ZA931776B - Substituted pipecolinic acid derivatives as HIV protease inhibitors. - Google Patents
Substituted pipecolinic acid derivatives as HIV protease inhibitors.Info
- Publication number
- ZA931776B ZA931776B ZA931776A ZA931776A ZA931776B ZA 931776 B ZA931776 B ZA 931776B ZA 931776 A ZA931776 A ZA 931776A ZA 931776 A ZA931776 A ZA 931776A ZA 931776 B ZA931776 B ZA 931776B
- Authority
- ZA
- South Africa
- Prior art keywords
- acid derivatives
- protease inhibitors
- hiv protease
- pipecolinic acid
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85071692A | 1992-03-13 | 1992-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA931776B true ZA931776B (en) | 1993-09-24 |
Family
ID=25308925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA931776A ZA931776B (en) | 1992-03-13 | 1993-03-12 | Substituted pipecolinic acid derivatives as HIV protease inhibitors. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5807870A (de) |
| EP (1) | EP0560268B1 (de) |
| JP (1) | JP3258422B2 (de) |
| KR (1) | KR950700253A (de) |
| AP (1) | AP393A (de) |
| AT (1) | ATE116640T1 (de) |
| AU (1) | AU670582B2 (de) |
| CA (1) | CA2131185C (de) |
| CZ (1) | CZ285589B6 (de) |
| DE (1) | DE69300043T2 (de) |
| DK (1) | DK0560268T3 (de) |
| ES (1) | ES2066623T3 (de) |
| FI (1) | FI944217A (de) |
| GR (1) | GR3015622T3 (de) |
| HU (2) | HUT70617A (de) |
| IL (1) | IL105035A (de) |
| NO (1) | NO302570B1 (de) |
| NZ (1) | NZ251267A (de) |
| OA (1) | OA10092A (de) |
| PH (1) | PH30734A (de) |
| PL (1) | PL176362B1 (de) |
| RU (1) | RU2140911C1 (de) |
| SK (1) | SK280161B6 (de) |
| WO (1) | WO1993018003A1 (de) |
| ZA (1) | ZA931776B (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69333270T2 (de) | 1992-03-11 | 2004-08-05 | Narhex Ltd. | Aminderivate von oxo- und hydroxy- substituierten kohlenwasserstoffen |
| NZ249789A (en) | 1992-03-11 | 1997-07-27 | Narhex Ltd | Hydrazine, carbazate and 1,2-diazacyclic derivatives and pharmaceutical compositions |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
| KR100336699B1 (ko) | 1992-08-25 | 2002-05-13 | 윌리암스 로저 에이 | 레트로바이러스 프로테아제 저해제로서 유용한히드록시에틸아미노 술폰아미드 |
| US5846993A (en) * | 1992-12-22 | 1998-12-08 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US5484926A (en) * | 1993-10-07 | 1996-01-16 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| EP0610745A3 (en) * | 1993-02-09 | 1994-09-28 | Miles Inc | Novel aminomethylene derivatives as immunosuppressants. |
| IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
| US5527829A (en) * | 1994-05-23 | 1996-06-18 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| CA2137406C (en) * | 1994-12-06 | 2005-09-13 | Pierre Louis Beaulieu | Process for key intermediates for hiv protease inhibitors |
| US6037157A (en) | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
| US5914332A (en) | 1995-12-13 | 1999-06-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
| US5925759A (en) | 1996-09-05 | 1999-07-20 | Agouron Pharmaceuticals, Inc. | Methods of making HIV-protease inhibitors and intermediates for making HIV-protease inhibitors |
| US5962725A (en) * | 1996-09-05 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Intermediate compounds useful for making HIV protease inhibitors such as nelfinavir |
| US5705647A (en) * | 1996-09-05 | 1998-01-06 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US6232333B1 (en) | 1996-11-21 | 2001-05-15 | Abbott Laboratories | Pharmaceutical composition |
| US6001851A (en) * | 1997-03-13 | 1999-12-14 | Agouron Pharmaceuticals, Inc. | HIV protease inhibitors |
| US6084107A (en) * | 1997-09-05 | 2000-07-04 | Agouron Pharmaceuticals, Inc. | Intermediates for making HIV-protease inhibitors |
| US6251906B1 (en) | 1998-05-15 | 2001-06-26 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| DE60038899D1 (de) | 2000-01-19 | 2008-06-26 | Abbott Lab | Hiv-proteasehemmern |
| US6992081B2 (en) | 2000-03-23 | 2006-01-31 | Elan Pharmaceuticals, Inc. | Compounds to treat Alzheimer's disease |
| WO2001070672A2 (en) * | 2000-03-23 | 2001-09-27 | Elan Pharmaceuticals, Inc. | Compounds and methods to treat alzheimer's disease |
| US20030096864A1 (en) * | 2000-06-30 | 2003-05-22 | Fang Lawrence Y. | Compounds to treat alzheimer's disease |
