ZA919127B - Polyazamacrocyclic compounds for complexation of metal ions. - Google Patents
Polyazamacrocyclic compounds for complexation of metal ions.Info
- Publication number
- ZA919127B ZA919127B ZA919127A ZA919127A ZA919127B ZA 919127 B ZA919127 B ZA 919127B ZA 919127 A ZA919127 A ZA 919127A ZA 919127 A ZA919127 A ZA 919127A ZA 919127 B ZA919127 B ZA 919127B
- Authority
- ZA
- South Africa
- Prior art keywords
- complexation
- metal ions
- polyazamacrocyclic
- compound
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229910021645 metal ion Inorganic materials 0.000 title abstract 2
- 238000010668 complexation reaction Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Laminated Bodies (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/662,075 US4639365A (en) | 1984-10-18 | 1984-10-18 | Gadolinium chelates as NMR contrast agents |
| US07/615,619 US5342606A (en) | 1984-10-18 | 1990-11-19 | Polyazamacrocyclic compounds for complexation of metal ions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA919127B true ZA919127B (en) | 1993-05-18 |
Family
ID=34922814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA919127A ZA919127B (en) | 1984-10-18 | 1991-11-18 | Polyazamacrocyclic compounds for complexation of metal ions. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5342606A (no) |
| JP (1) | JP3334717B2 (no) |
| CN (2) | CN1036717C (no) |
| AT (1) | ATE144522T1 (no) |
| AU (1) | AU654987B2 (no) |
| CA (1) | CA2095615C (no) |
| DE (1) | DE69122881T2 (no) |
| ES (1) | ES2093816T3 (no) |
| FI (1) | FI932231A0 (no) |
| HK (1) | HK88897A (no) |
| HU (1) | HUT64768A (no) |
| IE (1) | IE914001A1 (no) |
| IL (1) | IL100073A (no) |
| MX (1) | MX9102116A (no) |
| NO (1) | NO307380B1 (no) |
| NZ (1) | NZ240626A (no) |
| PT (1) | PT99556B (no) |
| SG (1) | SG48154A1 (no) |
| WO (1) | WO1992008725A1 (no) |
| ZA (1) | ZA919127B (no) |
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| US5532006A (en) * | 1993-04-23 | 1996-07-02 | The Board Of Trustees Of The University Of Illinois | Magnetic gels which change volume in response to voltage changes for MRI |
| US5393892A (en) * | 1993-05-07 | 1995-02-28 | Ibc Advanced Technologies, Inc. | Processes for removing, separating and concentrating lead, thallium, alkali metals, alkaline earth metals from concentrated matrices using macrocyclic polyether cryptand ligands bonded to inorganic supports |
| US5554749A (en) * | 1994-01-14 | 1996-09-10 | Mallinckrodt Medical, Inc. | Functionalized macrocyclic ligands for imaging applications |
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| US5622687A (en) * | 1994-11-15 | 1997-04-22 | Molecular Biosystems, Inc. | Calixarene conjugates useful as MRI and CT diagnostic imaging agents |
| ES2094101B1 (es) * | 1995-06-13 | 1997-08-01 | Univ Madrid Nac Educacion | Complexonas de naturaleza de acidos n-2-(azol-1(2)-il)etiliminodiaceticos, sintesis, estudio analitico y aplicaciones biologicas. |
| EP0955044B1 (en) * | 1995-06-26 | 2005-11-16 | Chelator LLC | Method of inhibiting bacterial or fungal growth using a complexing agent |
| US5834456A (en) * | 1996-02-23 | 1998-11-10 | The Dow Chemical Company | Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents |
| US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| US6776977B2 (en) | 2001-01-09 | 2004-08-17 | Bristol-Myers Squibb Pharma Company | Polypodal chelants for metallopharmaceuticals |
