ZA91392B - Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase - Google Patents

Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Info

Publication number
ZA91392B
ZA91392B ZA91392A ZA91392A ZA91392B ZA 91392 B ZA91392 B ZA 91392B ZA 91392 A ZA91392 A ZA 91392A ZA 91392 A ZA91392 A ZA 91392A ZA 91392 B ZA91392 B ZA 91392B
Authority
ZA
South Africa
Prior art keywords
squalene
tetra
inhibitors
fluoro analogs
epoxidase
Prior art date
Application number
ZA91392A
Other languages
English (en)
Inventor
Esa Tero Jarvi
Tero Jarvi Esa
Michael Louis Edwards
Louis Edwards Michael
James Ray Mccarthy
Ray Mccarthy James
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA91392B publication Critical patent/ZA91392B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C21/00—Acyclic unsaturated compounds containing halogen atoms
    • C07C21/02—Acyclic unsaturated compounds containing halogen atoms containing carbon-to-carbon double bonds
    • C07C21/215—Halogenated polyenes with more than two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Steroid Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
  • Pyrrole Compounds (AREA)
ZA91392A 1990-03-30 1991-01-18 Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase ZA91392B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/502,203 US5011859A (en) 1990-03-30 1990-03-30 Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Publications (1)

Publication Number Publication Date
ZA91392B true ZA91392B (en) 1991-10-30

Family

ID=23996803

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA91392A ZA91392B (en) 1990-03-30 1991-01-18 Di-and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase

Country Status (19)

Country Link
US (1) US5011859A (fr)
EP (1) EP0448934B1 (fr)
JP (1) JP2911239B2 (fr)
KR (1) KR0162659B1 (fr)
CN (1) CN1055172A (fr)
AT (1) ATE118756T1 (fr)
AU (1) AU629726B2 (fr)
CA (1) CA2034612C (fr)
DE (1) DE69107488T2 (fr)
ES (1) ES2071131T3 (fr)
FI (1) FI910425A (fr)
HU (1) HU208103B (fr)
IE (1) IE910181A1 (fr)
IL (1) IL97356A0 (fr)
NO (1) NO910263L (fr)
NZ (1) NZ236800A (fr)
PH (1) PH27365A (fr)
PT (1) PT96654A (fr)
ZA (1) ZA91392B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995004025A1 (fr) * 1993-07-29 1995-02-09 Chugai Seiyaku Kabushiki Kaisha Derive d'acide tricarboxylique a activite d'inhibition de la squalene-synthetase
DE19754795A1 (de) * 1997-12-10 1999-06-17 Boehringer Ingelheim Pharma Neue Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung
US6103733A (en) * 1998-09-09 2000-08-15 Bachmann; Kenneth A. Method for increasing HDL cholesterol levels using heteroaromatic phenylmethanes
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
AR063275A1 (es) * 2006-10-12 2009-01-14 Epix Delaware Inc Compuestos de carboxamida, una composicion farmaceutica que los comprende y su uso en la preparacion de un medicamento para el tratamiento de enfermedades mediadas por la activacion de ccr2.
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
WO2009076404A1 (fr) * 2007-12-10 2009-06-18 Epix Delaware, Inc. Composés de carboxyamide et leur utilisation comme antagonistes du récepteur ccr2de la chimiokine
AU2008335135A1 (en) 2007-12-11 2009-06-18 Cytopathfinder, Inc. Carboxamide compounds and their use as chemokine receptor agonists
JP2013528172A (ja) 2010-05-21 2013-07-08 ファイザー・インク ２−フェニルベンゾイルアミド
WO2012120414A2 (fr) 2011-03-04 2012-09-13 Pfizer Inc. Peptides de type edn3 et utilisations associées
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.
CN112678833B (zh) * 2020-11-17 2023-08-04 广西中烟工业有限责任公司 纳米二氧化硅改性角鲨烯有机硅颗粒及其制备和使用方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876672A (en) * 1972-02-21 1975-04-08 Du Pont Hydroformylation of olefins
DE2913677C2 (de) * 1979-04-05 1983-03-03 Union Rheinische Braunkohlen Kraftstoff AG, 5000 Köln Verfahren zur Herstellung von Acetaldehyddimethylacetal
US4455441A (en) * 1982-09-24 1984-06-19 Research Foundation Of State University Of New York Attractant termiticidal compounds, compositions and methods of use therefor
DE3618115A1 (de) * 1986-05-30 1987-12-03 Bayer Ag Halogenolefine
US4876295A (en) * 1987-03-11 1989-10-24 The Dow Chemical Company Flexible thermoplastic epoxy resin and coatings prepared therefrom

Also Published As

Publication number Publication date
KR910016660A (ko) 1991-11-05
ATE118756T1 (de) 1995-03-15
IE910181A1 (en) 1991-10-09
IL97356A0 (en) 1992-05-25
KR0162659B1 (ko) 1999-01-15
EP0448934A3 (en) 1991-11-27
HUT56533A (en) 1991-09-30
CN1055172A (zh) 1991-10-09
PT96654A (pt) 1991-10-31
JPH04221327A (ja) 1992-08-11
AU629726B2 (en) 1992-10-08
EP0448934A2 (fr) 1991-10-02
US5011859A (en) 1991-04-30
DE69107488D1 (de) 1995-03-30
PH27365A (en) 1993-06-21
DE69107488T2 (de) 1995-06-14
EP0448934B1 (fr) 1995-02-22
HU910174D0 (en) 1991-08-28
NZ236800A (en) 1993-05-26
CA2034612C (fr) 2001-05-15
AU6946891A (en) 1991-10-03
ES2071131T3 (es) 1995-06-16
JP2911239B2 (ja) 1999-06-23
HU208103B (en) 1993-08-30
FI910425A0 (fi) 1991-01-29
NO910263L (no) 1991-10-01
CA2034612A1 (fr) 1991-10-01
NO910263D0 (no) 1991-01-23
FI910425A (fi) 1991-10-01

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