ZA892105B - Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives - Google Patents

Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives

Info

Publication number
ZA892105B
ZA892105B ZA892105A ZA892105A ZA892105B ZA 892105 B ZA892105 B ZA 892105B ZA 892105 A ZA892105 A ZA 892105A ZA 892105 A ZA892105 A ZA 892105A ZA 892105 B ZA892105 B ZA 892105B
Authority
ZA
South Africa
Prior art keywords
cyano
adenosine derivatives
aristeromycin
allenic
novel acetylenic
Prior art date
Application number
ZA892105A
Other languages
English (en)
Inventor
Michael L Edwards
L Edwards Michael
James R Mccarthy
R Mccarthy James
Nellikunja J Prakash
J Prakash Nellikunja
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA892105B publication Critical patent/ZA892105B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA892105A 1988-03-25 1989-03-20 Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives ZA892105B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,782 US4996308A (en) 1988-03-25 1988-03-25 Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (1)

Publication Number Publication Date
ZA892105B true ZA892105B (en) 1989-11-29

Family

ID=22633462

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA892105A ZA892105B (en) 1988-03-25 1989-03-20 Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives

Country Status (21)

Country Link
US (1) US4996308A (pt)
EP (1) EP0334361B1 (pt)
JP (1) JP2829737B2 (pt)
KR (1) KR0135529B1 (pt)
CN (1) CN1023804C (pt)
AR (1) AR247403A1 (pt)
AT (1) ATE121415T1 (pt)
AU (1) AU606792B2 (pt)
CA (1) CA1322195C (pt)
DE (1) DE68922235T2 (pt)
DK (1) DK171645B1 (pt)
ES (1) ES2074060T3 (pt)
FI (1) FI90877C (pt)
HU (1) HU203561B (pt)
IE (1) IE67543B1 (pt)
IL (1) IL89689A0 (pt)
NO (1) NO171856C (pt)
NZ (1) NZ228422A (pt)
PH (1) PH26776A (pt)
PT (1) PT90080B (pt)
ZA (1) ZA892105B (pt)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
AU629988B2 (en) * 1989-10-11 1992-10-15 Merrell Dow Pharmaceuticals Inc. Inosine/guanosine derivatives as antineoplastic agents
NZ235577A (en) * 1989-10-11 1993-01-27 Merrell Dow Pharma 4'-vinylhalo-inosine/guanosine derivatives and pharmaceutical compositions thereof
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
JPH0421682A (ja) * 1990-05-11 1992-01-24 Asahi Chem Ind Co Ltd ２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
WO1994021659A1 (en) * 1993-03-18 1994-09-29 Yamasa Corporation Novel 2'-methylidenenucleotide compound, process for producing the same, and pharmaceutical use thereof
WO1996011200A1 (en) * 1994-10-05 1996-04-18 Chiroscience Limited Purine and guanine compounds as inhibitors of pnp
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CZ9901996A3 (cs) * 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
AU784794B2 (en) * 1999-06-09 2006-06-22 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) * 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
CA2410579C (en) * 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN102746304B (zh) * 2012-06-21 2014-03-19 成都苑东药业有限公司 一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1113851A (en) * 1965-05-29 1968-05-15 Upjohn Co Decoyinine derivatives
US3472837A (en) * 1966-10-10 1969-10-14 Syntex Corp Unsaturated nucleosides and process for their preparation
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3585189A (en) * 1969-06-27 1971-06-15 Syntex Corp Unsaturated nucleosides and processes for their preparation
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore
EP0184365B1 (en) * 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
KR890014573A (ko) 1989-10-24
EP0334361A2 (en) 1989-09-27
DK171645B1 (da) 1997-03-03
KR0135529B1 (ko) 1998-04-23
CN1023804C (zh) 1994-02-16
FI90877B (fi) 1993-12-31
NO891248L (no) 1989-09-26
HUT49367A (en) 1989-09-28
FI891339A0 (fi) 1989-03-21
FI891339A (fi) 1989-09-26
ES2074060T3 (es) 1995-09-01
JP2829737B2 (ja) 1998-12-02
HU203561B (en) 1991-08-28
ATE121415T1 (de) 1995-05-15
AU3173789A (en) 1989-09-28
PT90080B (pt) 1994-06-30
NO171856B (no) 1993-02-01
DE68922235D1 (de) 1995-05-24
DK145289D0 (da) 1989-03-22
PT90080A (pt) 1989-11-10
DK145289A (da) 1989-09-26
PH26776A (en) 1992-10-13
US4996308A (en) 1991-02-26
NO171856C (no) 1993-05-12
CN1036579A (zh) 1989-10-25
EP0334361B1 (en) 1995-04-19
EP0334361A3 (en) 1991-04-03
IE67543B1 (en) 1996-04-17
IE890953L (en) 1989-09-25
IL89689A0 (en) 1989-09-28
DE68922235T2 (de) 1995-08-31
NO891248D0 (no) 1989-03-21
AU606792B2 (en) 1991-02-14
AR247403A1 (es) 1994-12-29
CA1322195C (en) 1993-09-14
NZ228422A (en) 1991-04-26
FI90877C (fi) 1994-04-11
JPH01283285A (ja) 1989-11-14

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