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| US3932451A (en) * | 1973-11-27 | 1976-01-13 | E. I. Du Pont De Nemours & Company | 1,4,7,10-Tetraazatetracyclo[5.5.1.04,13.010,13 ]tridecane and its conjugate acids |
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| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| GB8903023D0 (en) * | 1989-02-10 | 1989-03-30 | Parker David | Chemical compounds |
| GB8914543D0 (en) * | 1989-06-23 | 1989-08-09 | Parker David | Chemical compounds |
| DK0455380T3 (da) * | 1990-04-18 | 1997-02-03 | Celltech Therapeutics Ltd | Tetraaza-makrocykler, fremgangsmåder til fremstilling deraf og deres anvendelse til magnetisk resona ns-visualisering |
-
1990
- 1990-11-19 US US07/615,619 patent/US5342606A/en not_active Expired - Fee Related
-
1991
- 1991-11-12 AT AT92901960T patent/ATE144522T1/de not_active IP Right Cessation
- 1991-11-12 CA CA002095615A patent/CA2095615C/en not_active Expired - Fee Related
- 1991-11-12 JP JP50107392A patent/JP3334717B2/ja not_active Expired - Fee Related
- 1991-11-12 HU HU9301431A patent/HUT64768A/hu unknown
- 1991-11-12 WO PCT/US1991/008438 patent/WO1992008725A1/en active IP Right Grant
- 1991-11-12 DE DE69122881T patent/DE69122881T2/de not_active Expired - Fee Related
- 1991-11-12 AU AU90770/91A patent/AU654987B2/en not_active Ceased
- 1991-11-12 SG SG1996007416A patent/SG48154A1/en unknown
- 1991-11-12 ES ES92901960T patent/ES2093816T3/es not_active Expired - Lifetime
- 1991-11-18 NZ NZ240626A patent/NZ240626A/en not_active IP Right Cessation
- 1991-11-18 IL IL100073A patent/IL100073A/xx not_active IP Right Cessation
- 1991-11-18 IE IE400191A patent/IE914001A1/en not_active IP Right Cessation
- 1991-11-18 MX MX9102116A patent/MX9102116A/es not_active IP Right Cessation
- 1991-11-18 ZA ZA919127A patent/ZA919127B/xx unknown
- 1991-11-19 PT PT99556A patent/PT99556B/pt not_active IP Right Cessation
- 1991-11-19 CN CN91107597A patent/CN1036717C/zh not_active Expired - Fee Related
-
1993
- 1993-05-17 FI FI932231A patent/FI932231A0/fi unknown
- 1993-05-18 NO NO931793A patent/NO307380B1/no unknown
-
1996
- 1996-10-31 CN CN96122080A patent/CN1193625A/zh active Pending
-
1997
- 1997-06-26 HK HK88897A patent/HK88897A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ240626A (en) | 1994-11-25 |
| NO931793L (no) | 1993-05-18 |
| CN1036717C (zh) | 1997-12-17 |
| ATE144522T1 (de) | 1996-11-15 |
| SG48154A1 (en) | 1998-04-17 |
| DE69122881T2 (de) | 1997-04-03 |
| NO307380B1 (no) | 2000-03-27 |
| HU9301431D0 (en) | 1993-12-28 |
| DE69122881D1 (de) | 1996-11-28 |
| FI932231A (fi) | 1993-05-17 |
| MX9102116A (es) | 1992-06-01 |
| IE914001A1 (en) | 1992-05-20 |
| IL100073A0 (en) | 1992-08-18 |
| WO1992008725A1 (en) | 1992-05-29 |
| US5342606A (en) | 1994-08-30 |
| NO931793D0 (no) | 1993-05-18 |
| JP3334717B2 (ja) | 2002-10-15 |
| CA2095615A1 (en) | 1992-05-20 |
| CA2095615C (en) | 2003-07-08 |
| CN1066073A (zh) | 1992-11-11 |
| JPH06502645A (ja) | 1994-03-24 |
| HUT64768A (en) | 1994-02-28 |
| AU9077091A (en) | 1992-06-11 |
| IL100073A (en) | 1997-11-20 |
| CN1193625A (zh) | 1998-09-23 |
| FI932231A0 (fi) | 1993-05-17 |
| HK88897A (en) | 1997-06-27 |
| PT99556A (pt) | 1992-10-30 |
| AU654987B2 (en) | 1994-12-01 |
| PT99556B (pt) | 1999-04-30 |
| ES2093816T3 (es) | 1997-01-01 |
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