| PE20020276A1 (es) | 2000-06-30 | 2002-04-06 | Elan Pharm Inc | COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| ATE314343T1 (de) * | 2000-06-30 | 2006-01-15 | Elan Pharm Inc | Verbindungen zur behandlung der alzheimerischen krankheit |
| EP1666452A2 (de) | 2000-06-30 | 2006-06-07 | Elan Pharmaceuticals, Inc. | Verbindungen zur Behandlung der Alzheimerischen Krankheit |
| MXPA04000140A (es) * | 2001-06-27 | 2004-06-03 | Elan Pharm Inc | Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer. |
| US20070213407A1 (en) * | 2001-06-29 | 2007-09-13 | Elan Pharmaceuticals And Pharmacia & Upjohn Company Llc | Compounds to treat Alzheimer's disease |
| US7662852B2 (en) | 2003-05-22 | 2010-02-16 | Lead Chemical Co., Ltd. | Compounds and preparations having antiviral effect |
| CN101006051B (zh) * | 2004-06-10 | 2014-09-10 | 密歇根州州立大学托管理事会 | 由赖氨酸合成己内酰胺 |
| EP1910317B1 (de) * | 2005-07-20 | 2013-07-03 | Eli Lilly And Company | 1-amino-verbundene verbindungen |
| BRPI0804506A2 (pt) * | 2007-02-20 | 2011-08-30 | Univ Michigan State | processos para preparar caprolactama ou um derivado da mesma e ácido pipecolìnico, caprolactama ou um derivado da mesma, e, ácido pipecolìnico ou um derivado do mesmo |
| JP5448854B2 (ja) | 2007-03-12 | 2014-03-19 | ウェルズ ファーゴ バンク ナショナル アソシエイション | オリゴマー−プロテアーゼ阻害剤複合体 |
| US9095620B2 (en) | 2008-03-12 | 2015-08-04 | Nektar Therapeutics | Reagents |
| WO2010011967A1 (en) * | 2008-07-24 | 2010-01-28 | Draths Corporation | Methods of making cyclic amide monomers, and related derivatives and methods |
| US20120108501A1 (en) | 2009-06-12 | 2012-05-03 | Nektar Therapeutics | Protease Inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0264106B1 (de) * | 1986-10-14 | 1994-03-16 | Banyu Pharmaceutical Co., Ltd. | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung |
| CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| GB8927915D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Novel alcohols |
| GB8927913D0 (en) * | 1989-12-11 | 1990-02-14 | Hoffmann La Roche | Amino acid derivatives |
| MY110227A (en) * | 1991-08-12 | 1998-03-31 | Ciba Geigy Ag | 1-acylpiperindine compounds. |
| ZA931777B (en) * | 1992-03-13 | 1993-09-23 | Bio Mega Boehringer Ingelheim | Substituted pyrrolidine derivatives as HIV protease inhibitors. |
| IL110255A (en) * | 1993-07-16 | 1998-12-06 | Merck & Co Inc | Creation and resolution of 2 tert-butylcarboxamidopiprazine |
| US5480887A (en) * | 1994-02-02 | 1996-01-02 | Eli Lilly And Company | Protease inhibitors |
| GB2292146A (en) * | 1994-08-11 | 1996-02-14 | Merck & Co Inc | HIV protease inhibitors useful for the treatment of AIDS |
-
1993
- 1993-03-09 ES ES93103712T patent/ES2066623T3/es not_active Expired - Lifetime
- 1993-03-09 AT AT93103712T patent/ATE116640T1/de active
- 1993-03-09 EP EP93103712A patent/EP0560268B1/de not_active Expired - Lifetime
- 1993-03-09 DK DK93103712.1T patent/DK0560268T3/da active
- 1993-03-09 DE DE69300043T patent/DE69300043T2/de not_active Expired - Lifetime
- 1993-03-10 AP APAP/P/1993/000495A patent/AP393A/en active
- 1993-03-11 PH PH45862A patent/PH30734A/en unknown
- 1993-03-12 CZ CZ942232A patent/CZ285589B6/cs not_active IP Right Cessation
- 1993-03-12 ZA ZA931776A patent/ZA931776B/xx unknown
- 1993-03-12 IL IL105035A patent/IL105035A/xx not_active IP Right Cessation
- 1993-03-12 NZ NZ251267A patent/NZ251267A/en unknown
- 1993-03-12 AU AU38808/93A patent/AU670582B2/en not_active Ceased
- 1993-03-12 RU RU94040841A patent/RU2140911C1/ru active
- 1993-03-12 SK SK1090-94A patent/SK280161B6/sk unknown
- 1993-03-12 HU HU9402613A patent/HUT70617A/hu unknown
- 1993-03-12 CA CA002131185A patent/CA2131185C/en not_active Expired - Lifetime
- 1993-03-12 PL PL93305166A patent/PL176362B1/pl unknown
- 1993-03-12 WO PCT/CA1993/000096 patent/WO1993018003A1/en active IP Right Grant
- 1993-03-15 JP JP05414293A patent/JP3258422B2/ja not_active Expired - Fee Related
-
1994
- 1994-08-05 OA OA60550A patent/OA10092A/en unknown
- 1994-09-12 NO NO943383A patent/NO302570B1/no unknown
- 1994-09-13 KR KR1019940703190A patent/KR950700253A/ko active IP Right Grant
- 1994-09-13 FI FI944217A patent/FI944217A/fi unknown
-
1995
- 1995-03-27 GR GR950400700T patent/GR3015622T3/el unknown
- 1995-06-23 HU HU95P/P00429P patent/HU211854A9/hu unknown
-
1996
- 1996-12-11 US US08/763,464 patent/US5807870A/en not_active Expired - Lifetime
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