ZA9110166B - 1,4-benzothiazepine derivatives - Google Patents

1,4-benzothiazepine derivatives

Info

Publication number
ZA9110166B
ZA9110166B ZA9110166A ZA9110166A ZA9110166B ZA 9110166 B ZA9110166 B ZA 9110166B ZA 9110166 A ZA9110166 A ZA 9110166A ZA 9110166 A ZA9110166 A ZA 9110166A ZA 9110166 B ZA9110166 B ZA 9110166B
Authority
ZA
South Africa
Prior art keywords
lower alkoxy
benzothiazepine derivatives
phenyl
acyl
inhibits
Prior art date
Application number
ZA9110166A
Other languages
English (en)
Inventor
Noboru Kaneko
Kaneko Noboru
Tatsushi Osawa
Osawa Tatsushi
Teruyuki Sakai
Sakai Teruyuki
Hideo Ohta
Ohta Hideo
Original Assignee
Kaneko Noboru
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneko Noboru filed Critical Kaneko Noboru
Publication of ZA9110166B publication Critical patent/ZA9110166B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA9110166A 1990-12-28 1991-12-27 1,4-benzothiazepine derivatives ZA9110166B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2416066A JP2703408B2 (ja) 1990-12-28 1990-12-28 １，４‐ベンゾチアゼピン誘導体

Publications (1)

Publication Number Publication Date
ZA9110166B true ZA9110166B (en) 1992-09-30

Family

ID=18524314

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9110166A ZA9110166B (en) 1990-12-28 1991-12-27 1,4-benzothiazepine derivatives

Country Status (13)

Country Link
US (1) US5416066A (zh)
EP (1) EP0565721B1 (zh)
JP (1) JP2703408B2 (zh)
KR (1) KR0165131B1 (zh)
CN (1) CN1028992C (zh)
AT (1) ATE125539T1 (zh)
AU (1) AU9107491A (zh)
CA (1) CA2098495C (zh)
DE (1) DE69111619T2 (zh)
DK (1) DK0565721T3 (zh)
RU (1) RU2089550C1 (zh)
WO (1) WO1992012148A1 (zh)
ZA (1) ZA9110166B (zh)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41342C2 (uk) * 1992-11-09 2001-09-17 Дзе Бутс Компані Плс 2,3,4,5-тетрагідро-1,4-бензотіазепіни, їх стереоізомери або їх фармацевтично прийнятні солі, спосіб їх одержання та фармацевтична композиція на їх основі
US5608110A (en) * 1993-06-15 1997-03-04 Bracco International B.V. Heteroatom-bearing ligands and metal complexes thereof
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
ATE314852T1 (de) * 1998-12-28 2006-02-15 Noboru Kaneko Verwendung von 1,4-benzothiazepinen zur herstellung eines medikaments zur behandlung der vorhof-fibrillation
CN1178663C (zh) * 1999-05-19 2004-12-08 金子升 1,4-苯并硫氮杂�衍生物作为抗癌药抗性克服用药物的用途
EP1244457B1 (en) * 1999-12-29 2004-10-27 Glaxo Group Limited Use of modulators of annexin for the manufacture of a medicament for the treatment and/or prevention of arthritis and arthritic diseases
US6489125B1 (en) * 2000-05-10 2002-12-03 The Trustees Of Columbia University In The City Of New York Methods for identifying chemical compounds that inhibit dissociation of FKBP12.6 binding protein from type 2 ryanodine receptor
US20040048780A1 (en) * 2000-05-10 2004-03-11 The Trustees Of Columbia University In The City Of New York Method for treating and preventing cardiac arrhythmia
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7393652B2 (en) * 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US20040229781A1 (en) * 2000-05-10 2004-11-18 Marks Andrew Robert Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias
US20060293266A1 (en) * 2000-05-10 2006-12-28 The Trustees Of Columbia Phosphodiesterase 4D in the ryanodine receptor complex protects against heart failure
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) * 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7544678B2 (en) * 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
EP1603450A4 (en) 2003-03-07 2009-07-29 Univ Columbia METHODS USING TYPE 1 RYANODINE RECEPTOR
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
KR20110071112A (ko) * 2004-04-28 2011-06-28 가부시키가이샤 아에타스 파루마 근이완 촉진제 및 근이완 부전등의 근조직계 질병의 치료약
US7704990B2 (en) * 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US20110263569A1 (en) * 2007-08-22 2011-10-27 President And Fellows Of Harvard College Ryanodine channel binders and uses thereof
RS52172B (en) 2008-03-03 2012-08-31 Les Laboratoires Servier PROCEDURE FOR THE PRODUCTION OF BENZOTHIAZEPINE FROM GAMA-AMINOALKYLBENZENE
KR101337244B1 (ko) 2009-02-25 2013-12-06 노보루 카네코 1,4-벤조티아제핀-1-옥사이드 유도체 및 이를 이용한 의약 조성물
WO2010120382A1 (en) 2009-04-15 2010-10-21 State Of Oregon By And Through The State Board Of Higher Education On Behalf Of Portland State University Compounds and methods for modulating activity of calcium release channels
EP3176164B1 (en) 2014-07-30 2019-08-21 Aetas Pharma Co. Ltd. Optical isomer of 1,4-benzothiazepine-1-oxide derivative, and pharmaceutical composition prepared using same
ES2643856B1 (es) 2016-05-24 2018-08-03 Universidad Del Pais Vasco / Euskal Herriko Unibertsitatea Triazoles para la regulación de la homeostasis de calcio intracelular
WO2018165171A1 (en) 2017-03-06 2018-09-13 Washington University Treatment for wolfram syndrome and other endoplasmic reticulum stress disorders
EP3725315B1 (en) 2017-12-11 2023-10-04 Aetas Pharma Co. Ltd. Renal dysfunction improving drug comprising optical isomer of 1,4-benzothiazepine-1-oxide derivative

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3794639A (en) * 1966-03-10 1974-02-26 Squibb & Sons Inc Benzoxazepines and benzothiazepines
EP0107930B1 (en) * 1982-09-30 1990-11-28 A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) Fused aromatic oxazepinones and sulphur analogues thereof and their preparation and use in counteracting histamine
ZA836994B (en) * 1982-09-30 1984-05-30 Robins Co Inc A H Fused aromatic oxazepinones and sulfur analogs thereof
JPS6140651A (ja) * 1984-07-31 1986-02-26 Hitachi Ltd 記憶装置へのフアイル割当て方法および割当て決定装置
JP2871811B2 (ja) * 1990-02-28 1999-03-17 サントリー株式会社 縮合７員環系化合物
JP2935541B2 (ja) * 1990-06-28 1999-08-16 サントリー株式会社 縮合複素環化合物
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor

Also Published As

Publication number Publication date
RU2089550C1 (ru) 1997-09-10
AU9107491A (en) 1992-08-17
CN1028992C (zh) 1995-06-21
JPH04230681A (ja) 1992-08-19
KR930703303A (ko) 1993-11-29
DE69111619T2 (de) 1996-01-18
DK0565721T3 (da) 1995-11-06
DE69111619D1 (de) 1995-08-31
WO1992012148A1 (fr) 1992-07-23
EP0565721A1 (en) 1993-10-20
JP2703408B2 (ja) 1998-01-26
EP0565721A4 (en) 1994-06-01
KR0165131B1 (ko) 1999-02-18
CA2098495A1 (en) 1992-06-29
CN1063491A (zh) 1992-08-12
US5416066A (en) 1995-05-16
CA2098495C (en) 1999-11-30
EP0565721B1 (en) 1995-07-26
ATE125539T1 (de) 1995-08-15

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