ZA906675B - Sequence of anti-direction,anti-messenger rna,oligonucleotides of alpha tnf,preparation process,use as medicaments and pharmaceutical compositions - Google Patents
Sequence of anti-direction,anti-messenger rna,oligonucleotides of alpha tnf,preparation process,use as medicaments and pharmaceutical compositionsInfo
- Publication number
- ZA906675B ZA906675B ZA906675A ZA906675A ZA906675B ZA 906675 B ZA906675 B ZA 906675B ZA 906675 A ZA906675 A ZA 906675A ZA 906675 A ZA906675 A ZA 906675A ZA 906675 B ZA906675 B ZA 906675B
- Authority
- ZA
- South Africa
- Prior art keywords
- sequence
- oligonucleotides
- messenger rna
- medicaments
- pharmaceutical compositions
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Substances 0.000 abstract 1
- 239000000074 antisense oligonucleotide Substances 0.000 abstract 1
- 238000012230 antisense oligonucleotides Methods 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
-
- H—ELECTRICITY
- H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
- H02K—DYNAMO-ELECTRIC MACHINES
- H02K2203/00—Specific aspects not provided for in the other groups of this subclass relating to the windings
- H02K2203/03—Machines characterised by the wiring boards, i.e. printed circuit boards or similar structures for connecting the winding terminations
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Silver Salt Photography Or Processing Solution Therefor (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Thin Magnetic Films (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8911171A FR2651130B1 (fr) | 1989-08-23 | 1989-08-23 | Sequence d'oligonucleotides anti-sens, anti-arn message du tnf alpha, procede de preparation, application a titre de medicaments et compositions pharmaceutiques. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA906675B true ZA906675B (en) | 1991-10-30 |
Family
ID=9384878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA906675A ZA906675B (en) | 1989-08-23 | 1990-08-22 | Sequence of anti-direction,anti-messenger rna,oligonucleotides of alpha tnf,preparation process,use as medicaments and pharmaceutical compositions |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5705389A (ja) |
| EP (1) | EP0414607B1 (ja) |
| JP (1) | JPH0391485A (ja) |
| KR (1) | KR0151153B1 (ja) |
| CN (1) | CN1028760C (ja) |
| AT (1) | ATE120201T1 (ja) |
| AU (1) | AU642423B2 (ja) |
| CA (1) | CA2023899C (ja) |
| DE (1) | DE69017983T2 (ja) |
| DK (1) | DK0414607T3 (ja) |
| ES (1) | ES2069715T3 (ja) |
| FR (1) | FR2651130B1 (ja) |
| GR (1) | GR3015527T3 (ja) |
| HU (1) | HU215242B (ja) |
| IE (1) | IE68592B1 (ja) |
| IL (1) | IL95342A (ja) |
| PT (1) | PT95067B (ja) |
| RU (1) | RU2066325C1 (ja) |
| ZA (1) | ZA906675B (ja) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1250722B (it) * | 1991-07-30 | 1995-04-21 | Univ Degli Studi Milano | Oligonucleotidi antisenso |
| TW323284B (ja) * | 1992-03-23 | 1997-12-21 | Novartis Ag | |
| US5891679A (en) * | 1993-02-03 | 1999-04-06 | N.V. Innogenetics S.A. | TNF-alpha muteins and a process for preparing them |
| US6090382A (en) * | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| AU1249299A (en) * | 1997-11-25 | 1999-06-15 | Brax Genomics Limited | Chimeric antisense oligonucleotides against tnf-alpha and their uses |
| US20020077276A1 (en) * | 1999-04-27 | 2002-06-20 | Fredeking Terry M. | Compositions and methods for treating hemorrhagic virus infections and other disorders |
| US20040006036A1 (en) * | 2000-04-12 | 2004-01-08 | Gmr, A Delaware Corporation | Silencing transcription by methylation |
| CA2868614A1 (en) | 2001-06-08 | 2002-12-08 | Abbott Laboratories (Bermuda) Ltd. | Methods of administering anti-tnf.alpha. antibodies |
| US20040009172A1 (en) * | 2002-04-26 | 2004-01-15 | Steven Fischkoff | Use of anti-TNFalpha antibodies and another drug |
| KR20150043568A (ko) * | 2002-07-19 | 2015-04-22 | 애브비 바이오테크놀로지 리미티드 | ＴＮＦα 관련 질환의 치료 |
| WO2006041970A2 (en) * | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
| TWI399384B (zh) | 2005-05-16 | 2013-06-21 | Abbott Biotech Ltd | ＴＮＦα抑制劑於治療侵蝕型多發性關節炎之用途 |
| US20070041905A1 (en) * | 2005-08-19 | 2007-02-22 | Hoffman Rebecca S | Method of treating depression using a TNF-alpha antibody |
| US9624295B2 (en) | 2006-04-10 | 2017-04-18 | Abbvie Biotechnology Ltd. | Uses and compositions for treatment of psoriatic arthritis |
| US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
| EP2010214A4 (en) | 2006-04-10 | 2010-06-16 | Abbott Biotech Ltd | USES AND COMPOSITIONS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS |
| US9605064B2 (en) | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
| US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
| WO2008154543A2 (en) * | 2007-06-11 | 2008-12-18 | Abbott Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis |
| CN101235064B (zh) * | 2008-02-27 | 2011-08-10 | 东南大学 | 可脱保护的硫代核苷酸单体 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0090789A1 (en) * | 1982-03-26 | 1983-10-05 | Monsanto Company | Chemical DNA synthesis |
| US4959314A (en) * | 1984-11-09 | 1990-09-25 | Cetus Corporation | Cysteine-depleted muteins of biologically active proteins |
| FR2584090B1 (fr) | 1985-06-27 | 1987-08-28 | Roussel Uclaf | Nouveaux supports, leur preparation et les intermediaires obtenus, leur application a la synthese d'oligonucleotides et les nouveaux nucleosides et oligonucleotides relies aux supports ainsi obtenus |
| AU1346488A (en) * | 1987-02-26 | 1988-09-26 | Cetus Corporation | Arginine-depleted human tumor necrosis factor |
| JPH03505672A (ja) * | 1988-07-05 | 1991-12-12 | ベイラー カレッジ オブ メディシン | 高分子合成オペロンの相補アンチセンス オリゴヌクレオチド抗菌、バクテリヤ感染の処置方法 |
-
1989
- 1989-08-23 FR FR8911171A patent/FR2651130B1/fr not_active Expired - Fee Related
-
1990
- 1990-08-10 IL IL9534290A patent/IL95342A/en unknown
- 1990-08-22 ES ES90402329T patent/ES2069715T3/es not_active Expired - Lifetime
- 1990-08-22 IE IE303690A patent/IE68592B1/en not_active IP Right Cessation
- 1990-08-22 EP EP90402329A patent/EP0414607B1/fr not_active Expired - Lifetime
- 1990-08-22 ZA ZA906675A patent/ZA906675B/xx unknown
- 1990-08-22 AT AT90402329T patent/ATE120201T1/de not_active IP Right Cessation
- 1990-08-22 DE DE69017983T patent/DE69017983T2/de not_active Expired - Lifetime
- 1990-08-22 KR KR1019900013041A patent/KR0151153B1/ko not_active IP Right Cessation
- 1990-08-22 DK DK90402329.8T patent/DK0414607T3/da active
- 1990-08-22 AU AU61190/90A patent/AU642423B2/en not_active Expired
- 1990-08-22 PT PT95067A patent/PT95067B/pt not_active IP Right Cessation
- 1990-08-23 CN CN90107162A patent/CN1028760C/zh not_active Expired - Lifetime
- 1990-08-23 JP JP2220177A patent/JPH0391485A/ja active Pending
- 1990-08-23 CA CA002023899A patent/CA2023899C/fr not_active Expired - Lifetime
- 1990-08-23 HU HU905302A patent/HU215242B/hu unknown
-
1991
- 1991-12-24 RU SU915010468A patent/RU2066325C1/ru active
-
1994
- 1994-11-18 US US08/342,338 patent/US5705389A/en not_active Expired - Lifetime
-
1995
- 1995-03-23 GR GR940401796T patent/GR3015527T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2651130A1 (fr) | 1991-03-01 |
| CN1049668A (zh) | 1991-03-06 |
| IL95342A0 (en) | 1991-06-30 |
| EP0414607A3 (en) | 1991-04-03 |
| CN1028760C (zh) | 1995-06-07 |
| HUT56113A (en) | 1991-07-29 |
| ATE120201T1 (de) | 1995-04-15 |
| ES2069715T3 (es) | 1995-05-16 |
| RU2066325C1 (ru) | 1996-09-10 |
| PT95067A (pt) | 1991-04-18 |
| AU6119090A (en) | 1991-02-28 |
