ZA886820B - Steroids containing a spiro ring with 3,4 or 6 links in position 17,the process and intermediates for their preparation,their use as medicaments and the pharmaceutical compositions containing them - Google Patents
Steroids containing a spiro ring with 3,4 or 6 links in position 17,the process and intermediates for their preparation,their use as medicaments and the pharmaceutical compositions containing themInfo
- Publication number
- ZA886820B ZA886820B ZA886820A ZA886820A ZA886820B ZA 886820 B ZA886820 B ZA 886820B ZA 886820 A ZA886820 A ZA 886820A ZA 886820 A ZA886820 A ZA 886820A ZA 886820 B ZA886820 B ZA 886820B
- Authority
- ZA
- South Africa
- Prior art keywords
- intermediates
- preparation
- pharmaceutical compositions
- medicaments
- links
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Glass Compositions (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8712937A FR2620707B1 (fr) | 1987-09-18 | 1987-09-18 | Nouveaux steroides comportant un cycle spirannique a 3, 4 ou 6 chainons en position 17, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA886820B true ZA886820B (en) | 1989-11-29 |
Family
ID=9355024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA886820A ZA886820B (en) | 1987-09-18 | 1988-09-13 | Steroids containing a spiro ring with 3,4 or 6 links in position 17,the process and intermediates for their preparation,their use as medicaments and the pharmaceutical compositions containing them |
Country Status (18)
Country | Link |
---|---|
US (1) | US4921846A (pt) |
EP (1) | EP0308345B1 (pt) |
JP (1) | JP2794297B2 (pt) |
KR (1) | KR960013446B1 (pt) |
CN (1) | CN1031942C (pt) |
AT (1) | ATE88716T1 (pt) |
CA (1) | CA1340344C (pt) |
DE (1) | DE3880601T2 (pt) |
DK (1) | DK174268B1 (pt) |
ES (1) | ES2054844T3 (pt) |
FR (1) | FR2620707B1 (pt) |
GR (1) | GR3008221T3 (pt) |
HU (1) | HU199505B (pt) |
IE (1) | IE61751B1 (pt) |
MX (1) | MX174142B (pt) |
PT (1) | PT88536B (pt) |
SU (1) | SU1665877A3 (pt) |
ZA (1) | ZA886820B (pt) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2665901B2 (fr) * | 1989-02-24 | 1994-07-29 | Roussel Uclaf | Nouveaux 19-nor sterouides ayant en position 11beta une chaine carbonee comportant une fonction amide, leur preparation, leur application comme medicaments. |
DE3921059A1 (de) * | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
JP3202224B2 (ja) * | 1989-08-04 | 2001-08-27 | シエーリング アクチエンゲゼルシヤフト | 11β―アリール―ゴナ―4,9―ジエン―3―オン、その製造方法及びそれを含有する調剤学的調製剤 |
FR2651233B1 (fr) * | 1989-08-23 | 1991-12-13 | Roussel Uclaf | Nouveaux acides omega-phenylamino alcanouiques substitues sur le noyau aromatique par un radical derive de 19-norsterouides, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant. |
DE4008584A1 (de) * | 1990-03-15 | 1991-09-26 | Schering Ag | Verfahren zur herstellung von zwischenprodukten fuer die antigestagensynthese (onapristonsynthese) |
EP0471612B1 (fr) * | 1990-08-14 | 1998-01-28 | Roussel Uclaf | Nouveaux 19-Nor stéroides ayant en position 11béta une chaíne carbonée comportant une fonction amide, leur préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant |
US5407928A (en) * | 1990-08-15 | 1995-04-18 | Schering Aktiengesellschaft | 11β-aryl-gona-4,9-dien-3-ones |
CA2100514C (en) * | 1992-07-29 | 2005-03-29 | Johannes A. M. Hamersma | 17-spiromethylene steroids |
FR2757399B1 (fr) * | 1996-12-23 | 1999-12-17 | Hoechst Marion Roussel Inc | Application de composes steroides substitues en 11 pour la fabrication de medicaments ayant une activite estrogene dissociee |
US6020328A (en) * | 1998-03-06 | 2000-02-01 | Research Triangle Institute | 20-keto-11β-arylsteroids and their derivatives having agonist or antagonist hormonal properties |
EP1079859B1 (en) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Crを含むタンパク質に対して特異的な受容体−結合タンパク質(rap)変異体を含む組成物およびその使用 |
EP1862468A1 (de) * | 2006-06-02 | 2007-12-05 | Bayer Schering Pharma Aktiengesellschaft | Kristallines 11beta-(4-Acetylphenyl)-20,20,21,21,21-pentafluor-17-hydroxy-19-nor-17alpha-pregna-4,9-dien-3-on |
DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
DE102009034367A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-benzyliden-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102009034366A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-methylenoxyalkylenaryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034368A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-acyloxyalkylenphenyl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034362A1 (de) | 2009-07-20 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034525A1 (de) | 2009-07-21 | 2011-01-27 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Behandlung von Krankheiten |
