IT1275594B1 - Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide - Google Patents

Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide

Info

Publication number
IT1275594B1
IT1275594B1 IT95MI001587A ITMI951587A IT1275594B1 IT 1275594 B1 IT1275594 B1 IT 1275594B1 IT 95MI001587 A IT95MI001587 A IT 95MI001587A IT MI951587 A ITMI951587 A IT MI951587A IT 1275594 B1 IT1275594 B1 IT 1275594B1
Authority
IT
Italy
Prior art keywords
carbossamide
5alfa
17beta
androst
phenylprop
Prior art date
Application number
IT95MI001587A
Other languages
English (en)
Italian (it)
Inventor
Achille Panzeri
Marcella Nesi
Salle Enrico Di
Original Assignee
Pharmacia S P A Ora Pharmacia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia S P A Ora Pharmacia filed Critical Pharmacia S P A Ora Pharmacia
Publication of ITMI951587A0 publication Critical patent/ITMI951587A0/it
Priority to IT95MI001587A priority Critical patent/IT1275594B1/it
Priority to PCT/EP1996/002830 priority patent/WO1997004002A1/en
Priority to CA002199273A priority patent/CA2199273A1/en
Priority to BR9606527A priority patent/BR9606527A/pt
Priority to AU64183/96A priority patent/AU6418396A/en
Priority to KR1019970701797A priority patent/KR970706298A/ko
Priority to PL96319351A priority patent/PL319351A1/xx
Priority to MX9701948A priority patent/MX9701948A/es
Priority to HU9702465A priority patent/HUP9702465A3/hu
Priority to IL12034396A priority patent/IL120343A0/xx
Priority to JP9506217A priority patent/JPH10506411A/ja
Priority to CN96190785A priority patent/CN1159195A/zh
Priority to EP96923968A priority patent/EP0782582A1/en
Priority to ZA965678A priority patent/ZA965678B/xx
Priority to ARP960103652A priority patent/AR003967A1/es
Publication of ITMI951587A1 publication Critical patent/ITMI951587A1/it
Priority to NO971196A priority patent/NO971196L/no
Priority to EA199700045A priority patent/EA199700045A1/ru
Application granted granted Critical
Publication of IT1275594B1 publication Critical patent/IT1275594B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT95MI001587A 1995-07-21 1995-07-21 Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide IT1275594B1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT95MI001587A IT1275594B1 (it) 1995-07-21 1995-07-21 Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
HU9702465A HUP9702465A3 (en) 1995-07-21 1996-06-28 Epimers of (22rs)-n-(1,1,1,-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alfa-androst-1-ene-17beta-carboxamide, process for producing them and pharmaceutical compositions containing the same
JP9506217A JPH10506411A (ja) 1995-07-21 1996-06-28 （２２ＲＳ）−Ｎ−（１，１，１−トリフルオロ−２−フェニルプロプ−２−イル）−３−オキソ−４−アザ−５α−アンドロスト−１−エン−１７β−カルボキサミド
BR9606527A BR9606527A (pt) 1995-07-21 1996-06-28 Epímeros processo para a preparação de um epimero composição farmacêutica que compreende um epímero e composto
AU64183/96A AU6418396A (en) 1995-07-21 1996-06-28 Epimers of (22RS)-N-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-ox-4-aza-5alp ha-androst-1-ene-17beta-carboxamide
KR1019970701797A KR970706298A (ko) 1995-07-21 1996-06-28 (22RS)-N-(1,1,1-트리플루오로-2-페닐프로프-2-일)-3-옥소-4-아자-5α-안드로스트-1-엔-17β-카복스아미드의 에피머(Epimers of(22RS)-N-(1,1,1,-Trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5α-androst-1-ene-17β-carboxamide)
PL96319351A PL319351A1 (en) 1995-07-21 1996-06-28 Epimers of (22rs)-n-(1,1,1-trifluoro-2-phenyprop-2-y)-3-oxo-4-aza-5a-androst-1-ene-17b carboxylamide
MX9701948A MX9701948A (es) 1995-07-21 1996-06-28 Epimeros de (22rs-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-oxo-4-aza-5alfa-androst-1-e n-17beta-carboxamida.
PCT/EP1996/002830 WO1997004002A1 (en) 1995-07-21 1996-06-28 EPIMERS OF (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5α-ANDROST-1-ENE-17β-CARBOXAMIDE
IL12034396A IL120343A0 (en) 1995-07-21 1996-06-28 Epimers of (22RS)-N-(1,1,1-trifluoro-2-phenylprop-2-YL)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
CA002199273A CA2199273A1 (en) 1995-07-21 1996-06-28 Epimers of (22rs)-n-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5.alpha.-androst-1-ene-17.beta.-carboxamide
CN96190785A CN1159195A (zh) 1995-07-21 1996-06-28 (22RS)-N-(1，1，1-三氟-2-苯基丙-2-基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-羧酰胺的差向异构体
EP96923968A EP0782582A1 (en) 1995-07-21 1996-06-28 EPIMERS OF (22RS)-N-(1,1,1-TRIFLUORO-2-PHENYLPROP-2-YL)-3-OXO-4-AZA-5$g(a)-ANDROST-1-ENE-17$g(b)-CARBOXAMIDE
ZA965678A ZA965678B (en) 1995-07-21 1996-07-04 Epimers of (22rs)-n-(1,1,1-trifluoro-2-phenylprop-2-yl)-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxamide
ARP960103652A AR003967A1 (es) 1995-07-21 1996-07-19 Epimeros de (22r)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-oxo-4-aza-5alfa- androst-1-eno-17beta-carboxamida, un proceso para su preparacion y unacomposicion farmaceutica que los comprenden.
NO971196A NO971196L (no) 1995-07-21 1997-03-14 Epimerer av (22RS)-N-(1,1,1-trifluor-2-fenylprop-2-yl)-3-okso-4-aza-5<alfa>-androst-1-en-17<beta>-karboksamid
EA199700045A EA199700045A1 (ru) 1995-07-21 1997-04-18 ЭПИМЕРЫ (22RS)-N-(1,1,1-ТРИФТОР-2-ФЕНИЛПРОП-2-ИЛ)-3-ОКСО-4-АЗА-5α-АНДРОСТ-1-ЕН-17β-КАРБОКСАМИДА

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001587A IT1275594B1 (it) 1995-07-21 1995-07-21 Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide

Publications (3)

Publication Number Publication Date
ITMI951587A0 ITMI951587A0 (it) 1995-07-21
ITMI951587A1 ITMI951587A1 (it) 1997-01-21
IT1275594B1 true IT1275594B1 (it) 1997-08-06

Family

ID=11372032

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95MI001587A IT1275594B1 (it) 1995-07-21 1995-07-21 Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide

Country Status (17)

Country Link
EP (1) EP0782582A1 (ru)
JP (1) JPH10506411A (ru)
KR (1) KR970706298A (ru)
CN (1) CN1159195A (ru)
AR (1) AR003967A1 (ru)
AU (1) AU6418396A (ru)
BR (1) BR9606527A (ru)
CA (1) CA2199273A1 (ru)
EA (1) EA199700045A1 (ru)
HU (1) HUP9702465A3 (ru)
IL (1) IL120343A0 (ru)
IT (1) IT1275594B1 (ru)
MX (1) MX9701948A (ru)
NO (1) NO971196L (ru)
PL (1) PL319351A1 (ru)
WO (1) WO1997004002A1 (ru)
ZA (1) ZA965678B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000013509A1 (en) * 1998-09-09 2000-03-16 Merck & Co., Inc. Method of determining and reducing the risk of bph-related urologic events
EP1146873B1 (en) * 1999-01-25 2005-03-16 Smithkline Beecham Corporation Anti-androgens and methods for treating disease
CN100355772C (zh) * 2005-12-28 2007-12-19 天津大学 具有5α－还原酶抑制活性的甾体化合物及其制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9216284D0 (en) * 1992-07-31 1992-09-16 Erba Carlo Spa Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives

Also Published As

Publication number Publication date
ITMI951587A1 (it) 1997-01-21
NO971196D0 (no) 1997-03-14
CA2199273A1 (en) 1997-02-06
ITMI951587A0 (it) 1995-07-21
IL120343A0 (en) 1997-06-10
BR9606527A (pt) 1997-12-23
PL319351A1 (en) 1997-08-04
ZA965678B (en) 1997-01-24
HUP9702465A2 (hu) 1998-05-28
AU6418396A (en) 1997-02-18
JPH10506411A (ja) 1998-06-23
MX9701948A (es) 1997-06-28
CN1159195A (zh) 1997-09-10
HUP9702465A3 (en) 1998-11-30
EA199700045A1 (ru) 1997-12-30
EP0782582A1 (en) 1997-07-09
AR003967A1 (es) 1998-09-30
WO1997004002A1 (en) 1997-02-06
NO971196L (no) 1997-03-14
KR970706298A (ko) 1997-11-03

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