) 1997-02-06

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