DE102009034526A1 (de) | 2009-07-21 | 2011-02-10 | Bayer Schering Pharma Aktiengesellschaft | 17-Hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-ethinylphenyl-Derivate, Verfahren zu deren Herstellung und deren Verwendung zur Behandlung von Krankheiten |
DE102010007719A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
DE102010007722A1 (de) | 2010-02-10 | 2011-08-11 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Progesteronrezeptorantagonisten |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3364207A (en) * | 1962-08-13 | 1968-01-16 | Searle & Co | Polyhydrospiro[estr/androst-4-ene-17, 2'-furan/pyran]-3-one and intermediates |
US3422096A (en) * | 1967-08-08 | 1969-01-14 | Searle & Co | Spiro(estrene/androstene-17,2'-oxetane)-3-one and intermediates |
FR2377418A1 (fr) * | 1977-01-13 | 1978-08-11 | Roussel Uclaf | Nouveaux derives steroides 4,9-dieniques 11b-substitues, leur procede de preparation et leur application comme medicaments |
DE3026783C2 (de) * | 1980-07-11 | 1982-07-29 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 5β-Hydroxy-δ↑6↑-steroiden |
FR2528434B1 (fr) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
FR2522328B1 (fr) * | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
DE3461090D1 (en) * | 1983-02-18 | 1986-12-04 | Schering Ag | 11-beta-aryl-estradienes, process for their preparation and pharmaceutical compositions containing them |
DE3347126A1 (de) * | 1983-12-22 | 1985-07-11 | Schering AG, 1000 Berlin und 4709 Bergkamen | 11ss-aryl-estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate |
DE3410880A1 (de) * | 1984-03-21 | 1985-10-03 | Schering AG, Berlin und Bergkamen, 1000 Berlin | 17-substituierte estradiene und estratriene |
FR2596395B1 (fr) * | 1986-03-26 | 1989-05-26 | Roussel Uclaf | Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant |
-
1987
- 1987-09-18 FR FR8712937A patent/FR2620707B1/fr not_active Expired
-
1988
- 1988-09-13 DK DK198805090A patent/DK174268B1/da not_active IP Right Cessation
- 1988-09-13 ZA ZA886820A patent/ZA886820B/xx unknown
- 1988-09-15 MX MX013052A patent/MX174142B/es unknown
- 1988-09-16 US US07/245,750 patent/US4921846A/en not_active Expired - Lifetime
- 1988-09-16 DE DE88402344T patent/DE3880601T2/de not_active Expired - Fee Related
- 1988-09-16 AT AT88402344T patent/ATE88716T1/de not_active IP Right Cessation
- 1988-09-16 KR KR1019880012057A patent/KR960013446B1/ko not_active IP Right Cessation
- 1988-09-16 IE IE281388A patent/IE61751B1/en not_active IP Right Cessation
- 1988-09-16 PT PT88536A patent/PT88536B/pt not_active IP Right Cessation
- 1988-09-16 HU HU884882A patent/HU199505B/hu not_active IP Right Cessation
- 1988-09-16 SU SU884356859A patent/SU1665877A3/ru active
- 1988-09-16 CA CA000577578A patent/CA1340344C/fr not_active Expired - Fee Related
- 1988-09-16 EP EP88402344A patent/EP0308345B1/fr not_active Expired - Lifetime
- 1988-09-16 ES ES88402344T patent/ES2054844T3/es not_active Expired - Lifetime
- 1988-09-17 CN CN88106811A patent/CN1031942C/zh not_active Expired - Fee Related
- 1988-09-19 JP JP63232746A patent/JP2794297B2/ja not_active Expired - Fee Related
-
1993
- 1993-06-18 GR GR920402858T patent/GR3008221T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2054844T3 (es) | 1994-08-16 |
DK509088A (da) | 1989-05-23 |
HUT48275A (en) | 1989-05-29 |
CN1034207A (zh) | 1989-07-26 |
PT88536A (pt) | 1988-10-01 |
IE882813L (en) | 1989-03-18 |
US4921846A (en) | 1990-05-01 |
DK509088D0 (da) | 1988-09-13 |
JPH01106899A (ja) | 1989-04-24 |
CA1340344C (fr) | 1999-01-26 |
FR2620707A1 (fr) | 1989-03-24 |
CN1031942C (zh) | 1996-06-05 |
EP0308345B1 (fr) | 1993-04-28 |
HU199505B (en) | 1990-02-28 |
JP2794297B2 (ja) | 1998-09-03 |
EP0308345A1 (fr) | 1989-03-22 |
GR3008221T3 (pt) | 1993-09-30 |
SU1665877A3 (ru) | 1991-07-23 |
KR890005143A (ko) | 1989-05-13 |
KR960013446B1 (ko) | 1996-10-05 |
DE3880601T2 (de) | 1993-10-07 |
MX174142B (es) | 1994-04-25 |
PT88536B (pt) | 1992-11-30 |
FR2620707B1 (fr) | 1989-12-08 |
IE61751B1 (en) | 1994-11-30 |
MX13052A (es) | 1993-09-01 |
DE3880601D1 (de) | 1993-06-03 |
DK174268B1 (da) | 2002-10-28 |
ATE88716T1 (de) | 1993-05-15 |
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