| FR2651130B1 (fr) | 1991-12-13 |
| AU642423B2 (en) | 1993-10-21 |
| EP0414607B1 (fr) | 1995-03-22 |
| CA2023899A1 (fr) | 1991-02-24 |
| KR0151153B1 (ko) | 1998-08-17 |
| PT95067B (pt) | 1997-05-28 |
| HU215242B (hu) | 1998-11-30 |
| DE69017983D1 (de) | 1995-04-27 |
| JPH0391485A (ja) | 1991-04-17 |
| DE69017983T2 (de) | 1995-09-28 |
| EP0414607A2 (fr) | 1991-02-27 |
| US5705389A (en) | 1998-01-06 |
| IL95342A (en) | 1995-01-24 |
| IE68592B1 (en) | 1996-06-26 |
| GR3015527T3 (en) | 1995-06-30 |
| IE903036A1 (en) | 1991-02-27 |
| DK0414607T3 (da) | 1995-06-06 |
| HU905302D0 (en) | 1991-02-28 |
| CA2023899C (fr) | 2002-05-14 |
| KR910004198A (ko) | 1991-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL95342A0 (en) | Sequence of anti-direction,anti-messenger rna oligonucleotides and alpha tnf,preparation process,use as medicaments and pharmaceutical compositions | |
| MY107056A (en) | Lactam free cyclic amino acids. | |
| IL95691A0 (en) | Thienylcarboxylates of amino alcohols,their preparation and pharmaceutical compositions containing them | |
| CA2307820A1 (en) | Novel tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them | |
| AU568067B2 (en) | Oligonucleotide therapeutic agent and methods of making same | |
| EP0221041A3 (en) | Benzimidazole derivatives, process for their preparation and their pharmaceutical use | |
| GR3026218T3 (en) | Antiviral 4-substituted-2-deoxy-2,3-didehydro derivatives of alpha D-neuraminic acid | |
| KR960700062A (ko) | 산성 pH에서의 안정성을 개선시키기 위해 변형된 올리고누클레오티드(OLIGONUCLEOTIDES MODIFIED TO IMPROVE STABILITY AT ACIC pH) | |
| MY101784A (en) | Novel pharmacological compounds | |
| PT84662B (en) | Process for the preparation of pharmaceutical compositions containing 7,alpha-]1(s)-hydroxy-1-methylbuthyl"-6,14-endoetheno-6,7,8,14-tetrahydro-oripavine (etorphine) | |
| HUT52040A (en) | Process for producing diaryl-derivatives and pharmaceutical compositions containing them | |
| EP1122252A4 (en) | CONDENSED HEREROCYCLIC NITROGEN COMPOUNDS; MANUFACTURING PROCESS AND AGENTS CONTAINING THEM | |
| EP0362860A3 (en) | Alcohol-modified silicone ester derivative and cosmetic composition containing same | |
| OA09201A (fr) | "Dérivés sulfonyles de la thiéno-triazolo-diazépine, un procédé pour leur préparation et des compositions thérapeutiques en contenant". | |
| HUT41025A (en) | Process for preparing octahydro-indolizine derivatives and pharmaceutical compositions containing such compounds as active ingredients | |
| EP0328913A3 (de) | Neue basisch substituierte 5-Halogen-Thienoisothiazol-3(2H)-on-1,1-dioxide, ein Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate | |
| KR880013938A (ko) | 활성 화합물들 | |
| FR2701952B1 (fr) | Nouveaux dérivés cyclopeptidiques de l'angiopeptine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. | |
| GB8608893D0 (en) | D-nor-7-ergoline derivatives | |
| EP0382854A4 (en) | Indoleacetic acid derivatives, process for their preparation, and medicines containing same as active ingredients | |
| EP0107261A3 (en) | (2-((nitropyridinyl)amino)phenyl)arylmethanones and salts, their use in medicine, pharmaceutical compositions containing them and their use in the preparation of (2-((aminopyridinyl)amino)phenyl)arylmethanones and pyrido(1,4)benzodiazepines | |
| ES8900140A1 (es) | Un procedimiento para preparar compuestos de azatricicloalqueno. | |
| GEP20022796B (en) | Novel Aryloxy-Alkyl-Dialkylamines | |
| BG90361A (en) | Composition and method for the preparation of water soluble powder containing erythromycin thiocyanate | |
| IL83543A0 (en) | Pharmaceutical compositions containing dopamine-beta-hydroxylase inhibiting aralkylimidazoles derivatives,some new such compounds and their preparation |