ZA931645B - Antitumor compositions and methods of treatment - Google Patents

Antitumor compositions and methods of treatment

Info

Publication number
ZA931645B
ZA931645B ZA931645A ZA931645A ZA931645B ZA 931645 B ZA931645 B ZA 931645B ZA 931645 A ZA931645 A ZA 931645A ZA 931645 A ZA931645 A ZA 931645A ZA 931645 B ZA931645 B ZA 931645B
Authority
ZA
South Africa
Prior art keywords
treatment
methods
antitumor compositions
antitumor
compositions
Prior art date
Application number
ZA931645A
Other languages
English (en)
Inventor
Fariborz Mohamadi
Michael Marriott Spees
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ZA931645B publication Critical patent/ZA931645B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
ZA931645A 1992-03-13 1993-03-08 Antitumor compositions and methods of treatment ZA931645B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/850,531 US5169860A (en) 1992-03-13 1992-03-13 Antitumor compositions and methods of treatment

Publications (1)

Publication Number Publication Date
ZA931645B true ZA931645B (en) 1994-09-08

Family

ID=25308394

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA931645A ZA931645B (en) 1992-03-13 1993-03-08 Antitumor compositions and methods of treatment

Country Status (19)

Country Link
US (1) US5169860A (Direct)
EP (1) EP0560554A2 (Direct)
JP (1) JPH0649052A (Direct)
KR (1) KR930019655A (Direct)
CN (1) CN1076447A (Direct)
AU (2) AU662605B2 (Direct)
BR (1) BR9301137A (Direct)
CA (1) CA2091207A1 (Direct)
CZ (1) CZ36893A3 (Direct)
FI (1) FI931085L (Direct)
HU (1) HUT63830A (Direct)
IL (1) IL104981A0 (Direct)
MX (1) MX9301296A (Direct)
MY (1) MY111178A (Direct)
NO (1) NO930891L (Direct)
NZ (1) NZ247083A (Direct)
TW (1) TW215083B (Direct)
YU (1) YU16893A (Direct)
ZA (1) ZA931645B (Direct)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254582A (en) * 1992-02-05 1993-10-19 Eli Lilly And Company Antitumor compositions and methods
US5270329A (en) * 1992-12-10 1993-12-14 Eli Lilly And Company Antitumor compositions and methods of treatment
CA2110524A1 (en) * 1992-12-10 1994-06-11 Gerald Burr Grindey Antitumor compositions and methods of treatment
ZA941500B (en) * 1993-03-10 1995-09-04 Lilly Co Eli Antitumor compositions and methods of treatment
US5529999A (en) * 1994-03-04 1996-06-25 Eli Lilly And Company Antitumor compositions and methods of treatment
CO4410191A1 (es) 1994-09-19 1997-01-09 Lilly Co Eli SINTESIS DE 3-[4-(2-AMINOETOXI)BENZOIL]-2-ARIL-6- HIDROXIBENZO [b] TIOFENOS
US5629425A (en) * 1994-09-19 1997-05-13 Eli Lilly And Company Haloalkyl hemisolvates of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-piperidinoethoxy)-benzoyl]benzo[b]thiophene
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US6008377A (en) * 1996-03-19 1999-12-28 Eli Lilly And Company Synthesis of 3-[4-(2-aminoethoxy)-benzoyl]-2-aryl-6-hydroxy-benzo[B]thiophenes
DE69708340T2 (de) * 1996-08-22 2002-05-16 Dong Wha Pharmaceutical Industrial Co. Ltd., Seoul Arylsulfonylimidazolon-derivate als antitumormittel
EP0929540A4 (en) * 1996-10-04 2001-12-12 Lilly Co Eli ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS
JP2000247949A (ja) * 1999-02-26 2000-09-12 Eisai Co Ltd スルホンアミド含有インドール化合物
ES2156550B1 (es) * 1999-04-19 2002-02-01 Univ Navarra Publica Derivados de benzo(b) tiofenosulfonamida-1,1-dioxido y su uso como agentes antineoplasicos.
JP4505876B2 (ja) * 1999-05-25 2010-07-21 東ソー株式会社 ４−ハロベンゾフラン誘導体及びその製造方法
TWI281916B (en) * 2001-10-25 2007-06-01 Lilly Co Eli Antitumor compounds and methods
US20050119318A1 (en) * 2003-10-31 2005-06-02 Hudyma Thomas W. Inhibitors of HCV replication
AU2008329677B2 (en) 2007-11-28 2015-02-19 Sequoia Pharmaceuticals, Inc. Compositions and methods for inhibiting cytochrome P450 2D6
KR101300702B1 (ko) * 2011-01-20 2013-08-26 대우조선해양 주식회사 탈가스 장치
CN103450149B (zh) * 2012-06-01 2015-10-14 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物及其制备方法和用途
CN104564805B (zh) * 2013-10-29 2017-11-10 海尔集团公司 一种离心风机的扇叶结构、离心风机及嵌入式空调内机
SMT202000192T1 (it) 2015-02-16 2020-05-08 Univ Queensland Solfoniluree e composti correlati e utilizzo degli stessi
MA44729A (fr) 2016-04-18 2021-05-12 Novartis Ag Composés et compositions pour traiter des états associés à une activité de nlrp
EP3661925B1 (en) 2017-07-07 2021-11-24 Inflazome Limited Novel sulfonamide carboxamide compounds
CA3068836A1 (en) 2017-07-24 2019-01-31 Novartis Inflammasome Research, Inc. Compounds and compositions for treating conditions associated with nlrp activity
RU2020110219A (ru) 2017-08-15 2021-09-17 Инфлазоум Лимитед Сульфонилмочевины и сульфонилтиомочевины в качестве ингибиторов nlrp3
WO2019034692A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
EP3668843A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors
BR112020008981A2 (pt) 2017-11-09 2020-11-17 Inflazome Limited novos compostos de sulfonamida carboxamida
US12221434B2 (en) 2017-11-09 2025-02-11 Inflazome Limited Sulfonamide carboxamide compounds
US11905252B2 (en) 2018-03-02 2024-02-20 Inflazome Limited Compounds
JP2022505525A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Ｎｌｒｐ活性に関連する状態を治療するための化合物及び組成物
CN109384764B (zh) * 2018-12-12 2021-09-03 中国科学院上海有机化学研究所 苯基噻吩磺酰胺类化合物、药物组合物、其制备方法和应用
WO2022022646A1 (zh) * 2020-07-29 2022-02-03 南京明德新药研发有限公司 含硒五元杂芳环化合物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3083207A (en) * 1963-03-26 Indolinesulfonylureas
DE1144259B (de) * 1956-05-29 1963-02-28 Hoechst Ag Verfahren zur Herstellung von Sulfonylharnstoffen
US3097242A (en) * 1960-06-29 1963-07-09 Olin Mathieson Hydrindene sulfonylureas
DE1240866B (de) * 1961-06-29 1967-05-24 Heyden Chem Fab Verfahren zur Herstellung von Indolin-6-sulfonylharnstoffen
US3102121A (en) * 1961-06-29 1963-08-27 Olin Mathieson Novel cumaransulfonylureas and 2,3-dihydrothionaphthenesulfonylureas
GB1050447A (Direct) * 1962-04-11
US3849110A (en) * 1963-01-07 1974-11-19 Lilly Co Eli Herbicidal method employing aryl-sulfonylureas or salts thereof
US3736122A (en) * 1969-04-10 1973-05-29 C Tung Method of controlling plant growth
IL69621A0 (en) * 1982-09-02 1983-12-30 Duphar Int Res Pharmaceutical compositions having antitumor activity,comprising certain phenylurea derivatives
CA1208561A (en) * 1984-01-19 1986-07-29 Marius S. Brouwer Pharmaceutical compositions containing benzoylurea compounds
US4845128A (en) * 1984-06-27 1989-07-04 Eli Lilly And Company N([(4-trifluoromethylphenyl)amino]carbonyl)benzene sulfonamides
IL80032A (en) * 1985-09-23 1992-07-15 Lilly Co Eli Anti-tumor phenyl-aminocarbonylsulfonamides,their preparation and pharmaceutical compositions containing them
CA1331464C (en) * 1987-05-12 1994-08-16 Eli Lilly And Company Anti-tumor method and compounds
NZ238911A (en) * 1990-07-17 1993-10-26 Lilly Co Eli Furyl, pyrrolyl and thienyl sulphonyl urea derivatives, pharmaceutical compositions and intermediates therefor

Also Published As

Publication number Publication date
CZ36893A3 (en) 1994-04-13
JPH0649052A (ja) 1994-02-22
AU3519893A (en) 1993-09-16
MX9301296A (es) 1993-10-01
NO930891L (no) 1993-09-14
YU16893A (sh) 1996-07-24
CN1076447A (zh) 1993-09-22
FI931085A0 (fi) 1993-03-11
CA2091207A1 (en) 1993-09-14
HUT63830A (en) 1993-10-28
NZ247083A (en) 1995-09-26
NO930891D0 (no) 1993-03-11
IL104981A0 (en) 1993-07-08
EP0560554A2 (en) 1993-09-15
AU662605B2 (en) 1995-09-07
BR9301137A (pt) 1993-09-28
EP0560554A3 (Direct) 1994-01-19
HU9300688D0 (en) 1993-05-28
FI931085A7 (fi) 1993-09-14
KR930019655A (ko) 1993-10-18
US5169860A (en) 1992-12-08
TW215083B (Direct) 1993-10-21
FI931085L (fi) 1993-09-14
AU4028995A (en) 1996-02-15
MY111178A (en) 1999-09-30

Similar Documents

Publication Publication Date Title
ZA931645B (en) Antitumor compositions and methods of treatment
ZA915371B (en) Antitumor compositions and methods of treatment
EP0581581A3 (en) Bioadhesive treatment compositions and methods of use
AU3691793A (en) Gas well treatment compositions and methods
GB9301802D0 (en) Manufacture and processing of components
SG44524A1 (en) Methods and compositions of treating malaria and other diseases
GB2269164B (en) Treatment of polyvinylchloride
GB9014307D0 (en) Method of treatment and compositions therefor
FI930453A7 (fi) Kasvaimia torjuvia koostumuksia ja käsittelymenetelmiä
GB2294637B (en) Therapeutic compositions and methods of use
GB9010058D0 (en) Method and composition for the treatment of cancer
IL104755A0 (en) Treatment of glaucoma
GB9202196D0 (en) Method of treatment
ZA938897B (en) Antioxidant neuroprotective use of and method of treatment using hydroxycarbazole compounds
ZA936166B (en) Methods of treating cancer
EP0929540A4 (en) ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS
PL303822A1 (en) Therapeutic compositions containing ipsapyrone and method of obtaining them
GB2250217B (en) Treatment of gas
GB9201391D0 (en) Method of treatment
EP0949916A4 (en) ANTI-TUMOR COMPOSITIONS AND THERAPEUTIC METHODS
GB9212535D0 (en) Treatment of boimass
GB2266241B (en) Treatment of pastures
GB9226032D0 (en) Treatment of cancer
AU4391093A (en) Compositions and methods for the prevention and treatment of thrombosis
GB9112552D0 (en) Method and composition for the treatment of cancer