EP0594586A4 - Hiv protease inhibitors - Google Patents
Hiv protease inhibitorsInfo
- Publication number
- EP0594586A4 EP0594586A4 EP9191903689A EP91903689A EP0594586A4 EP 0594586 A4 EP0594586 A4 EP 0594586A4 EP 9191903689 A EP9191903689 A EP 9191903689A EP 91903689 A EP91903689 A EP 91903689A EP 0594586 A4 EP0594586 A4 EP 0594586A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- protease inhibitors
- hiv protease
- hiv
- inhibitors
- protease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US469891 | 1983-02-25 | ||
US46266990A | 1990-01-09 | 1990-01-09 | |
US462669 | 1990-01-09 | ||
US46989190A | 1990-01-23 | 1990-01-23 | |
PCT/US1991/000178 WO1991010442A1 (en) | 1990-01-09 | 1991-01-09 | Hiv protease inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0594586A1 EP0594586A1 (en) | 1994-05-04 |
EP0594586A4 true EP0594586A4 (en) | 1994-08-17 |
Family
ID=27040413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP9191903689A Withdrawn EP0594586A4 (en) | 1990-01-09 | 1991-01-09 | Hiv protease inhibitors |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0594586A4 (en) |
JP (1) | JPH05503703A (en) |
WO (1) | WO1991010442A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2055685A1 (en) * | 1990-11-19 | 1992-05-20 | Samuel L. Graham | Hiv protease inhibitors having polyether substituents |
US5436339A (en) * | 1991-03-06 | 1995-07-25 | Abbott Laboratories | Process for the preparation of a substituted diaminoalcohol |
WO1993005026A1 (en) * | 1991-09-11 | 1993-03-18 | Smithkline Beecham Corporation | Peptide isoters containing a heterocycle as h.i.v. inhibitors |
DE4215874A1 (en) * | 1992-05-14 | 1993-11-18 | Bayer Ag | Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostear type |
US5559256A (en) * | 1992-07-20 | 1996-09-24 | E. R. Squibb & Sons, Inc. | Aminediol protease inhibitors |
ES2068739B1 (en) * | 1993-01-21 | 1995-11-01 | Smithkline Beecham Corp | RETROVIRABLE PROTEASE INHIBITORS. |
IL110898A0 (en) * | 1993-09-10 | 1994-11-28 | Narhex Australia Pty Ltd | Polar-substituted hydrocarbons |
DE69527405T2 (en) * | 1994-10-19 | 2003-03-13 | Novartis Ag | Antiviral ethers of aspartate protease substrate isosteres |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0337714A2 (en) * | 1988-04-12 | 1989-10-18 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
EP0352000A2 (en) * | 1988-07-08 | 1990-01-24 | Smithkline Beecham Corporation | Retroviral protease binding peptides |
EP0386611A2 (en) * | 1989-03-06 | 1990-09-12 | F. Hoffmann-La Roche Ag | Amino acid derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8322414D0 (en) * | 1983-08-19 | 1983-09-21 | Szelke M | Renin inhibitors |
-
1991
- 1991-01-09 WO PCT/US1991/000178 patent/WO1991010442A1/en active Search and Examination
- 1991-01-09 JP JP3503872A patent/JPH05503703A/en active Pending
- 1991-01-09 EP EP9191903689A patent/EP0594586A4/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0337714A2 (en) * | 1988-04-12 | 1989-10-18 | Merck & Co. Inc. | HIV protease inhibitors useful for the treatment of aids |
EP0352000A2 (en) * | 1988-07-08 | 1990-01-24 | Smithkline Beecham Corporation | Retroviral protease binding peptides |
EP0386611A2 (en) * | 1989-03-06 | 1990-09-12 | F. Hoffmann-La Roche Ag | Amino acid derivatives |
Non-Patent Citations (2)
Title |
---|
G.B.DREYER ET AL: "Inhibition of HIV 1 protease in vitro; Rational design of substrate analogue inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 86, December 1989 (1989-12-01), WASHINGTON US, pages 9752 - 9756, XP000151090, DOI: doi:10.1073/pnas.86.24.9752 * |
See also references of WO9110442A1 * |
Also Published As
Publication number | Publication date |
---|---|
JPH05503703A (en) | 1993-06-17 |
WO1991010442A1 (en) | 1991-07-25 |
EP0594586A1 (en) | 1994-05-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA929869B (en) | Hiv protease inhibitors | |
KR100190517B1 (en) | Hiv protease inhibitors | |
AU9122391A (en) | Hiv protease inhibitors | |
HU9302080D0 (en) | Amine-diole protease inhibitors | |
HU912541D0 (en) | Serine protease inhibitors | |
ZA915269B (en) | Retroviral protease inhibitors | |
PH31249A (en) | Inhibitors of hiv protease. | |
PL307858A1 (en) | Sulphonamidic inhibitors of aspartilic hiv protease | |
IL102534A0 (en) | Retroviral protease inhibitors | |
EP0480714A3 (en) | Hiv protease inhibitors having symmetrical structure | |
IL108006A0 (en) | Retroviral protease inhibitors | |
EP0535092A4 (en) | Protease nexin-i variants | |
EP0443559A3 (en) | Hiv protease inhibiting agents | |
EP0691345A3 (en) | HIV protease inhibitor combinations | |
EP0487270A3 (en) | Hiv protease inhibitors having polyether substituents | |
EP0443560A3 (en) | Hiv protease inhibitors | |
ZA914136B (en) | Hiv protease inhibitors and processes for their preparation | |
EP0594586A4 (en) | Hiv protease inhibitors | |
EP0575500A4 (en) | Hiv protease inhibitors | |
ZA928396B (en) | HIV protease inhibitors. | |
GB9318445D0 (en) | Hiv protease in inhibitor compounds | |
ZA919721B (en) | Hiv protease inhibitors | |
SG49247A1 (en) | Hiv protease inhibitors | |
ZA928164B (en) | HIV protease inhibitors. | |
IL100085A0 (en) | Retroviral protease inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19920702 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
RHK1 | Main classification (correction) |
Ipc: C07K 5/02 |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 19940630 |
|
AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 19940922 |