ZA942092B - Unsaturated phosphonate derivatives of purines and pyrimidines - Google Patents
Unsaturated phosphonate derivatives of purines and pyrimidinesInfo
- Publication number
- ZA942092B ZA942092B ZA942092A ZA942092A ZA942092B ZA 942092 B ZA942092 B ZA 942092B ZA 942092 A ZA942092 A ZA 942092A ZA 942092 A ZA942092 A ZA 942092A ZA 942092 B ZA942092 B ZA 942092B
- Authority
- ZA
- South Africa
- Prior art keywords
- pyrimidines
- purines
- phosphonate derivatives
- unsaturated phosphonate
- antiviral agents
- Prior art date
Links
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 title abstract 2
- 150000003212 purines Chemical class 0.000 title abstract 2
- 150000003230 pyrimidines Chemical class 0.000 title abstract 2
- 239000003443 antiviral agent Substances 0.000 abstract 2
- 241000450599 DNA viruses Species 0.000 abstract 1
- 241000700605 Viruses Species 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000005740 tumor formation Effects 0.000 abstract 1
- 241001430294 unidentified retrovirus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dental Preparations (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93400842A EP0618214A1 (en) | 1993-04-01 | 1993-04-01 | Unsaturated phosphonate derivatives of purines and pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA942092B true ZA942092B (en) | 1994-10-24 |
Family
ID=8214695
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA942092A ZA942092B (en) | 1993-04-01 | 1994-03-24 | Unsaturated phosphonate derivatives of purines and pyrimidines |
Country Status (17)
| Country | Link |
|---|---|
| EP (2) | EP0618214A1 (ja) |
| JP (1) | JPH08508481A (ja) |
| CN (2) | CN1046288C (ja) |
| AT (1) | ATE154605T1 (ja) |
| AU (1) | AU681395B2 (ja) |
| CA (1) | CA2159451C (ja) |
| DE (1) | DE69403910T2 (ja) |
| DK (1) | DK0701562T3 (ja) |
| ES (1) | ES2105684T3 (ja) |
| FI (1) | FI113539B (ja) |
| GR (1) | GR3024788T3 (ja) |
| HU (1) | HUT72459A (ja) |
| IL (1) | IL109152A0 (ja) |
| NO (1) | NO953878L (ja) |
| NZ (1) | NZ263904A (ja) |
| WO (1) | WO1994022882A1 (ja) |
| ZA (1) | ZA942092B (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5977061A (en) * | 1995-04-21 | 1999-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | N6 - substituted nucleotide analagues and their use |
| TW369536B (en) * | 1996-01-18 | 1999-09-11 | Mitsubishi Chem Corp | Phosphonate nucleotide compounds |
| FR2781229B1 (fr) * | 1998-07-17 | 2001-11-30 | Univ Nice Sophia Antipolis | Nouveaux composes analogues des nucleotides, leurs procedes de preparation et leurs applications |
| GB9821058D0 (en) | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| IL159494A0 (en) * | 2001-06-29 | 2004-06-01 | Acad Of Science Czech Republic | 6-2'-(phosphonomethoxy) alkoxy pyrimidine derivatives having antiviral activity |
| JP2005508924A (ja) * | 2001-08-30 | 2005-04-07 | 三菱ウェルファーマ株式会社 | 抗ウイルス剤 |
| CA2527805C (en) | 2003-06-16 | 2012-08-21 | Institute Of Organic Chemistry And Biochemistry, Academy Of Sciences Of The Czech Republic | Pyrimidine compounds having phosphonate groups as antiviral nucleotide analogs |
| US20060252729A1 (en) | 2003-07-30 | 2006-11-09 | Krawczyk Steven H | Nucleobase phosphonate analogs for antiviral treatment |
| JP5242375B2 (ja) * | 2005-04-01 | 2013-07-24 | ザ レゲントス オブ ザ ユニバーシティ オブ カリフォルニア | ホスホノ−ペント−２−エン−１−イルヌクレオシド及び類似体 |
| AU2006239677A1 (en) * | 2005-04-25 | 2006-11-02 | Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic | Use of compounds to enhance processivity of telomerase |
| CN100352823C (zh) * | 2005-08-19 | 2007-12-05 | 浙江车头制药有限公司 | 一种腺嘌呤衍生物的制备方法 |
