ZA904174B - Monoclonal antibodies for inducing tolerance - Google Patents

Monoclonal antibodies for inducing tolerance

Info

Publication number
ZA904174B
ZA904174B ZA904174A ZA904174A ZA904174B ZA 904174 B ZA904174 B ZA 904174B ZA 904174 A ZA904174 A ZA 904174A ZA 904174 A ZA904174 A ZA 904174A ZA 904174 B ZA904174 B ZA 904174B
Authority
ZA
South Africa
Prior art keywords
depleting
monoclonal antibodies
inducing tolerance
monoclonal antibody
tolerance
Prior art date
Application number
ZA904174A
Other languages
English (en)
Inventor
Stephen Paul Cobbold
Paul Cobbold Stephen
Herman Waldmann
Waldmann Herman
Original Assignee
Cobbold Stephen P
Waldmann Herman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cobbold Stephen P, Waldmann Herman filed Critical Cobbold Stephen P
Publication of ZA904174B publication Critical patent/ZA904174B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2815—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2812—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA904174A 1989-05-31 1990-05-30 Monoclonal antibodies for inducing tolerance ZA904174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898912497A GB8912497D0 (en) 1989-05-31 1989-05-31 Monoclonal antibodies

Publications (1)

Publication Number Publication Date
ZA904174B true ZA904174B (en) 1992-02-26

Family

ID=10657649

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA904174A ZA904174B (en) 1989-05-31 1990-05-30 Monoclonal antibodies for inducing tolerance

Country Status (19)

Country Link
EP (1) EP0474691B1 (hu)
JP (1) JP2763197B2 (hu)
KR (1) KR0183029B1 (hu)
AT (1) ATE145246T1 (hu)
AU (1) AU657255B2 (hu)
CA (1) CA2055615C (hu)
DD (1) DD296843A5 (hu)
DE (1) DE69029134T2 (hu)
DK (1) DK0474691T3 (hu)
ES (1) ES2096588T3 (hu)
GB (1) GB8912497D0 (hu)
HU (1) HUT61341A (hu)
IE (1) IE80735B1 (hu)
IL (1) IL94566A0 (hu)
MY (1) MY135673A (hu)
NZ (1) NZ233889A (hu)
PT (1) PT94214B (hu)
WO (1) WO1990015152A1 (hu)
ZA (1) ZA904174B (hu)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100741D0 (en) * 1991-01-14 1991-02-27 Univ London Treatment of disease
US6136310A (en) * 1991-07-25 2000-10-24 Idec Pharmaceuticals Corporation Recombinant anti-CD4 antibodies for human therapy
CA2140933A1 (en) * 1992-08-21 1994-02-22 Paula M. Jardieu Method for treating an lfa-1 mediated disorder
US6270766B1 (en) 1992-10-08 2001-08-07 The Kennedy Institute Of Rheumatology Anti-TNF antibodies and methotrexate in the treatment of arthritis and crohn's disease
CA2221350A1 (en) * 1995-05-18 1996-11-21 Ortho Pharmaceutical Corporation Induction of immunological tolerance by the use of non-depleting anti-cd4 antibodies
CN1371416B (zh) 1999-08-24 2012-10-10 梅达里克斯公司 人ctla-4抗体及其应用
US7011952B2 (en) 2000-02-22 2006-03-14 University Of Iowa Research Foundation Diagnostics and therapeutics for macular degeneration-related disorders
DK1287364T3 (da) 2000-04-29 2009-03-02 Univ Iowa Res Found Diagnostisk og terapi til makulære degenerationsrelaterede lidelser
US7541443B2 (en) * 2001-06-14 2009-06-02 Tolerrx, Inc. Anti-CD4 antibodies
JP4448906B2 (ja) * 2001-06-14 2010-04-14 イシス イノベーション リミテッド Ｃｄ４特異的抗体ｔｒｘ１およびその使用
EP1460088A1 (en) 2003-03-21 2004-09-22 Biotest AG Humanized anti-CD4 antibody with immunosuppressive properties
GB0314461D0 (en) * 2003-06-20 2003-07-23 Isis Innovation Suppression of transplant rejection
CA2570849A1 (en) * 2004-06-22 2006-01-05 Tolerrx, Inc. Optimized dosing with anti-cd4 antibodies for tolerance induction in primates
CA2718184A1 (en) 2008-03-13 2009-10-08 Biotest Ag Agent for treating disease
CN102027016A (zh) 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
CN102027018A (zh) 2008-03-13 2011-04-20 生物测试股份公司 一种治疗疾病的试剂
BRPI0915582A2 (pt) * 2008-06-06 2016-01-26 Baylor Res Inst anticorpos anto-cd8 que bloqueiam a sensibilização de efetores citotóxicos e levam à geração de células t cd8+ reguladoras
US20100021460A1 (en) * 2008-07-15 2010-01-28 Genentech, Inc. Methods of Treating Autoimmune Diseases Using CD4 Antibodies
GB0920944D0 (en) 2009-11-30 2010-01-13 Biotest Ag Agents for treating disease
WO2024112867A1 (en) 2022-11-23 2024-05-30 University Of Georgia Research Foundation, Inc. Compositions and methods of use thereof for increasing immune responses

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8608068D0 (en) * 1986-04-02 1986-05-08 Cobbold S P Monoclonal antibodies

Also Published As

Publication number Publication date
NZ233889A (en) 1997-06-24
HU905134D0 (en) 1992-02-28
IE901949L (en) 1990-11-30
DE69029134T2 (de) 1997-03-06
EP0474691A1 (en) 1992-03-18
PT94214B (pt) 1997-03-31
GB8912497D0 (en) 1989-07-19
HUT61341A (en) 1992-12-28
WO1990015152A1 (en) 1990-12-13
KR0183029B1 (ko) 1999-04-01
IL94566A0 (en) 1991-03-10
ES2096588T3 (es) 1997-03-16
EP0474691B1 (en) 1996-11-13
ATE145246T1 (de) 1996-11-15
JPH04505919A (ja) 1992-10-15
JP2763197B2 (ja) 1998-06-11
CA2055615A1 (en) 1990-12-13
CA2055615C (en) 2001-07-17
AU5725890A (en) 1991-01-07
MY135673A (en) 2008-06-30
DK0474691T3 (da) 1996-12-02
DE69029134D1 (de) 1996-12-19
IE80735B1 (en) 1998-12-30
DD296843A5 (de) 1991-12-19
PT94214A (pt) 1991-02-08
AU657255B2 (en) 1995-03-09

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