DE69403910D1 - Ungesättigte phosphonat-derivate von purinen und pyrimidinen - Google Patents

Ungesättigte phosphonat-derivate von purinen und pyrimidinen

Info

Publication number
DE69403910D1
DE69403910D1 DE69403910T DE69403910T DE69403910D1 DE 69403910 D1 DE69403910 D1 DE 69403910D1 DE 69403910 T DE69403910 T DE 69403910T DE 69403910 T DE69403910 T DE 69403910T DE 69403910 D1 DE69403910 D1 DE 69403910D1
Authority
DE
Germany
Prior art keywords
purines
pyrimidins
phosphonate derivatives
unsaturated phosphonate
antiviral agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69403910T
Other languages
English (en)
Other versions
DE69403910T2 (de
Inventor
Patrick Casara
Jean-Francoise Nave
Serge Halazy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69403910D1 publication Critical patent/DE69403910D1/de
Application granted granted Critical
Publication of DE69403910T2 publication Critical patent/DE69403910T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Preparations (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Saccharide Compounds (AREA)
DE69403910T 1993-04-01 1994-02-25 Ungesättigte phosphonat-derivate von purinen und pyrimidinen Expired - Fee Related DE69403910T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93400842A EP0618214A1 (de) 1993-04-01 1993-04-01 Ungesättigte Phosphonatderivate Purinen und Pyrimidinen
PCT/US1994/001837 WO1994022882A1 (en) 1993-04-01 1994-02-25 Unsaturated phosphonates derivatives of purines and pyrimidines

Publications (2)

Publication Number Publication Date
DE69403910D1 true DE69403910D1 (de) 1997-07-24
DE69403910T2 DE69403910T2 (de) 1998-01-29

Family

ID=8214695

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69403910T Expired - Fee Related DE69403910T2 (de) 1993-04-01 1994-02-25 Ungesättigte phosphonat-derivate von purinen und pyrimidinen

Country Status (17)

Country Link
EP (2) EP0618214A1 (de)
JP (1) JPH08508481A (de)
CN (2) CN1046288C (de)
AT (1) ATE154605T1 (de)
AU (1) AU681395B2 (de)
CA (1) CA2159451C (de)
DE (1) DE69403910T2 (de)
DK (1) DK0701562T3 (de)
ES (1) ES2105684T3 (de)
FI (1) FI113539B (de)
GR (1) GR3024788T3 (de)
HU (1) HUT72459A (de)
IL (1) IL109152A0 (de)
NO (1) NO953878L (de)
NZ (1) NZ263904A (de)
WO (1) WO1994022882A1 (de)
ZA (1) ZA942092B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977061A (en) * 1995-04-21 1999-11-02 Institute Of Organic Chemistry And Biochemistry Of The Academy Of Sciences Of The Czech Republic N6 - substituted nucleotide analagues and their use
TW369536B (en) * 1996-01-18 1999-09-11 Mitsubishi Chem Corp Phosphonate nucleotide compounds
FR2781229B1 (fr) * 1998-07-17 2001-11-30 Univ Nice Sophia Antipolis Nouveaux composes analogues des nucleotides, leurs procedes de preparation et leurs applications
GB9821058D0 (en) 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
KR100891366B1 (ko) 2001-06-29 2009-04-02 인스티튜트 오브 오르가닉 케미스트리 앤드 바이오케미스트리, 어케더미 오브 사이언시스 오브 더 체크 리퍼블릭 항 바이러스 활성을 갖는 6-'2-(포스포노메톡시)알콕시 피리미딘 유도체
JP2005508924A (ja) * 2001-08-30 2005-04-07 三菱ウェルファーマ株式会社 抗ウイルス剤
DK1644389T3 (da) 2003-06-16 2011-05-09 Acad Of Science Czech Republic Pyrinidinforbindelser med phosphonatgrupper som antivirale nukleotidanaloger
US7579332B2 (en) 2003-07-30 2009-08-25 Gilead Sciences, Inc. Nucleobase phosphonate analogs for antiviral treatment
EP1866319B1 (de) * 2005-04-01 2011-11-23 The Regents of The University of California Phosphono-pent-2-en-1-yl-nukleoside und analoga
WO2006114064A2 (en) * 2005-04-25 2006-11-02 Institute Of Organic Chemistry And Biochemistry Ofthe Academy Of Sciences Of The Czech Republic Use of compounds to enhance processivity of telomerase
CN100352823C (zh) * 2005-08-19 2007-12-05 浙江车头制药有限公司 一种腺嘌呤衍生物的制备方法
WO2008100447A2 (en) 2007-02-09 2008-08-21 Gilead Sciences, Inc. Nucleoside analogs for antiviral treatment
TWI444384B (zh) 2008-02-20 2014-07-11 Gilead Sciences Inc 核苷酸類似物及其在治療惡性腫瘤上的用途
DK2794624T3 (da) 2011-12-22 2019-07-22 Geron Corp Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
CN117482102A (zh) 2016-02-18 2024-02-02 伊维萨股份有限公司 使用5′-腺苷二磷酸核糖(adpr)的方法
WO2019191026A2 (en) 2018-03-27 2019-10-03 Invirsa, Inc. Methods for the use of 5'-adenosine diphosphate ribose (adpr)
CN108383872B (zh) * 2018-04-18 2019-07-12 南京师范大学 一种-1,1-二氟-3-磺酰基-2,4-戊二烯膦酸酯类化合物及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2017054C (en) * 1990-05-16 1999-08-10 Jack S. Wilson Automatic storage and retrieval system
HU9300132D0 (en) * 1990-07-19 1993-04-28 Beecham Group Plc Method for producing phosphono-alkene-purine derivatives and medical preparatives of anti-viral effect containing them
EP0531597A1 (de) * 1991-09-12 1993-03-17 Merrell Dow Pharmaceuticals Inc. Ungesättigte azyklische Phosphonsäure Purinderivats und Pyrimidinderivate
KR0184530B1 (ko) * 1991-10-11 1999-05-15 카렐 마르티넥 항비루스 비고리 포스포노메톡시알킬치환, 알켄일 및 알킨일 퓨린 및 피리미딘 유도체

Also Published As

Publication number Publication date
CA2159451C (en) 1999-04-13
WO1994022882A1 (en) 1994-10-13
GR3024788T3 (en) 1998-01-30
IL109152A0 (en) 1994-06-24
FI113539B (fi) 2004-05-14
EP0618214A1 (de) 1994-10-05
CN1229084A (zh) 1999-09-22
ES2105684T3 (es) 1997-10-16
DK0701562T3 (da) 1997-07-07
ZA942092B (en) 1994-10-24
EP0701562A1 (de) 1996-03-20
CA2159451A1 (en) 1994-10-13
FI954615A0 (fi) 1995-09-28
JPH08508481A (ja) 1996-09-10
NZ263904A (en) 1996-11-26
CN1120338A (zh) 1996-04-10
AU6516294A (en) 1994-10-24
ATE154605T1 (de) 1997-07-15
HU9502854D0 (en) 1995-11-28
CN1046288C (zh) 1999-11-10
DE69403910T2 (de) 1998-01-29
NO953878D0 (no) 1995-09-29
AU681395B2 (en) 1997-08-28
HUT72459A (en) 1996-04-29
FI954615A (fi) 1995-09-28
NO953878L (no) 1995-12-01
EP0701562B1 (de) 1997-06-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee