ZA914165B - Pharmacologically active CNS compounds. - Google Patents

Pharmacologically active CNS compounds.

Info

Publication number
ZA914165B
ZA914165B ZA914165A ZA914165A ZA914165B ZA 914165 B ZA914165 B ZA 914165B ZA 914165 A ZA914165 A ZA 914165A ZA 914165 A ZA914165 A ZA 914165A ZA 914165 B ZA914165 B ZA 914165B
Authority
ZA
South Africa
Prior art keywords
hydrogen
halo
alkyl
compounds
pharmacologically active
Prior art date
Application number
ZA914165A
Other languages
English (en)
Inventor
Michael John Leach
Malcolm Stuart Nobbs
Ramachandran Iyer
Clive Leonard Yeates
Philip Alan Skone
Original Assignee
Wellcom Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcom Foundation Limited filed Critical Wellcom Foundation Limited
Publication of ZA914165B publication Critical patent/ZA914165B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Liquid Crystal Substances (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA914165A 1990-06-01 1991-05-30 Pharmacologically active CNS compounds. ZA914165B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909012316A GB9012316D0 (en) 1990-06-01 1990-06-01 Pharmacologically active cns compounds

Publications (1)

Publication Number Publication Date
ZA914165B true ZA914165B (en) 1993-03-01

Family

ID=10676964

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA914165A ZA914165B (en) 1990-06-01 1991-05-30 Pharmacologically active CNS compounds.

Country Status (25)

Country Link
EP (2) EP0679645A1 (fi)
JP (1) JPH06340634A (fi)
KR (1) KR920000733A (fi)
AT (1) ATE141263T1 (fi)
AU (2) AU652753B2 (fi)
CA (1) CA2043640A1 (fi)
CZ (1) CZ281070B6 (fi)
DE (1) DE69121317T2 (fi)
DK (1) DK0459819T3 (fi)
ES (1) ES2093078T3 (fi)
FI (1) FI912623A (fi)
GB (1) GB9012316D0 (fi)
GR (1) GR3021237T3 (fi)
HU (2) HUT58707A (fi)
IE (1) IE911861A1 (fi)
IL (2) IL113599A (fi)
MY (2) MY136248A (fi)
NO (1) NO180375C (fi)
NZ (3) NZ238360A (fi)
PL (2) PL166656B1 (fi)
PT (1) PT97827B (fi)
RU (1) RU2091374C1 (fi)
SK (1) SK278444B6 (fi)
TW (1) TW224460B (fi)
ZA (1) ZA914165B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
GB2257363B (en) * 1991-01-30 1994-09-28 Wellcome Found Water dispersible tablets containing acyclovir
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
GB9226377D0 (en) * 1992-12-18 1993-02-10 Babbedge Rachel C Pharmaceutical compositions
JPH08504798A (ja) * 1992-12-18 1996-05-21 ザ ウエルカム ファウンデーション リミテッド 酵素阻害薬としての，ピリミジン，ピリジン，プテリジノンおよびインダゾール誘導体
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
GB9319341D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Novel process
FR2741879A1 (fr) * 1995-12-05 1997-06-06 Esteve Labor Dr Derives de fluorophenyl-triazines et pyrimidines, leur preparation et leur application en tant que medicament
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
GB9726987D0 (en) 1997-12-22 1998-02-18 Glaxo Group Ltd Compounds
US6583148B1 (en) 1999-04-08 2003-06-24 Krenitsky Pharmaceuticals, Inc. Neurotrophic substituted pyrimidines
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
MY123528A (en) 1999-09-16 2006-05-31 Mitsubihsi Tanabe Pharma Corp Aromatic nitrogen-containing 6-membered cyclic compounds.
KR100711042B1 (ko) 2000-04-28 2007-04-24 다나베 세이야꾸 가부시키가이샤 환상 화합물
US7273868B2 (en) 2000-04-28 2007-09-25 Tanabe Seiyaku Co., Ltd. Pyrazine derivatives
ES2346513T3 (es) * 2000-07-24 2010-10-18 Krenitsky Pharmaceuticals, Inc. 5-alquinil pirimidinas sustituidas que tienen actividad neurotrofica.
EP1364950A4 (en) 2001-02-26 2005-03-09 Tanabe Seiyaku Co PYRIDOPYRIMIDINE OR NAPHTHYRIDINE DERIVATIVE
CN1628109A (zh) * 2002-02-05 2005-06-15 诺沃挪第克公司 新颖的芳基－与杂芳基－哌嗪
TW200637556A (en) * 2005-01-31 2006-11-01 Basf Ag Substituted 5-phenyl pyrimidines I in therapy
CA2614116A1 (en) 2005-07-04 2007-01-11 Novo Nordisk A/S Novel medicaments
US8318927B2 (en) 2006-05-23 2012-11-27 High Point Pharmaceuticals, Llc 6-(4-cyclopropylpiperazin-1-yl)-2′-methyl-[3, 4′]-bipyridine and its uses as a medicament
CN102295606A (zh) 2006-05-29 2011-12-28 高点制药有限责任公司 合成3-（1，3-苯并间二氧杂环戊烯-5-基）-6-（4-环丙基哌嗪-1-基）-哒嗪的方法及其适用的中间体
EP2014656A3 (en) 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
DK2718270T3 (da) 2011-06-10 2022-08-01 Merck Patent Gmbh Sammensætninger og fremgangsmåder til fremstillingen af pyrimidin- og pyridinforbindelser med btk-hæmmende aktivitet
JO3517B1 (ar) 2014-01-17 2020-07-05 Novartis Ag ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2
WO2015107493A1 (en) * 2014-01-17 2015-07-23 Novartis Ag 1 -pyridazin-/triazin-3-yl-piper(-azine)/idine/pyrolidine derivatives and and compositions thereof for inhibiting the activity of shp2
RU2744988C2 (ru) 2016-06-14 2021-03-17 Новартис Аг Соединения и композиции для подавления активности shp2
CN110730678B (zh) 2017-01-10 2022-07-15 诺华股份有限公司 包含alk抑制剂和shp2抑制剂的药物组合

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE518622A (fi) *
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
US5136080A (en) * 1989-12-04 1992-08-04 Burroughs Wellcome Co. Nitrile compounds

Also Published As

Publication number Publication date
IL113599A (en) 1997-09-30
TW224460B (fi) 1994-06-01
EP0679645A1 (en) 1995-11-02
FI912623A0 (fi) 1991-05-31
DK0459819T3 (da) 1996-09-02
GB9012316D0 (en) 1990-07-18
HU211649A9 (en) 1995-12-28
DE69121317D1 (de) 1996-09-19
IE911861A1 (en) 1991-12-04
NZ238360A (en) 1997-03-24
NZ248501A (en) 1997-03-24
MY109958A (en) 1997-10-31
PT97827A (pt) 1992-03-31
RU2091374C1 (ru) 1997-09-27
CS164391A3 (en) 1992-02-19
IL98330A0 (en) 1992-06-21
NO180375C (no) 1997-04-09
NO912100D0 (no) 1991-05-31
SK278444B6 (en) 1997-05-07
DE69121317T2 (de) 1997-01-02
NO912100L (no) 1991-12-02
EP0459819A3 (en) 1992-03-11
AU6745594A (en) 1994-09-15
IL113599A0 (en) 1995-08-31
AU680252B2 (en) 1997-07-24
CA2043640A1 (en) 1991-12-02
EP0459819B1 (en) 1996-08-14
EP0459819A2 (en) 1991-12-04
HU911826D0 (en) 1991-12-30
JPH06340634A (ja) 1994-12-13
IL98330A (en) 1996-10-31
FI912623A (fi) 1991-12-02
KR920000733A (ko) 1992-01-29
PL166656B1 (pl) 1995-06-30
GR3021237T3 (en) 1997-01-31
ES2093078T3 (es) 1996-12-16
NO180375B (no) 1996-12-30
MY136248A (en) 2008-08-29
NZ272001A (en) 1997-03-24
HUT58707A (en) 1992-03-30
PL170373B1 (pl) 1996-12-31
ATE141263T1 (de) 1996-08-15
PT97827B (pt) 1998-10-30
CZ281070B6 (cs) 1996-06-12
AU7809791A (en) 1991-12-05
AU652753B2 (en) 1994-09-08

Similar Documents

Publication Publication Date Title
EP0459819A3 (en) Pharmacologically active cns compounds
FI89709B (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara arylderivat
HUP9901113A1 (hu) Herbicid hatású és növényi növekedést szabályozó hatású 2-amino-4-biciklo-amino-1,3,5-triazinok
HUT59562A (en) Cys-carboxamide derivatives, process for producing them and herbicide compositions containing them
EP0324387A3 (en) Composition for treatment of ischemic disorder in organs
IL86462A0 (en) Alkanesulfonanilide derivatives,processes for preparation thereof and pharmaceutical composition comprising the same
ES8801639A1 (es) Procedimiento para la obtencion de derivados del acido barbiturico
ZA882374B (en) Biologically active compounds
EP0726269A4 (en) QUINOLINE CARBONIC ACID DERIVATIVE AND ITS SALTS
ES8703861A1 (es) Un procedimiento para preparar nuevas 1,2,4-tiadiazinas
HU9600597D0 (en) 4-alkylthio-pyrimidin-5-yl acetic acid derivates and fungicidal compositions containing them as an active ingredient
NO954109L (no) Analogifremgangsmåte for fremstilling av terapeutisk aktive substituerte 5-arylpyrimidiner
TH11828EX (th) สารประกอบต่าง ๆ ที่เกี่ยวกับ cns ซึ่งออกฤทธิ์ทางเภสัชวิทยา
MY104630A (en) 4(1h) ouinoline derivatives
DE3464053D1 (en) Pyrazine compounds, their preparation and their use, compositions containing them and method of combating undesired plant growth