| US8324179B2 (en) | 2007-02-09 | 2012-12-04 | Gilead Sciences, Inc. | Nucleoside analogs for antiviral treatment |
| TWI444384B (zh) | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
| DK2794624T3 (da) | 2011-12-22 | 2019-07-22 | Geron Corp | Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde |
| JP6946353B2 (ja) | 2016-02-18 | 2021-10-06 | インバーサ， インコーポレイテッド | ５′−アデノシン二リン酸リボース（ａｄｐｒ）の使用方法 |
| ES2949441T3 (es) | 2018-03-27 | 2023-09-28 | Invirsa Inc | Métodos para el uso de 5'-adenosina difosfato ribosa (ADPR) |
| CN108383872B (zh) * | 2018-04-18 | 2019-07-12 | 南京师范大学 | 一种-1,1-二氟-3-磺酰基-2,4-戊二烯膦酸酯类化合物及其合成方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2017054C (en) * | 1990-05-16 | 1999-08-10 | Jack S. Wilson | Automatic storage and retrieval system |
| JPH05509307A (ja) * | 1990-07-19 | 1993-12-22 | ビーチャム・グループ・パブリック・リミテッド・カンパニー | プリンの抗ウイルス性ホスホノ―アルケン誘導体 |
| EP0531597A1 (en) * | 1991-09-12 | 1993-03-17 | Merrell Dow Pharmaceuticals Inc. | Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine |
| CZ287745B6 (cs) * | 1991-10-11 | 2001-01-17 | Ústav organické chemie a biochemie AV ČR | Acyklické fosfonomethoxyalkylsubstituované alkenylové a alkinylové deriváty purinu a pyrimidinu |
-
1993
- 1993-04-01 EP EP93400842A patent/EP0618214A1/en not_active Withdrawn
-
1994
- 1994-02-25 DK DK94912742.7T patent/DK0701562T3/da active
- 1994-02-25 DE DE69403910T patent/DE69403910T2/de not_active Expired - Fee Related
- 1994-02-25 NZ NZ263904A patent/NZ263904A/en unknown
- 1994-02-25 AU AU65162/94A patent/AU681395B2/en not_active Ceased
- 1994-02-25 EP EP94912742A patent/EP0701562B1/en not_active Expired - Lifetime
- 1994-02-25 AT AT94912742T patent/ATE154605T1/de not_active IP Right Cessation
- 1994-02-25 CN CN94191641A patent/CN1046288C/zh not_active Expired - Fee Related
- 1994-02-25 ES ES94912742T patent/ES2105684T3/es not_active Expired - Lifetime
- 1994-02-25 WO PCT/US1994/001837 patent/WO1994022882A1/en active IP Right Grant
- 1994-02-25 JP JP6522053A patent/JPH08508481A/ja not_active Ceased
- 1994-02-25 HU HU9502854A patent/HUT72459A/hu unknown
- 1994-02-25 CA CA002159451A patent/CA2159451C/en not_active Expired - Fee Related
- 1994-03-24 ZA ZA942092A patent/ZA942092B/xx unknown
- 1994-03-29 IL IL10915294A patent/IL109152A0/xx unknown
-
1995
- 1995-09-28 FI FI954615A patent/FI113539B/fi not_active IP Right Cessation
- 1995-09-29 NO NO953878A patent/NO953878L/no unknown
-
1997
- 1997-09-17 GR GR970402412T patent/GR3024788T3/el unknown
-
1999
- 1999-01-07 CN CN99101008A patent/CN1229084A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69403910T2 (de) | 1998-01-29 |
| HUT72459A (en) | 1996-04-29 |
| EP0701562A1 (en) | 1996-03-20 |
| DK0701562T3 (da) | 1997-07-07 |
| HU9502854D0 (en) | 1995-11-28 |
| EP0618214A1 (en) | 1994-10-05 |
| EP0701562B1 (en) | 1997-06-18 |
| CA2159451C (en) | 1999-04-13 |
| NZ263904A (en) | 1996-11-26 |
| AU681395B2 (en) | 1997-08-28 |
| JPH08508481A (ja) | 1996-09-10 |
| CN1120338A (zh) | 1996-04-10 |
| CA2159451A1 (en) | 1994-10-13 |
| NO953878D0 (no) | 1995-09-29 |
| FI113539B (fi) | 2004-05-14 |
| AU6516294A (en) | 1994-10-24 |
| CN1229084A (zh) | 1999-09-22 |
| CN1046288C (zh) | 1999-11-10 |
| NO953878L (no) | 1995-12-01 |
| ATE154605T1 (de) | 1997-07-15 |
| IL109152A0 (en) | 1994-06-24 |
| FI954615A0 (fi) | 1995-09-28 |
| WO1994022882A1 (en) | 1994-10-13 |
| ES2105684T3 (es) | 1997-10-16 |
| FI954615A (fi) | 1995-09-28 |
| GR3024788T3 (en) | 1998-01-30 |
| DE69403910D1 (de) | 1997-07-24 |
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