ZA927115B - Dihydropyridine derivatives useful in antitumor therapy. - Google Patents
Dihydropyridine derivatives useful in antitumor therapy.Info
- Publication number
- ZA927115B ZA927115B ZA927115A ZA927115A ZA927115B ZA 927115 B ZA927115 B ZA 927115B ZA 927115 A ZA927115 A ZA 927115A ZA 927115 A ZA927115 A ZA 927115A ZA 927115 B ZA927115 B ZA 927115B
- Authority
- ZA
- South Africa
- Prior art keywords
- chem
- alkoxy
- group
- alkyl optionally
- dihydropyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Saccharide Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919119983A GB9119983D0 (en) | 1991-09-19 | 1991-09-19 | Dihydropyridine derivatives useful in antitumor therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA927115B true ZA927115B (en) | 1993-03-22 |
Family
ID=10701636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA927115A ZA927115B (en) | 1991-09-19 | 1992-09-17 | Dihydropyridine derivatives useful in antitumor therapy. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5362729A (de) |
| EP (1) | EP0533504B1 (de) |
| JP (1) | JPH05213935A (de) |
| KR (1) | KR930006002A (de) |
| AT (1) | ATE148698T1 (de) |
| AU (1) | AU651001B2 (de) |
| CA (1) | CA2078606A1 (de) |
| DE (1) | DE69217308T2 (de) |
| DK (1) | DK0533504T3 (de) |
| ES (1) | ES2099800T3 (de) |
| FI (1) | FI98215C (de) |
| GB (1) | GB9119983D0 (de) |
| GR (1) | GR3022988T3 (de) |
| HU (1) | HUT61994A (de) |
| IL (1) | IL103019A (de) |
| MX (1) | MX9205207A (de) |
| MY (1) | MY129935A (de) |
| NZ (1) | NZ244280A (de) |
| RU (1) | RU2086548C1 (de) |
| TW (1) | TW283147B (de) |
| ZA (1) | ZA927115B (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5508410A (en) * | 1993-11-30 | 1996-04-16 | Reilly Industries, Inc. | Process for preparing 2-halo-5-substituted pyridines |
| US5668151A (en) * | 1995-06-07 | 1997-09-16 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: piperidine derivatives |
| US5554621A (en) * | 1995-06-07 | 1996-09-10 | Bristol-Myers Squibb Company | Dihydropyridine NPY antagonists: nitrogen heterocyclic derivatives |
| GB9515445D0 (en) * | 1995-07-27 | 1995-09-27 | Pharmacia Spa | Dihydropyridine and pyridine derivatives and process for their preparation |
| GB2310136A (en) * | 1996-02-16 | 1997-08-20 | Pharmacia Spa | Dihydropyridine derivatives as aromatase inhibitors |
| US5889016A (en) * | 1997-06-26 | 1999-03-30 | Bristol-Myers Squibb Company | Dihydropyrimidone derivatives as NPY antagonists |
| ES2151850B1 (es) * | 1998-10-26 | 2001-08-16 | Esteve Quimica Sa | Intermedio para la sintesis de amlodipino para su obtencion y utilizacion correspondiente. |
| CA2377698A1 (en) | 1999-06-21 | 2000-12-28 | Bristol-Myers Squibb Company | Dihydropyrazine derivatives as npy antagonists |
| US6693099B2 (en) | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US6376514B1 (en) | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| WO2010009146A1 (en) * | 2008-07-15 | 2010-01-21 | University Of Kansas | Nanoclusters for delivery of poorly water soluble drug nanoparticles |
| US8906392B2 (en) * | 2005-12-16 | 2014-12-09 | University Of Kansas | Nanocluster compositions and methods |
| US10258498B2 (en) | 2011-11-24 | 2019-04-16 | Richter Gedeon Nyrt. | 1,4-dihydropyridine derivatives with Hsp modulating activity |
| CN105175326B (zh) * | 2015-08-19 | 2018-02-27 | 四川国康药业有限公司 | 5‑甲基‑2(1h)吡啶酮衍生物及其制备方法和用途 |
| KR102528669B1 (ko) * | 2016-06-10 | 2023-05-04 | 엘지전자 주식회사 | 식기 세척기 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
| DE2508181A1 (de) * | 1975-02-26 | 1976-09-09 | Bayer Ag | 1,4-dihydropyridincarbonsaeurearal- kylester, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| SU725406A1 (ru) * | 1978-08-08 | 1981-07-30 | Ордена Трудового Красного Знамениинститут Органического Синтеза Ah Латвий-Ской Ccp | Эфиры диметил дигидропиридин диКАРбОНОВОй КиСлОТы,ОблАдАющиЕ АНТи-МЕТАСТАТичЕСКОй АКТиВНОСТью |
| JPS58159490A (ja) * | 1982-02-23 | 1983-09-21 | Nikken Kagaku Kk | １，４−ジヒドロピリジン化合物 |
| DE3478685D1 (en) * | 1983-03-04 | 1989-07-20 | Nikken Chemicals Co Ltd | 1,4-dihydropyridine compound |
| US4906646A (en) * | 1983-03-31 | 1990-03-06 | Board Of Governors Of Wayne State University | Method and composition for the treatment of tumors by administering a platinum coordination compound and a calcium channel blocker compound of the dihydropyridine class |
| US4690935A (en) * | 1983-03-31 | 1987-09-01 | Wayne State University | Inhibition of tumor growth and metastasis with calcium channel blocker compounds |
| DE3326384A1 (de) * | 1983-07-22 | 1985-01-31 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
| SU1125957A1 (ru) * | 1983-10-20 | 1986-03-23 | Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср | 4-(3-Метилпиразолил-4)-2,6-диметил-3,5-диэтоксикарбонил-1,4-дигидропиридин ,об ладающий гепатопротекторной активностью |
| IT1201454B (it) * | 1985-08-19 | 1989-02-02 | Boehringer Biochemia Srl | 1,4-diidropiridine-2-sostituite |
| DE3601196A1 (de) * | 1986-01-17 | 1987-07-23 | Merck Patent Gmbh | 1,4-dihydropyridine |
| IT1204459B (it) * | 1986-02-20 | 1989-03-01 | Glaxo Spa | Derivati eterociclici |
| JPS63135381A (ja) * | 1986-11-26 | 1988-06-07 | Kyorin Pharmaceut Co Ltd | 多剤耐性癌細胞に対する感受性増強剤及びその製造方法 |
| DE3711991A1 (de) * | 1987-04-09 | 1988-10-20 | Bayer Ag | Dihydropyridinamide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| JPH02167262A (ja) * | 1988-06-05 | 1990-06-27 | Taisho Pharmaceut Co Ltd | １，４―ジヒドロピリジン誘導体 |
| JP2640245B2 (ja) * | 1988-07-28 | 1997-08-13 | 日研化学株式会社 | １，４−ジヒドロピリジン誘導体 |
| EP0359377B1 (de) * | 1988-07-28 | 1993-10-13 | Nikken Chemicals Co., Ltd. | 1,4-Dihydropyridin-Derivate |
| IL92646A0 (en) * | 1988-12-15 | 1990-08-31 | Erba Carlo Spa | Imidazolyl and pyridyl derivatives of phenyl substituted 1,4-dihydropyridines,their preparation and pharmaceutical compositions containing them |
-
1991
- 1991-09-19 GB GB919119983A patent/GB9119983D0/en active Pending
-
1992
- 1992-09-01 US US07/937,681 patent/US5362729A/en not_active Expired - Fee Related
- 1992-09-02 IL IL10301992A patent/IL103019A/en not_active IP Right Cessation
- 1992-09-07 TW TW081107052A patent/TW283147B/zh not_active IP Right Cessation
- 1992-09-10 NZ NZ244280A patent/NZ244280A/en unknown
- 1992-09-11 MX MX9205207A patent/MX9205207A/es unknown
- 1992-09-14 AU AU23593/92A patent/AU651001B2/en not_active Ceased
- 1992-09-14 FI FI924110A patent/FI98215C/fi not_active IP Right Cessation
- 1992-09-14 HU HU9202934A patent/HUT61994A/hu unknown
- 1992-09-17 ZA ZA927115A patent/ZA927115B/xx unknown
- 1992-09-18 MY MYPI92001674A patent/MY129935A/en unknown
- 1992-09-18 EP EP92308561A patent/EP0533504B1/de not_active Expired - Lifetime
- 1992-09-18 RU SU925052896A patent/RU2086548C1/ru active
- 1992-09-18 DK DK92308561.7T patent/DK0533504T3/da active
- 1992-09-18 AT AT92308561T patent/ATE148698T1/de not_active IP Right Cessation
- 1992-09-18 KR KR1019920016987A patent/KR930006002A/ko not_active Application Discontinuation
- 1992-09-18 ES ES92308561T patent/ES2099800T3/es not_active Expired - Lifetime
- 1992-09-18 CA CA002078606A patent/CA2078606A1/en not_active Abandoned
- 1992-09-18 JP JP4249635A patent/JPH05213935A/ja active Pending
- 1992-09-18 DE DE69217308T patent/DE69217308T2/de not_active Expired - Fee Related
-
1997
- 1997-04-01 GR GR970400662T patent/GR3022988T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL103019A (en) | 1996-10-31 |
| CA2078606A1 (en) | 1993-03-20 |
| DE69217308D1 (de) | 1997-03-20 |
| KR930006002A (ko) | 1993-04-20 |
| ATE148698T1 (de) | 1997-02-15 |
| ES2099800T3 (es) | 1997-06-01 |
| FI98215B (fi) | 1997-01-31 |
| HU9202934D0 (en) | 1992-11-30 |
| US5362729A (en) | 1994-11-08 |
| FI924110A (fi) | 1993-03-20 |
| JPH05213935A (ja) | 1993-08-24 |
| MY129935A (en) | 2007-05-31 |
| NZ244280A (en) | 1995-02-24 |
| HUT61994A (en) | 1993-03-29 |
| FI924110A0 (fi) | 1992-09-14 |
| FI98215C (fi) | 1997-05-12 |
| AU651001B2 (en) | 1994-07-07 |
| TW283147B (de) | 1996-08-11 |
| EP0533504B1 (de) | 1997-02-05 |
| AU2359392A (en) | 1993-03-25 |
| DK0533504T3 (da) | 1997-04-07 |
| GB9119983D0 (en) | 1991-11-06 |
| DE69217308T2 (de) | 1997-05-28 |
| MX9205207A (es) | 1993-03-01 |
| EP0533504A1 (de) | 1993-03-24 |
| RU2086548C1 (ru) | 1997-08-10 |
| IL103019A0 (en) | 1993-02-21 |
| GR3022988T3 (en) | 1997-07-30 |
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