DE68922235D1 - Durch Acetylen, Cyan oder Allen substituierte Aristeromycin- oder Adenosin-Derivate. - Google Patents

Durch Acetylen, Cyan oder Allen substituierte Aristeromycin- oder Adenosin-Derivate.

Info

Publication number
DE68922235D1
DE68922235D1 DE68922235T DE68922235T DE68922235D1 DE 68922235 D1 DE68922235 D1 DE 68922235D1 DE 68922235 T DE68922235 T DE 68922235T DE 68922235 T DE68922235 T DE 68922235T DE 68922235 D1 DE68922235 D1 DE 68922235D1
Authority
DE
Germany
Prior art keywords
aristeromycin
allen
acetylene
cyan
derivatives substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68922235T
Other languages
English (en)
Other versions
DE68922235T2 (de
Inventor
Michael L Edwards
Nellikunja J Prakash
James R Mccarthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE68922235D1 publication Critical patent/DE68922235D1/de
Application granted granted Critical
Publication of DE68922235T2 publication Critical patent/DE68922235T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE68922235T 1988-03-25 1989-03-23 Durch Acetylen, Cyan oder Allen substituierte Aristeromycin- oder Adenosin-Derivate. Expired - Fee Related DE68922235T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,782 US4996308A (en) 1988-03-25 1988-03-25 Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (2)

Publication Number Publication Date
DE68922235D1 true DE68922235D1 (de) 1995-05-24
DE68922235T2 DE68922235T2 (de) 1995-08-31

Family

ID=22633462

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68922235T Expired - Fee Related DE68922235T2 (de) 1988-03-25 1989-03-23 Durch Acetylen, Cyan oder Allen substituierte Aristeromycin- oder Adenosin-Derivate.

Country Status (21)

Country Link
US (1) US4996308A (de)
EP (1) EP0334361B1 (de)
JP (1) JP2829737B2 (de)
KR (1) KR0135529B1 (de)
CN (1) CN1023804C (de)
AR (1) AR247403A1 (de)
AT (1) ATE121415T1 (de)
AU (1) AU606792B2 (de)
CA (1) CA1322195C (de)
DE (1) DE68922235T2 (de)
DK (1) DK171645B1 (de)
ES (1) ES2074060T3 (de)
FI (1) FI90877C (de)
HU (1) HU203561B (de)
IE (1) IE67543B1 (de)
IL (1) IL89689A0 (de)
NO (1) NO171856C (de)
NZ (1) NZ228422A (de)
PH (1) PH26776A (de)
PT (1) PT90080B (de)
ZA (1) ZA892105B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
CA2027023C (en) * 1989-10-11 2001-12-25 Esa T. Jarvi Inosine/guanosine derivatives
AU629988B2 (en) * 1989-10-11 1992-10-15 Merrell Dow Pharmaceuticals Inc. Inosine/guanosine derivatives as antineoplastic agents
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
JPH0421682A (ja) * 1990-05-11 1992-01-24 Asahi Chem Ind Co Ltd ２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
EP0690068A4 (de) * 1993-03-18 1996-07-31 Akira Matsuda 2'-methyliden nukleotid-verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
HUT77436A (hu) * 1994-10-05 1998-04-28 Darwin Discovery Limited Purin- és guaninszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CZ9901996A3 (cs) * 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
AU784794B2 (en) * 1999-06-09 2006-06-22 Anticancer, Inc. Modulators of methylation for control of bacterial virulence
US6579857B1 (en) * 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
NZ547204A (en) * 2000-05-26 2008-01-31 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN102746304B (zh) * 2012-06-21 2014-03-19 成都苑东药业有限公司 一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1113851A (en) * 1965-05-29 1968-05-15 Upjohn Co Decoyinine derivatives
US3472837A (en) * 1966-10-10 1969-10-14 Syntex Corp Unsaturated nucleosides and process for their preparation
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3585189A (en) * 1969-06-27 1971-06-15 Syntex Corp Unsaturated nucleosides and processes for their preparation
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
ZA892105B (en) 1989-11-29
CA1322195C (en) 1993-09-14
CN1036579A (zh) 1989-10-25
US4996308A (en) 1991-02-26
NO171856C (no) 1993-05-12
AU3173789A (en) 1989-09-28
PH26776A (en) 1992-10-13
NO891248D0 (no) 1989-03-21
FI891339A (fi) 1989-09-26
EP0334361B1 (de) 1995-04-19
ES2074060T3 (es) 1995-09-01
FI891339A0 (fi) 1989-03-21
DE68922235T2 (de) 1995-08-31
ATE121415T1 (de) 1995-05-15
DK145289A (da) 1989-09-26
EP0334361A3 (de) 1991-04-03
KR0135529B1 (ko) 1998-04-23
IE890953L (en) 1989-09-25
JP2829737B2 (ja) 1998-12-02
AR247403A1 (es) 1994-12-29
KR890014573A (ko) 1989-10-24
JPH01283285A (ja) 1989-11-14
FI90877B (fi) 1993-12-31
FI90877C (fi) 1994-04-11
NO171856B (no) 1993-02-01
HUT49367A (en) 1989-09-28
CN1023804C (zh) 1994-02-16
EP0334361A2 (de) 1989-09-27
PT90080B (pt) 1994-06-30
NZ228422A (en) 1991-04-26
AU606792B2 (en) 1991-02-14
DK145289D0 (da) 1989-03-22
HU203561B (en) 1991-08-28
NO891248L (no) 1989-09-26
IL89689A0 (en) 1989-09-28
PT90080A (pt) 1989-11-10
DK171645B1 (da) 1997-03-03
IE67543B1 (en) 1996-04-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee