ATE121415T1 - Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate. - Google Patents

Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate.

Info

Publication number
ATE121415T1
ATE121415T1 AT89105254T AT89105254T ATE121415T1 AT E121415 T1 ATE121415 T1 AT E121415T1 AT 89105254 T AT89105254 T AT 89105254T AT 89105254 T AT89105254 T AT 89105254T AT E121415 T1 ATE121415 T1 AT E121415T1
Authority
AT
Austria
Prior art keywords
aristeromycin
cyane
acetylene
derivatives substituted
adenosine derivatives
Prior art date
Application number
AT89105254T
Other languages
English (en)
Inventor
Michael L Edwards
Nellikunja J Prakash
James R Mccarthy
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of ATE121415T1 publication Critical patent/ATE121415T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT89105254T 1988-03-25 1989-03-23 Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate. ATE121415T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/173,782 US4996308A (en) 1988-03-25 1988-03-25 Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (1)

Publication Number Publication Date
ATE121415T1 true ATE121415T1 (de) 1995-05-15

Family

ID=22633462

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89105254T ATE121415T1 (de) 1988-03-25 1989-03-23 Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate.

Country Status (21)

Country Link
US (1) US4996308A (de)
EP (1) EP0334361B1 (de)
JP (1) JP2829737B2 (de)
KR (1) KR0135529B1 (de)
CN (1) CN1023804C (de)
AR (1) AR247403A1 (de)
AT (1) ATE121415T1 (de)
AU (1) AU606792B2 (de)
CA (1) CA1322195C (de)
DE (1) DE68922235T2 (de)
DK (1) DK171645B1 (de)
ES (1) ES2074060T3 (de)
FI (1) FI90877C (de)
HU (1) HU203561B (de)
IE (1) IE67543B1 (de)
IL (1) IL89689A0 (de)
NO (1) NO171856C (de)
NZ (1) NZ228422A (de)
PH (1) PH26776A (de)
PT (1) PT90080B (de)
ZA (1) ZA892105B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3924424A1 (de) * 1989-07-24 1991-01-31 Boehringer Mannheim Gmbh Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
NZ235577A (en) * 1989-10-11 1993-01-27 Merrell Dow Pharma 4'-vinylhalo-inosine/guanosine derivatives and pharmaceutical compositions thereof
ZA907998B (en) * 1989-10-11 1991-07-31 Merrell Dow Pharma Inosine/guanosine derivatives as antineoplastic agents
GB8926417D0 (en) * 1989-11-22 1990-01-10 Wellcome Found Heterocyclic compounds
JPH0421682A (ja) * 1990-05-11 1992-01-24 Asahi Chem Ind Co Ltd ２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
EP0690068A4 (de) * 1993-03-18 1996-07-31 Akira Matsuda 2'-methyliden nukleotid-verbindungen, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
JPH10507171A (ja) * 1994-10-05 1998-07-14 カイロサイエンス・リミテッド Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
CZ9901996A3 (cs) * 1999-06-04 2001-01-17 Ústav organické chemie a biochemie AV ČR Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
EP1183034B1 (de) * 1999-06-09 2005-11-23 Anticancer, Inc. Modulatoren der methylierung zur kontrolle von bakterieller virulenz
US6579857B1 (en) * 1999-06-11 2003-06-17 Evanston Northwestern Healthcare Research Institute Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
JP5230052B2 (ja) * 2000-05-26 2013-07-10 イデニクス（ケイマン）リミテツド フラビウイルスおよびペスチウイルス治療のための方法および組成物
US20040162422A1 (en) * 2001-03-20 2004-08-19 Adrian Hall Chemical compounds
KR20040036417A (ko) * 2002-10-25 2004-04-30 정낙신 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) * 2005-01-20 2012-08-15 独立行政法人理化学研究所 イミダゾピリジン誘導体
CN102746304B (zh) * 2012-06-21 2014-03-19 成都苑东药业有限公司 一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1113851A (en) * 1965-05-29 1968-05-15 Upjohn Co Decoyinine derivatives
US3472837A (en) * 1966-10-10 1969-10-14 Syntex Corp Unsaturated nucleosides and process for their preparation
US3575959A (en) * 1969-05-13 1971-04-20 Merck & Co Inc 5'-substituted ribofuranosyl nucleosides
US3585189A (en) * 1969-06-27 1971-06-15 Syntex Corp Unsaturated nucleosides and processes for their preparation
US3910885A (en) * 1974-03-12 1975-10-07 Syntex Inc 4-Alkoxy nucleosides and intermediates therefore
EP0184365B1 (de) * 1984-12-04 1993-08-04 Eli Lilly And Company Tumorbehandlung bei Säugetieren
GB8708050D0 (en) * 1987-04-03 1987-05-07 Wellcome Found Therapeutic nucleosides
NZ225906A (en) * 1987-08-26 1990-10-26 Merrell Dow Pharma Aristeromycin/adenosine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
NO891248D0 (no) 1989-03-21
CN1023804C (zh) 1994-02-16
NO891248L (no) 1989-09-26
JP2829737B2 (ja) 1998-12-02
ES2074060T3 (es) 1995-09-01
AU3173789A (en) 1989-09-28
DE68922235T2 (de) 1995-08-31
EP0334361A2 (de) 1989-09-27
FI891339A (fi) 1989-09-26
DE68922235D1 (de) 1995-05-24
PH26776A (en) 1992-10-13
FI90877B (fi) 1993-12-31
JPH01283285A (ja) 1989-11-14
ZA892105B (en) 1989-11-29
DK171645B1 (da) 1997-03-03
AU606792B2 (en) 1991-02-14
FI891339A0 (fi) 1989-03-21
CN1036579A (zh) 1989-10-25
IE67543B1 (en) 1996-04-17
FI90877C (fi) 1994-04-11
NO171856B (no) 1993-02-01
PT90080B (pt) 1994-06-30
HU203561B (en) 1991-08-28
DK145289D0 (da) 1989-03-22
IL89689A0 (en) 1989-09-28
HUT49367A (en) 1989-09-28
NO171856C (no) 1993-05-12
NZ228422A (en) 1991-04-26
IE890953L (en) 1989-09-25
KR0135529B1 (ko) 1998-04-23
PT90080A (pt) 1989-11-10
KR890014573A (ko) 1989-10-24
DK145289A (da) 1989-09-26
EP0334361B1 (de) 1995-04-19
CA1322195C (en) 1993-09-14
AR247403A1 (es) 1994-12-29
EP0334361A3 (de) 1991-04-03
US4996308A (en) 1991-02-26

