EP0703905A1
(fr)
*
|
1993-06-18 |
1996-04-03 |
Merck & Co. Inc. |
Inhibiteurs de farnesyle-proteine transferase
|
US5856326A
(en)
*
|
1995-03-29 |
1999-01-05 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
IL117798A
(en)
*
|
1995-04-07 |
2001-11-25 |
Schering Plough Corp |
Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them
|
IL117797A0
(en)
*
|
1995-04-07 |
1996-08-04 |
Pharmacopeia Inc |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5712280A
(en)
*
|
1995-04-07 |
1998-01-27 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5801175A
(en)
*
|
1995-04-07 |
1998-09-01 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
WO1997002817A1
(fr)
*
|
1995-07-13 |
1997-01-30 |
University Of Cincinnati |
Composes utiles dans le traitement des neurofibromatoses
|
AU725649B2
(en)
*
|
1996-06-07 |
2000-10-19 |
F. Hoffmann-La Roche Ag |
Dibenzo-oxazepine and -dioxepine derivatives and their use as anti-tumor agents
|
US6451816B1
(en)
|
1997-06-20 |
2002-09-17 |
Klinge Pharma Gmbh |
Use of pyridyl alkane, pyridyl alkene and/or pyridyl alkine acid amides in the treatment of tumors or for immunosuppression
|
DE19624704A1
(de)
|
1996-06-20 |
1998-01-08 |
Klinge Co Chem Pharm Fab |
Neue Pyridylalkansäureamide
|
DE19624659A1
(de)
|
1996-06-20 |
1998-01-08 |
Klinge Co Chem Pharm Fab |
Neue Pyridylalken- und Pyridylalkinsäureamide
|
KR20000068550A
(ko)
*
|
1996-09-13 |
2000-11-25 |
쉐링 코포레이션 |
파르네실 단백질 전이효소의 억제에 유용한 화합물
|
US5958890A
(en)
*
|
1996-09-13 |
1999-09-28 |
Schering Corporation |
Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
US5985879A
(en)
*
|
1996-09-13 |
1999-11-16 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
ES2235252T3
(es)
*
|
1996-09-13 |
2005-07-01 |
Schering Corporation |
Inhibidores triciclicos de la farnesil proteina transferasa.
|
US5945429A
(en)
*
|
1996-09-13 |
1999-08-31 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
DE69732123T2
(de)
*
|
1996-09-13 |
2005-12-08 |
Schering Corp. |
Trizyklische Verindung mit Farnesylproteintransferase inhibierender Wirkung
|
CZ83499A3
(cs)
*
|
1996-09-13 |
1999-07-14 |
Schering Corporation |
Tricyklické sloučeniny, farmaceutický prostředek je obsahující a jejich použití
|
US6071907A
(en)
*
|
1996-09-13 |
2000-06-06 |
Schering Corporation |
Tricyclic compounds useful as FPT inhibitors
|
BR9712825A
(pt)
*
|
1996-09-13 |
1999-11-23 |
Schering Corp |
Derivados de benzocicloheptaridina substituìdos úteis para a inibição de transferase de proteìna de farnesila.
|
US6030982A
(en)
|
1996-09-13 |
2000-02-29 |
Schering Corporationm |
Compounds useful for inhibition of farnesyl protein transferase
|
US5861395A
(en)
*
|
1996-09-13 |
1999-01-19 |
Schering Corporation |
Compounds useful for inhibition of farnesyl proteins transferase
|
CA2282683A1
(fr)
*
|
1997-02-18 |
1998-08-20 |
Canji, Inc. |
Combinaison therapie genique suppressive de tumeurs - chimiotherapie utilisee dans le traitement de neoplasmes
|
US20030060434A1
(en)
|
1997-02-18 |
2003-03-27 |
Loretta Nielsen |
Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
|
JP2002504150A
(ja)
*
|
1997-06-17 |
2002-02-05 |
シェーリング コーポレイション |
ファルネシルタンパク質トランスフェラーゼの新規フェニル置換三環式インヒビター
|
US5877177A
(en)
*
|
1997-06-17 |
1999-03-02 |
Schering Corporation |
Carboxy piperidylacetamide tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
|
CN1267290A
(zh)
*
|
1997-06-17 |
2000-09-20 |
先灵公司 |
新的法呢基-蛋白转移酶的三环磺酰胺抑制剂
|
US6218401B1
(en)
|
1997-06-17 |
2001-04-17 |
Schering Corporation |
Phenyl-substituted tricyclic inhibitors of farnesyl-protein transferase
|
US6689789B2
(en)
|
1997-06-17 |
2004-02-10 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6426352B1
(en)
|
1997-06-17 |
2002-07-30 |
Schering Corporation |
Sulfonamide inhibitors of farnesyl-protein transferase
|
US6903118B1
(en)
|
1997-12-17 |
2005-06-07 |
Klinge Pharma Gmbh |
Piperazinyl-substituted pyridylalkane, alkene and alkine carboxamides
|
DE19756261A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
|
DE19756235A1
(de)
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
|
DE19756212A1
(de)
*
|
1997-12-17 |
1999-07-01 |
Klinge Co Chem Pharm Fab |
Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
|
AU760027B2
(en)
*
|
1998-07-02 |
2003-05-08 |
Merck & Co., Inc. |
Inhibitors of prenyl-protein transferase
|
EP1031564A1
(fr)
|
1999-02-26 |
2000-08-30 |
Klinge Pharma GmbH |
Inhibiteurs de la formation du nicotinamide mononucléotide et leur utilisation dans le traitement du cancer
|
CA2429720C
(fr)
*
|
2000-11-29 |
2009-12-29 |
Schering Corporation |
Composes tricycliques servant a inhiber la farnesyl proteine transferase
|
EP1443936A4
(fr)
|
2001-11-13 |
2006-01-11 |
Bristol Myers Squibb Co |
Procede de preparation de composes de 3,7-disubstitue-2,3,4,5- tetrahydro-1h-1,4-benzodiazepine
|
EP1542986B1
(fr)
*
|
2002-09-24 |
2007-01-24 |
Morepen Laboratories Ltd. |
Procede pour la production de desloratadine
|
US7417026B2
(en)
|
2003-08-13 |
2008-08-26 |
Children's Hospital Medical Center |
Mobilization of hematopoietic cells
|
EP1888050B1
(fr)
|
2005-05-17 |
2012-03-21 |
Merck Sharp & Dohme Ltd. |
Acide cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl) cyclohexanepropanoique pour le traitement du cancer
|
GB0603041D0
(en)
|
2006-02-15 |
2006-03-29 |
Angeletti P Ist Richerche Bio |
Therapeutic compounds
|
MX2008013427A
(es)
|
2006-04-19 |
2008-11-04 |
Novartis Ag |
Compuestos de benzoxazole y benzotiazole sustituidos-6-0 y metodos para inhibir la señalizacion csf-1r.
|
WO2008039327A2
(fr)
|
2006-09-22 |
2008-04-03 |
Merck & Co., Inc. |
Procédé de traitement utilisant des inhibiteurs de synthèse d'acide gras
|
US20110218176A1
(en)
|
2006-11-01 |
2011-09-08 |
Barbara Brooke Jennings-Spring |
Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
|
MX2009007200A
(es)
|
2007-01-10 |
2009-07-15 |
Angeletti P Ist Richerche Bio |
Indazoles sustituidos con amida como inhibidores de poli(adp-ribosa)polimerasa (parp).
|
EP2132177B1
(fr)
|
2007-03-01 |
2013-07-17 |
Novartis AG |
Inhibiteurs de pim kinase et procédés de leur utilisation
|
EP2152700B1
(fr)
|
2007-05-21 |
2013-12-11 |
Novartis AG |
Inhibiteurs du csf-1r, compositions et procédés d'utilisation
|
AU2008269154B2
(en)
|
2007-06-27 |
2014-06-12 |
Merck Sharp & Dohme Llc |
4-carboxybenzylamino derivatives as histone deacetylase inhibitors
|
WO2010114780A1
(fr)
|
2009-04-01 |
2010-10-07 |
Merck Sharp & Dohme Corp. |
Inhibiteurs de l'activité akt
|
JP6073677B2
(ja)
|
2009-06-12 |
2017-02-01 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
縮合複素環式化合物およびそれらの使用
|
EA023838B1
(ru)
|
2009-10-14 |
2016-07-29 |
Мерк Шарп Энд Домэ Корп. |
ЗАМЕЩЕННЫЕ ПИПЕРИДИНЫ, КОТОРЫЕ ПОВЫШАЮТ АКТИВНОСТЬ p53, И ИХ ПРИМЕНЕНИЕ
|
US9180127B2
(en)
|
2009-12-29 |
2015-11-10 |
Dana-Farber Cancer Institute, Inc. |
Type II Raf kinase inhibitors
|
CA2791613A1
(fr)
|
2010-03-16 |
2011-09-22 |
Dana-Farber Cancer Institute, Inc. |
Composes d'indazole et leurs utilisations
|
EP2584903B1
(fr)
|
2010-06-24 |
2018-10-24 |
Merck Sharp & Dohme Corp. |
Nouveaux composés hétérocycliques utilisés comme inhibiteurs de erk
|
WO2012018754A2
(fr)
|
2010-08-02 |
2012-02-09 |
Merck Sharp & Dohme Corp. |
Inhibition à médiation par interférence arn de caténine (protéine associée à cadhérine), expression du gène bêta 1 (ctnnb1) à l'aide de petit acide nucléique interférent (sian)
|
CA2807307C
(fr)
|
2010-08-17 |
2021-02-09 |
Merck Sharp & Dohme Corp. |
Inhibition mediee par des arn interferents de l'expression genique du virus de l'hepatite b (vhb) a l'aide de petits acides nucleiques interferents (pani)
|
EP2608669B1
(fr)
|
2010-08-23 |
2016-06-22 |
Merck Sharp & Dohme Corp. |
Nouveaux dérivés de pyrazolo[1,5-a]pyrimidine utilisés comme inhibiteurs de mtor
|
US8946216B2
(en)
|
2010-09-01 |
2015-02-03 |
Merck Sharp & Dohme Corp. |
Indazole derivatives useful as ERK inhibitors
|
EP2615916B1
(fr)
|
2010-09-16 |
2017-01-04 |
Merck Sharp & Dohme Corp. |
Dérivés condensés de pyrazole utilisés comme nouveaux inhibiteurs erk
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
EP2654748B1
(fr)
|
2010-12-21 |
2016-07-27 |
Merck Sharp & Dohme Corp. |
Dérivés d'indazole utiles en tant qu'inhibiteurs de erk
|
AU2012245971A1
(en)
|
2011-04-21 |
2013-10-17 |
Piramal Enterprises Limited |
A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
|
US9023865B2
(en)
|
2011-10-27 |
2015-05-05 |
Merck Sharp & Dohme Corp. |
Compounds that are ERK inhibitors
|
AU2012340200B2
(en)
|
2011-11-17 |
2017-10-12 |
Dana-Farber Cancer Institute, Inc. |
Inhibitors of c-Jun-N-Terminal Kinase (JNK)
|
EP3453762B1
(fr)
|
2012-05-02 |
2021-04-21 |
Sirna Therapeutics, Inc. |
Compositions d'acide nucléique interférent court (sina)
|
JP6280554B2
(ja)
|
2012-09-28 |
2018-02-14 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
Erk阻害剤である新規化合物
|
WO2014063068A1
(fr)
|
2012-10-18 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de cycline-dépendante kinase 7 (cdk7)
|
WO2014063061A1
(fr)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Petites molécules marquées de façon hydrophobe en tant qu'inducteurs de la dégradation de protéine
|
WO2014063054A1
(fr)
|
2012-10-19 |
2014-04-24 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de kinase moelle osseuse sur chromosome x (bmx) et leurs utilisations
|
CN102924430B
(zh)
*
|
2012-10-31 |
2014-10-15 |
天津药物研究院 |
地氯雷他定衍生物及其制备方法和用途
|
ME02925B
(fr)
|
2012-11-28 |
2018-04-20 |
Merck Sharp & Dohme |
Compositions et procédés pour traiter le cancer
|
TW201429969A
(zh)
|
2012-12-20 |
2014-08-01 |
Merck Sharp & Dohme |
作爲hdm2抑制劑之經取代咪唑吡啶
|
EP2951180B1
(fr)
|
2013-01-30 |
2018-05-02 |
Merck Sharp & Dohme Corp. |
Purines 2,6,7,8-substituées utilisées en tant qu'inhibiteurs de hdm2
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
JP6491202B2
(ja)
|
2013-10-18 |
2019-03-27 |
デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド |
サイクリン依存性キナーゼ7(cdk7)の多環阻害剤
|
ES2676734T3
(es)
|
2013-10-18 |
2018-07-24 |
Syros Pharmaceuticals, Inc. |
Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas
|
WO2015164604A1
(fr)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de janus kinase marqués de manière hydrophobe et utilisations associées
|
WO2015164614A1
(fr)
|
2014-04-23 |
2015-10-29 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de janus kinase et leurs utilisations
|
JO3589B1
(ar)
|
2014-08-06 |
2020-07-05 |
Novartis Ag |
مثبطات كيناز البروتين c وطرق استخداماتها
|
EP3236959A4
(fr)
|
2014-12-23 |
2018-04-25 |
Dana Farber Cancer Institute, Inc. |
Inhibiteurs de la kinase cycline-dépendante 7 (cdk7)
|
CA2978518C
(fr)
|
2015-03-27 |
2023-11-21 |
Nathanael S. Gray |
Inhibiteurs de kinases cycline-dependantes
|
AU2016276963C1
(en)
|
2015-06-12 |
2021-08-05 |
Dana-Farber Cancer Institute, Inc. |
Combination therapy of transcription inhibitors and kinase inhibitors
|
CA2996978A1
(fr)
|
2015-09-09 |
2017-03-16 |
Dana-Farber Cancer Institute, Inc. |
Inhibiteurs de kinases cycline-dependantes
|
JOP20190055A1
(ar)
|
2016-09-26 |
2019-03-24 |
Merck Sharp & Dohme |
أجسام مضادة ضد cd27
|
EP3609922A2
(fr)
|
2017-04-13 |
2020-02-19 |
Aduro Biotech Holdings, Europe B.V. |
Anticorps anti-sirp alpha
|
WO2019094311A1
(fr)
|
2017-11-08 |
2019-05-16 |
Merck Sharp & Dohme Corp. |
Inhibiteurs de prmt5
|
WO2019148412A1
(fr)
|
2018-02-01 |
2019-08-08 |
Merck Sharp & Dohme Corp. |
Anticorps bispécifiques anti-pd-1/lag3
|
US11993602B2
(en)
|
2018-08-07 |
2024-05-28 |
Merck Sharp & Dohme Llc |
PRMT5 inhibitors
|
EP3833667B1
(fr)
|
2018-08-07 |
2024-03-13 |
Merck Sharp & Dohme LLC |
Inhibiteurs de prmt5
|