HUP9702465A2 - A (22RS)-N-(1,1,1-trifluor-2-fenil-2-propil)-3-oxo-4-aza-5alfa-androszt-1-én-17béta-karboxamid epimerjei, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények - Google Patents

A (22RS)-N-(1,1,1-trifluor-2-fenil-2-propil)-3-oxo-4-aza-5alfa-androszt-1-én-17béta-karboxamid epimerjei, eljárás előállításukra és ezeket tartalmazó gyógyszerkészítmények

Info

Publication number
HUP9702465A2
HUP9702465A2 HU9702465A HUP9702465A HUP9702465A2 HU P9702465 A2 HUP9702465 A2 HU P9702465A2 HU 9702465 A HU9702465 A HU 9702465A HU P9702465 A HUP9702465 A HU P9702465A HU P9702465 A2 HUP9702465 A2 HU P9702465A2
Authority
HU
Hungary
Prior art keywords
epimers
androst
aza
trifluoro
ene
Prior art date
Application number
HU9702465A
Other languages
English (en)
Inventor
Enrico Di Salle
Marcella Nesi
Achille Panzeri
Original Assignee
Pharmacia & Upjohn S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn S.P.A. filed Critical Pharmacia & Upjohn S.P.A.
Publication of HUP9702465A2 publication Critical patent/HUP9702465A2/hu
Publication of HUP9702465A3 publication Critical patent/HUP9702465A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A találmány a tesztőszerőn 5a-redűktáz enzim inhibitőraikéntfelhasználható (I) és (II) képletű epimerekre, azaz a (22R)-N-(1,1,1-triflűőr-2-fenil-2-prőpil)-3-őxő-4-aza-5a-andrőszt-1-én-17-karbőxa-midra[(I) képletű vegyület] és a (22S)-N-(1,1,1-triflűőr-2-fenil-2-prőpil)-3-őxő-4-aza-5a-andrőszt-1-én-17-karbőxamidra[(II) képletűvegyület], az epimerek előállítási eljárásaira és az epimerekettartalmazó, antiandrőgén hatású gyógyszerkészítményekre vőnatkőzik.(I) (II)ŕ
HU9702465A 1995-07-21 1996-06-28 Epimers of (22rs)-n-(1,1,1,-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alfa-androst-1-ene-17beta-carboxamide, process for producing them and pharmaceutical compositions containing the same HUP9702465A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001587A IT1275594B1 (it) 1995-07-21 1995-07-21 Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide

Publications (2)

Publication Number Publication Date
HUP9702465A2 true HUP9702465A2 (hu) 1998-05-28
HUP9702465A3 HUP9702465A3 (en) 1998-11-30

Family

ID=11372032

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9702465A HUP9702465A3 (en) 1995-07-21 1996-06-28 Epimers of (22rs)-n-(1,1,1,-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alfa-androst-1-ene-17beta-carboxamide, process for producing them and pharmaceutical compositions containing the same

Country Status (17)

Country Link
EP (1) EP0782582A1 (hu)
JP (1) JPH10506411A (hu)
KR (1) KR970706298A (hu)
CN (1) CN1159195A (hu)
AR (1) AR003967A1 (hu)
AU (1) AU6418396A (hu)
BR (1) BR9606527A (hu)
CA (1) CA2199273A1 (hu)
EA (1) EA199700045A1 (hu)
HU (1) HUP9702465A3 (hu)
IL (1) IL120343A0 (hu)
IT (1) IT1275594B1 (hu)
MX (1) MX9701948A (hu)
NO (1) NO971196L (hu)
PL (1) PL319351A1 (hu)
WO (1) WO1997004002A1 (hu)
ZA (1) ZA965678B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000013509A1 (en) * 1998-09-09 2000-03-16 Merck & Co., Inc. Method of determining and reducing the risk of bph-related urologic events
EP1146873B1 (en) * 1999-01-25 2005-03-16 Smithkline Beecham Corporation Anti-androgens and methods for treating disease
CN100355772C (zh) * 2005-12-28 2007-12-19 天津大学 具有5α－还原酶抑制活性的甾体化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Also Published As

Publication number Publication date
ITMI951587A1 (it) 1997-01-21
NO971196D0 (no) 1997-03-14
CA2199273A1 (en) 1997-02-06
ITMI951587A0 (it) 1995-07-21
IL120343A0 (en) 1997-06-10
BR9606527A (pt) 1997-12-23
PL319351A1 (en) 1997-08-04
ZA965678B (en) 1997-01-24
AU6418396A (en) 1997-02-18
JPH10506411A (ja) 1998-06-23
MX9701948A (es) 1997-06-28
CN1159195A (zh) 1997-09-10
HUP9702465A3 (en) 1998-11-30
IT1275594B1 (it) 1997-08-06
EA199700045A1 (ru) 1997-12-30
EP0782582A1 (en) 1997-07-09
AR003967A1 (es) 1998-09-30
WO1997004002A1 (en) 1997-02-06
NO971196L (no) 1997-03-14
KR970706298A (ko) 1997-11-03

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