Similar Documents

Publication Publication Date Title
ATE121415T1 (de) Durch acetylen, cyan oder allen substituierte aristeromycin- oder adenosin-derivate.
FI891348A0 (fi) Foerfarande foer tillverkning av papper eller kartong av aoterfoerbrukade, med entzymer behandlade fibrer.
FI840229A (fi) Elektroniskt ledande polypyrroler och kopolymerer av pyrrol, dessa innehaollande kompositioner, foerfaranden foer deras framstaellning och elektrokemiska celler, i vilka de anvaends.
ATE110271T1 (de) 3'-azido-2',3'-dideoxyuridin anti-retrovirale zusammensetzung.
NL192782B (nl) Hoekslagboormachine, alsmede hoekvoorzetstuk hiervoor.
DE3577848D1 (de) -6-substituierte-4-dialkylaminotetrahydrobenz(c,d)indole.
FI850275A0 (fi) Nya 6-susbtituerade furo-(3,4-c) -pyridinderivat.
NO881537L (no) Fremgangsmaate for fremstilling av 6-substituert-2',3'-dideoksynukleosider.
FI873626A (fi) Derivat av 2,5-dihydrofuran med en triazol- eller imidazolgrupp, framstaellningsfoerfarande anvaendning som fungicid.
DE3768334D1 (de) Motorrad mit verkleidung.
FI880916A0 (fi) Anordning foer stabilisering av en materialbana, isynnerhet foer stabilisering av en pappersbana i torkpartiet i en pappersmaskin.
NO895303D0 (no) Boreanordning.
FI881612A (fi) Nya pyrrolidin-2-(1,3-dikarbonyl) -derivat, foerfaranden foer deras framstaellning, dessa innehaollande aemnen saovael som deras anvaendning.
DE3574976D1 (de) N6-substituierte adenosine.
IT1091598B (it) Bloccasterzo,particolarmente per motocicli
FI875397A0 (fi) Substituerade aminometyl-5,6,7,8 -tetrahydronaftyl-oxiaettikasyror, nya mellanprodukter, foerfarande foer deras framstaellning samt deras anvaendning i laekemedel.
DE3682244D1 (de) Substituierte dihydroimidazo(1,2-a)chinoxalinderivate.
ATA3983A (de) Drehschlag-, dreh- oder schlagwerk
YU43157B (en) Process for the recemization of (d)-acid isomers of new derivatives of 5-(2-furoyl)-,5-(2-thenoyl)-,5-(3-furoyl)-and 5-(3-thenoyl)-1,2-dihydro-3h-pyrrolo
NO864987L (no) Heteroaromatiske acetylener, brukbare som antihypertensive midler.
FI871520A (fi) Skivmaterial, foeretraedesvis foer anvaendning som gjutformskiva, uppbyggt av kompositlaminat med glasfibersnoeren i ytterskikten.
FI854180A0 (fi) Foerfarande foer framstaellning av nya 6-fenetylaminoalkyl-furo-(3,4-c)-pyridinderivat.
DE3781748D1 (de) Beschichtungssystem, bestehend aus mehreren kammern.
NO892755D0 (no) Fremgangsmaate til fremstilling av 5,6,7,8-tetrahydro-4h-isoksazol(4,5-d)-azepin-3-olderivater.
FI854774A0 (fi) Syntetisk, organisk tvaettmedelskomposition med antistatisk verkan.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee