UA41342C2 - 2,3,4,5-тетрагідро-1,4-бензотіазепіни, їх стереоізомери або їх фармацевтично прийнятні солі, спосіб їх одержання та фармацевтична композиція на їх основі - Google Patents
2,3,4,5-тетрагідро-1,4-бензотіазепіни, їх стереоізомери або їх фармацевтично прийнятні солі, спосіб їх одержання та фармацевтична композиція на їх основіInfo
- Publication number
- UA41342C2 UA41342C2 UA95062705A UA95062705A UA41342C2 UA 41342 C2 UA41342 C2 UA 41342C2 UA 95062705 A UA95062705 A UA 95062705A UA 95062705 A UA95062705 A UA 95062705A UA 41342 C2 UA41342 C2 UA 41342C2
- Authority
- UA
- Ukraine
- Prior art keywords
- methyl
- tetrahydro
- benzothiazepines
- pharmaceutically acceptable
- acceptable salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Цей винахід належить до похідних 2,3,4,5-тетрагідро-1,4-бензотіазепінів, до фармацевтичних композицій. 2,3,4,5-тетрагідро-1,4-бензотіазепіни загальної формули II, що містять їх: їх стереоізомери і їх фармацевтично прийнятні солі, де n=0 або 1, R1, R2, R1 і R7 кожен є Н, R3 і R3 незалежно представляють Н або метил, або разом представляють іміно, метиліміно, фениліміно, гідроксиіміно або метоксиіміно групу, R5 представляє Н або метил, або, коли R3 і R4 незалежно представляють Н або метил, то R5 представляє Н, метил, форміл, ацетил, пропіоніл, бензоіл, метилсульфініл, метилсульфоніл або етилсульфоніл, R8 представляє Н, метил, фтор або хлор, і R9, R10 и R11 кожен представляє Н, за умови, що: i) R1-R11 не всі представляють Н, ii) коли n = 0 и R1-R4 і R6-R11 представляє І, то R5 не є бензоїлом або ацетилом, і iii) коли n = 0 або 1, і R1-R3 і R5-R11 кожен представляє водень, то R4 не є метилом.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929223443A GB9223443D0 (en) | 1992-11-09 | 1992-11-09 | Therapeutic agents |
| GB929223441A GB9223441D0 (en) | 1992-11-09 | 1992-11-09 | Therapeutic agents |
| PCT/EP1993/003123 WO1994011360A1 (en) | 1992-11-09 | 1993-11-06 | 1,4-benzothiazepines useful as neurological agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA41342C2 true UA41342C2 (uk) | 2001-09-17 |
Family
ID=26301938
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA95062705A UA41342C2 (uk) | 1992-11-09 | 1993-11-06 | 2,3,4,5-тетрагідро-1,4-бензотіазепіни, їх стереоізомери або їх фармацевтично прийнятні солі, спосіб їх одержання та фармацевтична композиція на їх основі |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US5580866A (uk) |
| EP (1) | EP0667866B1 (uk) |
| JP (1) | JPH08503202A (uk) |
| KR (1) | KR100313649B1 (uk) |
| AT (1) | ATE163927T1 (uk) |
| BG (1) | BG62519B1 (uk) |
| BR (1) | BR9307387A (uk) |
| CA (1) | CA2148584A1 (uk) |
| CZ (1) | CZ288595B6 (uk) |
| DE (1) | DE69317436T2 (uk) |
| DK (1) | DK0667866T3 (uk) |
| ES (1) | ES2113081T3 (uk) |
| FI (1) | FI952204A0 (uk) |
| GR (1) | GR3026386T3 (uk) |
| HU (1) | HUT71819A (uk) |
| NO (1) | NO304467B1 (uk) |
| NZ (1) | NZ257843A (uk) |
| PL (1) | PL179401B1 (uk) |
| RU (1) | RU2115650C1 (uk) |
| SK (1) | SK280522B6 (uk) |
| UA (1) | UA41342C2 (uk) |
| WO (1) | WO1994011360A1 (uk) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
| DE69232854T2 (de) * | 1991-06-28 | 2003-09-04 | Smith-Kline Beecham Corp., King Of Prussia | Bizyklische fibrinogenantagonisten |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
| GB9506382D0 (en) * | 1995-03-29 | 1995-05-17 | Boots Co Plc | Pharmaceutical compositions |
| US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
| ZA9610853B (en) | 1995-12-29 | 1998-04-06 | Smithkline Beecham Corp | Processes and intermediates for preparing pharmaceuticals. |
| GB9616279D0 (en) * | 1996-08-02 | 1996-09-11 | Knoll Ag | Chemical process |
| EP0864582B1 (en) * | 1997-03-14 | 2003-06-04 | Aventis Pharma Deutschland GmbH | Hypolipidemic 1,4-benzothiazepine-1,-dioxides |
| GB9914745D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| US7718644B2 (en) * | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
| US7393652B2 (en) | 2000-05-10 | 2008-07-01 | The Trustees Of Columbia University In The City Of New York | Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2) |
| US20040229781A1 (en) * | 2000-05-10 | 2004-11-18 | Marks Andrew Robert | Compounds and methods for treating and preventing exercise-induced cardiac arrhythmias |
| US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US7544678B2 (en) | 2002-11-05 | 2009-06-09 | The Trustees Of Columbia University In The City Of New York | Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) |
| JP2007525165A (ja) | 2003-03-07 | 2007-09-06 | トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | タイプ１ライアノジン受容体に基づく方法 |
| US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
| US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
| US8618282B2 (en) * | 2008-03-03 | 2013-12-31 | Les Laboratoires Servier | Process for preparing benzothiazepines from gamma-aminoalkylbenzenes |
| WO2013064231A1 (en) | 2011-10-31 | 2013-05-10 | Phenex Pharmaceuticals Ag | SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3) |
| EP2708535A1 (en) | 2012-05-11 | 2014-03-19 | Les Laboratoires Servier | Agents for treating disorders involving modulation of ryanodine receptors |
| KR102157141B1 (ko) | 2018-11-27 | 2020-09-17 | 주식회사 파미니티 | 으아리 추출물을 유효 성분으로 포함하는 인지 기능 개선용 조성물 |
| KR102172916B1 (ko) | 2018-12-07 | 2020-11-02 | 주식회사 파미니티 | 실크 펩타이드 및 천연 추출물을 포함하는 인지 기능 개선용 조성물 |
| EP4247778A1 (en) * | 2020-11-17 | 2023-09-27 | Armgo Pharma, Inc. | Agents for treating disorders involving ryanodine receptors |
| CN116887839A (zh) | 2021-01-08 | 2023-10-13 | 阿姆果制药有限公司 | 兰诺定受体调节剂的结晶形式及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3362962A (en) * | 1964-01-24 | 1968-01-09 | Hoffmann La Roche | Certain benzothiazepine derivatives |
| US3682962A (en) * | 1970-03-17 | 1972-08-08 | Sterling Drug Inc | 1-substituted-1,2,3,5-tetrahydro-4,1-benzothiozepines |
| DE58901634D1 (de) * | 1988-11-05 | 1992-07-16 | Bayer Ag | Verfahren zur kernchlorierung von aromatischen kohlenwasserstoffen. |
| JP2703408B2 (ja) * | 1990-12-28 | 1998-01-26 | 麒麟麦酒株式会社 | １，４‐ベンゾチアゼピン誘導体 |
| GB9111376D0 (en) * | 1991-05-25 | 1991-07-17 | Boots Co Plc | Therapeutic agents |
| GB9203347D0 (en) * | 1992-02-17 | 1992-04-01 | Wellcome Found | Hypolipidaemic compounds |
-
1993
- 1993-11-06 ES ES94900113T patent/ES2113081T3/es not_active Expired - Lifetime
- 1993-11-06 RU RU95112484/04A patent/RU2115650C1/ru not_active IP Right Cessation
- 1993-11-06 CZ CZ19951176A patent/CZ288595B6/cs not_active IP Right Cessation
- 1993-11-06 DK DK94900113.5T patent/DK0667866T3/da active
- 1993-11-06 DE DE69317436T patent/DE69317436T2/de not_active Expired - Fee Related
- 1993-11-06 HU HU9501352A patent/HUT71819A/hu unknown
- 1993-11-06 CA CA002148584A patent/CA2148584A1/en not_active Abandoned
- 1993-11-06 NZ NZ257843A patent/NZ257843A/en unknown
- 1993-11-06 AT AT94900113T patent/ATE163927T1/de not_active IP Right Cessation
- 1993-11-06 SK SK588-95A patent/SK280522B6/sk unknown
- 1993-11-06 US US08/424,464 patent/US5580866A/en not_active Expired - Fee Related
- 1993-11-06 UA UA95062705A patent/UA41342C2/uk unknown
- 1993-11-06 BR BR9307387-9A patent/BR9307387A/pt not_active Application Discontinuation
- 1993-11-06 WO PCT/EP1993/003123 patent/WO1994011360A1/en active IP Right Grant
- 1993-11-06 KR KR1019950701831A patent/KR100313649B1/ko not_active IP Right Cessation
- 1993-11-06 PL PL93308757A patent/PL179401B1/pl unknown
- 1993-11-06 EP EP94900113A patent/EP0667866B1/en not_active Expired - Lifetime
- 1993-11-06 JP JP6511695A patent/JPH08503202A/ja not_active Withdrawn
-
1995
- 1995-05-08 NO NO951797A patent/NO304467B1/no not_active IP Right Cessation
- 1995-05-08 FI FI952204A patent/FI952204A0/fi unknown
- 1995-05-30 BG BG99679A patent/BG62519B1/bg unknown
-
1998
- 1998-03-17 GR GR980400582T patent/GR3026386T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0667866A1 (en) | 1995-08-23 |
| SK280522B6 (sk) | 2000-03-13 |
| HU9501352D0 (en) | 1995-06-28 |
| EP0667866B1 (en) | 1998-03-11 |
| US5580866A (en) | 1996-12-03 |
| HUT71819A (en) | 1996-02-28 |
| ATE163927T1 (de) | 1998-03-15 |
| KR100313649B1 (ko) | 2002-02-28 |
| RU2115650C1 (ru) | 1998-07-20 |
| NO951797D0 (no) | 1995-05-08 |
| AU680639B2 (en) | 1997-08-07 |
| NZ257843A (en) | 1996-10-28 |
| FI952204A (fi) | 1995-05-08 |
| AU5464494A (en) | 1994-06-08 |
| KR950704283A (ko) | 1995-11-17 |
| RU95112484A (ru) | 1997-04-20 |
| NO304467B1 (no) | 1998-12-21 |
| JPH08503202A (ja) | 1996-04-09 |
| NO951797L (no) | 1995-05-24 |
| GR3026386T3 (en) | 1998-06-30 |
| BR9307387A (pt) | 1999-08-31 |
| PL308757A1 (en) | 1995-08-21 |
| DE69317436T2 (de) | 1998-07-02 |
| SK58895A3 (en) | 1995-09-13 |
| BG62519B1 (bg) | 2000-01-31 |
| PL179401B1 (pl) | 2000-08-31 |
| DE69317436D1 (de) | 1998-04-16 |
| WO1994011360A1 (en) | 1994-05-26 |
| DK0667866T3 (da) | 1998-05-25 |
| ES2113081T3 (es) | 1998-04-16 |
| CZ117695A3 (en) | 1996-06-12 |
| CZ288595B6 (cs) | 2001-07-11 |
| CA2148584A1 (en) | 1994-05-26 |
| FI952204A0 (fi) | 1995-05-08 |
| BG99679A (bg) | 1996-04-30 |
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