ZA892407B - 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof - Google Patents

6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof

Info

Publication number
ZA892407B
ZA892407B ZA892407A ZA892407A ZA892407B ZA 892407 B ZA892407 B ZA 892407B ZA 892407 A ZA892407 A ZA 892407A ZA 892407 A ZA892407 A ZA 892407A ZA 892407 B ZA892407 B ZA 892407B
Authority
ZA
South Africa
Prior art keywords
group
atom
oxygen atom
active ingredient
same
Prior art date
Application number
ZA892407A
Other languages
English (en)
Inventor
Tasashi Miyasaka
Miyasaka Tasashi
Hiromichi Tanaka
Tanaka Hiromichi
Erik Desire Alice De Clercq
Desire Alice De Clercq Erik
Richard Thomas Walker
Thomas Walker Richard
Masaru Ubasawa
Ubasawa Masaru
Masonori Baba
Baba Masonori
Original Assignee
Mitsubishi Chem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chem Ind filed Critical Mitsubishi Chem Ind
Publication of ZA892407B publication Critical patent/ZA892407B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA892407A 1988-03-31 1989-03-31 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof ZA892407B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7667788 1988-03-31

Publications (1)

Publication Number Publication Date
ZA892407B true ZA892407B (en) 1989-11-29

Family

ID=13612062

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892407A ZA892407B (en) 1988-03-31 1989-03-31 6-substituted acyclopyrimidine nucleoside derivative and antiviral agent containing the same as active ingredient thereof

Country Status (12)

Country Link
US (1) US5112835A (fr)
EP (1) EP0371139B1 (fr)
KR (1) KR950006713B1 (fr)
AT (1) ATE112767T1 (fr)
CA (1) CA1334535C (fr)
CH (1) CH676712A5 (fr)
DD (1) DD283613A5 (fr)
DE (1) DE68918804T2 (fr)
ES (1) ES2013664A6 (fr)
HU (1) HU206328B (fr)
WO (1) WO1989009213A1 (fr)
ZA (1) ZA892407B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE37979E1 (en) 1989-09-29 2003-02-04 Mitsubishi Chemical Corporation Pyrimidine derivatives and anti-viral agent containing the same as active ingredient thereof
KR0155168B1 (ko) * 1989-09-29 1998-11-16 미우라 아끼라 6-치환된 아시클로피리미딘 뉴클레오시드 유도체 및 이를 활성성분으로 함유하는 항비루스제
HU205917B (en) * 1989-09-29 1992-07-28 Mitsubishi Chem Ind Process for producing 6-substituted pyrimidine derivatives and antiviral pharmaceutical compositions containing them as active components
CA2039039C (fr) * 1990-03-29 2001-05-15 Tadashi Miyasaka Derive de nucleoside pyrimidique et agent antiviral contenant le derive en tant qu'ingredient actif
SG49855A1 (en) 1990-07-19 1998-06-15 Wellcome Found Enzyme inactivators
GB9020930D0 (en) 1990-09-26 1990-11-07 Wellcome Found Pharmaceutical combinations
WO1993002044A1 (fr) * 1991-07-22 1993-02-04 Baker Cummins Pharmaceuticals, Inc. Nucleosides acycliques de 6-phenylselenyle pyrimidine
US5792868A (en) * 1991-09-18 1998-08-11 Ajinomoto Co., Inc. Process for producing acyclic nucleosides and process for separating purine nucleosides
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
US6051576A (en) * 1994-01-28 2000-04-18 University Of Kentucky Research Foundation Means to achieve sustained release of synergistic drugs by conjugation
US5889013A (en) * 1994-02-28 1999-03-30 Sunkyong Industries Co., Inc. Pyrimidine acyclonucleoside derivatives
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
KR100658489B1 (ko) 1998-11-10 2006-12-18 얀센 파마슈티카 엔.브이. Ｈｉｖ 복제를 억제하는 피리미딘
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
KR100785360B1 (ko) 1999-09-24 2007-12-18 얀센 파마슈티카 엔.브이. 항바이러스 조성물
GB0400290D0 (en) * 2004-01-08 2004-02-11 Medivir Ab dUTPase inhibitors
JP2010532350A (ja) * 2007-06-29 2010-10-07 コレア リサーチ インスティテュート オブ ケミカル テクノロジー 新規のｈｉｖ逆転写酵素阻害剤
WO2009005693A1 (fr) * 2007-06-29 2009-01-08 Gilead Sciences, Inc. Nouveaux inhibiteurs de la transcriptase inverse de vih
WO2009085797A1 (fr) * 2007-12-21 2009-07-09 Gilead Sciences, Inc. Procédés de préparation d'inhibiteurs de la transcriptase inverse du vih
HRPK20090508B3 (hr) 2009-09-25 2012-12-31 Sveučilište u Zagrebu Novi 6-supstituirani derivati pirimidina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5434751B2 (fr) * 1972-08-11 1979-10-29
US3947444A (en) * 1973-06-21 1976-03-30 Solomon Aronovich Giller Process for producing N1 -(Dihydroxyalkyl)-5-substituted uracils
JPS5032186A (fr) * 1973-07-17 1975-03-28
JPS5188974A (fr) * 1975-02-03 1976-08-04
JPS5738774A (en) * 1980-08-19 1982-03-03 Chugai Pharmaceut Co Ltd Uracil derivative and its preparation
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
JP3245191B2 (ja) * 1991-07-30 2002-01-07 ヤマハ発動機株式会社 自動二輪車のメインスタンドロック装置
JPH05188974A (ja) * 1992-01-08 1993-07-30 Pioneer Electron Corp 多入力音量調整装置
JPH06156171A (ja) * 1992-11-18 1994-06-03 Mitsubishi Electric Corp 車載用レーダ装置

Also Published As

Publication number Publication date
KR950006713B1 (ko) 1995-06-21
HU206328B (en) 1992-10-28
AU3357589A (en) 1989-10-16
AU611284B2 (en) 1991-06-06
EP0371139A4 (en) 1991-08-28
EP0371139B1 (fr) 1994-10-12
DD283613A5 (de) 1990-10-17
EP0371139A1 (fr) 1990-06-06
ES2013664A6 (es) 1990-05-16
DE68918804D1 (de) 1994-11-17
CH676712A5 (fr) 1991-02-28
KR900700463A (ko) 1990-08-13
ATE112767T1 (de) 1994-10-15
DE68918804T2 (de) 1995-02-23
US5112835A (en) 1992-05-12
CA1334535C (fr) 1995-02-21
WO1989009213A1 (fr) 1989-10-05

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