EP0594586A4 - Hiv protease inhibitors - Google Patents

Hiv protease inhibitors

Info

Publication number
EP0594586A4
EP0594586A4 EP9191903689A EP91903689A EP0594586A4 EP 0594586 A4 EP0594586 A4 EP 0594586A4 EP 9191903689 A EP9191903689 A EP 9191903689A EP 91903689 A EP91903689 A EP 91903689A EP 0594586 A4 EP0594586 A4 EP 0594586A4
Authority
EP
European Patent Office
Prior art keywords
protease inhibitors
hiv protease
hiv
inhibitors
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP9191903689A
Other versions
EP0594586A1 (en
Inventor
Geoffrey Bainbridge Dreyer
Thomas Joseph Carr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0594586A1 publication Critical patent/EP0594586A1/en
Publication of EP0594586A4 publication Critical patent/EP0594586A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/021Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02Linear peptides containing at least one abnormal peptide link
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
EP9191903689A 1990-01-09 1991-01-09 Hiv protease inhibitors Withdrawn EP0594586A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US469891 1983-02-25
US46266990A 1990-01-09 1990-01-09
US462669 1990-01-09
US46989190A 1990-01-23 1990-01-23
PCT/US1991/000178 WO1991010442A1 (en) 1990-01-09 1991-01-09 Hiv protease inhibitors

Publications (2)

Publication Number Publication Date
EP0594586A1 EP0594586A1 (en) 1994-05-04
EP0594586A4 true EP0594586A4 (en) 1994-08-17

Family

ID=27040413

Family Applications (1)

Application Number Title Priority Date Filing Date
EP9191903689A Withdrawn EP0594586A4 (en) 1990-01-09 1991-01-09 Hiv protease inhibitors

Country Status (3)

Country Link
EP (1) EP0594586A4 (en)
JP (1) JPH05503703A (en)
WO (1) WO1991010442A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2055685A1 (en) * 1990-11-19 1992-05-20 Samuel L. Graham Hiv protease inhibitors having polyether substituents
US5436339A (en) * 1991-03-06 1995-07-25 Abbott Laboratories Process for the preparation of a substituted diaminoalcohol
WO1993005026A1 (en) * 1991-09-11 1993-03-18 Smithkline Beecham Corporation Peptide isoters containing a heterocycle as h.i.v. inhibitors
DE4215874A1 (en) * 1992-05-14 1993-11-18 Bayer Ag Dithiolanylglycine-containing HIV protease inhibitors of the hydroxyethylene isostear type
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
ES2068739B1 (en) * 1993-01-21 1995-11-01 Smithkline Beecham Corp RETROVIRABLE PROTEASE INHIBITORS.
IL110898A0 (en) * 1993-09-10 1994-11-28 Narhex Australia Pty Ltd Polar-substituted hydrocarbons
DE69527405T2 (en) * 1994-10-19 2003-03-13 Novartis Ag Antiviral ethers of aspartate protease substrate isosteres

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337714A2 (en) * 1988-04-12 1989-10-18 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0352000A2 (en) * 1988-07-08 1990-01-24 Smithkline Beecham Corporation Retroviral protease binding peptides
EP0386611A2 (en) * 1989-03-06 1990-09-12 F. Hoffmann-La Roche Ag Amino acid derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8322414D0 (en) * 1983-08-19 1983-09-21 Szelke M Renin inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0337714A2 (en) * 1988-04-12 1989-10-18 Merck & Co. Inc. HIV protease inhibitors useful for the treatment of aids
EP0352000A2 (en) * 1988-07-08 1990-01-24 Smithkline Beecham Corporation Retroviral protease binding peptides
EP0386611A2 (en) * 1989-03-06 1990-09-12 F. Hoffmann-La Roche Ag Amino acid derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
G.B.DREYER ET AL: "Inhibition of HIV 1 protease in vitro; Rational design of substrate analogue inhibitors", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 86, December 1989 (1989-12-01), WASHINGTON US, pages 9752 - 9756, XP000151090, DOI: doi:10.1073/pnas.86.24.9752 *
See also references of WO9110442A1 *

Also Published As

Publication number Publication date
JPH05503703A (en) 1993-06-17
WO1991010442A1 (en) 1991-07-25
EP0594586A1 (en) 1994-05-04

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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