ZA896914B - Stable bioactive somatotropins - Google Patents

Stable bioactive somatotropins

Info

Publication number
ZA896914B
ZA896914B ZA896914A ZA896914A ZA896914B ZA 896914 B ZA896914 B ZA 896914B ZA 896914 A ZA896914 A ZA 896914A ZA 896914 A ZA896914 A ZA 896914A ZA 896914 B ZA896914 B ZA 896914B
Authority
ZA
South Africa
Prior art keywords
stable bioactive
somatotropins
bioactive somatotropins
stable
bioactive
Prior art date
Application number
ZA896914A
Other languages
English (en)
Inventor
Zafar I Randawa
I Randawa Zafar
James E Seely
E Seely James
Original Assignee
Pitman Moore Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pitman Moore Inc filed Critical Pitman Moore Inc
Publication of ZA896914B publication Critical patent/ZA896914B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA896914A 1988-09-12 1989-09-11 Stable bioactive somatotropins ZA896914B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/242,542 US5079230A (en) 1988-09-12 1988-09-12 Stable bioactive somatotropins

Publications (1)

Publication Number Publication Date
ZA896914B true ZA896914B (en) 1990-10-31

Family

ID=22915193

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA896914A ZA896914B (en) 1988-09-12 1989-09-11 Stable bioactive somatotropins

Country Status (16)

Country Link
US (1) US5079230A (de)
EP (1) EP0433395A1 (de)
JP (1) JPH04500519A (de)
CN (1) CN1037845C (de)
AU (1) AU4330889A (de)
CA (1) CA1339759C (de)
DD (1) DD289544A5 (de)
ES (1) ES2018397A6 (de)
GR (1) GR1002144B (de)
HU (2) HU206375B (de)
NZ (1) NZ230610A (de)
PL (1) PL162822B1 (de)
RU (1) RU2073686C1 (de)
UA (1) UA26853C2 (de)
WO (1) WO1990002758A1 (de)
ZA (1) ZA896914B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0355460B1 (de) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
US5849694A (en) * 1990-07-16 1998-12-15 Synenki; Richard M. Stable and bioactive modified porcine somatotropin and pharmaceutical compositions thereof
US5169834A (en) * 1990-11-30 1992-12-08 American Cyanamid Company Compositions and method for reducing vial breakage during lyophilization
ZA94169B (en) * 1993-01-26 1994-09-07 Lilly Co Eli Non-denaturing potency assay for bovine somatotropin
US5567620A (en) * 1993-01-26 1996-10-22 Eli Lilly And Company Non-denaturing potency assay for somatotropin
DE4303744A1 (de) * 1993-02-09 1994-08-11 Univ Autonoma De Nuevo Leon Mo Hundewachstumshormon
DK44593D0 (da) * 1993-04-20 1993-04-20 Novo Nordisk As Fremgangsmaade til fremstilling af et polypeptid
ZA9711731B (en) * 1996-12-31 1998-07-01 Monsanto Co Aqueous glycerol formulations of somatotropin
AU7493198A (en) * 1997-05-15 1998-12-08 Geoffrey J Schmidt Method of reducing immunological tolerance to malignancy
ZA985545B (en) * 1997-06-25 1999-04-01 Applied Research Systems Disulfide crosslinking glycoprotein hormone analogs and their preparation and use
CA2412277A1 (en) * 2000-09-08 2002-03-14 Gryphon Therapeutics, Inc. Synthetic erythropoiesis stimulating proteins
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
ES2343518T3 (es) * 2002-09-09 2010-08-03 Hanall Biopharma Co., Ltd. Polipeptidos interferon alfa modificados resistentes a proteasas.
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
RU2605627C2 (ru) 2010-01-22 2016-12-27 Ново Нордиск Хелс Кеа Аг Гормоны роста с пролонгированной эффективностью in vivo
EP2446898A1 (de) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Verwendung von Wachstumshormonen zur Verbesserung der Immunantwort bei immunsupprimierten Patienten
ES2841123T3 (es) 2013-04-05 2021-07-07 Formulacion Del Compuesto De La Hormona De Crecimiento Formulación del compuesto de la hormona de crecimiento
CN108828237B (zh) * 2018-08-24 2021-04-02 浙江理工大学 一种分析羊毛角蛋白中氨基酸键合折叠分布的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853832A (en) * 1971-04-27 1974-12-10 Harmone Res Foundation Synthetic human pituitary growth hormone and method of producing it
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
JPS5630925A (en) * 1979-08-21 1981-03-28 Sumitomo Chem Co Ltd Purification of human growth hormone
EP0103395A3 (de) * 1982-08-17 1985-05-22 Biogen N.V. DNS-Sequenzen, rekombinante DNS-Moleküle und Verfahren zur Herstellung von rinderwachstumshormonähnlichen Polypeptiden, mit grosser Ausbeute
CA1341012C (en) * 1982-09-27 2000-06-06 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides
IE56026B1 (en) * 1982-10-19 1991-03-27 Cetus Corp Cysteine-depleted muteins of biologically active proteins
US4620948A (en) * 1982-12-22 1986-11-04 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US6916914B1 (en) * 1985-06-26 2005-07-12 Pharmacia & Upjohn Co. Purification of somatotropin from transformed microorganisms
US4766205A (en) * 1985-11-13 1988-08-23 Beatrice Companies, Inc. Method for isolation of recombinant polypeptides in biologically active forms
US4816568A (en) * 1986-05-16 1989-03-28 International Minerals & Chemical Corp. Stabilization of growth hormones
EP0355460B1 (de) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung

Also Published As

Publication number Publication date
HU910787D0 (en) 1991-09-30
AU4330889A (en) 1990-04-02
ES2018397A6 (es) 1991-04-01
NZ230610A (en) 1991-12-23
HU206375B (en) 1992-10-28
GR1002144B (en) 1996-02-16
UA26853C2 (uk) 1999-12-29
PL162822B1 (pl) 1994-01-31
US5079230A (en) 1992-01-07
HUT56856A (en) 1991-10-28
CA1339759C (en) 1998-03-17
DD289544A5 (de) 1991-05-02
CN1041160A (zh) 1990-04-11
EP0433395A1 (de) 1991-06-26
WO1990002758A1 (en) 1990-03-22
JPH04500519A (ja) 1992-01-30
GR890100562A (el) 1990-10-31
RU2073686C1 (ru) 1997-02-20
CN1037845C (zh) 1998-03-25

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